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c_corpus

Id Subject Object Predicate Lexical cue
T1 16-33 D015179 denotes colorectal tumors
T2 16-33 D015179 denotes colorectal tumors
T5 53-89 D003123 denotes hereditary nonpolyposis colon cancer
T6 53-89 D003123 denotes hereditary nonpolyposis colon cancer
T7 77-82 UBERON:0001155 denotes colon
T11 120-134 SO:0000289 denotes microsatellite
T12 120-146 D053842 denotes microsatellite instability
T13 120-146 D053842 denotes microsatellite instability
T14 152-162 UBERON:0012652 denotes colorectum
T15 167-186 UBERON:0001295 denotes uterine endometrium
T18 232-268 D003123 denotes hereditary nonpolyposis colon cancer
T19 232-268 D003123 denotes hereditary nonpolyposis colon cancer
T20 256-261 UBERON:0001155 denotes colon
T24 303-308 UBERON:0000062 denotes organ
T25 303-308 UBERON:0003103 denotes organ
T26 344-357 D063646 denotes tumorigenesis
T27 344-357 D063646 denotes tumorigenesis
T30 390-393 SO:0000352 denotes DNA
T28 390-393 GO:0005574 denotes DNA
T29 390-393 CHEBI:16991 denotes DNA
T31 390-393 D004247 denotes DNA
T32 394-409 GO:0006298 denotes mismatch repair
T33 411-414 GO:0006298 denotes MMR
T34 411-414 CVCL_E779 denotes MMR
T35 411-414 P22897 denotes MMR
T36 411-414 PR:000002972 denotes MMR
T37 411-414 Q61830 denotes MMR
T38 469-483 SO:0000289 denotes microsatellite
T39 513-532 D016889 denotes endometrial cancers
T40 513-532 D016889 denotes endometrial cancers
T43 592-595 GO:0006298 denotes MMR
T44 592-595 CVCL_E779 denotes MMR
T45 592-595 P22897 denotes MMR
T46 592-595 PR:000002972 denotes MMR
T47 592-595 Q61830 denotes MMR
T51 602-606 CVCL_G669 denotes MLH1
T48 602-606 PR:Q9ZRV4 denotes MLH1
T49 602-606 PR:P38920 denotes MLH1
T50 602-606 PR:Q54KD8 denotes MLH1
T52 602-606 PR:Q9JK91 denotes MLH1
T53 602-606 PR:P97679 denotes MLH1
T54 602-606 PR:Q9P7W6 denotes MLH1
T55 602-606 PR:000010442 denotes MLH1
T56 602-606 PR:P40692 denotes MLH1
T58 610-613 CHEBI:16768 denotes MSH
T62 610-613 D009074 denotes MSH
T63 610-613 D009074 denotes MSH
T64 610-614 PR:000010666 denotes MSH2
T65 610-614 PR:P25847 denotes MSH2
T66 610-614 PR:P43246 denotes MSH2
T67 610-614 P22711 denotes MSH2
T68 610-614 PR:P22711 denotes MSH2
T69 610-614 PR:P54275 denotes MSH2
T70 610-614 PR:O74773 denotes MSH2
T71 610-614 PR:P43247 denotes MSH2
T72 610-614 PR:Q553L4 denotes MSH2
T73 610-614 PR:O24617 denotes MSH2
T74 640-643 Q63276 denotes BAT
T75 640-643 PR:000004614 denotes BAT
T77 640-643 Q14032 denotes BAT
T78 640-643 Q91X34 denotes BAT
T76 640-643 UBERON:0001348 denotes BAT
T79 647-650 Q63276 denotes BAT
T80 647-650 PR:000004614 denotes BAT
T82 647-650 Q14032 denotes BAT
T83 647-650 Q91X34 denotes BAT
T81 647-650 UBERON:0001348 denotes BAT
T84 658-661 Q63276 denotes BAT
T85 658-661 PR:000004614 denotes BAT
T87 658-661 Q14032 denotes BAT
T88 658-661 Q91X34 denotes BAT
T86 658-661 UBERON:0001348 denotes BAT
T89 676-690 CHEBI:29075 denotes mononucleotide
T91 700-703 CHEBI:16768 denotes MSH
T95 700-703 D009074 denotes MSH
T96 700-703 D009074 denotes MSH
T97 700-704 PR:P52701 denotes MSH6
T98 700-704 PR:P54276 denotes MSH6
T99 700-704 PR:Q9VUM0 denotes MSH6
T100 700-704 PR:Q55GU9 denotes MSH6
