PubMed:11030742 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11030742","sourcedb":"PubMed","sourceid":"11030742","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11030742","text":"Molecular dynamics simulation of human prion protein including both N-linked oligosaccharides and the GPI anchor.\nAlthough glycosylation appears to protect prion protein (PrP(C)) from the conformational transition to the disease-associated scrapie form (PrP(Sc)), available NMR structures are for non-glycosylated PrP(C), only. To investigate the influence of both the two N-linked glycans, Asn181 and Asn197, and of the GPI anchor attached to Ser230, on the structural, dynamical and electrostatic behavior of PrP, we have undertaken molecular dynamics simulations on the C-terminal region of human prion protein HU:PrP(90-230), with and without the three glycans. The simulations used the AMBER94 force field in a periodic box model with explicit water molecules, considering all long-range electrostatic interactions. The results suggest the structured part of the protein, HU:PrP(127-227) is stabilized overall from addition of the glycans, specifically by extensions of Helix-B and Helix-C and reduced flexibility of the linking turn containing Asn197, although some regions such as residues in the turn (165-170) between Strand-B and Helix-B have increased flexibility. The stabilization appears indirect, by reducing the mobility of the surrounding water molecules, and not from specific interactions such as H bonds or ion pairs. The results are consistent with glycosylation at Asn197 having a stabilizing role, while that at Asn181, in a region with already stable secondary structure, having a more functional role, in agreement with literature suggestions. Due to three negatively charged SiaLe(x) groups per N-glycan, the surface electrostatic properties change to a negative electrostatic field covering most of the C-terminal part, including the surface of Helix-B and Helix-C, while the positively charged N-terminal part PrP(90-126) of undefined structure creates a positive potential. The unusual hydrophilic Helix-A (144-152) is not covered by either of these dominant electrostatic fields, and modeling shows it could readily dimerize in anti parallel fashion. In combination with separate simulations of the GPI anchor in a membrane model, the results show the GPI anchor is highly flexible and would maintain the protein at a distance between 9 and 13 A from the membrane surface, with little influence on its structure or orientational freedom.","tracks":[{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":113},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":114,"end":327},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":328,"end":665},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":666,"end":820},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":821,"end":1175},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":1176,"end":1337},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":1338,"end":1568},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1569,"end":1902},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":1903,"end":2080},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":2081,"end":2367},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":113},"obj":"Sentence"},{"id":"T2","span":{"begin":114,"end":327},"obj":"Sentence"},{"id":"T3","span":{"begin":328,"end":665},"obj":"Sentence"},{"id":"T4","span":{"begin":666,"end":820},"obj":"Sentence"},{"id":"T5","span":{"begin":821,"end":1175},"obj":"Sentence"},{"id":"T6","span":{"begin":1176,"end":1337},"obj":"Sentence"},{"id":"T7","span":{"begin":1338,"end":1568},"obj":"Sentence"},{"id":"T8","span":{"begin":1569,"end":1902},"obj":"Sentence"},{"id":"T9","span":{"begin":1903,"end":2080},"obj":"Sentence"},{"id":"T10","span":{"begin":2081,"end":2367},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":113},"obj":"Sentence"},{"id":"T2","span":{"begin":114,"end":327},"obj":"Sentence"},{"id":"T3","span":{"begin":328,"end":665},"obj":"Sentence"},{"id":"T4","span":{"begin":666,"end":820},"obj":"Sentence"},{"id":"T5","span":{"begin":821,"end":1175},"obj":"Sentence"},{"id":"T6","span":{"begin":1176,"end":1337},"obj":"Sentence"},{"id":"T7","span":{"begin":1338,"end":1568},"obj":"Sentence"},{"id":"T8","span":{"begin":1569,"end":1902},"obj":"Sentence"},{"id":"T9","span":{"begin":1903,"end":2080},"obj":"Sentence"},{"id":"T10","span":{"begin":2081,"end":2367},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"}]},{"project":"ICD10","denotations":[{"id":"T1","span":{"begin":1215,"end":1236},"obj":"http://purl.bioontology.org/ontology/ICD10/Z74.0"}],"attributes":[{"subj":"T1","pred":"source","obj":"ICD10"}]},{"project":"GlycoBiology-FMA","denotations":[{"id":"_T1","span":{"begin":45,"end":52},"obj":"FMAID:165447"},{"id":"_T2","span":{"begin":45,"end":52},"obj":"FMAID:67257"},{"id":"_T3","span":{"begin":77,"end":93},"obj":"FMAID:82742"},{"id":"_T4","span":{"begin":77