PubMed:11129784 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11129784","sourcedb":"PubMed","sourceid":"11129784","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11129784","text":"Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94.\nIt has been shown recently that matrix metalloproteinases (MMPs) are elevated after cerebral ischemia. In the current study, we investigated the pathophysiologic role for MMP-9 (gelatinase B, EC.3.4.24.35) in a mouse model of permanent focal cerebral ischemia, using a combination of genetic and pharmacologic approaches. Zymography and Western blot analysis demonstrated that MMP-9 protein levels were rapidly up-regulated in brain after ischemic onset. Reverse transcription polymerase chain reaction showed increased transcription of MMP-9. There were no differences in systemic hemodynamic parameters and gross cerebrovascular anatomy between wild type mice and mutant mice with a targeted knockout of the MMP-9 gene. After induction of focal ischemia, similar reductions in cerebral blood flow were obtained. In the MMP-9 knockout mice, ischemic lesion volumes were significantly reduced compared with wild type littermates in male and female mice. In normal wild type mice, the broad spectrum MMP inhibitor BB-94 (batimastat) also significantly reduced ischemic lesion size. However, BB-94 had no detectable protective effect when administered to MMP-9 knockout mice subjected to focal cerebral ischemia. These data demonstrate that MMP-9 plays a deleterious role in the development of brain injury after focal ischemia.","tracks":[{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":126,"end":228},"obj":"DRI_Background"},{"id":"T2","span":{"begin":229,"end":447},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":448,"end":580},"obj":"DRI_Background"},{"id":"T4","span":{"begin":581,"end":669},"obj":"DRI_Background"},{"id":"T5","span":{"begin":670,"end":847},"obj":"DRI_Outcome"},{"id":"T6","span":{"begin":848,"end":939},"obj":"DRI_Background"},{"id":"T7","span":{"begin":940,"end":1079},"obj":"DRI_Outcome"},{"id":"T8","span":{"begin":1080,"end":1206},"obj":"DRI_Outcome"},{"id":"T9","span":{"begin":1207,"end":1336},"obj":"DRI_Background"},{"id":"T10","span":{"begin":1337,"end":1452},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T10","pred":"source","obj":"PubMed_ArguminSci"}]},{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":9,"end":15},"obj":"UBERON:0027368"},{"id":"T3","span":{"begin":9,"end":35},"obj":"P14780"},{"id":"T4","span":{"begin":9,"end":35},"obj":"P41246"},{"id":"T5","span":{"begin":9,"end":35},"obj":"P41245"},{"id":"T6","span":{"begin":9,"end":35},"obj":"P50282"},{"id":"T7","span":{"begin":9,"end":35},"obj":"PR:000010491"},{"id":"T8","span":{"begin":9,"end":35},"obj":"P52176"},{"id":"T9","span":{"begin":9,"end":35},"obj":"O18733"},{"id":"T2","span":{"begin":9,"end":35},"obj":"D020780"},{"id":"T10","span":{"begin":48,"end":65},"obj":"D002545"},{"id":"T11","span":{"begin":48,"end":65},"obj":"D002545"},{"id":"T14","span":{"begin":78,"end":82},"obj":"SO:0000704"},{"id":"T15","span":{"begin":119,"end":124},"obj":"C080985"},{"id":"T16","span":{"begin":119,"end":124},"obj":"C080985"},{"id":"T17","span":{"begin":158,"end":164},"obj":"UBERON:0027368"},{"id":"T18","span":{"begin":158,"end":183},"obj":"D020782"},{"id":"T20","span":{"begin":185,"end":189},"obj":"D020782"},{"id":"T21","span":{"begin":210,"end":227},"obj":"D002545"},{"id":"T22","span":{"begin":210,"end":227},"obj":"D002545"},{"id":"T25","span":{"begin":297,"end