PubMed:12226101 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/12226101","sourcedb":"PubMed","sourceid":"12226101","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/12226101","text":"Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger.\nThe calcineurin B homologous protein (designated CHP1) has been shown to be a common essential cofactor for the plasma membrane Na(+)/H(+) exchangers (NHEs) (Pang, T., Su, X., Wakabayashi, S., and Shigekawa, M. (2001) J. Biol. Chem. 276, 17367-17372). In this study, we characterized the function of another isoform of CHP (designated CHP2) that has a 61% amino acid identity with CHP1. CHP2, like CHP1, conferred the ability to NHEs 1-3 to express a high exchange activity by binding to the juxtamembrane region of the cytoplasmic domain of the exchanger, but it interacts more strongly (approximately 5-fold) with NHE1 than does CHP1. Although CHP1 is expressed ubiquitously at relatively high levels, CHP2 expression was extremely low in most human tissues but was higher in tumor cells. We produced stable cell clones overexpressing either CHP1 or CHP2 in which one of them is predominantly bound to NHE1. Serum (10%) induced a significant cytoplasmic alkalinization (0.1-0.2 pH unit) in cells co-expressing CHP1 and NHE1 but not in cells co-expressing CHP2 and NHE1. In the latter, pH(i) was high (7.4-7.5) even in the absence of serum, suggesting that NHE1 was already activated. Surprisingly, most (\u003e80%) of CHP2/NHE1 cells unlike CHP1/NHE1 cells were viable even after long serum starvation (\u003e7 days). Thus, the expression of CHP2 appears to protect cells from serum deprivation-induced death by increasing pH(i). These properties of CHP2/NHE1 cells are similar to those of malignantly transformed cells. We propose that serum-independent activation of NHE1 by bound CHP2 is one of the key mechanisms for the maintenance of high pH(i) and the resistance to serum deprivation-induced cell death in malignantly transformed cells.","tracks":[{"project":"GlyCosmos6-UBERON","denotations":[{"id":"T1","span":{"begin":58,"end":63},"obj":"Body_part"},{"id":"T2","span":{"begin":84,"end":88},"obj":"Body_part"},{"id":"T3","span":{"begin":98,"end":103},"obj":"Body_part"},{"id":"T4","span":{"begin":260,"end":275},"obj":"Body_part"},{"id":"T5","span":{"begin":640,"end":653},"obj":"Body_part"},{"id":"T6","span":{"begin":668,"end":679},"obj":"Body_part"},{"id":"T7","span":{"begin":958,"end":962},"obj":"Body_part"},{"id":"T8","span":{"begin":1058,"end":1063},"obj":"Body_part"},{"id":"T9","span":{"begin":1092,"end":1103},"obj":"Body_part"},{"id":"T10","span":{"begin":1283,"end":1288},"obj":"Body_part"},{"id":"T11","span":{"begin":1430,"end":1435},"obj":"Body_part"},{"id":"T12","span":{"begin":1517,"end":1522},"obj":"Body_part"},{"id":"T13","span":{"begin":1677,"end":1682},"obj":"Body_part"},{"id":"T14","span":{"begin":1813,"end":1818},"obj":"Body_part"},{"id":"T15","span":{"begin":1839,"end":1843},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/GO_0005886"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/GO_0005886"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/GO_0005737"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/GO_0005737"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"subj":"T1","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T2","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T3","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T4","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T5","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T6","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T7","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T8","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T9","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