PubMed:11489449 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	111-314	DRI_Challenge	denotes	This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device.
T2	315-450	DRI_Background	denotes	TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury.
T3	451-507	DRI_Background	denotes	Treatment of rats with memantine (10 and 20 mg/Kg, i.p.)
T4	508-607	DRI_Outcome	denotes	immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions.
T5	608-726	DRI_Challenge	denotes	This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.

Id	Subject	Object	Predicate	Lexical cue
T1	143-152	something	denotes	memantine
T2	200-250	something	denotes	neuroprotective after traumatic brain injury (TBI)

Id	Subject	Object	Predicate	Lexical cue
T1	0-110	DRI_Challenge	denotes	Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats.
T2	111-314	DRI_Challenge	denotes	This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device.
T3	315-450	DRI_Background	denotes	TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury.
T4	451-507	DRI_Background	denotes	Treatment of rats with memantine (10 and 20 mg/Kg, i.p.)
T5	508-607	DRI_Outcome	denotes	immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions.
T6	608-726	DRI_Challenge	denotes	This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.