":300},"obj":"CHEBI:340824"},{"id":"T28","span":{"begin":297,"end":300},"obj":"CHEBI:59761"},{"id":"T29","span":{"begin":297,"end":302},"obj":"PR:P50282"},{"id":"T30","span":{"begin":297,"end":302},"obj":"PR:P14780"},{"id":"T31","span":{"begin":297,"end":302},"obj":"P14780"},{"id":"T32","span":{"begin":297,"end":302},"obj":"PR:P41245"},{"id":"T33","span":{"begin":297,"end":302},"obj":"P41246"},{"id":"T34","span":{"begin":297,"end":302},"obj":"P41245"},{"id":"T35","span":{"begin":297,"end":302},"obj":"PR:P52176"},{"id":"T36","span":{"begin":297,"end":302},"obj":"P50282"},{"id":"T38","span":{"begin":297,"end":302},"obj":"PR:000010491"},{"id":"T39","span":{"begin":297,"end":302},"obj":"P52176"},{"id":"T40","span":{"begin":297,"end":302},"obj":"O18733"},{"id":"T37","span":{"begin":297,"end":302},"obj":"GO:0004229"},{"id":"T44","span":{"begin":304,"end":316},"obj":"P14780"},{"id":"T45","span":{"begin":304,"end":316},"obj":"P41246"},{"id":"T46","span":{"begin":304,"end":316},"obj":"P41245"},{"id":"T47","span":{"begin":304,"end":316},"obj":"P50282"},{"id":"T48","span":{"begin":304,"end":316},"obj":"PR:000010491"},{"id":"T49","span":{"begin":304,"end":316},"obj":"P52176"},{"id":"T50","span":{"begin":304,"end":316},"obj":"O18733"},{"id":"T43","span":{"begin":304,"end":316},"obj":"D020780"},{"id":"T51","span":{"begin":318,"end":322},"obj":"CVCL_5V07"},{"id":"T52","span":{"begin":335,"end":342},"obj":"MGI:87853"},{"id":"T53","span":{"begin":337,"end":342},"obj":"10090"},{"id":"T54","span":{"begin":337,"end":342},"obj":"D051379"},{"id":"T55","span":{"begin":368,"end":385},"obj":"D002545"},{"id":"T56","span":{"begin":368,"end":385},"obj":"D002545"},{"id":"T59","span":{"begin":503,"end":506},"obj":"CHEBI:340824"},{"id":"T62","span":{"begin":503,"end":506},"obj":"CHEBI:59761"},{"id":"T63","span":{"begin":503,"end":508},"obj":"PR:P50282"},{"id":"T64","span":{"begin":503,"end":508},"obj":"PR:P14780"},{"id":"T65","span":{"begin":503,"end":508},"obj":"P14780"},{"id":"T66","span":{"begin":503,"end":508},"obj":"PR:P41245"},{"id":"T67","span":{"begin":503,"end":508},"obj":"P41246"},{"id":"T68","span":{"begin":503,"end":508},"obj":"P41245"},{"id":"T69","span":{"begin":503,"end":508},"obj":"PR:P52176"},{"id":"T70","span":{"begin":503,"end":508},"obj":"P50282"},{"id":"T72","span":{"begin":503,"end":508},"obj":"PR:000010491"},{"id":"T73","span":{"begin":503,"end":508},"obj":"P52176"},{"id":"T74","span":{"begin":503,"end":508},"obj":"O18733"},{"id":"T71","span":{"begin":503,"end":508},"obj":"GO:0004229"},{"id":"T79","span":{"begin":509,"end":516},"obj":"SO:0000104"},{"id":"T78","span":{"begin":509,"end":516},"obj":"PR:000000001"},{"id":"T76","span":{"begin":509,"end":516},"obj":"CHEBI:36080"},{"id":"T77","span":{"begin":509,"end":516},"obj":"CHEBI:11122"},{"id":"T75","span":{"begin":509,"end":516},"obj":"GO:0003675"},{"id":"T80","span":{"begin":540,"end":549},"obj":"SO:0000119"},{"id":"T81","span":{"begin":553,"end":558},"obj":"UBERON:6110636"},{"id":"T82","span":{"begin":553,"end":558},"obj":"UBERON:0000955"},{"id":"T83","span":{"begin":581,"end":588},"obj":"SO:0001031"},{"id":"T84","span":{"begin":581,"end":602},"obj":"GO:0001171"},{"id":"T86","span":{"begin":614,"end":619},"obj":"SO:0000419"},{"id":"T87","span":{"begin":614,"end":628},"obj":"MOP:0000635"},{"id":"T88","span":{"begin":646,"end":659},"obj":"GO:0006351"},{"id":"T89","span":{"begin":663,"end":666},"obj":"CHEBI:340824"},{"id":"T92","span":{"begin":663,"end":666},"obj":"CHEBI:59761"},{"id":"T93","span":{"begin":663,"end":668},"obj":"PR:P50