PubMed:11792966 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11792966","sourcedb":"PubMed","sourceid":"11792966","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11792966","text":"Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome.\nPURPOSE: Chronic prostatitis-chronic pelvic pain syndrome is a disease of unknown pathogenesis. We investigated whether the chronic inflammation and pain experienced by patients may be caused by an imbalance of proinflammatory versus anti-inflammatory cytokines within the prostate, namely interleukin (IL)-8, interferon-gamma and IL-2 versus IL-10. We measured these inflammatory cytokines in seminal plasma as a reflection of the prostate environment.\nMATERIALS AND METHODS: We measured levels of IL-8, interferon-gamma, IL-2 and IL-10 in the seminal plasma of 31 patients with chronic prostatitis-chronic pelvic pain syndrome and 14 controls using enzyme-linked immunosorbent assay. Results were correlated with health related quality of life, as measured by the Multidimensional Pain Inventory, McGill pain questionnaire and International Prostate Symptom Score.\nRESULTS: The cytokines analyzed were detectable in the seminal plasma of patients with chronic prostatitis-chronic pelvic pain syndrome and controls. Interferon-gamma, IL-2 and IL-10 levels were statistically greater in patients. Furthermore, IL-10 levels correlated directly with measures of life interference (r = 0.52, p \u003c0.01) and pain severity (r = 0.53, p \u003c0 0.01), and inversely with spousal support (r = -0.39, p \u003c0.04).\nCONCLUSIONS: Our study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis-chronic pelvic pain 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