T101 700-704 PR:O04716 denotes MSH6
T102 700-704 PR:Q03834 denotes MSH6
T103 700-704 PR:O74502 denotes MSH6
T104 700-704 PR:000010670 denotes MSH6
T106 706-709 CHEBI:16768 denotes MSH
T110 706-709 D009074 denotes MSH
T111 706-709 D009074 denotes MSH
T112 706-710 PR:O65607 denotes MSH3
T113 706-710 PR:000010667 denotes MSH3
T114 706-710 PR:Q59Y41 denotes MSH3
T115 706-710 PR:P25336 denotes MSH3
T116 706-710 PR:P20585 denotes MSH3
T117 706-710 PR:P26359 denotes MSH3
T118 706-710 PR:P13705 denotes MSH3
T119 706-710 PR:Q1ZXH0 denotes MSH3
T120 712-716 PR:F4JN26 denotes MLH3
T121 712-716 PR:Q12083 denotes MLH3
T122 712-716 PR:000010443 denotes MLH3
T123 712-716 PR:Q9UHC1 denotes MLH3
T125 718-721 PR:000035019 denotes BAX
T126 718-721 PR:Q07813 denotes BAX
T127 718-721 PR:P27297 denotes BAX
T128 718-721 PR:Q07812 denotes BAX
T129 718-721 PR:Q63690 denotes BAX
T130 718-721 PR:000002193 denotes BAX
T124 718-721 CVCL_N585 denotes BAX
T133 723-727 D007335 denotes IGF2
T136 723-727 D007335 denotes IGF2
T139 723-728 PR:000001333 denotes IGF2R
T140 723-728 PR:Q07113 denotes IGF2R
T141 723-728 PR:P11717 denotes IGF2R
T142 730-738 PR:000000046 denotes TGF beta
T143 730-738 D016212 denotes TGF beta
T144 730-738 D016212 denotes TGF beta
T147 748-752 PR:P60484 denotes PTEN
T149 748-752 PR:O08586 denotes PTEN
T150 748-752 PR:Q8T9S7 denotes PTEN
T151 748-752 PR:000028746 denotes PTEN
T148 748-752 D006223 denotes PTEN
T152 766-770 PR:Q9ZRV4 denotes MLH1
T153 766-770 PR:P38920 denotes MLH1
T154 766-770 PR:Q54KD8 denotes MLH1
T156 766-770 PR:Q9JK91 denotes MLH1
T157 766-770 PR:P97679 denotes MLH1
T158 766-770 PR:Q9P7W6 denotes MLH1
T159 766-770 PR:000010442 denotes MLH1
T160 766-770 PR:P40692 denotes MLH1
T155 766-770 CVCL_G669 denotes MLH1
T162 776-779 CHEBI:16768 denotes MSH
T166 776-779 D009074 denotes MSH
T167 776-779 D009074 denotes MSH
T168 776-780 PR:000010666 denotes MSH2
T169 776-780 PR:P25847 denotes MSH2
T170 776-780 PR:P43246 denotes MSH2
T171 776-780 P22711 denotes MSH2
T172 776-780 PR:P22711 denotes MSH2
T173 776-780 PR:P54275 denotes MSH2
T174 776-780 PR:O74773 denotes MSH2
T175 776-780 PR:P43247 denotes MSH2
T176 776-780 PR:Q553L4 denotes MSH2
T177 776-780 PR:O24617 denotes MSH2
T178 788-800 CHEBI:47885 denotes dinucleotide
T179 822-825 PR:000004924 denotes CA7
T180 822-825 PR:P43166 denotes CA7
T181 822-825 PR:Q9ERQ8 denotes CA7
T182 912-917 D009369 denotes tumor
T183 912-917 D009369 denotes tumor
T184 933-951 D015179 denotes colorectal cancers
T185 933-951 D015179 denotes colorectal cancers
T188 1017-1020 Q63276 denotes BAT
T189 1017-1020 PR:000004614 denotes BAT
T191 1017-1020 Q14032 denotes BAT
T192 1017-1020 Q91X34 denotes BAT
T190 1017-1020 UBERON:0001348 denotes BAT
T193 1037-1043 D009369 denotes tumors
T194 1037-1043 D009369 denotes tumors
T195 1046-1054 PR:000000046 denotes TGF beta
T196 1046-1054 D016212 denotes TGF beta
T197 1046-1054 D016212 denotes TGF beta
T200 1066-1078 CHEBI:47885 denotes dinucleotide
T202 1094-1097 CHEBI:16768 denotes MSH
T206 1094-1097 D009074 denotes MSH
T207 1094-1097 D009074 denotes MSH
T208 1094-1098 PR:O65607 denotes MSH3
T209 1094-1098 PR:000010667 denotes MSH3