282"},{"id":"T94","span":{"begin":663,"end":668},"obj":"PR:P14780"},{"id":"T95","span":{"begin":663,"end":668},"obj":"P14780"},{"id":"T96","span":{"begin":663,"end":668},"obj":"PR:P41245"},{"id":"T97","span":{"begin":663,"end":668},"obj":"P41246"},{"id":"T98","span":{"begin":663,"end":668},"obj":"P41245"},{"id":"T99","span":{"begin":663,"end":668},"obj":"PR:P52176"},{"id":"T100","span":{"begin":663,"end":668},"obj":"P50282"},{"id":"T102","span":{"begin":663,"end":668},"obj":"PR:000010491"},{"id":"T103","span":{"begin":663,"end":668},"obj":"P52176"},{"id":"T104","span":{"begin":663,"end":668},"obj":"O18733"},{"id":"T101","span":{"begin":663,"end":668},"obj":"GO:0004229"},{"id":"T105","span":{"begin":773,"end":782},"obj":"SO:0000817"},{"id":"T106","span":{"begin":783,"end":787},"obj":"PR:000005054"},{"id":"T108","span":{"begin":783,"end":787},"obj":"O89094"},{"id":"T107","span":{"begin":783,"end":787},"obj":"D051379"},{"id":"T109","span":{"begin":783,"end":787},"obj":"10095"},{"id":"T110","span":{"begin":799,"end":803},"obj":"PR:000005054"},{"id":"T112","span":{"begin":799,"end":803},"obj":"O89094"},{"id":"T111","span":{"begin":799,"end":803},"obj":"D051379"},{"id":"T113","span":{"begin":799,"end":803},"obj":"10095"},{"id":"T114","span":{"begin":836,"end":839},"obj":"CHEBI:340824"},{"id":"T117","span":{"begin":836,"end":839},"obj":"CHEBI:59761"},{"id":"T118","span":{"begin":836,"end":841},"obj":"PR:P50282"},{"id":"T119","span":{"begin":836,"end":841},"obj":"PR:P14780"},{"id":"T120","span":{"begin":836,"end":841},"obj":"P14780"},{"id":"T121","span":{"begin":836,"end":841},"obj":"PR:P41245"},{"id":"T122","span":{"begin":836,"end":841},"obj":"P41246"},{"id":"T123","span":{"begin":836,"end":841},"obj":"P41245"},{"id":"T124","span":{"begin":836,"end":841},"obj":"PR:P52176"},{"id":"T125","span":{"begin":836,"end":841},"obj":"P50282"},{"id":"T127","span":{"begin":836,"end":841},"obj":"PR:000010491"},{"id":"T128","span":{"begin":836,"end":841},"obj":"P52176"},{"id":"T129","span":{"begin":836,"end":841},"obj":"O18733"},{"id":"T126","span":{"begin":836,"end":841},"obj":"GO:0004229"},{"id":"T130","span":{"begin":842,"end":846},"obj":"SO:0000704"},{"id":"T131","span":{"begin":873,"end":881},"obj":"D007511"},{"id":"T132","span":{"begin":873,"end":881},"obj":"D007511"},{"id":"T133","span":{"begin":947,"end":950},"obj":"CHEBI:340824"},{"id":"T136","span":{"begin":947,"end":950},"obj":"CHEBI:59761"},{"id":"T137","span":{"begin":947,"end":952},"obj":"PR:P50282"},{"id":"T138","span":{"begin":947,"end":952},"obj":"PR:P14780"},{"id":"T139","span":{"begin":947,"end":952},"obj":"P14780"},{"id":"T140","span":{"begin":947,"end":952},"obj":"PR:P41245"},{"id":"T141","span":{"begin":947,"end":952},"obj":"P41246"},{"id":"T142","span":{"begin":947,"end":952},"obj":"P41245"},{"id":"T143","span":{"begin":947,"end":952},"obj":"PR:P52176"},{"id":"T144","span":{"begin":947,"end":952},"obj":"P50282"},{"id":"T146","span":{"begin":947,"end":952},"obj":"PR:000010491"},{"id":"T147","span":{"begin":947,"end":952},"obj":"P52176"},{"id":"T148","span":{"begin":947,"end":952},"obj":"O18733"},{"id":"T145","span":{"begin":947,"end":952},"obj":"GO:0004229"},{"id":"T149","span":{"begin":953,"end":966},"obj":"D018345"},{"id":"T150","span":{"begin":962,"end":966},"obj":"PR:000005054"},{"id":"T152","span":{"begin":962,"end":966},"obj":"O89094"},{"id":"T154","span":{"begin":1033,"end":1042},"obj":"SO:0000817"},{"id":"T155","span":{"begin":1058,"end":1062},"obj":"UBERON:0003101"},{"id":"T156","span":{"begin":1058,"end":1062},"