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PubMed:11485999 JSONTXT

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GGDB-2020

Id Subject Object Predicate Lexical cue
T1 39-71 https://acgg.asia/db/ggdb/info/gg077 denotes beta-1,4-galactosyltransferase I
T2 209-241 https://acgg.asia/db/ggdb/info/gg077 denotes beta-1,4-Galactosyltransferase 1
T3 375-380 https://acgg.asia/db/ggdb/info/gg184 denotes Gal-T
T4 660-665 https://acgg.asia/db/ggdb/info/gg184 denotes Gal-T

ggdb-test

Id Subject Object Predicate Lexical cue
T1 39-71 https://acgg.asia/db/ggdb/info/gg077 denotes beta-1,4-galactosyltransferase I
T2 209-241 https://acgg.asia/db/ggdb/info/gg077 denotes beta-1,4-Galactosyltransferase 1
T3 375-380 https://acgg.asia/db/ggdb/info/gg184 denotes Gal-T
T4 660-665 https://acgg.asia/db/ggdb/info/gg184 denotes Gal-T

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 99-106 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T2 116-123 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T3 127-146 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T4 204-207 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T5 243-246 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T6 261-270 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T8 272-275 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T9 286-289 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T10 293-312 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T11 375-378 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T12 448-451 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T13 455-458 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T14 523-530 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T15 532-535 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T16 546-549 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T17 599-602 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T18 660-663 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T19 775-778 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T20 879-882 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T21 1077-1080 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T22 1195-1198 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T23 1222-1225 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T24 1320-1323 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T25 1399-1402 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T26 1427-1430 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T27 1528-1531 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T28 1536-1539 Glycan_Motif denotes Gal https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T29 1654-1657 Glycan_Motif denotes Glc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG

sentences

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes alpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine.
T2 148-208 Sentence denotes Crystal structure of beta 4Gal-T1 x LA complex with UDP-Glc.
T3 209-391 Sentence denotes beta-1,4-Galactosyltransferase 1 (Gal-T1) transfers galactose (Gal) from UDP-Gal to N-acetylglucosamine (GlcNAc), which constitutes its normal galactosyltransferase (Gal-T) activity.
T4 392-504 Sentence denotes In the presence of alpha-lactalbumin (LA), it transfers Gal to Glc, which is its lactose synthase (LS) activity.
T5 505-675 Sentence denotes It also transfers glucose (Glc) from UDP-Glc to GlcNAc, constituting the glucosyltransferase (Glc-T) activity, albeit at an efficiency of only 0.3-0.4% of Gal-T activity.
T6 676-753 Sentence denotes In the present study, we show that LA increases this activity almost 30-fold.
T7 754-846 Sentence denotes It also enhances the Glc-T activity toward various N-acyl substituted glucosamine acceptors.
T8 847-981 Sentence denotes Steady state kinetic studies of Glc-T reaction show that the K(m) for the donor and acceptor substrates are high in the absence of LA.
T9 982-1107 Sentence denotes In the presence of LA, the K(m) for the acceptor substrate is reduced 30-fold, whereas for UDP-Glc it is reduced only 5-fold.
T10 1108-1335 Sentence denotes In order to understand this property, we have determined the crystal structures of the Gal-T1.LA complex with UDP-Glc x Mn(2+) and with N-butanoyl-glucosamine (N-butanoyl-GlcN), a preferred sugar acceptor in the Glc-T activity.
T11 1336-1543 Sentence denotes The crystal structures reveal that although the binding of UDP-Glc is quite similar to UDP-Gal, there are few significant differences observed in the hydrogen bonding interactions between UDP-Glc and Gal-T1.
T12 1544-1687 Sentence denotes Based on the present kinetic and crystal structural studies, a possible explanation for the role of LA in the Glc-T activity has been proposed.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 99-106 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T2 116-123 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T3 127-146 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T4 261-270 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T5 261-270 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose
T6 293-312 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T7 523-530 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

glycogenes

Id Subject Object Predicate Lexical cue
PD-GlycoGenes20190927-B_T1 209-241 https://acgg.asia/db/ggdb/info/gg077 denotes beta-1,4-Galactosyltransferase 1
PD-GlycoGenes20190927-B_T2 375-380 https://acgg.asia/db/ggdb/info/gg184 denotes Gal-T
PD-GlycoGenes20190927-B_T3 660-665 https://acgg.asia/db/ggdb/info/gg184 denotes Gal-T
PD-GlycoGenes20190927-B_T4 1669-1672 https://acgg.asia/db/ggdb/info/gg135 denotes has