T210 1094-1098 PR:Q59Y41 denotes MSH3
T211 1094-1098 PR:P25336 denotes MSH3
T212 1094-1098 PR:P20585 denotes MSH3
T213 1094-1098 PR:P26359 denotes MSH3
T214 1094-1098 PR:P13705 denotes MSH3
T215 1094-1098 PR:Q1ZXH0 denotes MSH3
T217 1110-1113 PR:000035019 denotes BAX
T218 1110-1113 PR:Q07813 denotes BAX
T219 1110-1113 PR:P27297 denotes BAX
T220 1110-1113 PR:Q07812 denotes BAX
T221 1110-1113 PR:Q63690 denotes BAX
T222 1110-1113 PR:000002193 denotes BAX
T216 1110-1113 CVCL_N585 denotes BAX
T223 1163-1182 D016889 denotes endometrial cancers
T224 1163-1182 D016889 denotes endometrial cancers
T227 1284-1289 D009369 denotes tumor
T228 1284-1289 D009369 denotes tumor
T229 1305-1324 D016889 denotes endometrial cancers
T230 1305-1324 D016889 denotes endometrial cancers
T233 1341-1359 D015179 denotes colorectal cancers
T234 1341-1359 D015179 denotes colorectal cancers
T237 1403-1406 Q63276 denotes BAT
T238 1403-1406 PR:000004614 denotes BAT
T240 1403-1406 Q14032 denotes BAT
T241 1403-1406 Q91X34 denotes BAT
T239 1403-1406 UBERON:0001348 denotes BAT
T242 1444-1463 D016889 denotes endometrial cancers
T243 1444-1463 D016889 denotes endometrial cancers
T246 1473-1477 CHEBI:131461 denotes 3 bp
T247 1482-1500 D015179 denotes colorectal cancers
T248 1482-1500 D015179 denotes colorectal cancers
T251 1559-1563 PR:P60484 denotes PTEN
T253 1559-1563 PR:O08586 denotes PTEN
T254 1559-1563 PR:Q8T9S7 denotes PTEN
T255 1559-1563 PR:000028746 denotes PTEN
T252 1559-1563 D006223 denotes PTEN
T256 1596-1615 D016889 denotes endometrial cancers
T257 1596-1615 D016889 denotes endometrial cancers
T260 1620-1628 PR:000000046 denotes TGF beta
T261 1620-1628 D016212 denotes TGF beta
T262 1620-1628 D016212 denotes TGF beta
T265 1650-1655 UBERON:0001155 denotes colon
T266 1650-1663 D003110 denotes colon cancers
T267 1650-1663 D003110 denotes colon cancers
T270 1719-1737 D015179 denotes colorectal cancers
T271 1719-1737 D015179 denotes colorectal cancers
T274 1756-1778 D020022 denotes genetic predisposition
T275 1756-1778 D020022 denotes genetic predisposition
T276 1790-1795 UBERON:0000062 denotes organ
T277 1790-1795 UBERON:0003103 denotes organ
T278 1865-1870 D009369 denotes tumor
T279 1865-1870 D009369 denotes tumor

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 256-268 HP_0003003 denotes colon cancer
T2 256-268 HP_0100273 denotes colon cancer
T3 262-268 HP_0002664 denotes cancer
T4 525-532 HP_0002664 denotes cancers
T5 912-917 HP_0002664 denotes tumor
T6 944-951 HP_0002664 denotes cancers
T7 1037-1043 HP_0002664 denotes tumors
T8 1175-1182 HP_0002664 denotes cancers
T9 1284-1289 HP_0002664 denotes tumor
T10 1317-1324 HP_0002664 denotes cancers
T11 1352-1359 HP_0002664 denotes cancers
T12 1456-1463 HP_0002664 denotes cancers
T13 1493-1500 HP_0002664 denotes cancers
T14 1608-1615 HP_0002664 denotes cancers
T15 1650-1663 HP_0003003 denotes colon cancers
T16 1650-1663 HP_0100273 denotes colon cancers
T17 1656-1663 HP_0002664 denotes cancers
T18 1730-1737 HP_0002664 denotes cancers
T19 1865-1870 HP_0002664 denotes tumor

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-147 DRI_Background denotes Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability.
