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PubMed:11274152 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-176 Sentence denotes Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages.
T2 177-321 Sentence denotes Eukaryotic initiation factor (eIF) 4B interacts with several components of the initiation pathway and is targeted for cleavage during apoptosis.
T3 322-442 Sentence denotes In a cell-free system, cleavage of eIF4B by caspase-3 coincides with a general inhibition of protein synthetic activity.
T4 443-665 Sentence denotes Affinity chromatography demonstrates that mammalian eIF4B interacts with the poly(A)-binding protein and that a region consisting of the N-terminal 80 amino acids of eIF4B is both necessary and sufficient for such binding.
T5 666-771 Sentence denotes This interaction is lost when eIF4B is cleaved by caspase-3, which removes the N-terminal 45 amino acids.
T6 772-904 Sentence denotes Similarly, the association of eIF4B with the poly(A)-binding protein in vivo is reduced when cells are induced to undergo apoptosis.
T7 905-1032 Sentence denotes Cleavage of the poly(A)-binding protein itself, using human rhinovirus 3C protease, also eliminates the interaction with eIF4B.
T8 1033-1277 Sentence denotes Thus, disruption of the association between mammalian eIF4B and the poly(A)-binding protein can occur during both apoptosis and picornaviral infection and is likely to contribute to the inhibition of translation observed under these conditions.

2015-BEL-Sample

Id Subject Object Predicate Lexical cue
T1 322-441 cat(p(HGNC:CASP3)) increases deg(p(HGNC:EIF4B)) denotes In a cell-free system, cleavage of eIF4B by caspase-3 coincides with a general inhibition of protein synthetic activity

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20000284 772-903 bp(GOBP:"apoptotic process") decreases complex(p(HGNC:EIF4B),p(HGNC:PABPN1)) denotes Similarly, the association of eIF4B with the poly(A)-binding protein in vivo is reduced when cells are induced to undergo apoptosis
BEL:20000286 322-441 cat(p(HGNC:CASP3)) increases deg(p(HGNC:EIF4B)) denotes In a cell-free system, cleavage of eIF4B by caspase-3 coincides with a general inhibition of protein synthetic activity
BEL:20000282 177-320 bp(GOBP:"apoptotic process") increases deg(p(HGNC:EIF4B)) denotes Eukaryotic initiation factor (eIF) 4B interacts with several components of the initiation pathway and is targeted for cleavage during apoptosis
BEL:20000284 772-903 bp(GOBP:"apoptotic process") decreases complex(p(HGNC:EIF4B),p(HGNC:PABPN1)) denotes Similarly, the association of eIF4B with the poly(A)-binding protein in vivo is reduced when cells are induced to undergo apoptosis
BEL:20000286 322-441 cat(p(HGNC:CASP3)) increases deg(p(HGNC:EIF4B)) denotes In a cell-free system, cleavage of eIF4B by caspase-3 coincides with a general inhibition of protein synthetic activity
BEL:20029108 177-441 bp(GOBP:"apoptotic process") increases deg(p(HGNC:EIF4B)) denotes Eukaryotic initiation factor (eIF) 4B interacts with several components of the initiation pathway and is targeted for cleavage during apoptosis. In a cell-free system, cleavage of eIF4B by caspase-3 coincides with a general inhibition of protein synthetic activity
BEL:20029476 177-441 cat(p(HGNC:CASP3)) increases deg(p(HGNC:EIF4B)) denotes Eukaryotic initiation factor (eIF) 4B interacts with several components of the initiation pathway and is targeted for cleavage during apoptosis. In a cell-free system, cleavage of eIF4B by caspase-3 coincides with a general inhibition of protein synthetic activity

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1174-1183 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 959-964 OrganismTaxon denotes human 9606

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 102-106 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T3 520-524 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T5 817-821 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T7 921-925 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T9 1101-1105 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775