T10","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T11","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T12","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T13","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T14","pred":"source","obj":"GlyCosmos6-UBERON"},{"subj":"T15","pred":"source","obj":"GlyCosmos6-UBERON"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":147},"obj":"Sentence"},{"id":"T2","span":{"begin":148,"end":368},"obj":"Sentence"},{"id":"T3","span":{"begin":369,"end":374},"obj":"Sentence"},{"id":"T4","span":{"begin":375,"end":380},"obj":"Sentence"},{"id":"T5","span":{"begin":381,"end":399},"obj":"Sentence"},{"id":"T6","span":{"begin":400,"end":534},"obj":"Sentence"},{"id":"T7","span":{"begin":535,"end":784},"obj":"Sentence"},{"id":"T8","span":{"begin":785,"end":938},"obj":"Sentence"},{"id":"T9","span":{"begin":939,"end":1057},"obj":"Sentence"},{"id":"T10","span":{"begin":1058,"end":1219},"obj":"Sentence"},{"id":"T11","span":{"begin":1220,"end":1333},"obj":"Sentence"},{"id":"T12","span":{"begin":1334,"end":1457},"obj":"Sentence"},{"id":"T13","span":{"begin":1458,"end":1569},"obj":"Sentence"},{"id":"T14","span":{"begin":1570,"end":1660},"obj":"Sentence"},{"id":"T15","span":{"begin":1661,"end":1883},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T15","pred":"source","obj":"sentences"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":467,"end":470},"obj":"Disease"},{"id":"T2","span":{"begin":926,"end":931},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0019789"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"}]},{"project":"GlyCosmos6-CLO","denotations":[{"id":"T1","span":{"begin":84,"end":88},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":116,"end":126},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T3","span":{"begin":613,"end":621},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T4","span":{"begin":932,"end":937},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T5","span":{"begin":958,"end":962},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6","span":{"begin":1140,"end":1145},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7","span":{"begin":1185,"end":1190},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T8","span":{"begin":1323,"end":1332},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T9","span":{"begin":1373,"end":1378},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T10","span":{"begin":1396,"end":1401},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T11","span":{"begin":1506,"end":1511},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T12","span":{"begin":1600,"end":1605},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T13","span":{"begin":1654,"end":1659},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14","span":{"begin":1695,"end":1705},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T15","span":{"begin":1839,"end":1843},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16","span":{"begin":1877,"end":1882},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T2","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T3","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T4","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T5","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T6","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T7","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T8","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T9","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T10","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T11","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T12","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T13","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T14","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