T2 148-340 DRI_Background denotes The colorectum and uterine endometrium are the two most commonly affected organs in hereditary nonpolyposis colon cancer (HNPCC), but the genetic basis of organ selection is poorly understood.
T3 341-615 DRI_Outcome denotes As tumorigenesis in HNPCC is driven by deficient DNA mismatch repair (MMR), we compared its typical consequence, instability at microsatellite sequences, in colorectal and endometrial cancers from patients with identical predisposing mutations in the MMR genes MLH1 or MSH2.
T4 616-924 DRI_Unspecified denotes Analysis of non-coding (BAT25, BAT26, and BAT40) and coding mononucleotide repeats (MSH6, MSH3, MLH3, BAX, IGF2R, TGF beta RII, and PTEN), as well as MLH1- and MSH2-linked dinucleotide repeats (D3S1611 and CA7) revealed significant differences, both quantitative and qualitative, between the two tumor types.
T5 925-1183 DRI_Outcome denotes Whereas colorectal cancers displayed a predominant pattern consisting of instability at the BAT loci (in 89% of tumors), TGF beta RII (73%), dinucleotide repeats (70%), MSH3 (43%), and BAX (30%), no such single pattern was discernible in endometrial cancers.
T6 1184-1513 DRI_Approach denotes Instead, the pattern was more heterogeneous and involved a lower proportion of unstable markers per tumor (mean 0.27 for endometrial cancers versus 0.45 for colorectal cancers, P < 0.001) and shorter allelic shifts for BAT markers (average 5.1 bp for unstable endometrial cancers versus 9.3 bp for colorectal cancers, P < 0.001).
T7 1514-1664 DRI_Outcome denotes Among the individual putative "target" loci, PTEN instability was associated with endometrial cancers and TGF beta RII instability with colon cancers.
