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PubMed:12226101 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 926-937 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063

sentences

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger.
T2 148-368 Sentence denotes The calcineurin B homologous protein (designated CHP1) has been shown to be a common essential cofactor for the plasma membrane Na(+)/H(+) exchangers (NHEs) (Pang, T., Su, X., Wakabayashi, S., and Shigekawa, M. (2001) J.
T3 369-374 Sentence denotes Biol.
T4 375-380 Sentence denotes Chem.
T5 381-399 Sentence denotes 276, 17367-17372).
T6 400-534 Sentence denotes In this study, we characterized the function of another isoform of CHP (designated CHP2) that has a 61% amino acid identity with CHP1.
T7 535-784 Sentence denotes CHP2, like CHP1, conferred the ability to NHEs 1-3 to express a high exchange activity by binding to the juxtamembrane region of the cytoplasmic domain of the exchanger, but it interacts more strongly (approximately 5-fold) with NHE1 than does CHP1.
T8 785-938 Sentence denotes Although CHP1 is expressed ubiquitously at relatively high levels, CHP2 expression was extremely low in most human tissues but was higher in tumor cells.
T9 939-1057 Sentence denotes We produced stable cell clones overexpressing either CHP1 or CHP2 in which one of them is predominantly bound to NHE1.
T10 1058-1219 Sentence denotes Serum (10%) induced a significant cytoplasmic alkalinization (0.1-0.2 pH unit) in cells co-expressing CHP1 and NHE1 but not in cells co-expressing CHP2 and NHE1.
T11 1220-1333 Sentence denotes In the latter, pH(i) was high (7.4-7.5) even in the absence of serum, suggesting that NHE1 was already activated.
T12 1334-1457 Sentence denotes Surprisingly, most (>80%) of CHP2/NHE1 cells unlike CHP1/NHE1 cells were viable even after long serum starvation (>7 days).
T13 1458-1569 Sentence denotes Thus, the expression of CHP2 appears to protect cells from serum deprivation-induced death by increasing pH(i).
T14 1570-1660 Sentence denotes These properties of CHP2/NHE1 cells are similar to those of malignantly transformed cells.
T15 1661-1883 Sentence denotes We propose that serum-independent activation of NHE1 by bound CHP2 is one of the key mechanisms for the maintenance of high pH(i) and the resistance to serum deprivation-induced cell death in malignantly transformed cells.

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 14-48 protein denotes calcineurin B homologous protein 2
T2 130-146 protein denotes Na+/H+ exchanger
T3 152-184 protein denotes calcineurin B homologous protein
T4 197-201 protein denotes CHP1
T5 276-297 protein denotes Na(+)/H(+) exchangers
T6 299-303 protein denotes NHEs
T7 467-470 protein denotes CHP
T8 483-487 protein denotes CHP2
T9 529-533 protein denotes CHP1
T10 535-539 protein denotes CHP2
T11 546-550 protein denotes CHP1
T12 577-585 protein denotes NHEs 1-3
T13 764-768 protein denotes NHE1
T14 779-783 protein denotes CHP1
T15 794-798 protein denotes CHP1
T16 852-856 protein denotes CHP2
T17 992-996 protein denotes CHP1
T18 1000-1004 protein denotes CHP2
T19 1052-1056 protein denotes NHE1
T20 1160-1164 protein denotes CHP1
T21 1169-1173 protein denotes NHE1
T22 1205-1209 protein denotes CHP2
T23 1214-1218 protein denotes NHE1
T24 1306-1310 protein denotes NHE1
T25 1363-1367 protein denotes CHP2
T26 1368-1372 protein denotes NHE1
T27 1386-1390 protein denotes CHP1
T28 1391-1395 protein denotes NHE1
T29 1482-1486 protein denotes CHP2
T30 1590-1594 protein denotes CHP2
T31 1595-1599 protein denotes NHE1
T32 1709-1713 protein denotes NHE1
T33 1723-1727 protein denotes CHP2

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 14-48 protein denotes calcineurin B homologous protein 2
T2 130-136 protein denotes Na+/H+
T3 152-184 protein denotes calcineurin B homologous protein
T4 197-201 protein denotes CHP1
T5 260-286 protein denotes plasma membrane Na(+)/H(+)
T6 456-470 protein denotes isoform of CHP
T7 483-487 protein denotes CHP2
T8 529-533 protein denotes CHP1
T9 535-539 protein denotes CHP2
T10 546-550 protein denotes CHP1
T11 577-583 protein denotes NHEs 1
T12 694-703 protein denotes exchanger
T13 764-768 protein denotes NHE1
T14 779-783 protein denotes CHP1
T15 794-798 protein denotes CHP1
T16 852-856 protein denotes CHP2
T17 992-996 protein denotes CHP1
T18 1000-1004 protein denotes CHP2
T19 1052-1056 protein denotes NHE1
T20 1160-1164 protein denotes CHP1
T21 1169-1173 protein denotes NHE1
T22 1205-1209 protein denotes CHP2
T23 1214-1218 protein denotes NHE1
T24 1306-1310 protein denotes NHE1
T25 1363-1367 protein denotes CHP2
T26 1368-1372 protein denotes NHE1
T27 1386-1390 protein denotes CHP1
T28 1391-1395 protein denotes NHE1
T29 1482-1486 protein denotes CHP2
T30 1590-1594 protein denotes CHP2
T31 1595-1599 protein denotes NHE1
T32 1709-1713 protein denotes NHE1
T33 1723-1727 protein denotes CHP2
T44 577-585 long_form denotes NHEs 1-3

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 14-48 protein denotes calcineurin B homologous protein 2
T2 130-136 protein denotes Na+/H+
T3 152-184 protein denotes calcineurin B homologous protein
T4 197-201 acronym denotes CHP1
T5 276-286 protein denotes Na(+)/H(+)
T6 299-303 acronym denotes NHEs
T7 456-470 protein denotes isoform of CHP
T8 483-487 protein denotes CHP2
T9 529-533 protein denotes CHP1
T10 535-539 protein denotes CHP2
T11 546-550 protein denotes CHP1
T12 577-585 compound-protein denotes NHEs 1-3
T13 694-703 protein denotes exchanger
T14 764-768 protein denotes NHE1
T15 779-783 protein denotes CHP1
T16 794-798 protein denotes CHP1
T17 852-856 protein denotes CHP2
T18 992-996 protein denotes CHP1
T19 1000-1004 protein denotes CHP2
T20 1052-1056 protein denotes NHE1
T21 1160-1164 protein denotes CHP1
T22 1169-1173 protein denotes NHE1
T23 1205-1209 protein denotes CHP2
T24 1214-1218 protein denotes NHE1
T25 1306-1310 protein denotes NHE1
T26 1482-1486 protein denotes CHP2
T27 1709-1713 protein denotes NHE1
T28 1723-1727 protein denotes CHP2

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 926-931 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 467-470 Disease denotes CHP http://purl.obolibrary.org/obo/MONDO_0019789
T2 926-931 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 894-899 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 260-275 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T2 640-653 Body_part denotes juxtamembrane http://purl.obolibrary.org/obo/GO_0005886
T3 668-679 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T4 1092-1103 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737