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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 126-228 DRI_Background denotes It has been shown recently that matrix metalloproteinases (MMPs) are elevated after cerebral ischemia.
T2 229-447 DRI_Challenge denotes In the current study, we investigated the pathophysiologic role for MMP-9 (gelatinase B, EC.3.4.24.35) in a mouse model of permanent focal cerebral ischemia, using a combination of genetic and pharmacologic approaches.
T3 448-580 DRI_Background denotes Zymography and Western blot analysis demonstrated that MMP-9 protein levels were rapidly up-regulated in brain after ischemic onset.
T4 581-669 DRI_Background denotes Reverse transcription polymerase chain reaction showed increased transcription of MMP-9.
T5 670-847 DRI_Outcome denotes There were no differences in systemic hemodynamic parameters and gross cerebrovascular anatomy between wild type mice and mutant mice with a targeted knockout of the MMP-9 gene.
T6 848-939 DRI_Background denotes After induction of focal ischemia, similar reductions in cerebral blood flow were obtained.
T7 940-1079 DRI_Outcome denotes In the MMP-9 knockout mice, ischemic lesion volumes were significantly reduced compared with wild type littermates in male and female mice.
T8 1080-1206 DRI_Outcome denotes In normal wild type mice, the broad spectrum MMP inhibitor BB-94 (batimastat) also significantly reduced ischemic lesion size.
T9 1207-1336 DRI_Background denotes However, BB-94 had no detectable protective effect when administered to MMP-9 knockout mice subjected to focal cerebral ischemia.
T10 1337-1452 DRI_Challenge denotes These data demonstrate that MMP-9 plays a deleterious role in the development of brain injury after focal ischemia.

c_corpus

Id Subject Object Predicate Lexical cue
T1 9-15 UBERON:0027368 denotes matrix
T3 9-35 P14780 denotes matrix metalloproteinase 9
T4 9-35 P41246 denotes matrix metalloproteinase 9
T5 9-35 P41245 denotes matrix metalloproteinase 9
T6 9-35 P50282 denotes matrix metalloproteinase 9
T7 9-35 PR:000010491 denotes matrix metalloproteinase 9
T8 9-35 P52176 denotes matrix metalloproteinase 9
T9 9-35 O18733 denotes matrix metalloproteinase 9
T2 9-35 D020780 denotes matrix metalloproteinase 9
T10 48-65 D002545 denotes cerebral ischemia
T11 48-65 D002545 denotes cerebral ischemia
T14 78-82 SO:0000704 denotes gene
T15 119-124 C080985 denotes BB-94
T16 119-124 C080985 denotes BB-94
T17 158-164 UBERON:0027368 denotes matrix
T18 158-183 D020782 denotes matrix metalloproteinases
T20 185-189 D020782 denotes MMPs
T21 210-227 D002545 denotes cerebral ischemia
T22 210-227 D002545 denotes cerebral ischemia
T25 297-300 CHEBI:340824 denotes MMP
T28 297-300 CHEBI:59761 denotes MMP
T29 297-302 PR:P50282 denotes MMP-9
T30 297-302 PR:P14780 denotes MMP-9
T31 297-302 P14780 denotes MMP-9
T32 297-302 PR:P41245 denotes MMP-9
T33 297-302 P41246 denotes MMP-9
T34 297-302 P41245 denotes MMP-9
T35 297-302 PR:P52176 denotes MMP-9
T36 297-302 P50282 denotes MMP-9
T38 297-302 PR:000010491 denotes MMP-9
T39 297-302 P52176 denotes MMP-9
T40 297-302 O18733 denotes MMP-9
T37 297-302 GO:0004229 denotes MMP-9
T44 304-316 P14780 denotes gelatinase B
T45 304-316 P41246 denotes gelatinase B
T46 304-316 P41245 denotes gelatinase B
T47 304-316 P50282 denotes gelatinase B
T48 304-316 PR:000010491 denotes gelatinase B
T49 304-316 P52176 denotes gelatinase B
T50 304-316 O18733 denotes gelatinase B
T43 304-316 D020780 denotes gelatinase B
T51 318-322 CVCL_5V07 denotes EC.3
T52 335-342 MGI:87853 denotes a mouse
T53 337-342 10090 denotes mouse
T54 337-342 D051379 denotes mouse
T55 368-385 D002545 denotes cerebral ischemia
