> top > docs > PubMed:12239140 > annotations

PubMed:12239140 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.
T2 126-288 Sentence denotes We have identified and cloned a novel human cytokine with homology to cytokines of the interleukin-17 (IL-17) family, which we have termed human IL-17E (hIL-17E).
T3 289-415 Sentence denotes With the identification of several IL-17 family members, it is critical to understand the in vivo function of these molecules.
T4 416-523 Sentence denotes We have generated transgenic mice overexpressing hIL-17E using an apolipoprotein E (ApoE) hepatic promoter.
T5 524-699 Sentence denotes These mice displayed changes in the peripheral blood, particularly, a 3-fold increase in total leukocytes consisting of increases in eosinophils, lymphocytes, and neutrophils.
T6 700-819 Sentence denotes Splenomegaly and lymphoadenopathy were predominant and included marked eosinophil infiltrates and lymphoid hyperplasia.
T7 820-936 Sentence denotes CCR3(+) eosinophils increased in the blood and lymph nodes of the transgenic mice by 50- and 300-fold, respectively.
T8 937-1022 Sentence denotes Eosinophils also increased 8- to 18-fold in the bone marrow and spleen, respectively.
T9 1023-1094 Sentence denotes In the bone marrow, most of the eosinophils had an immature appearance.
T10 1095-1303 Sentence denotes CD19(+) B cells increased 2- to 5-fold in the peripheral blood, 2-fold in the spleen, and 10-fold in the lymph nodes of transgenic mice, whereas CD4(+) T lymphocytes increased 2-fold in both blood and spleen.
T11 1304-1440 Sentence denotes High serum levels of the cytokines IL-2, IL-4, IL-5, granulocyte colony-stimulating factor, eotaxin, and interferon gamma were observed.
T12 1441-1551 Sentence denotes Consistent with B-lymphocyte increases, serum immunoglobulin (Ig) M, IgG, and IgE were significantly elevated.
T13 1552-1720 Sentence denotes Antigenic challenge of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease in anti-KLH IgG accompanied by increases of anti-KLH IgA and IgE.
T14 1721-1851 Sentence denotes In situ hybridization of transgenic tissues revealed that IL-17Rh1 (IL-17BR/Evi27), a receptor that binds IL-17E, is up-regulated.
T15 1852-2007 Sentence denotes Taken together, these data indicate that IL-17E regulates hematopoietic and immune functions, stimulating the development of eosinophils and B lymphocytes.
T16 2008-2215 Sentence denotes The fact that hIL-17E overexpression results in high levels of circulating eosinophils, IL-4, IL-5, eotaxin, and IgE suggests that IL-17E may be a proinflammatory cytokine favoring Th2-type immune responses.
T1 0-125 Sentence denotes Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.
T2 126-288 Sentence denotes We have identified and cloned a novel human cytokine with homology to cytokines of the interleukin-17 (IL-17) family, which we have termed human IL-17E (hIL-17E).
T3 289-415 Sentence denotes With the identification of several IL-17 family members, it is critical to understand the in vivo function of these molecules.
T4 416-523 Sentence denotes We have generated transgenic mice overexpressing hIL-17E using an apolipoprotein E (ApoE) hepatic promoter.
T5 524-699 Sentence denotes These mice displayed changes in the peripheral blood, particularly, a 3-fold increase in total leukocytes consisting of increases in eosinophils, lymphocytes, and neutrophils.
T6 700-819 Sentence denotes Splenomegaly and lymphoadenopathy were predominant and included marked eosinophil infiltrates and lymphoid hyperplasia.
T7 820-936 Sentence denotes CCR3(+) eosinophils increased in the blood and lymph nodes of the transgenic mice by 50- and 300-fold, respectively.
T8 937-1022 Sentence denotes Eosinophils also increased 8- to 18-fold in the bone marrow and spleen, respectively.
T9 1023-1094 Sentence denotes In the bone marrow, most of the eosinophils had an immature appearance.
T10 1095-1303 Sentence denotes CD19(+) B cells increased 2- to 5-fold in the peripheral blood, 2-fold in the spleen, and 10-fold in the lymph nodes of transgenic mice, whereas CD4(+) T lymphocytes increased 2-fold in both blood and spleen.
T11 1304-1440 Sentence denotes High serum levels of the cytokines IL-2, IL-4, IL-5, granulocyte colony-stimulating factor, eotaxin, and interferon gamma were observed.
T12 1441-1551 Sentence denotes Consistent with B-lymphocyte increases, serum immunoglobulin (Ig) M, IgG, and IgE were significantly elevated.
T13 1552-1720 Sentence denotes Antigenic challenge of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease in anti-KLH IgG accompanied by increases of anti-KLH IgA and IgE.
T14 1721-1851 Sentence denotes In situ hybridization of transgenic tissues revealed that IL-17Rh1 (IL-17BR/Evi27), a receptor that binds IL-17E, is up-regulated.
T15 1852-2007 Sentence denotes Taken together, these data indicate that IL-17E regulates hematopoietic and immune functions, stimulating the development of eosinophils and B lymphocytes.
T16 2008-2215 Sentence denotes The fact that hIL-17E overexpression results in high levels of circulating eosinophils, IL-4, IL-5, eotaxin, and IgE suggests that IL-17E may be a proinflammatory cytokine favoring Th2-type immune responses.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 700-712 HP_0001744 denotes Splenomegaly

