PubMed:12226101
Annnotations
GlyCosmos6-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 58-63 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T2 | 84-88 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
T3 | 98-103 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T4 | 260-275 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
T5 | 640-653 | Body_part | denotes | juxtamembrane | http://purl.obolibrary.org/obo/GO_0005886 |
T6 | 668-679 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
T7 | 958-962 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
T8 | 1058-1063 | Body_part | denotes | Serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T9 | 1092-1103 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
T10 | 1283-1288 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T11 | 1430-1435 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T12 | 1517-1522 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T13 | 1677-1682 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T14 | 1813-1818 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T15 | 1839-1843 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-147 | Sentence | denotes | Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger. |
T2 | 148-368 | Sentence | denotes | The calcineurin B homologous protein (designated CHP1) has been shown to be a common essential cofactor for the plasma membrane Na(+)/H(+) exchangers (NHEs) (Pang, T., Su, X., Wakabayashi, S., and Shigekawa, M. (2001) J. |
T3 | 369-374 | Sentence | denotes | Biol. |
T4 | 375-380 | Sentence | denotes | Chem. |
T5 | 381-399 | Sentence | denotes | 276, 17367-17372). |
T6 | 400-534 | Sentence | denotes | In this study, we characterized the function of another isoform of CHP (designated CHP2) that has a 61% amino acid identity with CHP1. |
T7 | 535-784 | Sentence | denotes | CHP2, like CHP1, conferred the ability to NHEs 1-3 to express a high exchange activity by binding to the juxtamembrane region of the cytoplasmic domain of the exchanger, but it interacts more strongly (approximately 5-fold) with NHE1 than does CHP1. |
T8 | 785-938 | Sentence | denotes | Although CHP1 is expressed ubiquitously at relatively high levels, CHP2 expression was extremely low in most human tissues but was higher in tumor cells. |
T9 | 939-1057 | Sentence | denotes | We produced stable cell clones overexpressing either CHP1 or CHP2 in which one of them is predominantly bound to NHE1. |
T10 | 1058-1219 | Sentence | denotes | Serum (10%) induced a significant cytoplasmic alkalinization (0.1-0.2 pH unit) in cells co-expressing CHP1 and NHE1 but not in cells co-expressing CHP2 and NHE1. |
T11 | 1220-1333 | Sentence | denotes | In the latter, pH(i) was high (7.4-7.5) even in the absence of serum, suggesting that NHE1 was already activated. |
T12 | 1334-1457 | Sentence | denotes | Surprisingly, most (>80%) of CHP2/NHE1 cells unlike CHP1/NHE1 cells were viable even after long serum starvation (>7 days). |
T13 | 1458-1569 | Sentence | denotes | Thus, the expression of CHP2 appears to protect cells from serum deprivation-induced death by increasing pH(i). |
T14 | 1570-1660 | Sentence | denotes | These properties of CHP2/NHE1 cells are similar to those of malignantly transformed cells. |
T15 | 1661-1883 | Sentence | denotes | We propose that serum-independent activation of NHE1 by bound CHP2 is one of the key mechanisms for the maintenance of high pH(i) and the resistance to serum deprivation-induced cell death in malignantly transformed cells. |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 467-470 | Disease | denotes | CHP | http://purl.obolibrary.org/obo/MONDO_0019789 |
T2 | 926-931 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
GlyCosmos6-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 84-88 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T2 | 116-126 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T3 | 613-621 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T4 | 932-937 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5 | 958-962 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T6 | 1140-1145 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T7 | 1185-1190 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T8 | 1323-1332 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
T9 | 1373-1378 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T10 | 1396-1401 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T11 | 1506-1511 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T12 | 1600-1605 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T13 | 1654-1659 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T14 | 1695-1705 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T15 | 1839-1843 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T16 | 1877-1882 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 467-470 | OrganismTaxon | denotes | CHP | NCBItxid:11272 |
