> top > docs > PubMed:11404174 > annotations

PubMed:11404174 JSONTXT

Annnotations TAB JSON ListView MergeView

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-102 DRI_Background denotes Increased matrix metalloproteinase 9 activity and mRNA expression in lung ischemia-reperfusion injury.
T2 109-257 DRI_Challenge denotes IVES: In lung ischemia-reperfusion injury, neutrophil migration from the vasculature to the interstitial spaces plays a major role in tissue injury.
T3 258-393 DRI_Background denotes Degradation of the basement membrane, which is composed of extracellular matrix (ECM) molecules, is necessary for neutrophil migration.
T4 394-500 DRI_Approach denotes Matrix metalloproteinases (MMPs) might play a role in ECM degradation in lung ischemia-reperfusion injury.
T5 501-670 DRI_Approach denotes We evaluated the changes in the activity of MMP-2 and MMP-9, and tissue inhibitor of metalloproteinase 1 (TIMP-1) gene expressions using rat lung transplantation models.
T6 680-713 DRI_Approach denotes We divided animals into 4 groups.
T7 714-827 DRI_Approach denotes Groups I and II served as control groups with intact lungs (Group I) and 24-hour cold-preserved lungs (Group II).
T8 828-899 DRI_Background denotes Groups III and IV received lung grafts after 24-hour cold preservation.
T9 900-1002 DRI_Background denotes The recipient animals were sacrificed 1 hour (Group III) or 24 hours (Group IV) after transplantation.
T10 1003-1043 DRI_Approach denotes We evaluated lung injury histologically.
T11 1044-1086 DRI_Approach denotes We assessed MMP activity using zymography.
T12 1087-1208 DRI_Approach denotes We assessed MMP-2, MMP-9, and TIMP-1 gene expression using biplex reverse transcriptase-polymerase chain reaction method.
T13 1218-1284 DRI_Unspecified denotes In Groups III and IV, we noted severe ischemia-reperfusion injury.
T14 1285-1392 DRI_Approach denotes We noted no significant difference in enzyme activity and gene expression of MMP-2 between Groups I and IV.
T15 1393-1486 DRI_Background denotes The MMP-9 activity and gene expression were low during ischemia and increased on reperfusion.
T16 1487-1637 DRI_Background denotes TIMP-1 gene expression was low during ischemia and at the early phase of reperfusion, and showed a dramatic increase at the late phase of reperfusion.
T17 1651-1752 DRI_Approach denotes Matrix metalloproteinase 9, but not MMP-2, may play an important role in ischemia-reperfusion injury.
T18 1753-1848 DRI_Outcome denotes TIMP-1 increases at the late phase of reperfusion and may compensate for the activity of MMP-9.

c_corpus

Id Subject Object Predicate Lexical cue
T1 10-16 UBERON:0027368 denotes matrix
T3 10-36 P14780 denotes matrix metalloproteinase 9
T4 10-36 P41246 denotes matrix metalloproteinase 9
T5 10-36 P41245 denotes matrix metalloproteinase 9
T6 10-36 P50282 denotes matrix metalloproteinase 9
