PubMed:12145192 / 1341-1636 JSONTXT

{"project":"Glycan-Motif","denotations":[{"id":"T17","span":{"begin":45,"end":48},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T18","span":{"begin":45,"end":48},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T19","span":{"begin":291,"end":294},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T20","span":{"begin":291,"end":294},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T17","span":{"begin":45,"end":48},"obj":"Glycan_Motif"},{"id":"T19","span":{"begin":291,"end":294},"obj":"Glycan_Motif"}],"attributes":[{"id":"A17","pred":"image","subj":"T17","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK"},{"id":"A18","pred":"image","subj":"T17","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH"},{"id":"A19","pred":"image","subj":"T19","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK"},{"id":"A20","pred":"image","subj":"T19","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T9","span":{"begin":0,"end":295},"obj":"Sentence"},{"id":"T9","span":{"begin":0,"end":295},"obj":"Sentence"},{"id":"T9","span":{"begin":0,"end":295},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T17","span":{"begin":45,"end":48},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T18","span":{"begin":45,"end":48},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T19","span":{"begin":291,"end":294},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T20","span":{"begin":291,"end":294},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"GlycoBiology-FMA","denotations":[{"id":"_T34","span":{"begin":173,"end":181},"obj":"FMAID:82768"},{"id":"_T35","span":{"begin":173,"end":181},"obj":"FMAID:196757"},{"id":"_T36","span":{"begin":222,"end":227},"obj":"FMAID:169002"},{"id":"_T37","span":{"begin":222,"end":227},"obj":"FMAID:68646"},{"id":"_T38","span":{"begin":273,"end":278},"obj":"FMAID:169002"},{"id":"_T39","span":{"begin":273,"end":278},"obj":"FMAID:68646"},{"id":"_T40","span":{"begin":273,"end":287},"obj":"FMAID:226227"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"uniprot-human","denotations":[{"id":"T7","span":{"begin":106,"end":109},"obj":"http://www.uniprot.org/uniprot/P01133"},{"id":"T8","span":{"begin":159,"end":162},"obj":"http://www.uniprot.org/uniprot/P01133"},{"id":"T15","span":{"begin":64,"end":67},"obj":"http://www.uniprot.org/uniprot/Q9NNZ5"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"uniprot-mouse","denotations":[{"id":"T7","span":{"begin":106,"end":109},"obj":"http://www.uniprot.org/uniprot/P01132"},{"id":"T8","span":{"begin":159,"end":162},"obj":"http://www.uniprot.org/uniprot/P01132"},{"id":"T15","span":{"begin":64,"end":67},"obj":"http://www.uniprot.org/uniprot/Q99N14"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T9","span":{"begin":222,"end":227},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T10","span":{"begin":273,"end":278},"obj":"http://purl.bioontology.org/ontology/STY/T025"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"GO-BP","denotations":[{"id":"T20","span":{"begin":64,"end":67},"obj":"http://purl.obolibrary.org/obo/GO_0004673"},{"id":"T25","span":{"begin":260,"end":266},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T31","span":{"begin":182,"end":197},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"GO-MF","denotations":[{"id":"T7","span":{"begin":106,"end":109},"obj":"http://purl.obolibrary.org/obo/GO_0005154"},{"id":"T8","span":{"begin":159,"end":162},"obj":"http://purl.obolibrary.org/obo/GO_0005154"},{"id":"T9","span":{"begin":246,"end":249},"obj":"http://purl.obolibrary.org/obo/GO_0005154"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"GO-CC","denotations":[{"id":"T8","span":{"begin":222,"end":227},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T9","span":{"begin":273,"end":278},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T9","span":{"begin":45,"end":48},"obj":"Glycan"},{"id":"T10","span":{"begin":291,"end":294},"obj":"Glycan"}],"attributes":[{"id":"A9","pred":"glycosmos_id","subj":"T9","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A19","pred":"image","subj":"T9","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"},{"id":"A10","pred":"glycosmos_id","subj":"T10","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A20","pred":"image","subj":"T10","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T9","span":{"begin":0,"end":295},"obj":"Sentence"},{"id":"T9","span":{"begin":0,"end":295},"obj":"Sentence"},{"id":"T9","span":{"begin":0,"end":295},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T9","span":{"begin":0,"end":295},"obj":"Sentence"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T9","span":{"begin":45,"end":48},"obj":"Glycan"},{"id":"T10","span":{"begin":291,"end":294},"obj":"Glycan"}],"attributes":[{"id":"A9","pred":"glycosmos_id","subj":"T9","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A19","pred":"image","subj":"T9","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"},{"id":"A10","pred":"glycosmos_id","subj":"T10","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A20","pred":"image","subj":"T10","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"}],"text":"In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3."}