PubMed:11106653
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 905-910 | Cell | denotes | Delta | http://purl.obolibrary.org/obo/CL:0004124 |
| T2 | 940-945 | Cell | denotes | Delta | http://purl.obolibrary.org/obo/CL:0004124 |
| T3 | 1116-1121 | Cell | denotes | Delta | http://purl.obolibrary.org/obo/CL:0004124 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 31-42 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T2 | 688-699 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T3 | 1221-1232 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T4 | 1370-1381 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T5 | 1394-1401 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T7 | 1548-1559 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 31-42 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T2 | 688-699 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T3 | 1221-1232 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T4 | 1370-1381 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T5 | 1548-1559 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-128 | Sentence | denotes | Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development. |
| T2 | 129-281 | Sentence | denotes | In Alzheimer's disease, the major pathological features are diffuse and senile plaques that are primarily composed of the amyloid-beta (A beta) peptide. |
| T3 | 282-426 | Sentence | denotes | It has been proposed that proteoglycans and glycosaminoglycans (GAG) facilitate amyloid fibril formation and/or stabilize the plaque aggregates. |
| T4 | 427-565 | Sentence | denotes | To develop effective therapeutics based on A beta-GAG interactions, understanding the A beta binding motif on the GAG chain is imperative. |
| T5 | 566-835 | Sentence | denotes | Using electron microscopy, fluorescence spectroscopy, and competitive inhibition ELISAs, we have evaluated the ability of chondroitin sulfate-derived monosaccharides and disaccharides to induce the structural changes in A beta that are associated with GAG interactions. |
| T6 | 836-1190 | Sentence | denotes | Our results demonstrate that the disaccharides GalNAc-4-sulfate(4S), Delta UA-GalNAc-6-sulfate(6S), and Delta UA-GalNAc-4,6-sulfate(4S,6S), the iduronic acid-2-sulfate analogues, and the monosaccharides d-GalNAc-4S, d-GalNAc-6S, and d-GalNAc-4S,6S, but not d-GalNAc, d-GlcNAc, or Delta UA-GalNAc, induce the fibrillar features of A beta-GAG interactions. |
| T7 | 1191-1298 | Sentence | denotes | The binding affinities of all chondroitin sulfate-derived saccharides mimic those of the intact GAG chains. |
| T8 | 1299-1475 | Sentence | denotes | The sulfated monosaccharides and disaccharides compete with the intact chondroitin sulfate and heparin GAGs for A beta binding, as illustrated by competitive inhibition ELISAs. |
| T9 | 1476-1672 | Sentence | denotes | Therefore, the development of therapeutics based on the model of A beta-chondroitin sulfate binding may lead to effective inhibitors of the GAG-induced amyloid formation that is observed in vitro. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 31-42 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T2 | 688-699 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T3 | 1221-1232 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T4 | 1370-1381 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T5 | 1394-1401 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T6 | 1394-1401 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T7 | 1548-1559 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 1105-1111 | chem:24139 | denotes | GlcNAc |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 0-7 | Disease | denotes | Amyloid | http://purl.obolibrary.org/obo/MONDO_0019065 |
| T2 | 132-151 | Disease | denotes | Alzheimer's disease | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T3 | 251-258 | Disease | denotes | amyloid | http://purl.obolibrary.org/obo/MONDO_0019065 |
| T4 | 362-369 | Disease | denotes | amyloid | http://purl.obolibrary.org/obo/MONDO_0019065 |
| T5 | 1628-1635 | Disease | denotes | amyloid | http://purl.obolibrary.org/obo/MONDO_0019065 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 132-151 | Phenotype | denotes | Alzheimer's disease | HP:0002511 |
| T2 | 201-215 | Phenotype | denotes | senile plaques | HP:0100256 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 31-42 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 688-699 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 883-889 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 914-920 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T5 | 949-955 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T6 | 1041-1047 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T7 | 1054-1060 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T8 | 1071-1077 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T9 | 1095-1101 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T10 | 1125-1131 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T11 | 1221-1232 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T12 | 1370-1381 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T13 | 1548-1559 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 31-42 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 688-699 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 1221-1232 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T4 | 1370-1381 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T5 | 1548-1559 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 132-151 | Phenotype | denotes | Alzheimer's disease | HP:0002511 |
| T2 | 201-215 | Phenotype | denotes | senile plaques | HP:0100256 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 0-7 | Disease | denotes | Amyloid | http://purl.obolibrary.org/obo/MONDO_0019065 |
| T2 | 132-151 | Disease | denotes | Alzheimer's disease | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T3 | 251-258 | Disease | denotes | amyloid | http://purl.obolibrary.org/obo/MONDO_0019065 |
| T4 | 362-369 | Disease | denotes | amyloid | http://purl.obolibrary.org/obo/MONDO_0019065 |