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 35-41 protein denotes IL-17E
T2 170-178 protein denotes cytokine
T3 196-205 protein denotes cytokines
T4 213-242 protein denotes interleukin-17 (IL-17) family
T5 271-277 protein denotes IL-17E
T6 279-286 protein denotes hIL-17E
T7 324-336 protein denotes IL-17 family
T8 465-472 protein denotes hIL-17E
T9 482-498 protein denotes apolipoprotein E
T10 500-504 protein denotes ApoE
T11 820-824 protein denotes CCR3
T12 1095-1099 protein denotes CD19
T13 1240-1243 protein denotes CD4
T14 1329-1338 protein denotes cytokines
T15 1339-1343 protein denotes IL-2
T16 1345-1349 protein denotes IL-4
T17 1351-1355 protein denotes IL-5
T18 1357-1394 protein denotes granulocyte colony-stimulating factor
T19 1396-1403 protein denotes eotaxin
T20 1409-1425 protein denotes interferon gamma
T21 1487-1508 protein denotes immunoglobulin (Ig) M
T22 1510-1513 protein denotes IgG
T23 1519-1522 protein denotes IgE
T24 1600-1625 protein denotes keyhole limpet hemocyanin
T25 1627-1630 protein denotes KLH
T26 1663-1666 protein denotes KLH
T27 1667-1670 protein denotes IgG
T28 1704-1707 protein denotes KLH
T29 1708-1711 protein denotes IgA
T30 1716-1719 protein denotes IgE
T31 1779-1787 protein denotes IL-17Rh1
T32 1789-1796 protein denotes IL-17BR
T33 1797-1802 protein denotes Evi27
T34 1827-1833 protein denotes IL-17E
T35 1893-1899 protein denotes IL-17E
T36 2022-2029 protein denotes hIL-17E
T37 2096-2100 protein denotes IL-4
T38 2102-2106 protein denotes IL-5
T39 2108-2115 protein denotes eotaxin
T40 2121-2124 protein denotes IgE
T41 2139-2145 protein denotes IL-17E
T42 2171-2179 protein denotes cytokine

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 29-41 protein denotes human IL-17E
T2 170-178 protein denotes cytokine
T3 196-205 protein denotes cytokines
T4 213-235 protein denotes interleukin-17 (IL-17)
T5 265-270 protein denotes human
T6 324-329 protein denotes IL-17
T7 465-472 protein denotes hIL-17E
T8 482-505 protein denotes apolipoprotein E (ApoE)
T9 820-824 protein denotes CCR3
T10 1095-1099 protein denotes CD19
T11 1240-1243 protein denotes CD4
T12 1329-1343 protein denotes cytokines IL-2
T13 1345-1349 protein denotes IL-4
T14 1351-1355 protein denotes IL-5
T15 1357-1394 protein denotes granulocyte colony-stimulating factor
T16 1396-1403 protein denotes eotaxin
T17 1409-1419 protein denotes interferon
T18 1481-1486 protein denotes serum
T19 1510-1513 protein denotes IgG
T20 1519-1522 protein denotes IgE
T21 1600-1631 protein denotes keyhole limpet hemocyanin (KLH)
T22 1658-1670 protein denotes anti-KLH IgG
T23 1699-1711 protein denotes anti-KLH IgA
T24 1716-1719 protein denotes IgE
T25 1779-1787 protein denotes IL-17Rh1
T26 1789-1796 protein denotes IL-17BR
T27 1797-1802 protein denotes Evi27
T28 1807-1815 protein denotes receptor
T29 1827-1833 protein denotes IL-17E
T30 1893-1899 protein denotes IL-17E
T31 2022-2029 protein denotes hIL-17E
T32 2096-2100 protein denotes IL-4
T33 2102-2106 protein denotes IL-5
T34 2108-2115 protein denotes eotaxin
T35 2121-2124 protein denotes IgE
T36 2139-2145 protein denotes IL-17E
T37 2155-2179 protein denotes proinflammatory cytokine
T39 164-178 long_form denotes human cytokine