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 127-146 chem:24139 denotes N-acetylglucosamine
PD-NGLY1-deficiency-B_T2 293-312 chem:24139 denotes N-acetylglucosamine
PD-NGLY1-deficiency-B_T3 314-320 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T4 553-559 chem:24139 denotes GlcNAc

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 473-480 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 34-38 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913

sentences

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes alpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine.
T2 148-208 Sentence denotes Crystal structure of beta 4Gal-T1 x LA complex with UDP-Glc.
T3 209-391 Sentence denotes beta-1,4-Galactosyltransferase 1 (Gal-T1) transfers galactose (Gal) from UDP-Gal to N-acetylglucosamine (GlcNAc), which constitutes its normal galactosyltransferase (Gal-T) activity.
T4 392-504 Sentence denotes In the presence of alpha-lactalbumin (LA), it transfers Gal to Glc, which is its lactose synthase (LS) activity.
T5 505-675 Sentence denotes It also transfers glucose (Glc) from UDP-Glc to GlcNAc, constituting the glucosyltransferase (Glc-T) activity, albeit at an efficiency of only 0.3-0.4% of Gal-T activity.
T6 676-753 Sentence denotes In the present study, we show that LA increases this activity almost 30-fold.
T7 754-846 Sentence denotes It also enhances the Glc-T activity toward various N-acyl substituted glucosamine acceptors.
T8 847-981 Sentence denotes Steady state kinetic studies of Glc-T reaction show that the K(m) for the donor and acceptor substrates are high in the absence of LA.
T9 982-1107 Sentence denotes In the presence of LA, the K(m) for the acceptor substrate is reduced 30-fold, whereas for UDP-Glc it is reduced only 5-fold.
T10 1108-1335 Sentence denotes In order to understand this property, we have determined the crystal structures of the Gal-T1.LA complex with UDP-Glc x Mn(2+) and with N-butanoyl-glucosamine (N-butanoyl-GlcN), a preferred sugar acceptor in the Glc-T activity.
T11 1336-1543 Sentence denotes The crystal structures reveal that although the binding of UDP-Glc is quite similar to UDP-Gal, there are few significant differences observed in the hydrogen bonding interactions between UDP-Glc and Gal-T1.
T12 1544-1687 Sentence denotes Based on the present kinetic and crystal structural studies, a possible explanation for the role of LA in the Glc-T activity has been proposed.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes alpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine.
T2 148-208 Sentence denotes Crystal structure of beta 4Gal-T1 x LA complex with UDP-Glc.
T3 209-391 Sentence denotes beta-1,4-Galactosyltransferase 1 (Gal-T1) transfers galactose (Gal) from UDP-Gal to N-acetylglucosamine (GlcNAc), which constitutes its normal galactosyltransferase (Gal-T) activity.
T4 392-504 Sentence denotes In the presence of alpha-lactalbumin (LA), it transfers Gal to Glc, which is its lactose synthase (LS) activity.
T5 505-675 Sentence denotes It also transfers glucose (Glc) from UDP-Glc to GlcNAc, constituting the glucosyltransferase (Glc-T) activity, albeit at an efficiency of only 0.3-0.4% of Gal-T activity.
T6 676-753 Sentence denotes In the present study, we show that LA increases this activity almost 30-fold.
T7 754-846 Sentence denotes It also enhances the Glc-T activity toward various N-acyl substituted glucosamine acceptors.
T8 847-981 Sentence denotes Steady state kinetic studies of Glc-T reaction show that the K(m) for the donor and acceptor substrates are high in the absence of LA.
T9 982-1107 Sentence denotes In the presence of LA, the K(m) for the acceptor substrate is reduced 30-fold, whereas for UDP-Glc it is reduced only 5-fold.
T10 1108-1335 Sentence denotes In order to understand this property, we have determined the crystal structures of the Gal-T1.LA complex with UDP-Glc x Mn(2+) and with N-butanoyl-glucosamine (N-butanoyl-GlcN), a preferred sugar acceptor in the Glc-T activity.
T11 1336-1543 Sentence denotes The crystal structures reveal that although the binding of UDP-Glc is quite similar to UDP-Gal, there are few significant differences observed in the hydrogen bonding interactions between UDP-Glc and Gal-T1.
T12 1544-1687 Sentence denotes Based on the present kinetic and crystal structural studies, a possible explanation for the role of LA in the Glc-T activity has been proposed.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 473-480 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 34-38 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913