T7 10-36 PR:000010491 denotes matrix metalloproteinase 9
T8 10-36 P52176 denotes matrix metalloproteinase 9
T9 10-36 O18733 denotes matrix metalloproteinase 9
T2 10-36 D020780 denotes matrix metalloproteinase 9
T10 10-45 GO:0004229 denotes matrix metalloproteinase 9 activity
T13 50-54 SO:0000234 denotes mRNA
T11 50-54 D012333 denotes mRNA
T12 50-54 CHEBI:33699 denotes mRNA
T14 69-73 UBERON:0002048 denotes lung
T17 74-101 D015427 denotes ischemia-reperfusion injury
T18 74-101 D015427 denotes ischemia-reperfusion injury
T21 118-122 UBERON:0002048 denotes lung
T24 123-150 D015427 denotes ischemia-reperfusion injury
T25 123-150 D015427 denotes ischemia-reperfusion injury
T28 152-162 CL:0000775 denotes neutrophil
T29 152-172 GO:1990266 denotes neutrophil migration
T30 152-172 C563515 denotes neutrophil migration
T31 182-193 UBERON:0002049 denotes vasculature
T32 243-249 UBERON:0000479 denotes tissue
T33 277-294 GO:0005604 denotes basement membrane
T34 277-294 UBERON:0005769 denotes basement membrane
T39 317-337 GO:0031012 denotes extracellular matrix
T40 331-337 UBERON:0027368 denotes matrix
T41 339-342 PR:Q13201 denotes ECM
T43 339-342 PR:000010492 denotes ECM
T42 339-342 UBERON:4000022 denotes ECM
T44 344-353 CHEBI:25367 denotes molecules
T45 372-382 CL:0000775 denotes neutrophil
T46 372-392 GO:1990266 denotes neutrophil migration
T47 372-392 C563515 denotes neutrophil migration
T48 394-419 D020782 denotes Matrix metalloproteinases
T50 421-425 D020782 denotes MMPs
T51 448-451 PR:Q13201 denotes ECM
T53 448-451 PR:000010492 denotes ECM
T52 448-451 UBERON:4000022 denotes ECM
T54 452-463 GO:0009056 denotes degradation
T55 467-471 UBERON:0002048 denotes lung
T58 472-499 D015427 denotes ischemia-reperfusion injury
T59 472-499 D015427 denotes ischemia-reperfusion injury
T62 545-548 CHEBI:340824 denotes MMP
T65 545-548 CHEBI:59761 denotes MMP
T66 545-550 PR:P08253 denotes MMP-2
T67 545-550 Q9GLE5 denotes MMP-2
T68 545-550 P08253 denotes MMP-2
T69 545-550 Q90611 denotes MMP-2
T71 545-550 PR:Q8MPP3 denotes MMP-2
T72 545-550 P33436 denotes MMP-2
T73 545-550 PR:Q90611 denotes MMP-2
T74 545-550 PR:P33436 denotes MMP-2
T75 545-550 PR:000010479 denotes MMP-2
T76 545-550 PR:P33434 denotes MMP-2
T77 545-550 P33434 denotes MMP-2
T78 545-550 P50757 denotes MMP-2
T70 545-550 GO:0004228 denotes MMP-2
T79 555-558 CHEBI:340824 denotes MMP
T82 555-558 CHEBI:59761 denotes MMP
T83 555-560 PR:P50282 denotes MMP-9
T84 555-560 PR:P14780 denotes MMP-9
T85 555-560 P14780 denotes MMP-9
T86 555-560 PR:P41245 denotes MMP-9
T87 555-560 P41246 denotes MMP-9
T88 555-560 P41245 denotes MMP-9
T89 555-560 PR:P52176 denotes MMP-9
T90 555-560 P50282 denotes MMP-9
T92 555-560 PR:000010491 denotes MMP-9
T93 555-560 P52176 denotes MMP-9
T94 555-560 O18733 denotes MMP-9
T91 555-560 GO:0004229 denotes MMP-9
T95 566-572 UBERON:0000479 denotes tissue
T96 566-603 Q9VH14 denotes tissue inhibitor of metalloproteinase