T2 | 894-899 | OrganismTaxon | denotes | human | NCBItxid:9606 |
FSU-PRGE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 14-48 | protein | denotes | calcineurin B homologous protein 2 |
T2 | 130-146 | protein | denotes | Na+/H+ exchanger |
T3 | 152-184 | protein | denotes | calcineurin B homologous protein |
T4 | 197-201 | protein | denotes | CHP1 |
T5 | 276-297 | protein | denotes | Na(+)/H(+) exchangers |
T6 | 299-303 | protein | denotes | NHEs |
T7 | 467-470 | protein | denotes | CHP |
T8 | 483-487 | protein | denotes | CHP2 |
T9 | 529-533 | protein | denotes | CHP1 |
T10 | 535-539 | protein | denotes | CHP2 |
T11 | 546-550 | protein | denotes | CHP1 |
T12 | 577-585 | protein | denotes | NHEs 1-3 |
T13 | 764-768 | protein | denotes | NHE1 |
T14 | 779-783 | protein | denotes | CHP1 |
T15 | 794-798 | protein | denotes | CHP1 |
T16 | 852-856 | protein | denotes | CHP2 |
T17 | 992-996 | protein | denotes | CHP1 |
T18 | 1000-1004 | protein | denotes | CHP2 |
T19 | 1052-1056 | protein | denotes | NHE1 |
T20 | 1160-1164 | protein | denotes | CHP1 |
T21 | 1169-1173 | protein | denotes | NHE1 |
T22 | 1205-1209 | protein | denotes | CHP2 |
T23 | 1214-1218 | protein | denotes | NHE1 |
T24 | 1306-1310 | protein | denotes | NHE1 |
T25 | 1363-1367 | protein | denotes | CHP2 |
T26 | 1368-1372 | protein | denotes | NHE1 |
T27 | 1386-1390 | protein | denotes | CHP1 |
T28 | 1391-1395 | protein | denotes | NHE1 |
T29 | 1482-1486 | protein | denotes | CHP2 |
T30 | 1590-1594 | protein | denotes | CHP2 |
T31 | 1595-1599 | protein | denotes | NHE1 |
T32 | 1709-1713 | protein | denotes | NHE1 |
T33 | 1723-1727 | protein | denotes | CHP2 |
PIR-corpus2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 14-48 | protein | denotes | calcineurin B homologous protein 2 |
T2 | 130-136 | protein | denotes | Na+/H+ |
T3 | 152-184 | protein | denotes | calcineurin B homologous protein |
T4 | 197-201 | protein | denotes | CHP1 |
T5 | 260-286 | protein | denotes | plasma membrane Na(+)/H(+) |
T6 | 456-470 | protein | denotes | isoform of CHP |
T7 | 483-487 | protein | denotes | CHP2 |
T8 | 529-533 | protein | denotes | CHP1 |
T9 | 535-539 | protein | denotes | CHP2 |
T10 | 546-550 | protein | denotes | CHP1 |
T11 | 577-583 | protein | denotes | NHEs 1 |
T12 | 694-703 | protein | denotes | exchanger |
T13 | 764-768 | protein | denotes | NHE1 |
T14 | 779-783 | protein | denotes | CHP1 |
T15 | 794-798 | protein | denotes | CHP1 |
T16 | 852-856 | protein | denotes | CHP2 |
T17 | 992-996 | protein | denotes | CHP1 |
T18 | 1000-1004 | protein | denotes | CHP2 |
T19 | 1052-1056 | protein | denotes | NHE1 |
T20 | 1160-1164 | protein | denotes | CHP1 |
T21 | 1169-1173 | protein | denotes | NHE1 |
T22 | 1205-1209 | protein | denotes | CHP2 |
T23 | 1214-1218 | protein | denotes | NHE1 |
T24 | 1306-1310 | protein | denotes | NHE1 |
T25 | 1363-1367 | protein | denotes | CHP2 |
T26 | 1368-1372 | protein | denotes | NHE1 |
T27 | 1386-1390 | protein | denotes | CHP1 |
T28 | 1391-1395 | protein | denotes | NHE1 |
T29 | 1482-1486 | protein | denotes | CHP2 |
T30 | 1590-1594 | protein | denotes | CHP2 |
T31 | 1595-1599 | protein | denotes | NHE1 |
T32 | 1709-1713 | protein | denotes | NHE1 |
T33 | 1723-1727 | protein | denotes | CHP2 |
T44 | 577-585 | long_form | denotes | NHEs 1-3 |
PIR-corpus1
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 14-48 | protein | denotes | calcineurin B homologous protein 2 |
T2 | 130-136 | protein | denotes | Na+/H+ |
T3 | 152-184 | protein | denotes | calcineurin B homologous protein |
T4 | 197-201 | acronym | denotes | CHP1 |
T5 | 276-286 | protein | denotes | Na(+)/H(+) |
T6 | 299-303 | acronym | denotes | NHEs |
T7 | 456-470 | protein | denotes | isoform of CHP |
T8 | 483-487 | protein | denotes | CHP2 |
T9 | 529-533 | protein | denotes | CHP1 |
T10 | 535-539 | protein | denotes | CHP2 |
T11 | 546-550 | protein | denotes | CHP1 |
T12 | 577-585 | compound-protein | denotes | NHEs 1-3 |
T13 | 694-703 | protein | denotes | exchanger |
T14 | 764-768 | protein | denotes | NHE1 |
T15 | 779-783 | protein | denotes | CHP1 |
T16 | 794-798 | protein | denotes | CHP1 |
T17 | 852-856 | protein | denotes | CHP2 |
T18 | 992-996 | protein | denotes | CHP1 |
T19 | 1000-1004 | protein | denotes | CHP2 |
T20 | 1052-1056 | protein | denotes | NHE1 |
T21 | 1160-1164 | protein | denotes | CHP1 |
T22 | 1169-1173 | protein | denotes | NHE1 |
T23 | 1205-1209 | protein | denotes | CHP2 |
T24 | 1214-1218 | protein | denotes | NHE1 |
T25 | 1306-1310 | protein | denotes | NHE1 |
T26 | 1482-1486 | protein | denotes | CHP2 |
T27 | 1709-1713 | protein | denotes | NHE1 |
T28 | 1723-1727 | protein | denotes | CHP2 |