PubMed:11396184 JSON TXT

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sentences

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":133},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":134,"end":341},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":342,"end":445},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":446,"end":576},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":577,"end":704},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":705,"end":860},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":861,"end":1070},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1071,"end":1282},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":133},"obj":"Sentence"},{"id":"T2","span":{"begin":134,"end":341},"obj":"Sentence"},{"id":"T3","span":{"begin":342,"end":445},"obj":"Sentence"},{"id":"T4","span":{"begin":446,"end":576},"obj":"Sentence"},{"id":"T5","span":{"begin":577,"end":704},"obj":"Sentence"},{"id":"T6","span":{"begin":705,"end":860},"obj":"Sentence"},{"id":"T7","span":{"begin":861,"end":1070},"obj":"Sentence"},{"id":"T8","span":{"begin":1071,"end":1282},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.\nMutational inactivation of the human tumour suppressor gene adenomatous polyposis coli (APC) results in constitutive activation of beta-catenin/T cell factor-4 (Tcf-4) mediated transcription of target genes. Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC). We analysed 38 CRC for mutations in APC and beta-catenin and found an association between APC mutations and elevated COX-2 levels. Furthermore, APC mutations were predominantly observed in tumour tissues from the rectum compared to tumours of colonic origin. Western blot analysis revealed that nuclear beta-catenin levels were generally higher in tumours with APC mutations compared to tumours with wild type APC. However, there was also a higher level of nuclear beta-catenin in tumour compared to normal tissue, but nuclear Tcf-4 protein was constitutively expressed in tumour and normal tissue and showed no differences. An identified putative Tcf-4 binding element in the COX-2 promoter may partly explain the enhanced level of COX-2 and support the idea that COX-2 may be a downstream target of the APC/beta-catenin/Tcf-4 pathway."}

DisGeNET5_gene_disease

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"11396184-0#97#100#gene324","span":{"begin":97,"end":100},"obj":"gene324"},{"id":"11396184-0#115#132#diseaseC1527249","span":{"begin":115,"end":132},"obj":"diseaseC1527249"},{"id":"11396184-7#52#57#gene5743","span":{"begin":1123,"end":1128},"obj":"gene5743"},{"id":"11396184-7#108#113#gene5743","span":{"begin":1179,"end":1184},"obj":"gene5743"},{"id":"11396184-7#140#145#gene5743","span":{"begin":1211,"end":1216},"obj":"gene5743"},{"id":"11396184-7#180#183#diseaseC0032580","span":{"begin":1251,"end":1254},"obj":"diseaseC0032580"}],"relations":[{"id":"97#100#gene324115#132#diseaseC1527249","pred":"associated_with","subj":"11396184-0#97#100#gene324","obj":"11396184-0#115#132#diseaseC1527249"},{"id":"52#57#gene5743180#183#diseaseC0032580","pred":"associated_with","subj":"11396184-7#52#57#gene5743","obj":"11396184-7#180#183#diseaseC0032580"},{"id":"108#113#gene5743180#183#diseaseC0032580","pred":"associated_with","subj":"11396184-7#108#113#gene5743","obj":"11396184-7#180#183#diseaseC0032580"},{"id":"140#145#gene5743180#183#diseaseC0032580","pred":"associated_with","subj":"11396184-7#140#145#gene5743","obj":"11396184-7#180#183#diseaseC0032580"}],"text":"Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.\nMutational inactivation of the human tumour suppressor gene adenomatous polyposis coli (APC) results in constitutive activation of beta-catenin/T cell factor-4 (Tcf-4) mediated transcription of target genes. Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC). We analysed 38 CRC for mutations in APC and beta-catenin and found an association between APC mutations and elevated COX-2 levels. Furthermore, APC mutations were predominantly observed in tumour tissues from the rectum compared to tumours of colonic origin. Western blot analysis revealed that nuclear beta-catenin levels were generally higher in tumours with APC mutations compared to tumours with wild type APC. However, there was also a higher level of nuclear beta-catenin in tumour compared to normal tissue, but nuclear Tcf-4 protein was constitutively expressed in tumour and normal tissue and showed no differences. An identified putative Tcf-4 binding element in the COX-2 promoter may partly explain the enhanced level of COX-2 and support the idea that COX-2 may be a downstream target of the APC/beta-catenin/Tcf-4 pathway."}