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12239140-0#35#41#gene64806 35-41 gene64806 denotes IL-17E
12239140-0#53#65#diseaseC0014457 53-65 diseaseC0014457 denotes eosinophilia
12239140-0#53#65#diseaseC1306759 53-65 diseaseC1306759 denotes eosinophilia
12239140-6#0#4#gene1232 820-824 gene1232 denotes CCR3
12239140-6#8#29#diseaseC0014457 828-849 diseaseC0014457 denotes eosinophils increased
35#41#gene6480653#65#diseaseC0014457 12239140-0#35#41#gene64806 12239140-0#53#65#diseaseC0014457 associated_with IL-17E,eosinophilia
35#41#gene6480653#65#diseaseC1306759 12239140-0#35#41#gene64806 12239140-0#53#65#diseaseC1306759 associated_with IL-17E,eosinophilia
0#4#gene12328#29#diseaseC0014457 12239140-6#0#4#gene1232 12239140-6#8#29#diseaseC0014457 associated_with CCR3,eosinophils increased

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 35-41 protein denotes IL-17E
T2 170-178 protein denotes cytokine
T3 196-205 protein denotes cytokines
T4 271-277 protein denotes IL-17E
T5 279-286 acronym denotes hIL-17E
T6 405-414 protein denotes molecules
T7 465-472 protein denotes hIL-17E
T8 1329-1338 protein denotes cytokines
T9 1339-1343 protein denotes IL-2
T10 1345-1349 protein denotes IL-4
T11 1351-1355 protein denotes IL-5
T12 1357-1394 protein denotes granulocyte colony-stimulating factor
T13 1396-1403 protein denotes eotaxin
T14 1409-1419 protein denotes interferon
T15 1487-1508 protein denotes immunoglobulin (Ig) M
T16 1510-1513 protein denotes IgG
T17 1519-1522 protein denotes IgE
T18 1600-1625 protein denotes keyhole limpet hemocyanin
T19 1627-1630 acronym denotes KLH
T20 1658-1670 protein denotes anti-KLH IgG
T21 1699-1719 compound-protein denotes anti-KLH IgA and IgE
T22 1779-1787 protein denotes IL-17Rh1
T23 1789-1802 protein denotes IL-17BR/Evi27
T24 1807-1815 protein denotes receptor
T25 1827-1833 protein denotes IL-17E
T26 1893-1899 protein denotes IL-17E
T27 2022-2029 protein denotes hIL-17E
T28 2096-2100 protein denotes IL-4
T29 2102-2106 protein denotes IL-5
T30 2108-2115 protein denotes eotaxin
T31 2121-2124 protein denotes IgE
T32 2139-2145 protein denotes IL-17E
T33 2171-2179 protein denotes cytokine

DisGeNET

Id Subject Object Predicate Lexical cue
T0 35-41 gene:64806 denotes IL-17E
T1 53-65 disease:C1636667 denotes eosinophilia
T2 35-41 gene:64806 denotes IL-17E
T3 53-65 disease:C0014457 denotes eosinophilia
T4 35-41 gene:64806 denotes IL-17E
T5 53-65 disease:C1306759 denotes eosinophilia
T6 820-824 gene:1232 denotes CCR3
T7 828-849 disease:C0014457 denotes eosinophils increased
R1 T0 T1 associated_with IL-17E,eosinophilia
R2 T2 T3 associated_with IL-17E,eosinophilia
R3 T4 T5 associated_with IL-17E,eosinophilia
R4 T6 T7 associated_with CCR3,eosinophils increased