obj":"CHEBI:30780"},{"id":"T157","span":{"begin":1067,"end":1073},"obj":"UBERON:0003100"},{"id":"T158","span":{"begin":1074,"end":1078},"obj":"PR:000005054"},{"id":"T160","span":{"begin":1074,"end":1078},"obj":"O89094"},{"id":"T159","span":{"begin":1074,"end":1078},"obj":"D051379"},{"id":"T161","span":{"begin":1074,"end":1078},"obj":"10095"},{"id":"T162","span":{"begin":1090,"end":1099},"obj":"SO:0000817"},{"id":"T163","span":{"begin":1100,"end":1104},"obj":"PR:000005054"},{"id":"T165","span":{"begin":1100,"end":1104},"obj":"O89094"},{"id":"T164","span":{"begin":1100,"end":1104},"obj":"D051379"},{"id":"T166","span":{"begin":1100,"end":1104},"obj":"10095"},{"id":"T169","span":{"begin":1125,"end":1128},"obj":"PR:O04529"},{"id":"T168","span":{"begin":1125,"end":1128},"obj":"GO:0004235"},{"id":"T167","span":{"begin":1125,"end":1128},"obj":"CHEBI:340824"},{"id":"T170","span":{"begin":1125,"end":1128},"obj":"CHEBI:59761"},{"id":"T171","span":{"begin":1129,"end":1138},"obj":"CHEBI:35222"},{"id":"T172","span":{"begin":1139,"end":1144},"obj":"C080985"},{"id":"T173","span":{"begin":1139,"end":1144},"obj":"C080985"},{"id":"T174","span":{"begin":1146,"end":1156},"obj":"C080985"},{"id":"T175","span":{"begin":1146,"end":1156},"obj":"C080985"},{"id":"T176","span":{"begin":1216,"end":1221},"obj":"C080985"},{"id":"T177","span":{"begin":1216,"end":1221},"obj":"C080985"},{"id":"T178","span":{"begin":1279,"end":1282},"obj":"CHEBI:340824"},{"id":"T181","span":{"begin":1279,"end":1282},"obj":"CHEBI:59761"},{"id":"T182","span":{"begin":1279,"end":1284},"obj":"PR:P50282"},{"id":"T183","span":{"begin":1279,"end":1284},"obj":"PR:P14780"},{"id":"T184","span":{"begin":1279,"end":1284},"obj":"P14780"},{"id":"T185","span":{"begin":1279,"end":1284},"obj":"PR:P41245"},{"id":"T186","span":{"begin":1279,"end":1284},"obj":"P41246"},{"id":"T187","span":{"begin":1279,"end":1284},"obj":"P41245"},{"id":"T188","span":{"begin":1279,"end":1284},"obj":"PR:P52176"},{"id":"T189","span":{"begin":1279,"end":1284},"obj":"P50282"},{"id":"T191","span":{"begin":1279,"end":1284},"obj":"PR:000010491"},{"id":"T192","span":{"begin":1279,"end":1284},"obj":"P52176"},{"id":"T193","span":{"begin":1279,"end":1284},"obj":"O18733"},{"id":"T190","span":{"begin":1279,"end":1284},"obj":"GO:0004229"},{"id":"T194","span":{"begin":1285,"end":1298},"obj":"D018345"},{"id":"T195","span":{"begin":1294,"end":1298},"obj":"PR:000005054"},{"id":"T197","span":{"begin":1294,"end":1298},"obj":"O89094"},{"id":"T199","span":{"begin":1318,"end":1335},"obj":"D002545"},{"id":"T200","span":{"begin":1318,"end":1335},"obj":"D002545"},{"id":"T203","span":{"begin":1365,"end":1368},"obj":"CHEBI:340824"},{"id":"T206","span":{"begin":1365,"end":1368},"obj":"CHEBI:59761"},{"id":"T207","span":{"begin":1365,"end":1370},"obj":"PR:P50282"},{"id":"T208","span":{"begin":1365,"end":1370},"obj":"PR:P14780"},{"id":"T209","span":{"begin":1365,"end":1370},"obj":"P14780"},{"id":"T210","span":{"begin":1365,"end":1370},"obj":"PR:P41245"},{"id":"T211","span":{"begin":1365,"end":1370},"obj":"P41246"},{"id":"T212","span":{"begin":1365,"end":1370},"obj":"P41245"},{"id":"T213","span":{"begin":1365,"end":1370},"obj":"PR:P52176"},{"id":"T214","span":{"begin":1365,"end":1370},"obj":"P50282"},{"id":"T216","span":{"begin":1365,"end":1370},"obj":"PR:000010491"},{"id":"T217","span":{"begin":1365,"end":1370},"obj":"P52176"},{"id":"T218","span":{"begin":1365,"end":1370},"obj":"O18733"},{"id":"T215","span":{"begin":1365,"end":1370},"obj":"GO:0004229"},{"id":"T219","span":{"begin":1418,"end":1423