T56 368-385 D002545 denotes cerebral ischemia
T59 503-506 CHEBI:340824 denotes MMP
T62 503-506 CHEBI:59761 denotes MMP
T63 503-508 PR:P50282 denotes MMP-9
T64 503-508 PR:P14780 denotes MMP-9
T65 503-508 P14780 denotes MMP-9
T66 503-508 PR:P41245 denotes MMP-9
T67 503-508 P41246 denotes MMP-9
T68 503-508 P41245 denotes MMP-9
T69 503-508 PR:P52176 denotes MMP-9
T70 503-508 P50282 denotes MMP-9
T72 503-508 PR:000010491 denotes MMP-9
T73 503-508 P52176 denotes MMP-9
T74 503-508 O18733 denotes MMP-9
T71 503-508 GO:0004229 denotes MMP-9
T79 509-516 SO:0000104 denotes protein
T78 509-516 PR:000000001 denotes protein
T76 509-516 CHEBI:36080 denotes protein
T77 509-516 CHEBI:11122 denotes protein
T75 509-516 GO:0003675 denotes protein
T80 540-549 SO:0000119 denotes regulated
T81 553-558 UBERON:6110636 denotes brain
T82 553-558 UBERON:0000955 denotes brain
T83 581-588 SO:0001031 denotes Reverse
T84 581-602 GO:0001171 denotes Reverse transcription
T86 614-619 SO:0000419 denotes chain
T87 614-628 MOP:0000635 denotes chain reaction
T88 646-659 GO:0006351 denotes transcription
T89 663-666 CHEBI:340824 denotes MMP
T92 663-666 CHEBI:59761 denotes MMP
T93 663-668 PR:P50282 denotes MMP-9
T94 663-668 PR:P14780 denotes MMP-9
T95 663-668 P14780 denotes MMP-9
T96 663-668 PR:P41245 denotes MMP-9
T97 663-668 P41246 denotes MMP-9
T98 663-668 P41245 denotes MMP-9
T99 663-668 PR:P52176 denotes MMP-9
T100 663-668 P50282 denotes MMP-9
T102 663-668 PR:000010491 denotes MMP-9
T103 663-668 P52176 denotes MMP-9
T104 663-668 O18733 denotes MMP-9
T101 663-668 GO:0004229 denotes MMP-9
T105 773-782 SO:0000817 denotes wild type
T106 783-787 PR:000005054 denotes mice
T108 783-787 O89094 denotes mice
T107 783-787 D051379 denotes mice
T109 783-787 10095 denotes mice
T110 799-803 PR:000005054 denotes mice
T112 799-803 O89094 denotes mice
T111 799-803 D051379 denotes mice
T113 799-803 10095 denotes mice
T114 836-839 CHEBI:340824 denotes MMP
T117 836-839 CHEBI:59761 denotes MMP
T118 836-841 PR:P50282 denotes MMP-9
T119 836-841 PR:P14780 denotes MMP-9
T120 836-841 P14780 denotes MMP-9
T121 836-841 PR:P41245 denotes MMP-9
T122 836-841 P41246 denotes MMP-9
T123 836-841 P41245 denotes MMP-9
T124 836-841 PR:P52176 denotes MMP-9
T125 836-841 P50282 denotes MMP-9
T127 836-841 PR:000010491 denotes MMP-9
T128 836-841 P52176 denotes MMP-9
T129 836-841 O18733 denotes MMP-9
T126 836-841 GO:0004229 denotes MMP-9
T130 842-846 SO:0000704 denotes gene
T131 873-881 D007511 denotes ischemia
T132 873-881 D007511 denotes ischemia
T133 947-950 CHEBI:340824 denotes MMP
T136 947-950 CHEBI:59761 denotes MMP
T137 947-952 PR:P50282 denotes MMP-9
T138 947-952 PR:P14780 denotes MMP-9
T139 947-952 P14780 denotes MMP-9
T140 947-952 PR:P41245 denotes MMP-9
T141 947-952 P41246 denotes MMP-9
T142 947-952 P41245 denotes MMP-9
T143 947-952 PR:P52176 denotes MMP-9
T144 947-952 P50282 denotes MMP-9
T146 947-952 PR:000010491 denotes MMP-9
T147 947-952 P52176 denotes MMP-9
T148 947-952 O18733 denotes MMP-9
T145 947-952 GO:0004229 denotes MMP-9
T149 953-966 D018345 denotes knockout mice
T150 962-966 PR:000005054 denotes mice
T152 962-966 O89094 denotes mice
T154 1033-1042 SO:0000817 denotes wild type
T155 1058-1062 UBERON:0003101 denotes male
T156 1058-1062 CHEBI:30780 denotes male
T157 1067-1073 UBERON:0003100 denotes female
T158 1074-1078 PR:000005054 denotes mice
T160 1074-1078 O89094 denotes mice
T159 1074-1078 D051379 denotes mice
T161 1074-1078 10095 denotes mice
T162 1090-1099 SO:0000817 denotes wild type
T163 1100-1104 PR:000005054 denotes mice
T165 1100-1104 O89094 denotes mice
T164 1100-1104 D051379 denotes mice
T166 1100-1104 10095 denotes mice
T169 1125-1128 PR:O04529 denotes MMP
T168 1125-1128 GO:0004235 denotes MMP
