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PubMed:11396184 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-133 Sentence denotes Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.
TextSentencer_T2 134-341 Sentence denotes Mutational inactivation of the human tumour suppressor gene adenomatous polyposis coli (APC) results in constitutive activation of beta-catenin/T cell factor-4 (Tcf-4) mediated transcription of target genes.
TextSentencer_T3 342-445 Sentence denotes Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC).
TextSentencer_T4 446-576 Sentence denotes We analysed 38 CRC for mutations in APC and beta-catenin and found an association between APC mutations and elevated COX-2 levels.
TextSentencer_T5 577-704 Sentence denotes Furthermore, APC mutations were predominantly observed in tumour tissues from the rectum compared to tumours of colonic origin.
TextSentencer_T6 705-860 Sentence denotes Western blot analysis revealed that nuclear beta-catenin levels were generally higher in tumours with APC mutations compared to tumours with wild type APC.
TextSentencer_T7 861-1070 Sentence denotes However, there was also a higher level of nuclear beta-catenin in tumour compared to normal tissue, but nuclear Tcf-4 protein was constitutively expressed in tumour and normal tissue and showed no differences.
TextSentencer_T8 1071-1282 Sentence denotes An identified putative Tcf-4 binding element in the COX-2 promoter may partly explain the enhanced level of COX-2 and support the idea that COX-2 may be a downstream target of the APC/beta-catenin/Tcf-4 pathway.
T1 0-133 Sentence denotes Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.
T2 134-341 Sentence denotes Mutational inactivation of the human tumour suppressor gene adenomatous polyposis coli (APC) results in constitutive activation of beta-catenin/T cell factor-4 (Tcf-4) mediated transcription of target genes.
T3 342-445 Sentence denotes Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC).
T4 446-576 Sentence denotes We analysed 38 CRC for mutations in APC and beta-catenin and found an association between APC mutations and elevated COX-2 levels.
T5 577-704 Sentence denotes Furthermore, APC mutations were predominantly observed in tumour tissues from the rectum compared to tumours of colonic origin.
T6 705-860 Sentence denotes Western blot analysis revealed that nuclear beta-catenin levels were generally higher in tumours with APC mutations compared to tumours with wild type APC.
T7 861-1070 Sentence denotes However, there was also a higher level of nuclear beta-catenin in tumour compared to normal tissue, but nuclear Tcf-4 protein was constitutively expressed in tumour and normal tissue and showed no differences.
T8 1071-1282 Sentence denotes An identified putative Tcf-4 binding element in the COX-2 promoter may partly explain the enhanced level of COX-2 and support the idea that COX-2 may be a downstream target of the APC/beta-catenin/Tcf-4 pathway.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11396184-0#97#100#gene324 97-100 gene324 denotes APC
11396184-0#115#132#diseaseC1527249 115-132 diseaseC1527249 denotes colorectal cancer
11396184-7#52#57#gene5743 1123-1128 gene5743 denotes COX-2
11396184-7#108#113#gene5743 1179-1184 gene5743 denotes COX-2
11396184-7#140#145#gene5743 1211-1216 gene5743 denotes COX-2
11396184-7#180#183#diseaseC0032580 1251-1254 diseaseC0032580 denotes APC
97#100#gene324115#132#diseaseC1527249 11396184-0#97#100#gene324 11396184-0#115#132#diseaseC1527249 associated_with APC,colorectal cancer
52#57#gene5743180#183#diseaseC0032580 11396184-7#52#57#gene5743 11396184-7#180#183#diseaseC0032580 associated_with COX-2,APC
108#113#gene5743180#183#diseaseC0032580 11396184-7#108#113#gene5743 11396184-7#180#183#diseaseC0032580 associated_with COX-2,APC
140#145#gene5743180#183#diseaseC0032580 11396184-7#140#145#gene5743 11396184-7#180#183#diseaseC0032580 associated_with COX-2,APC

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2926 97-100 gene:324 denotes APC
T2927 115-132 disease:C1527249 denotes colorectal cancer
R1 T2926 T2927 associated_with APC,colorectal cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 642-649 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 953-959 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 1037-1043 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 659-665 http://purl.obolibrary.org/obo/UBERON_0001052 denotes rectum
PD-UBERON-AE-B_T5 689-696 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 642-649 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 953-959 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 1037-1043 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 689-696 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
PD-UBERON-AE-B_T5 659-665 http://purl.obolibrary.org/obo/UBERON_0001052 denotes rectum

DisGeNET

Id Subject Object Predicate Lexical cue
T0 171-188 gene:7248 denotes tumour suppressor
T1 194-220 disease:C0032580 denotes adenomatous polyposis coli
T2 171-188 gene:7248 denotes tumour suppressor
T3 222-225 disease:C0032580 denotes APC
T4 359-375 gene:5743 denotes cyclooxygenase-2
T5 440-443 disease:C0009402 denotes CRC
T6 359-375 gene:5743 denotes cyclooxygenase-2
T7 421-438 disease:C1527249 denotes colorectal cancer
T8 359-375 gene:5743 denotes cyclooxygenase-2
T9 421-438 disease:C0009402 denotes colorectal cancer
T10 359-375 gene:5743 denotes cyclooxygenase-2
T11 440-443 disease:C1527249 denotes CRC
T12 377-382 gene:5743 denotes COX-2
T13 421-438 disease:C0009402 denotes colorectal cancer
T14 377-382 gene:5743 denotes COX-2
T15 440-443 disease:C1527249 denotes CRC
T16 377-382 gene:5743 denotes COX-2
T17 440-443 disease:C0009402 denotes CRC
T18 377-382 gene:5743 denotes COX-2
T19 421-438 disease:C1527249 denotes colorectal cancer
T20 563-568 gene:5743 denotes COX-2
T21 536-539 disease:C0032580 denotes APC
T22 1179-1184 gene:5743 denotes COX-2
T23 1251-1254 disease:C0032580 denotes APC
T24 1123-1128 gene:5743 denotes COX-2
T25 1251-1254 disease:C0032580 denotes APC
T26 1211-1216 gene:5743 denotes COX-2
T27 1251-1254 disease:C0032580 denotes APC
R1 T0 T1 associated_with tumour suppressor,adenomatous polyposis coli
R2 T2 T3 associated_with tumour suppressor,APC
R3 T4 T5 associated_with cyclooxygenase-2,CRC
R4 T6 T7 associated_with cyclooxygenase-2,colorectal cancer
R5 T8 T9 associated_with cyclooxygenase-2,colorectal cancer
R6 T10 T11 associated_with cyclooxygenase-2,CRC
R7 T12 T13 associated_with COX-2,colorectal cancer
R8 T14 T15 associated_with COX-2,CRC
R9 T16 T17 associated_with COX-2,CRC
R10 T18 T19 associated_with COX-2,colorectal cancer
R11 T20 T21 associated_with COX-2,APC
R12 T22 T23 associated_with COX-2,APC
R13 T24 T25 associated_with COX-2,APC
R14 T26 T27 associated_with COX-2,APC