T8 1665-1880 DRI_Outcome denotes The different instability profiles in endometrial and colorectal cancers despite identical genetic predisposition underlines organ-specific differences that may be important determinants of the HNPCC tumor spectrum.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12057899-4#169#173#gene4437 1094-1098 gene4437 denotes MSH3
12057899-4#185#188#gene581 1110-1113 gene581 denotes BAX
12057899-4#238#257#diseaseC0476089 1163-1182 diseaseC0476089 denotes endometrial cancers
12057899-5#219#222#gene570 1403-1406 gene570 denotes BAT
12057899-5#121#140#diseaseC0476089 1305-1324 diseaseC0476089 denotes endometrial cancers
12057899-5#157#175#diseaseC1527249 1341-1359 diseaseC1527249 denotes colorectal cancers
12057899-5#260#279#diseaseC0476089 1444-1463 diseaseC0476089 denotes endometrial cancers
12057899-5#298#316#diseaseC1527249 1482-1500 diseaseC1527249 denotes colorectal cancers
12057899-6#45#49#gene5728 1557-1561 gene5728 denotes , PT
12057899-6#82#101#diseaseC0476089 1594-1613 diseaseC0476089 denotes h endometrial cance
12057899-6#136#149#diseaseC0007102 1648-1661 diseaseC0007102 denotes h colon cance
169#173#gene4437238#257#diseaseC0476089 12057899-4#169#173#gene4437 12057899-4#238#257#diseaseC0476089 associated_with MSH3,endometrial cancers
185#188#gene581238#257#diseaseC0476089 12057899-4#185#188#gene581 12057899-4#238#257#diseaseC0476089 associated_with BAX,endometrial cancers
219#222#gene570121#140#diseaseC0476089 12057899-5#219#222#gene570 12057899-5#121#140#diseaseC0476089 associated_with BAT,endometrial cancers
219#222#gene570157#175#diseaseC1527249 12057899-5#219#222#gene570 12057899-5#157#175#diseaseC1527249 associated_with BAT,colorectal cancers
219#222#gene570260#279#diseaseC0476089 12057899-5#219#222#gene570 12057899-5#260#279#diseaseC0476089 associated_with BAT,endometrial cancers
219#222#gene570298#316#diseaseC1527249 12057899-5#219#222#gene570 12057899-5#298#316#diseaseC1527249 associated_with BAT,colorectal cancers
45#49#gene572882#101#diseaseC0476089 12057899-6#45#49#gene5728 12057899-6#82#101#diseaseC0476089 associated_with ", PT",h endometrial cance
45#49#gene5728136#149#diseaseC0007102 12057899-6#45#49#gene5728 12057899-6#136#149#diseaseC0007102 associated_with ", PT",h colon cance

DisGeNET

Id Subject Object Predicate Lexical cue
T0 592-595 gene:4360 denotes MMR
T1 513-532 disease:C0476089 denotes endometrial cancers
T2 602-606 gene:4292 denotes MLH1
T3 513-532 disease:C0476089 denotes endometrial cancers
T4 610-614 gene:4436 denotes MSH2
T5 513-532 disease:C0476089 denotes endometrial cancers
T6 1110-1113 gene:581 denotes BAX
T7 1163-1182 disease:C0476089 denotes endometrial cancers
T8 1094-1098 gene:4437 denotes MSH3
T9 1163-1182 disease:C0476089 denotes endometrial cancers
T10 1017-1020 gene:570 denotes BAT
T11 933-951 disease:C1527249 denotes colorectal cancers
T12 1017-1020 gene:570 denotes BAT
T13 1163-1182 disease:C0476089 denotes endometrial cancers
T14 1403-1406 gene:570 denotes BAT
T15 1482-1500 disease:C1527249 denotes colorectal cancers
T16 1403-1406 gene:570 denotes BAT
T17 1444-1463 disease:C0476089 denotes endometrial cancers
T18 1403-1406 gene:570 denotes BAT
T19 1305-1324 disease:C0476089 denotes endometrial cancers
T20 1403-1406 gene:570 denotes BAT
T21 1341-1359 disease:C1527249 denotes colorectal cancers
T22 1559-1563 gene:5728 denotes PTEN
T23 1596-1615 disease:C0476089 denotes endometrial cancers
T24 1559-1563 gene:5728 denotes PTEN
T25 1650-1663 disease:C0007102 denotes colon cancers
R1 T0 T1 associated_with MMR,endometrial cancers
R2 T2 T3 associated_with MLH1,endometrial cancers
R3 T4 T5 associated_with MSH2,endometrial cancers
R4 T6 T7 associated_with BAX,endometrial cancers
R5 T8 T9 associated_with MSH3,endometrial cancers
R6 T10 T11 associated_with BAT,colorectal cancers
R7 T12 T13 associated_with BAT,endometrial cancers
R8 T14 T15 associated_with BAT,colorectal cancers
R9 T16 T17 associated_with BAT,endometrial cancers
R10 T18 T19 associated_with BAT,endometrial cancers
R11 T20 T21 associated_with BAT,colorectal cancers
R12 T22 T23 associated_with PTEN,endometrial cancers
R13 T24 T25 associated_with PTEN,colon cancers