| T5 | 1628-1635 | Disease | denotes | amyloid | http://purl.obolibrary.org/obo/MONDO_0019065 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 905-910 | Cell | denotes | Delta | http://purl.obolibrary.org/obo/CL:0004124 |
| T2 | 940-945 | Cell | denotes | Delta | http://purl.obolibrary.org/obo/CL:0004124 |
| T3 | 1116-1121 | Cell | denotes | Delta | http://purl.obolibrary.org/obo/CL:0004124 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 370-376 | Body_part | denotes | fibril | http://purl.obolibrary.org/obo/GO_0099512 |
| T2 | 408-414 | Body_part | denotes | plaque | http://purl.obolibrary.org/obo/UBERON_0016482 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-128 | Sentence | denotes | Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development. |
| T2 | 129-281 | Sentence | denotes | In Alzheimer's disease, the major pathological features are diffuse and senile plaques that are primarily composed of the amyloid-beta (A beta) peptide. |
| T3 | 282-426 | Sentence | denotes | It has been proposed that proteoglycans and glycosaminoglycans (GAG) facilitate amyloid fibril formation and/or stabilize the plaque aggregates. |
| T4 | 427-565 | Sentence | denotes | To develop effective therapeutics based on A beta-GAG interactions, understanding the A beta binding motif on the GAG chain is imperative. |
| T5 | 566-835 | Sentence | denotes | Using electron microscopy, fluorescence spectroscopy, and competitive inhibition ELISAs, we have evaluated the ability of chondroitin sulfate-derived monosaccharides and disaccharides to induce the structural changes in A beta that are associated with GAG interactions. |
| T6 | 836-1190 | Sentence | denotes | Our results demonstrate that the disaccharides GalNAc-4-sulfate(4S), Delta UA-GalNAc-6-sulfate(6S), and Delta UA-GalNAc-4,6-sulfate(4S,6S), the iduronic acid-2-sulfate analogues, and the monosaccharides d-GalNAc-4S, d-GalNAc-6S, and d-GalNAc-4S,6S, but not d-GalNAc, d-GlcNAc, or Delta UA-GalNAc, induce the fibrillar features of A beta-GAG interactions. |
| T7 | 1191-1298 | Sentence | denotes | The binding affinities of all chondroitin sulfate-derived saccharides mimic those of the intact GAG chains. |
| T8 | 1299-1475 | Sentence | denotes | The sulfated monosaccharides and disaccharides compete with the intact chondroitin sulfate and heparin GAGs for A beta binding, as illustrated by competitive inhibition ELISAs. |
| T9 | 1476-1672 | Sentence | denotes | Therefore, the development of therapeutics based on the model of A beta-chondroitin sulfate binding may lead to effective inhibitors of the GAG-induced amyloid formation that is observed in vitro. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-128 | Sentence | denotes | Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development. |
| T2 | 129-281 | Sentence | denotes | In Alzheimer's disease, the major pathological features are diffuse and senile plaques that are primarily composed of the amyloid-beta (A beta) peptide. |
| T3 | 282-426 | Sentence | denotes | It has been proposed that proteoglycans and glycosaminoglycans (GAG) facilitate amyloid fibril formation and/or stabilize the plaque aggregates. |
| T4 | 427-565 | Sentence | denotes | To develop effective therapeutics based on A beta-GAG interactions, understanding the A beta binding motif on the GAG chain is imperative. |
| T5 | 566-835 | Sentence | denotes | Using electron microscopy, fluorescence spectroscopy, and competitive inhibition ELISAs, we have evaluated the ability of chondroitin sulfate-derived monosaccharides and disaccharides to induce the structural changes in A beta that are associated with GAG interactions. |
| T6 | 836-1190 | Sentence | denotes | Our results demonstrate that the disaccharides GalNAc-4-sulfate(4S), Delta UA-GalNAc-6-sulfate(6S), and Delta UA-GalNAc-4,6-sulfate(4S,6S), the iduronic acid-2-sulfate analogues, and the monosaccharides d-GalNAc-4S, d-GalNAc-6S, and d-GalNAc-4S,6S, but not d-GalNAc, d-GlcNAc, or Delta UA-GalNAc, induce the fibrillar features of A beta-GAG interactions. |
| T7 | 1191-1298 | Sentence | denotes | The binding affinities of all chondroitin sulfate-derived saccharides mimic those of the intact GAG chains. |
| T8 | 1299-1475 | Sentence | denotes | The sulfated monosaccharides and disaccharides compete with the intact chondroitin sulfate and heparin GAGs for A beta binding, as illustrated by competitive inhibition ELISAs. |
| T9 | 1476-1672 | Sentence | denotes | Therefore, the development of therapeutics based on the model of A beta-chondroitin sulfate binding may lead to effective inhibitors of the GAG-induced amyloid formation that is observed in vitro. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 31-42 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 688-699 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 883-889 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 914-920 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T5 | 949-955 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T6 | 1041-1047 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T7 | 1054-1060 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T8 | 1071-1077 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T9 | 1095-1101 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T10 | 1125-1131 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T11 | 1221-1232 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T12 | 1370-1381 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T13 | 1548-1559 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 31-42 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 688-699 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 1221-1232 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T4 | 1370-1381 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T5 | 1548-1559 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 370-376 | Body_part | denotes | fibril | http://purl.obolibrary.org/obo/GO_0099512 |
| T2 | 408-414 | Body_part | denotes | plaque | http://purl.obolibrary.org/obo/UBERON_0016482 |