T97 566-605 D019715 denotes tissue inhibitor of metalloproteinase 1
T99 586-605 GO:0051405 denotes metalloproteinase 1
T104 607-613 P81546 denotes TIMP-1
T105 607-613 O02722 denotes TIMP-1
T106 607-613 P49061 denotes TIMP-1
T107 607-613 P50122 denotes TIMP-1
T108 607-613 P20614 denotes TIMP-1
T109 607-613 P12032 denotes TIMP-1
T110 607-613 P35624 denotes TIMP-1
T111 607-613 P20414 denotes TIMP-1
T112 607-613 Q95KL9 denotes TIMP-1
T113 607-613 Q5RC60 denotes TIMP-1
T114 607-613 PR:P30120 denotes TIMP-1
T115 607-613 P30120 denotes TIMP-1
T116 607-613 PR:000016352 denotes TIMP-1
T118 607-613 PR:P12032 denotes TIMP-1
T119 607-613 PR:P01033 denotes TIMP-1
T120 607-613 P01033 denotes TIMP-1
T117 607-613 D019715 denotes TIMP-1
T121 615-619 SO:0000704 denotes gene
T123 638-641 PR:P63003-1 denotes rat
T124 638-641 PR:Q2G0B1 denotes rat
T125 638-641 PR:Q8VHJ4 denotes rat
T122 638-641 10116 denotes rat
T126 638-641 D051381 denotes rat
T127 642-646 UBERON:0002048 denotes lung
T128 767-772 UBERON:0000170 denotes lungs
T129 810-815 UBERON:0000170 denotes lungs
T130 817-825 1334 denotes Group II
T131 855-859 UBERON:0002048 denotes lung
T132 1016-1020 UBERON:0002048 denotes lung
T133 1016-1027 D055370 denotes lung injury
T134 1016-1027 D055370 denotes lung injury
T137 1056-1059 PR:O04529 denotes MMP
T135 1056-1059 CHEBI:340824 denotes MMP
T138 1056-1059 CHEBI:59761 denotes MMP
T136 1056-1059 GO:0004235 denotes MMP
T139 1099-1102 CHEBI:340824 denotes MMP
T142 1099-1102 CHEBI:59761 denotes MMP
T143 1099-1104 PR:P08253 denotes MMP-2
T144 1099-1104 Q9GLE5 denotes MMP-2
T145 1099-1104 P08253 denotes MMP-2
T146 1099-1104 Q90611 denotes MMP-2
T148 1099-1104 PR:Q8MPP3 denotes MMP-2
T149 1099-1104 P33436 denotes MMP-2
T150 1099-1104 PR:Q90611 denotes MMP-2
T151 1099-1104 PR:P33436 denotes MMP-2
T152 1099-1104 PR:000010479 denotes MMP-2
T153 1099-1104 PR:P33434 denotes MMP-2
T154 1099-1104 P33434 denotes MMP-2
T155 1099-1104 P50757 denotes MMP-2
T147 1099-1104 GO:0004228 denotes MMP-2
T156 1103-1109 PR:O04529 denotes 2, MMP
T157 1106-1109 CHEBI:340824 denotes MMP
T160 1106-1109 CHEBI:59761 denotes MMP
T161 1106-1111 PR:P50282 denotes MMP-9
T162 1106-1111 PR:P14780 denotes MMP-9
T163 1106-1111 P14780 denotes MMP-9
T164 1106-1111 PR:P41245 denotes MMP-9
T165 1106-1111 P41246 denotes MMP-9
T166 1106-1111 P41245 denotes MMP-9
T167 1106-1111 PR:P52176 denotes MMP-9
T168 1106-1111 P50282 denotes MMP-9
T170 1106-1111 PR:000010491 denotes MMP-9
T171 1106-1111 P52176 denotes MMP-9
T172 1106-1111 O18733 denotes MMP-9
T169 1106-1111 GO:0004229 denotes MMP-9
T177 1117-1123 P81546 denotes TIMP-1
T178 1117-1123 O02722 denotes TIMP-1
T179 1117-1123 P49061 denotes TIMP-1
T180 1117-1123 P50122 denotes TIMP-1
T181 1117-1123 P20614 denotes TIMP-1
T182 1117-1123 P12032 denotes TIMP-1
T183 1117-1123 P35624 denotes TIMP-1
T184 1117-1123 P20414 denotes TIMP-1
