PubMed:11815617
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-119 | Sentence | denotes | Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. |
| T2 | 120-275 | Sentence | denotes | Apolipoprotein B (apoB) mRNA editing involves site-specific deamination of cytidine to form uridine, resulting in the production of an in-frame stop codon. |
| T3 | 276-452 | Sentence | denotes | Protein translated from edited mRNA is associated with a reduced risk of atherosclerosis, and hence the protein factors that regulate hepatic apoB mRNA editing are of interest. |
| T4 | 453-587 | Sentence | denotes | A human protein essential for apoB mRNA editing and an eight-amino acid-longer variant of no known function have been recently cloned. |
| T5 | 588-758 | Sentence | denotes | We report that both proteins, henceforth referred to as ACF64 and ACF65, supported APOBEC-1 (the catalytic subunit of the editosome) equivalently in editing of apoB mRNA. |
| T6 | 759-816 | Sentence | denotes | They are encoded by a single 82-kb gene on chromosome 10. |
| T7 | 817-961 | Sentence | denotes | The transcripts are encoded by 15 exons that are expressed from a tissue-specific promoter minimally contained within the -0.33-kb DNA sequence. |
| T8 | 962-1061 | Sentence | denotes | ACF64 and ACF65 mRNAs are expressed in both liver and intestinal cells in an approximate 1:4 ratio. |
| T9 | 1062-1191 | Sentence | denotes | Exon 11 is alternatively spliced to include or exclude 24 nucleotides of exon 12, thereby encoding ACF65 and ACF64, respectively. |
| T10 | 1192-1349 | Sentence | denotes | Recognition motifs for the serine/arginine-rich (SR) proteins SC35, SRp40, SRp55, and SF2/ASF involved in alternative RNA splicing were predicted in exon 12. |
| T11 | 1350-1519 | Sentence | denotes | Overexpression of these SR proteins in liver cells demonstrated that alternative splicing of a minigene-derived transcript to express ACF65 was enhanced 6-fold by SRp40. |
| T12 | 1520-1655 | Sentence | denotes | The data account for the expression of two editing factors and provide a possible explanation for their different levels of expression. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1006-1011 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T2 | 1016-1026 | http://purl.obolibrary.org/obo/MAT_0000043 | denotes | intestinal |
| T3 | 1389-1394 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
FSU-PRGE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-43 | protein | denotes | apolipoprotein B |
| T2 | 120-136 | protein | denotes | Apolipoprotein B |
| T3 | 138-142 | protein | denotes | apoB |
| T4 | 418-422 | protein | denotes | apoB |
| T5 | 483-487 | protein | denotes | apoB |
| T6 | 644-649 | protein | denotes | ACF64 |
| T7 | 654-659 | protein | denotes | ACF65 |
| T8 | 671-679 | protein | denotes | APOBEC-1 |
| T9 | 748-752 | protein | denotes | apoB |
| T10 | 962-967 | protein | denotes | ACF64 |
| T11 | 972-977 | protein | denotes | ACF65 |
| T12 | 1161-1166 | protein | denotes | ACF65 |
| T13 | 1171-1176 | protein | denotes | ACF64 |
| T14 | 1254-1258 | protein | denotes | SC35 |
| T15 | 1260-1265 | protein | denotes | SRp40 |
| T16 | 1267-1272 | protein | denotes | SRp55 |
| T17 | 1278-1281 | protein | denotes | SF2 |
| T18 | 1282-1285 | protein | denotes | ASF |
| T19 | 1484-1489 | protein | denotes | ACF65 |
| T20 | 1513-1518 | protein | denotes | SRp40 |
PIR-corpus2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-43 | protein | denotes | apolipoprotein B |
| T2 | 121-143 | protein | denotes | polipoprotein B (apoB) |
| T3 | 410-422 | protein | denotes | hepatic apoB |
| T4 | 483-487 | protein | denotes | apoB |
| T5 | 644-649 | protein | denotes | ACF64 |
| T6 | 654-659 | protein | denotes | ACF65 |
| T7 | 671-679 | protein | denotes | APOBEC-1 |
| T8 | 685-719 | protein | denotes | catalytic subunit of the editosome |
| T9 | 748-752 | protein | denotes | apoB |
| T10 | 962-967 | protein | denotes | ACF64 |
| T11 | 972-977 | protein | denotes | ACF65 |
| T12 | 1161-1166 | protein | denotes | ACF65 |
| T13 | 1171-1176 | protein | denotes | ACF64 |
| T14 | 1219-1258 | protein | denotes | serine/arginine-rich (SR) proteins SC35 |
| T15 | 1260-1265 | protein | denotes | SRp40 |
| T16 | 1267-1272 | protein | denotes | SRp55 |
| T17 | 1278-1281 | protein | denotes | SF2 |
| T18 | 1282-1285 | protein | denotes | ASF |
| T19 | 1374-1385 | protein | denotes | SR proteins |
| T20 | 1484-1489 | protein | denotes | ACF65 |
| T21 | 1513-1518 | protein | denotes | SRp40 |
PIR-corpus1
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-12 | protein | denotes | proteins |
| T2 | 121-136 | protein | denotes | polipoprotein B |
| T3 | 138-142 | acronym | denotes | apoB |
| T4 | 276-283 | protein | denotes | Protein |
| T5 | 380-395 | protein | denotes | protein factors |
| T6 | 461-468 | protein | denotes | protein |
| T7 | 608-616 | protein | denotes | proteins |
| T8 | 644-649 | protein | denotes | ACF64 |
| T9 | 654-659 | protein | denotes | ACF65 |
| T10 | 671-679 | protein | denotes | APOBEC-1 |
| T11 | 685-719 | protein | denotes | catalytic subunit of the editosome |
| T12 | 1161-1166 | protein | denotes | ACF65 |
| T13 | 1171-1176 | protein | denotes | ACF64 |
| T14 | 1219-1253 | protein | denotes | serine/arginine-rich (SR) proteins |
| T15 | 1254-1258 | protein | denotes | SC35 |
| T16 | 1260-1265 | protein | denotes | SRp40 |
| T17 | 1267-1272 | protein | denotes | SRp55 |
| T18 | 1278-1285 | protein | denotes | SF2/ASF |
| T19 | 1374-1385 | protein | denotes | SR proteins |
| T20 | 1484-1489 | protein | denotes | ACF65 |
| T21 | 1513-1518 | protein | denotes | SRp40 |
| T22 | 1563-1578 | protein | denotes | editing factors |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 349-364 | Phenotype | denotes | atherosclerosis | HP:0002621 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 349-364 | Disease | denotes | atherosclerosis | http://purl.obolibrary.org/obo/MONDO_0005311 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 455-460 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 802-812 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
| T2 | 883-889 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T3 | 1006-1011 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T4 | 1389-1394 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1006-1011 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T2 | 1016-1026 | Body_part | denotes | intestinal | http://purl.obolibrary.org/obo/MAT_0000043 |
| T3 | 1389-1394 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |