PubMed:11489449 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11489449","sourcedb":"PubMed","sourceid":"11489449","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11489449","text":"Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats.\nThis study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.","tracks":[{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":111,"end":314},"obj":"DRI_Challenge"},{"id":"T2","span":{"begin":315,"end":450},"obj":"DRI_Background"},{"id":"T3","span":{"begin":451,"end":507},"obj":"DRI_Background"},{"id":"T4","span":{"begin":508,"end":607},"obj":"DRI_Outcome"},{"id":"T5","span":{"begin":608,"end":726},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"}]},{"project":"SMAFIRA_Feedback_Research_Goal","denotations":[{"id":"T1","span":{"begin":143,"end":152},"obj":"something"},{"id":"T2","span":{"begin":200,"end":250},"obj":"something"}],"attributes":[{"subj":"T1","pred":"source","obj":"SMAFIRA_Feedback_Research_Goal"},{"subj":"T2","pred":"source","obj":"SMAFIRA_Feedback_Research_Goal"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":110},"obj":"DRI_Challenge"},{"id":"T2","span":{"begin":111,"end":314},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":315,"end":450},"obj":"DRI_Background"},{"id":"T4","span":{"begin":451,"end":507},"obj":"DRI_Background"},{"id":"T5","span":{"begin":508,"end":607},"obj":"DRI_Outcome"},{"id":"T6","span":{"begin":608,"end":726},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubMed_ArguminSci","color":"#ec9d93","default":true},{"id":"SMAFIRA_Feedback_Research_Goal","color":"#93a2ec"},{"id":"UseCases_ArguminSci_Discourse","color":"#bcec93"}]}]}}