T185 1117-1123 Q95KL9 denotes TIMP-1
T186 1117-1123 Q5RC60 denotes TIMP-1
T187 1117-1123 PR:P30120 denotes TIMP-1
T188 1117-1123 P30120 denotes TIMP-1
T189 1117-1123 PR:000016352 denotes TIMP-1
T191 1117-1123 PR:P12032 denotes TIMP-1
T192 1117-1123 PR:P01033 denotes TIMP-1
T193 1117-1123 P01033 denotes TIMP-1
T190 1117-1123 D019715 denotes TIMP-1
T194 1124-1128 SO:0000704 denotes gene
T195 1124-1139 GO:0010467 denotes gene expression
T196 1153-1160 SO:0001031 denotes reverse
T197 1153-1174 P23072 denotes reverse transcriptase
T198 1153-1174 P21329 denotes reverse transcriptase
T199 1153-1174 P23071 denotes reverse transcriptase
T200 1153-1174 P21328 denotes reverse transcriptase
T202 1153-1174 P23070 denotes reverse transcriptase
T203 1153-1174 Q9NBX4 denotes reverse transcriptase
T204 1153-1174 Q95SX7 denotes reverse transcriptase
T201 1153-1174 D012194 denotes reverse transcriptase
T210 1161-1174 GO:0003968 denotes transcriptase
T288 1161-1174 GO:0003899 denotes transcriptase
T312 1161-1174 GO:0034062 denotes transcriptase
T329 1186-1191 SO:0000419 denotes chain
T330 1186-1200 MOP:0000635 denotes chain reaction
T333 1256-1283 D015427 denotes ischemia-reperfusion injury
T334 1256-1283 D015427 denotes ischemia-reperfusion injury
T337 1323-1338 GO:0003824 denotes enzyme activity
T338 1343-1347 SO:0000704 denotes gene
T339 1343-1358 GO:0010467 denotes gene expression
T340 1362-1365 CHEBI:340824 denotes MMP
T343 1362-1365 CHEBI:59761 denotes MMP
T344 1362-1367 PR:P08253 denotes MMP-2
T345 1362-1367 Q9GLE5 denotes MMP-2
T346 1362-1367 P08253 denotes MMP-2
T347 1362-1367 Q90611 denotes MMP-2
T349 1362-1367 PR:Q8MPP3 denotes MMP-2
T350 1362-1367 P33436 denotes MMP-2
T351 1362-1367 PR:Q90611 denotes MMP-2
T352 1362-1367 PR:P33436 denotes MMP-2
T353 1362-1367 PR:000010479 denotes MMP-2
T354 1362-1367 PR:P33434 denotes MMP-2
T355 1362-1367 P33434 denotes MMP-2
T356 1362-1367 P50757 denotes MMP-2
T348 1362-1367 GO:0004228 denotes MMP-2
T357 1397-1400 CHEBI:340824 denotes MMP
T360 1397-1400 CHEBI:59761 denotes MMP
T361 1397-1402 PR:P50282 denotes MMP-9
T362 1397-1402 PR:P14780 denotes MMP-9
T363 1397-1402 P14780 denotes MMP-9
T364 1397-1402 PR:P41245 denotes MMP-9
T365 1397-1402 P41246 denotes MMP-9
T366 1397-1402 P41245 denotes MMP-9
T367 1397-1402 PR:P52176 denotes MMP-9
T368 1397-1402 P50282 denotes MMP-9
T370 1397-1402 PR:000010491 denotes MMP-9
T371 1397-1402 P52176 denotes MMP-9
T372 1397-1402 O18733 denotes MMP-9
T369 1397-1402 GO:0004229 denotes MMP-9
T373 1416-1420 SO:0000704 denotes gene
T374 1416-1431 GO:0010467 denotes gene expression
T375 1448-1456 D007511 denotes ischemia
T376 1448-1456 D007511 denotes ischemia
T381 1487-1493 P81546 denotes TIMP-1
T382 1487-1493 O02722 denotes TIMP-1
T383 1487-1493 P49061 denotes TIMP-1
T384 1487-1493 P50122 denotes TIMP-1
T385 1487-1493 P20614 denotes TIMP-1
T386 1487-1493 P12032 denotes TIMP-1
T387 1487-1493 P35624 denotes TIMP-1
T388 1487-1493 P20414 denotes TIMP-1
T389 1487-1493 Q95KL9 denotes TIMP-1
T390 1487-1493 Q5RC60 denotes TIMP-1
T391 1487-1493 PR:P30120 denotes TIMP-1
T392 1487-1493 P30120 denotes TIMP-1
T393 1487-1493 PR:000016352 denotes TIMP-1
T395 1487-1493 PR:P12032 denotes TIMP-1
T396 1487-1493 PR:P01033 denotes TIMP-1
T397 1487-1493 P01033 denotes TIMP-1
T394 1487-1493 D019715 denotes TIMP-1
T398 1494-1498 SO:0000704 denotes gene
T399 1494-1509 GO:0010467 denotes gene expression
T400 1525-1533 D007511 denotes ischemia
T401 1525-1533 D007511 denotes ischemia
T403 1651-1677 P14780 denotes Matrix metalloproteinase 9
T404 1651-1677 P41246 denotes Matrix metalloproteinase 9
T405 1651-1677 P41245 denotes Matrix metalloproteinase 9
T406 1651-1677 P50282 denotes Matrix metalloproteinase 9
T407 1651-1677 PR:000010491 denotes Matrix metalloproteinase 9
T408 1651-1677 P52176 denotes Matrix metalloproteinase 9
T409 1651-1677 O18733 denotes Matrix metalloproteinase 9
T402 1651-1677 D020780 denotes Matrix metalloproteinase 9
T410 1687-1690 CHEBI:340824 denotes MMP
T413 1687-1690 CHEBI:59761 denotes MMP
T414 1687-1692 PR:P08253 denotes MMP-2
T415 1687-1692 Q9GLE5 denotes MMP-2
T416 1687-1692 P08253 denotes MMP-2
T417 1687-1692 Q90611 denotes MMP-2
T419 1687-1692 PR:Q8MPP3 denotes MMP-2
T420 1687-1692 P33436 denotes MMP-2
T421 1687-1692 PR:Q90611 denotes MMP-2
T422 1687-1692 PR:P33436 denotes MMP-2
T423 1687-1692 PR:000010479 denotes MMP-2
T424 1687-1692 PR:P33434 denotes MMP-2
T425 1687-1692 P33434 denotes MMP-2
T426 1687-1692 P50757 denotes MMP-2
T418 1687-1692 GO:0004228 denotes MMP-2
T429 1724-1751 D015427 denotes ischemia-reperfusion injury
T430 1724-1751 D015427 denotes ischemia-reperfusion injury
T437 1753-1759 P81546 denotes TIMP-1
T438 1753-1759 O02722 denotes TIMP-1
T439 1753-1759 P49061 denotes TIMP-1
T440 1753-1759 P50122 denotes TIMP-1
T441 1753-1759 P20614 denotes TIMP-1
T442 1753-1759 P12032 denotes TIMP-1
T443 1753-1759 P35624 denotes TIMP-1
T444 1753-1759 P20414 denotes TIMP-1
T445 1753-1759 Q95KL9 denotes TIMP-1
T446 1753-1759 Q5RC60 denotes TIMP-1
T447 1753-1759 PR:P30120 denotes TIMP-1
T448 1753-1759 P30120 denotes TIMP-1
T449 1753-1759 PR:000016352 denotes TIMP-1
T451 1753-1759 PR:P12032 denotes TIMP-1
T452 1753-1759 PR:P01033 denotes TIMP-1
T453 1753-1759 P01033 denotes TIMP-1
T450 1753-1759 D019715 denotes TIMP-1
T454 1842-1845 CHEBI:340824 denotes MMP
T457 1842-1845 CHEBI:59761 denotes MMP
T458 1842-1847 PR:P50282 denotes MMP-9
T459 1842-1847 PR:P14780 denotes MMP-9
T460 1842-1847 P14780 denotes MMP-9
T461 1842-1847 PR:P41245 denotes MMP-9
T462 1842-1847 P41246 denotes MMP-9
T463 1842-1847 P41245 denotes MMP-9
T464 1842-1847 PR:P52176 denotes MMP-9
T465 1842-1847 P50282 denotes MMP-9
T467 1842-1847 PR:000010491 denotes MMP-9
T468 1842-1847 P52176 denotes MMP-9
T469 1842-1847 O18733 denotes MMP-9
T466 1842-1847 GO:0004229 denotes MMP-9