},"obj":"UBERON:6110636"},{"id":"T220","span":{"begin":1418,"end":1423},"obj":"UBERON:0000955"},{"id":"T221","span":{"begin":1418,"end":1430},"obj":"D001930"},{"id":"T222","span":{"begin":1418,"end":1430},"obj":"D001930"},{"id":"T223","span":{"begin":1443,"end":1451},"obj":"D007511"},{"id":"T224","span":{"begin":1443,"end":1451},"obj":"D007511"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T110","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T149","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T152","pred":"source","obj":"c_corpus"},{"subj":"T154","pred":"source","obj":"c_corpus"},{"subj":"T155","pred":"source","obj":"c_corpus"},{"subj":"T156","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T159","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T169","pred":"source","obj":"c_corpus"},{"subj":"T168","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T170","pred":"source","obj":"c_corpus"},{"subj":"T171","pred":"source","obj":"c_corpus"},{"subj":"T172","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T182","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T184","pred":"source","obj":"c_corpus"},{"subj":"T185","pred":"source","obj":"c_corpus"},{"subj":"T186","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T191","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"},{"subj":"T193","pred":"source","obj":"c_corpus"},{"subj":"T190","pred":"source","obj":"c_corpus"},{"subj":"T194","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T197","pred":"source","obj":"c_corpus"},{"subj":"T199","pred":"source","obj":"c_corpus"},{"subj":"T200","pred":"source","obj":"c_corpus"},{"subj":"T203","pred":"source","obj":"c_corpus"},{"subj":"T206","pred":"source","obj":"c_corpus"},{"subj":"T207","pred":"source","obj":"c_corpus"},{"subj":"T208","pred":"source","obj":"c_corpus"},{"subj":"T209","pred":"source","obj":"c_corpus"},{"subj":"T210","pred":"source","obj":"c_corpus"},{"subj":"T211","pred":"source","obj":"c_corpus"},{"subj":"T212","pred":"source","obj":"c_corpus"},{"subj":"T213","pred":"source","obj":"c_corpus"},{"subj":"T214","pred":"source","obj":"c_corpus"},{"subj":"T216","pred":"source","obj":"c_corpus"},{"subj":"T217","pred":"source","obj":"c_corpus"},{"subj":"T218","pred":"source","obj":"c_corpus"},{"subj":"T215","pred":"source","obj":"c_corpus"},{"subj":"T219","pred":"source","obj":"c_corpus"},{"subj":"T220","pred":"source","obj":"c_corpus"},{"subj":"T221","pred":"source","obj":"c_corpus"},{"subj":"T222","pred":"source","obj":"c_corpus"},{"subj":"T223","pred":"source","obj":"c_corpus"},{"subj":"T224","pred":"source","obj":"c_corpus"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":125},"obj":"DRI_Background"},{"id":"T2","span":{"begin":126,"end":228},"obj":"DRI_Background"},{"id":"T3","span":{"begin":229,"end":447},"obj":"DRI_Challenge"},{"id":"T4","span":{"begin":448,"end":580},"obj":"DRI_Background"},{"id":"T5","span":{"begin":581,"end":669},"obj":"DRI_Background"},{"id":"T6","span":{"begin":670,"end":847},"obj":"DRI_Outcome"},{"id":"T7","span":{"begin":848,"end":939},"obj":"DRI_Background"},{"id":"T8","span":{"begin":940,"end":1079},"obj":"DRI_Outcome"},{"id":"T9","span":{"begin":1080,"end":1206},"obj":"DRI_Outcome"},{"id":"T10","span":{"begin":1207,"end":1336},"obj":"DRI_Background"},{"id":"T11","span":{"begin":1337,"end":1452},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubMed_ArguminSci","color":"#ec9493","default":true},{"id":"c_corpus","color":"#93acec"},{"id":"UseCases_ArguminSci_Discourse","color":"#c6ec93"}]}]}}