PubMed:11792966 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":107},"obj":"Sentence"},{"id":"T2","span":{"begin":108,"end":116},"obj":"Sentence"},{"id":"T3","span":{"begin":117,"end":203},"obj":"Sentence"},{"id":"T4","span":{"begin":204,"end":457},"obj":"Sentence"},{"id":"T5","span":{"begin":458,"end":561},"obj":"Sentence"},{"id":"T6","span":{"begin":562,"end":584},"obj":"Sentence"},{"id":"T7","span":{"begin":585,"end":793},"obj":"Sentence"},{"id":"T8","span":{"begin":794,"end":974},"obj":"Sentence"},{"id":"T9","span":{"begin":975,"end":983},"obj":"Sentence"},{"id":"T10","span":{"begin":984,"end":1124},"obj":"Sentence"},{"id":"T11","span":{"begin":1125,"end":1204},"obj":"Sentence"},{"id":"T12","span":{"begin":1205,"end":1403},"obj":"Sentence"},{"id":"T13","span":{"begin":1404,"end":1416},"obj":"Sentence"},{"id":"T14","span":{"begin":1417,"end":1562},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":107},"obj":"Sentence"},{"id":"T2","span":{"begin":108,"end":116},"obj":"Sentence"},{"id":"T3","span":{"begin":117,"end":203},"obj":"Sentence"},{"id":"T4","span":{"begin":204,"end":457},"obj":"Sentence"},{"id":"T5","span":{"begin":458,"end":561},"obj":"Sentence"},{"id":"T6","span":{"begin":562,"end":584},"obj":"Sentence"},{"id":"T7","span":{"begin":585,"end":793},"obj":"Sentence"},{"id":"T8","span":{"begin":794,"end":974},"obj":"Sentence"},{"id":"T9","span":{"begin":975,"end":983},"obj":"Sentence"},{"id":"T10","span":{"begin":984,"end":1124},"obj":"Sentence"},{"id":"T11","span":{"begin":1125,"end":1204},"obj":"Sentence"},{"id":"T12","span":{"begin":1205,"end":1403},"obj":"Sentence"},{"id":"T13","span":{"begin":1404,"end":1416},"obj":"Sentence"},{"id":"T14","span":{"begin":1417,"end":1562},"obj":"Sentence"}],"text":"Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome.\nPURPOSE: Chronic prostatitis-chronic pelvic pain syndrome is a disease of unknown pathogenesis. We investigated whether the chronic inflammation and pain experienced by patients may be caused by an imbalance of proinflammatory versus anti-inflammatory cytokines within the prostate, namely interleukin (IL)-8, interferon-gamma and IL-2 versus IL-10. We measured these inflammatory cytokines in seminal plasma as a reflection of the prostate environment.\nMATERIALS AND METHODS: We measured levels of IL-8, interferon-gamma, IL-2 and IL-10 in the seminal plasma of 31 patients with chronic prostatitis-chronic pelvic pain syndrome and 14 controls using enzyme-linked immunosorbent assay. Results were correlated with health related quality of life, as measured by the Multidimensional Pain Inventory, McGill pain questionnaire and International Prostate Symptom Score.\nRESULTS: The cytokines analyzed were detectable in the seminal plasma of patients with chronic prostatitis-chronic pelvic pain syndrome and controls. Interferon-gamma, IL-2 and IL-10 levels were statistically greater in patients. Furthermore, IL-10 levels correlated directly with measures of life interference (r = 0.52, p \u003c0.01) and pain severity (r = 0.53, p \u003c0 0.01), and inversely with spousal support (r = -0.39, p \u003c0.04).\nCONCLUSIONS: Our study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis-chronic pelvic pain syndrome."}

{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":0,"end":14},"obj":"protein"},{"id":"T2","span":{"begin":360,"end":369},"obj":"protein"},{"id":"T3","span":{"begin":398,"end":416},"obj":"protein"},{"id":"T4","span":{"begin":418,"end":434},"obj":"protein"},{"id":"T5","span":{"begin":439,"end":443},"obj":"protein"},{"id":"T6","span":{"begin":451,"end":456},"obj":"protein"},{"id":"T7","span":{"begin":489,"end":498},"obj":"protein"},{"id":"T8","span":{"begin":607,"end":611},"obj":"protein"},{"id":"T9","span":{"begin":613,"end":629},"obj":"protein"},{"id":"T10","span":{"begin":631,"end":635},"obj":"protein"},{"id":"T11","span":{"begin":640,"end":645},"obj":"protein"},{"id":"T12","span":{"begin":988,"end":997},"obj":"protein"},{"id":"T13","span":{"begin":1125,"end":1141},"obj":"protein"},{"id":"T14","span":{"begin":1143,"end":1147},"obj":"protein"},{"id":"T15","span":{"begin":1152,"end":1157},"obj":"protein"},{"id":"T16","span":{"begin":1218,"end":1223},"obj":"protein"},{"id":"T17","span":{"begin":1441,"end":1446},"obj":"protein"}],"text":"Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome.\nPURPOSE: Chronic prostatitis-chronic pelvic pain syndrome is a disease of unknown pathogenesis. We investigated whether the chronic inflammation and pain experienced by patients may be caused by an imbalance of proinflammatory versus anti-inflammatory cytokines within the prostate, namely interleukin (IL)-8, interferon-gamma and IL-2 versus IL-10. We measured these inflammatory cytokines in seminal plasma as a reflection of the prostate environment.\nMATERIALS AND METHODS: We measured levels of IL-8, interferon-gamma, IL-2 and IL-10 in the seminal plasma of 31 patients with chronic prostatitis-chronic pelvic pain syndrome and 14 controls using enzyme-linked immunosorbent assay. Results were correlated with health related quality of life, as measured by the Multidimensional Pain Inventory, McGill pain questionnaire and International Prostate Symptom Score.\nRESULTS: The cytokines analyzed were detectable in the seminal plasma of patients with chronic prostatitis-chronic pelvic pain syndrome and controls. Interferon-gamma, IL-2 and IL-10 levels were statistically greater in patients. Furthermore, IL-10 levels correlated directly with measures of life interference (r = 0.52, p \u003c0.01) and pain severity (r = 0.53, p \u003c0 0.01), and inversely with spousal support (r = -0.39, p \u003c0.04).\nCONCLUSIONS: Our study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis-chronic pelvic pain syndrome."}

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":0,"end":14},"obj":"protein"},{"id":"T2","span":{"begin":398,"end":416},"obj":"protein"},{"id":"T3","span":{"begin":418,"end":434},"obj":"protein"},{"id":"T4","span":{"begin":439,"end":443},"obj":"protein"},{"id":"T5","span":{"begin":451,"end":456},"obj":"protein"},{"id":"T6","span":{"begin":607,"end":611},"obj":"protein"},{"id":"T7","span":{"begin":613,"end":629},"obj":"protein"},{"id":"T8","span":{"begin":631,"end":635},"obj":"protein"},{"id":"T9","span":{"begin":640,"end":645},"obj":"protein"},{"id":"T10","span":{"begin":1125,"end":1141},"obj":"protein"},{"id":"T11","span":{"begin":1143,"end":1147},"obj":"protein"},{"id":"T12","span":{"begin":1152,"end":1157},"obj":"protein"},{"id":"T13","span":{"begin":1218,"end":1223},"obj":"protein"},{"id":"T14","span":{"begin":1441,"end":1446},"obj":"protein"}],"text":"Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome.\nPURPOSE: Chronic prostatitis-chronic pelvic pain syndrome is a disease of unknown pathogenesis. We investigated whether the chronic inflammation and pain experienced by patients may be caused by an imbalance of proinflammatory versus anti-inflammatory cytokines within the prostate, namely interleukin (IL)-8, interferon-gamma and IL-2 versus IL-10. We measured these inflammatory cytokines in seminal plasma as a reflection of the prostate environment.\nMATERIALS AND METHODS: We measured levels of IL-8, interferon-gamma, IL-2 and IL-10 in the seminal plasma of 31 patients with chronic prostatitis-chronic pelvic pain syndrome and 14 controls using enzyme-linked immunosorbent assay. Results were correlated with health related quality of life, as measured by the Multidimensional Pain Inventory, McGill pain questionnaire and International Prostate Symptom Score.\nRESULTS: The cytokines analyzed were detectable in the seminal plasma of patients with chronic prostatitis-chronic pelvic pain syndrome and controls. Interferon-gamma, IL-2 and IL-10 levels were statistically greater in patients. Furthermore, IL-10 levels correlated directly with measures of life interference (r = 0.52, p \u003c0.01) and pain severity (r = 0.53, p \u003c0 0.01), and inversely with spousal support (r = -0.39, p \u003c0.04).\nCONCLUSIONS: Our study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis-chronic pelvic pain syndrome."}