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PubMed:11877386 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-58 Sentence denotes Structural determinants of BRCA1 translational regulation.
T2 59-158 Sentence denotes The BRCA1 gene is involved in sporadic breast and ovarian cancer mainly through reduced expression.
T3 159-247 Sentence denotes BRCA1 mRNAs containing different leader sequences show different patterns of expression.
T4 248-423 Sentence denotes In a normal mammary gland mRNA with a shorter leader sequence, 5'-UTRa is expressed only, whereas in breast cancer tissue mRNA with a longer leader, 5'-UTRb is expressed also.
T5 424-546 Sentence denotes We show that the translation efficiency of transcripts containing 5'-UTRb is 10 times lower than those containing 5'-UTRa.
T6 547-726 Sentence denotes The structures of 5'-UTRa and 5'-UTRb were determined by chemical and enzymatic probing aided by a new method developed for monitoring the number of co-existing stable conformers.
T7 727-892 Sentence denotes Specific factors responsible for reduced translation of mRNA containing 5'-UTRb were determined using a variety of transcripts with mutations in the leader sequence.
T8 893-1000 Sentence denotes These factors include a stable secondary structure formed by truncated Alu element and upstream AUG codons.
T9 1001-1102 Sentence denotes The novel mechanism by which BRCA1 may be involved in sporadic breast and ovarian cancer is proposed.
T10 1103-1198 Sentence denotes It is based on the expression patterns of BRCA1 mRNAs and differences in their translatability.
T11 1199-1473 Sentence denotes According to this mechanism the deregulation of the BRCA1 transcription in cancer, resulting in a higher proportion of translationally inhibited transcripts containing 5'-UTRb, contributes to the decrease in the BRCA1 protein observed in sporadic breast and ovarian cancers.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 260-273 http://purl.obolibrary.org/obo/MAT_0000073 denotes mammary gland
T2 268-273 http://purl.obolibrary.org/obo/MAT_0000021 denotes gland

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11877386-10#52#57#gene672 1251-1256 gene672 denotes BRCA1
11877386-10#212#217#gene672 1411-1416 gene672 denotes BRCA1
11877386-10#258#273#diseaseC0029925 1457-1472 diseaseC0029925 denotes ovarian cancers
11877386-10#258#273#diseaseC1140680 1457-1472 diseaseC1140680 denotes ovarian cancers
11877386-10#258#273#diseaseC0029925 1457-1472 diseaseC0029925 denotes ovarian cancers
11877386-10#258#273#diseaseC1140680 1457-1472 diseaseC1140680 denotes ovarian cancers
52#57#gene672258#273#diseaseC0029925 11877386-10#52#57#gene672 11877386-10#258#273#diseaseC0029925 associated_with BRCA1,ovarian cancers
52#57#gene672258#273#diseaseC1140680 11877386-10#52#57#gene672 11877386-10#258#273#diseaseC1140680 associated_with BRCA1,ovarian cancers
52#57#gene672258#273#diseaseC0029925 11877386-10#52#57#gene672 11877386-10#258#273#diseaseC0029925 associated_with BRCA1,ovarian cancers
52#57#gene672258#273#diseaseC1140680 11877386-10#52#57#gene672 11877386-10#258#273#diseaseC1140680 associated_with BRCA1,ovarian cancers
212#217#gene672258#273#diseaseC0029925 11877386-10#212#217#gene672 11877386-10#258#273#diseaseC0029925 associated_with BRCA1,ovarian cancers
212#217#gene672258#273#diseaseC1140680 11877386-10#212#217#gene672 11877386-10#258#273#diseaseC1140680 associated_with BRCA1,ovarian cancers
212#217#gene672258#273#diseaseC0029925 11877386-10#212#217#gene672 11877386-10#258#273#diseaseC0029925 associated_with BRCA1,ovarian cancers
212#217#gene672258#273#diseaseC1140680 11877386-10#212#217#gene672 11877386-10#258#273#diseaseC1140680 associated_with BRCA1,ovarian cancers

CoMAGC

Id Subject Object Predicate Lexical cue
T1 1411-1424 Gene denotes BRCA1 protein
E2 1395-1403 Negative_regulation denotes decrease
T2 1457-1472 ovarian cancer denotes ovarian cancers
R1 T1 E2 themeOf BRCA1 protein,decrease
R3 T1 T2 CGE-decreased BRCA1 protein,ovarian cancers
R4 T1 T2 CCS-normalTOcancer BRCA1 protein,ovarian cancers
R5 T1 T2 PT-observation BRCA1 protein,ovarian cancers
R3 T1 T2 IGE-unchanged BRCA1 protein,ovarian cancers

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1030-1035 gene:672 denotes BRCA1
T1 1075-1089 disease:C0029925 denotes ovarian cancer
T2 1030-1035 gene:672 denotes BRCA1
T3 1075-1089 disease:C1140680 denotes ovarian cancer
R1 T0 T1 associated_with BRCA1,ovarian cancer
R2 T2 T3 associated_with BRCA1,ovarian cancer

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 260-273 Body_part denotes mammary gland http://purl.obolibrary.org/obo/MAT_0000073

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 109-123 Phenotype denotes ovarian cancer HP:0100615
T2 349-362 Phenotype denotes breast cancer HP:0003002
T3 1075-1089 Phenotype denotes ovarian cancer HP:0100615
T4 1274-1280 Phenotype denotes cancer HP:0002664
T5 1457-1472 Phenotype denotes ovarian cancers HP:0100615

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 109-123 Disease denotes ovarian cancer http://purl.obolibrary.org/obo/MONDO_0008170
T2 349-362 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 1075-1089 Disease denotes ovarian cancer http://purl.obolibrary.org/obo/MONDO_0008170
T4 1274-1280 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T5 1457-1472 Disease denotes ovarian cancers http://purl.obolibrary.org/obo/MONDO_0008170

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 98-104 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 260-273 Body_part denotes mammary gland http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200
T4 349-355 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 363-369 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T6 1064-1070 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T7 1446-1452 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310