T15","pred":"source","obj":"GlyCosmos6-CLO"},{"subj":"T16","pred":"source","obj":"GlyCosmos6-CLO"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":467,"end":470},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":894,"end":899},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:11272"},{"id":"A2","pred":"db_id","subj":"T2","obj":"NCBItxid:9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"}]},{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":14,"end":48},"obj":"protein"},{"id":"T2","span":{"begin":130,"end":146},"obj":"protein"},{"id":"T3","span":{"begin":152,"end":184},"obj":"protein"},{"id":"T4","span":{"begin":197,"end":201},"obj":"protein"},{"id":"T5","span":{"begin":276,"end":297},"obj":"protein"},{"id":"T6","span":{"begin":299,"end":303},"obj":"protein"},{"id":"T7","span":{"begin":467,"end":470},"obj":"protein"},{"id":"T8","span":{"begin":483,"end":487},"obj":"protein"},{"id":"T9","span":{"begin":529,"end":533},"obj":"protein"},{"id":"T10","span":{"begin":535,"end":539},"obj":"protein"},{"id":"T11","span":{"begin":546,"end":550},"obj":"protein"},{"id":"T12","span":{"begin":577,"end":585},"obj":"protein"},{"id":"T13","span":{"begin":764,"end":768},"obj":"protein"},{"id":"T14","span":{"begin":779,"end":783},"obj":"protein"},{"id":"T15","span":{"begin":794,"end":798},"obj":"protein"},{"id":"T16","span":{"begin":852,"end":856},"obj":"protein"},{"id":"T17","span":{"begin":992,"end":996},"obj":"protein"},{"id":"T18","span":{"begin":1000,"end":1004},"obj":"protein"},{"id":"T19","span":{"begin":1052,"end":1056},"obj":"protein"},{"id":"T20","span":{"begin":1160,"end":1164},"obj":"protein"},{"id":"T21","span":{"begin":1169,"end":1173},"obj":"protein"},{"id":"T22","span":{"begin":1205,"end":1209},"obj":"protein"},{"id":"T23","span":{"begin":1214,"end":1218},"obj":"protein"},{"id":"T24","span":{"begin":1306,"end":1310},"obj":"protein"},{"id":"T25","span":{"begin":1363,"end":1367},"obj":"protein"},{"id":"T26","span":{"begin":1368,"end":1372},"obj":"protein"},{"id":"T27","span":{"begin":1386,"end":1390},"obj":"protein"},{"id":"T28","span":{"begin":1391,"end":1395},"obj":"protein"},{"id":"T29","span":{"begin":1482,"end":1486},"obj":"protein"},{"id":"T30","span":{"begin":1590,"end":1594},"obj":"protein"},{"id":"T31","span":{"begin":1595,"end":1599},"obj":"protein"},{"id":"T32","span":{"begin":1709,"end":1713},"obj":"protein"},{"id":"T33","span":{"begin":1723,"end":1727},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"FSU-PRGE"},{"subj":"T2","pred":"source","obj":"FSU-PRGE"},{"subj":"T3","pred":"source","obj":"FSU-PRGE"},{"subj":"T4","pred":"source","obj":"FSU-PRGE"},{"subj":"T5","pred":"source","obj":"FSU-PRGE"},{"subj":"T6","pred":"source","obj":"FSU-PRGE"},{"subj":"T7","pred":"source","obj":"FSU-PRGE"},{"subj":"T8","pred":"source","obj":"FSU-PRGE"},{"subj":"T9","pred":"source","obj":"FSU-PRGE"},{"subj":"T10","pred":"source","obj":"FSU-PRGE"},{"subj":"T11","pred":"source","obj":"FSU-PRGE"},{"subj":"T12","pred":"source","obj":"FSU-PRGE"},{"subj":"T13","pred":"source","obj":"FSU-PRGE"},{"subj":"T14","pred":"source","obj":"FSU-PRGE"},{"subj":"T15","pred":"source","obj":"FSU-PRGE"},{"subj":"T16","pred":"source","obj":"FSU-PRGE"},{"subj":"T17","pred":"source","obj":"FSU-PRGE"},{"subj":"T18","pred":"source","obj":"FSU-PRGE"},{"subj":"T19","pred":"source","obj":"FSU-PRGE"},{"subj":"T20","pred":"source","obj":"FSU-PRGE"},{"subj":"T21","pred":"source","obj":"FSU-PRGE"},{"subj":"T22","pred":"source","obj":"FSU-PRGE"},{"subj":"T23","pred":"source","obj":"FSU-PRGE"},{"subj":"T24","pred":"source","obj":"FSU-PRGE"},{"subj":"T25","pred":"source","obj":"FSU-PRGE"},{"subj":"T26","pred":"source","obj":"FSU-PRGE"},{"subj":"T27","pred":"source","obj":"FSU-PRGE"},{"subj":"T28","pred":"source","obj":"FSU-PRGE"},{"subj":"T29