DisGeNet-2017-sample

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T2926","span":{"begin":97,"end":100},"obj":"gene:324"},{"id":"T2927","span":{"begin":115,"end":132},"obj":"disease:C1527249"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T2926","obj":"T2927"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.\nMutational inactivation of the human tumour suppressor gene adenomatous polyposis coli (APC) results in constitutive activation of beta-catenin/T cell factor-4 (Tcf-4) mediated transcription of target genes. Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC). We analysed 38 CRC for mutations in APC and beta-catenin and found an association between APC mutations and elevated COX-2 levels. Furthermore, APC mutations were predominantly observed in tumour tissues from the rectum compared to tumours of colonic origin. Western blot analysis revealed that nuclear beta-catenin levels were generally higher in tumours with APC mutations compared to tumours with wild type APC. However, there was also a higher level of nuclear beta-catenin in tumour compared to normal tissue, but nuclear Tcf-4 protein was constitutively expressed in tumour and normal tissue and showed no differences. An identified putative Tcf-4 binding element in the COX-2 promoter may partly explain the enhanced level of COX-2 and support the idea that COX-2 may be a downstream target of the APC/beta-catenin/Tcf-4 pathway."}

UBERON-AE

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":642,"end":649},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":953,"end":959},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1037,"end":1043},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":659,"end":665},"obj":"http://purl.obolibrary.org/obo/UBERON_0001052"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":689,"end":696},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"}],"text":"Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.\nMutational inactivation of the human tumour suppressor gene adenomatous polyposis coli (APC) results in constitutive activation of beta-catenin/T cell factor-4 (Tcf-4) mediated transcription of target genes. Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC). We analysed 38 CRC for mutations in APC and beta-catenin and found an association between APC mutations and elevated COX-2 levels. Furthermore, APC mutations were predominantly observed in tumour tissues from the rectum compared to tumours of colonic origin. Western blot analysis revealed that nuclear beta-catenin levels were generally higher in tumours with APC mutations compared to tumours with wild type APC. However, there was also a higher level of nuclear beta-catenin in tumour compared to normal tissue, but nuclear Tcf-4 protein was constitutively expressed in tumour and normal tissue and showed no differences. An identified putative Tcf-4 binding element in the COX-2 promoter may partly explain the enhanced level of COX-2 and support the idea that COX-2 may be a downstream target of the APC/beta-catenin/Tcf-4 pathway."}

performance-test

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":642,"end":649},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":953,"end":959},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1037,"end":1043},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":689,"end":696},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":659,"end":665},"obj":"http://purl.obolibrary.org/obo/UBERON_0001052"}],"text":"Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.\nMutational inactivation of the human tumour suppressor gene adenomatous polyposis coli (APC) results in constitutive activation of beta-catenin/T cell factor-4 (Tcf-4) mediated transcription of target genes. Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC). We analysed 38 CRC for mutations in APC and beta-catenin and found an association between APC mutations and elevated COX-2 levels. Furthermore, APC mutations were predominantly observed in tumour tissues from the rectum compared to tumours of colonic origin. Western blot analysis revealed that nuclear beta-catenin levels were generally higher in tumours with APC mutations compared to tumours with wild type APC. However, there was also a higher level of nuclear beta-catenin in tumour compared to normal tissue, but nuclear Tcf-4 protein was constitutively expressed in tumour and normal tissue and showed no differences. An identified putative Tcf-4 binding element in the COX-2 promoter may partly explain the enhanced level of COX-2 and support the idea that COX-2 may be a downstream target of the APC/beta-catenin/Tcf-4 pathway."}

DisGeNET