T167 1125-1128 CHEBI:340824 denotes MMP
T170 1125-1128 CHEBI:59761 denotes MMP
T171 1129-1138 CHEBI:35222 denotes inhibitor
T172 1139-1144 C080985 denotes BB-94
T173 1139-1144 C080985 denotes BB-94
T174 1146-1156 C080985 denotes batimastat
T175 1146-1156 C080985 denotes batimastat
T176 1216-1221 C080985 denotes BB-94
T177 1216-1221 C080985 denotes BB-94
T178 1279-1282 CHEBI:340824 denotes MMP
T181 1279-1282 CHEBI:59761 denotes MMP
T182 1279-1284 PR:P50282 denotes MMP-9
T183 1279-1284 PR:P14780 denotes MMP-9
T184 1279-1284 P14780 denotes MMP-9
T185 1279-1284 PR:P41245 denotes MMP-9
T186 1279-1284 P41246 denotes MMP-9
T187 1279-1284 P41245 denotes MMP-9
T188 1279-1284 PR:P52176 denotes MMP-9
T189 1279-1284 P50282 denotes MMP-9
T191 1279-1284 PR:000010491 denotes MMP-9
T192 1279-1284 P52176 denotes MMP-9
T193 1279-1284 O18733 denotes MMP-9
T190 1279-1284 GO:0004229 denotes MMP-9
T194 1285-1298 D018345 denotes knockout mice
T195 1294-1298 PR:000005054 denotes mice
T197 1294-1298 O89094 denotes mice
T199 1318-1335 D002545 denotes cerebral ischemia
T200 1318-1335 D002545 denotes cerebral ischemia
T203 1365-1368 CHEBI:340824 denotes MMP
T206 1365-1368 CHEBI:59761 denotes MMP
T207 1365-1370 PR:P50282 denotes MMP-9
T208 1365-1370 PR:P14780 denotes MMP-9
T209 1365-1370 P14780 denotes MMP-9
T210 1365-1370 PR:P41245 denotes MMP-9
T211 1365-1370 P41246 denotes MMP-9
T212 1365-1370 P41245 denotes MMP-9
T213 1365-1370 PR:P52176 denotes MMP-9
T214 1365-1370 P50282 denotes MMP-9
T216 1365-1370 PR:000010491 denotes MMP-9
T217 1365-1370 P52176 denotes MMP-9
T218 1365-1370 O18733 denotes MMP-9
T215 1365-1370 GO:0004229 denotes MMP-9
T219 1418-1423 UBERON:6110636 denotes brain
T220 1418-1423 UBERON:0000955 denotes brain
T221 1418-1430 D001930 denotes brain injury
T222 1418-1430 D001930 denotes brain injury
T223 1443-1451 D007511 denotes ischemia
T224 1443-1451 D007511 denotes ischemia

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-125 DRI_Background denotes Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94.
T2 126-228 DRI_Background denotes It has been shown recently that matrix metalloproteinases (MMPs) are elevated after cerebral ischemia.
T3 229-447 DRI_Challenge denotes In the current study, we investigated the pathophysiologic role for MMP-9 (gelatinase B, EC.3.4.24.35) in a mouse model of permanent focal cerebral ischemia, using a combination of genetic and pharmacologic approaches.
T4 448-580 DRI_Background denotes Zymography and Western blot analysis demonstrated that MMP-9 protein levels were rapidly up-regulated in brain after ischemic onset.
T5 581-669 DRI_Background denotes Reverse transcription polymerase chain reaction showed increased transcription of MMP-9.
T6 670-847 DRI_Outcome denotes There were no differences in systemic hemodynamic parameters and gross cerebrovascular anatomy between wild type mice and mutant mice with a targeted knockout of the MMP-9 gene.
T7 848-939 DRI_Background denotes After induction of focal ischemia, similar reductions in cerebral blood flow were obtained.
T8 940-1079 DRI_Outcome denotes In the MMP-9 knockout mice, ischemic lesion volumes were significantly reduced compared with wild type littermates in male and female mice.
T9 1080-1206 DRI_Outcome denotes In normal wild type mice, the broad spectrum MMP inhibitor BB-94 (batimastat) also significantly reduced ischemic lesion size.
T10 1207-1336 DRI_Background denotes However, BB-94 had no detectable protective effect when administered to MMP-9 knockout mice subjected to focal cerebral ischemia.
T11 1337-1452 DRI_Challenge denotes These data demonstrate that MMP-9 plays a deleterious role in the development of brain injury after focal ischemia.