","pred":"source","obj":"FSU-PRGE"},{"subj":"T30","pred":"source","obj":"FSU-PRGE"},{"subj":"T31","pred":"source","obj":"FSU-PRGE"},{"subj":"T32","pred":"source","obj":"FSU-PRGE"},{"subj":"T33","pred":"source","obj":"FSU-PRGE"}]},{"project":"PIR-corpus2","denotations":[{"id":"T1","span":{"begin":14,"end":48},"obj":"protein"},{"id":"T2","span":{"begin":130,"end":136},"obj":"protein"},{"id":"T3","span":{"begin":152,"end":184},"obj":"protein"},{"id":"T4","span":{"begin":197,"end":201},"obj":"protein"},{"id":"T5","span":{"begin":260,"end":286},"obj":"protein"},{"id":"T6","span":{"begin":456,"end":470},"obj":"protein"},{"id":"T7","span":{"begin":483,"end":487},"obj":"protein"},{"id":"T8","span":{"begin":529,"end":533},"obj":"protein"},{"id":"T9","span":{"begin":535,"end":539},"obj":"protein"},{"id":"T10","span":{"begin":546,"end":550},"obj":"protein"},{"id":"T11","span":{"begin":577,"end":583},"obj":"protein"},{"id":"T12","span":{"begin":694,"end":703},"obj":"protein"},{"id":"T13","span":{"begin":764,"end":768},"obj":"protein"},{"id":"T14","span":{"begin":779,"end":783},"obj":"protein"},{"id":"T15","span":{"begin":794,"end":798},"obj":"protein"},{"id":"T16","span":{"begin":852,"end":856},"obj":"protein"},{"id":"T17","span":{"begin":992,"end":996},"obj":"protein"},{"id":"T18","span":{"begin":1000,"end":1004},"obj":"protein"},{"id":"T19","span":{"begin":1052,"end":1056},"obj":"protein"},{"id":"T20","span":{"begin":1160,"end":1164},"obj":"protein"},{"id":"T21","span":{"begin":1169,"end":1173},"obj":"protein"},{"id":"T22","span":{"begin":1205,"end":1209},"obj":"protein"},{"id":"T23","span":{"begin":1214,"end":1218},"obj":"protein"},{"id":"T24","span":{"begin":1306,"end":1310},"obj":"protein"},{"id":"T25","span":{"begin":1363,"end":1367},"obj":"protein"},{"id":"T26","span":{"begin":1368,"end":1372},"obj":"protein"},{"id":"T27","span":{"begin":1386,"end":1390},"obj":"protein"},{"id":"T28","span":{"begin":1391,"end":1395},"obj":"protein"},{"id":"T29","span":{"begin":1482,"end":1486},"obj":"protein"},{"id":"T30","span":{"begin":1590,"end":1594},"obj":"protein"},{"id":"T31","span":{"begin":1595,"end":1599},"obj":"protein"},{"id":"T32","span":{"begin":1709,"end":1713},"obj":"protein"},{"id":"T33","span":{"begin":1723,"end":1727},"obj":"protein"},{"id":"T44","span":{"begin":577,"end":585},"obj":"long_form"}],"attributes":[{"subj":"T1","pred":"source","obj":"PIR-corpus2"},{"subj":"T2","pred":"source","obj":"PIR-corpus2"},{"subj":"T3","pred":"source","obj":"PIR-corpus2"},{"subj":"T4","pred":"source","obj":"PIR-corpus2"},{"subj":"T5","pred":"source","obj":"PIR-corpus2"},{"subj":"T6","pred":"source","obj":"PIR-corpus2"},{"subj":"T7","pred":"source","obj":"PIR-corpus2"},{"subj":"T8","pred":"source","obj":"PIR-corpus2"},{"subj":"T9","pred":"source","obj":"PIR-corpus2"},{"subj":"T10","pred":"source","obj":"PIR-corpus2"},{"subj":"T11","pred":"source","obj":"PIR-corpus2"},{"subj":"T12","pred":"source","obj":"PIR-corpus2"},{"subj":"T13","pred":"source","obj":"PIR-corpus2"},{"subj":"T14","pred":"source","obj":"PIR-corpus2"},{"subj":"T15","pred":"source","obj":"PIR-corpus2"},{"subj":"T16","pred":"source","obj":"PIR-corpus2"},{"subj":"T17","pred":"source","obj":"PIR-corpus2"},{"subj":"T18","pred":"source","obj":"PIR-corpus2"},{"subj":"T19","pred":"source","obj":"PIR-corpus2"},{"subj":"T20","pred":"source","obj":"PIR-corpus2"},{"subj":"T21","pred":"source","obj":"PIR-corpus2"},{"subj":"T22","pred":"source","obj":"PIR-corpus2"},{"subj":"T23","pred":"source","obj":"PIR-corpus2"},{"subj":"T24","pred":"source","obj":"PIR-corpus2"},{"subj":"T25","pred":"source","obj":"PIR-corpus2"},{"subj":"T26","pred":"source","obj":"PIR-corpus2"},{"subj":"T27","pred":"source","obj":"PIR-corpus2"},{"subj":"T28","pred":"source","obj":"PIR-corpus2"},{"subj":"T29","pred":"source","obj":"PIR-corpus2"},{"subj":"T30","pred":"source","obj":"PIR-corpus2"},{"subj":"T31","pred":"source","obj":"PIR-corpus2"},{"subj":"T32","pred":"source","obj":"PIR-corpus2"},{"subj":"T33","pred":"source","obj":"PIR-corpus2"},{"subj":"T44","pred":"source","obj":"PIR-corpus2"}]},{"project":"PIR-corpus1","denotations":[{"id":"T1","span":{"begin":14,"end":48},"obj":"protein"},{"id":"T2","span":{"begin":130,"end":136},"obj":"protein"},{"id":"T3","span":{"begin":152,"end":184},"obj":"protein"},{"id":"T4","span":{"begin":197,"end":201},"obj":"acronym"},{"id":"T5","span":{"begin":276,"end":286},"obj":"protein"},{"id":"T6","span":{"begin":299,"end":303},"obj":"acronym"},{"id":"T7","span":{"begin":456,"end":470},"obj":"protein"},{"id":"T8","span":{"begin":483,"end":487},"obj":"protein"},{"id":"T9","span":{"begin":529,"end":533},"obj":"protein"},{"id":"T10","span":{"begin":535,"end":539},"obj":"protein"},{"id":"T11","span":{"begin":546,"end":550},"obj":"protein"},{"id":"T12","span":{"begin":577,"end":585},"obj":"compound-protein"},{"id":"T13","span":{"begin":694,"end":703},"obj":"protein"},{"id":"T14","span":{"begin":764,"end":768},"obj":"protein"},{"id":"T15","span":{"begin":779,"end":783},"obj":"protein"},{"id":"T16","span":{"begin":794,"end":798},"obj":"protein"},{"id":"T17","span":{"begin":852,"end":856},"obj":"protein"},{"id":"T18","span":{"begin":992,"end":996},"obj":"protein"},{"id":"T19","span":{"begin":1000,"end":1004},"obj":"protein"},{"id":"T20","span":{"begin":1052,"end":1056},"obj":"protein"},{"id":"T21","span":{"begin":1160,"end":1164},"obj":"protein"},{"id":"T22","span":{"begin":1169,"end":1173},"obj":"protein"},{"id":"T23","span":{"begin":1205,"end":1209},"obj":"protein"},{"id":"T24","span":{"begin":1214,"end":1218},"obj":"protein"},{"id":"T25","span":{"begin":1306,"end":1310},"obj":"protein"},{"id":"T26","span":{"begin":1482,"end":1486},"obj":"protein"},{"id":"T27","span":{"begin":1709,"end":1713},"obj":"protein"},{"id":"T28","span":{"begin":1723,"end":1727},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"PIR-corpus1"},{"subj":"T2","pred":"source","obj":"PIR-corpus1"},{"subj":"T3","pred":"source","obj":"PIR-corpus1"},{"subj":"T4","pred":"source","obj":"PIR-corpus1"},{"subj":"T5","pred":"source","obj":"PIR-corpus1"},{"subj":"T6","pred":"source","obj":"PIR-corpus1"},{"subj":"T7","pred":"source","obj":"PIR-corpus1"},{"subj":"T8","pred":"source","obj":"PIR-corpus1"},{"subj":"T9","pred":"source","obj":"PIR-corpus1"},{"subj":"T10","pred":"source","obj":"PIR-corpus1"},{"subj":"T11","pred":"source","obj":"PIR-corpus1"},{"subj":"T12","pred":"source","obj":"PIR-corpus1"},{"subj":"T13","pred":"source","obj":"PIR-corpus1"},{"subj":"T14","pred":"source","obj":"PIR-corpus1"},{"subj":"T15","pred":"source","obj":"PIR-corpus1"},{"subj":"T16","pred":"source","obj":"PIR-corpus1"},{"subj":"T17","pred":"source","obj":"PIR-corpus1"},{"subj":"T18","pred":"source","obj":"PIR-corpus1"},{"subj":"T19","pred":"source","obj":"PIR-corpus1"},{"subj":"T20","pred":"source","obj":"PIR-corpus1"},{"subj":"T21","pred":"source","obj":"PIR-corpus1"},{"subj":"T22","pred":"source","obj":"PIR-corpus1"},{"subj":"T23","pred":"source","obj":"PIR-corpus1"},{"subj":"T24","pred":"source","obj":"PIR-corpus1"},{"subj":"T25","pred":"source","obj":"PIR-corpus1"},{"subj":"T26","pred":"source","obj":"PIR-corpus1"},{"subj":"T27","pred":"source","obj":"PIR-corpus1"},{"subj":"T28","pred":"source","obj":"PIR-corpus1"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"GlyCosmos6-UBERON","color":"#93ecb7","default":true},{"id":"sentences","color":"#ec9d93"},{"id":"mondo_disease","color":"#93a2ec"},{"id":"GlyCosmos6-CLO","color":"#bdec93"},{"id":"NCBITAXON","color":"#ec93d7"},{"id":"FSU-PRGE","color":"#93ece7"},{"id":"PIR-corpus2","color":"#eccd93"},{"id":"PIR-corpus1","color":"#b393ec"}]}]}}