,"end":93},"obj":"FMAID:196731"},{"id":"_T5","span":{"begin":162,"end":169},"obj":"FMAID:165447"},{"id":"_T6","span":{"begin":162,"end":169},"obj":"FMAID:67257"},{"id":"_T7","span":{"begin":203,"end":213},"obj":"FMAID:70637"},{"id":"_T8","span":{"begin":203,"end":213},"obj":"FMAID:171495"},{"id":"_T9","span":{"begin":606,"end":613},"obj":"FMAID:67257"},{"id":"_T10","span":{"begin":606,"end":613},"obj":"FMAID:165447"},{"id":"_T11","span":{"begin":868,"end":875},"obj":"FMAID:165447"},{"id":"_T12","span":{"begin":868,"end":875},"obj":"FMAID:67257"},{"id":"_T13","span":{"begin":975,"end":980},"obj":"FMAID:60992"},{"id":"_T14","span":{"begin":975,"end":980},"obj":"FMAID:161427"},{"id":"_T15","span":{"begin":987,"end":992},"obj":"FMAID:161427"},{"id":"_T16","span":{"begin":987,"end":992},"obj":"FMAID:60992"},{"id":"_T17","span":{"begin":1140,"end":1145},"obj":"FMAID:60992"},{"id":"_T18","span":{"begin":1140,"end":1145},"obj":"FMAID:161427"},{"id":"_T19","span":{"begin":1635,"end":1642},"obj":"FMAID:50594"},{"id":"_T20","span":{"begin":1635,"end":1642},"obj":"FMAID:146300"},{"id":"_T21","span":{"begin":1761,"end":1768},"obj":"FMAID:50594"},{"id":"_T22","span":{"begin":1761,"end":1768},"obj":"FMAID:146300"},{"id":"_T23","span":{"begin":1772,"end":1777},"obj":"FMAID:60992"},{"id":"_T24","span":{"begin":1772,"end":1777},"obj":"FMAID:161427"},{"id":"_T25","span":{"begin":1784,"end":1789},"obj":"FMAID:60992"},{"id":"_T26","span":{"begin":1784,"end":1789},"obj":"FMAID:161427"},{"id":"_T27","span":{"begin":1927,"end":1932},"obj":"FMAID:60992"},{"id":"_T28","span":{"begin":1927,"end":1932},"obj":"FMAID:161427"},{"id":"_T29","span":{"begin":2222,"end":2230},"obj":"FMAID:214734"},{"id":"_T30","span":{"begin":2235,"end":2242},"obj":"FMAID:165447"},{"id":"_T31","span":{"begin":2235,"end":2242},"obj":"FMAID:67257"},{"id":"_T32","span":{"begin":2294,"end":2301},"obj":"FMAID:146300"},{"id":"_T33","span":{"begin":2294,"end":2301},"obj":"FMAID:50594"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"attributes":[{"subj":"_T1","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T2","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T3","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T4","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T5","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T6","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T7","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T8","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T9","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T10","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T11","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T12","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T13","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T14","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T15","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T16","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T17","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T18","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T19","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T20","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T21","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T22","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T23","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T24","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T25","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T26","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T27","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T28","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T29","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T30","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T31","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T32","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T33","pred":"source","obj":"GlycoBiology-FMA"}]},{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":102,"end":105},"obj":"http://www.uniprot.org/uniprot/P06744"},{"id":"T2","span":{"begin":421,"end":424},"obj":"http://www.uniprot.org/uniprot/P06744"},{"id":"T3","span":{"begin":2129,"end":2132},"obj":"http://www.uniprot.org/uniprot/P06744"},{"id":"T4","span":{"begin":2182,"end":2185},"obj":"http://www.uniprot.org/uniprot/P06744"},{"id":"T5","span":{"begin":2129,"end":2153},"obj":"http://www.uniprot.org/uniprot/Q14444"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-human"},{"subj":"T2","pred":"source","obj":"uniprot-human"},{"subj":"T3","pred":"source","obj":"uniprot-human"},{"subj":"T4","pred":"source","obj":"uniprot-human"},{"subj":"T5","pred":"source","obj":"uniprot-human"}]},{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":102,"end":105},"obj":"http://www.uniprot.org/uniprot/Q8C675"},{"id":"T2","span":{"begin":421,"end":424},"obj":"http://www.uniprot.org/uniprot/Q8C675"},{"id":"T3","span":{"begin":2129,"end":2132},"obj":"http://www.uniprot.org/uniprot/Q8C675"},{"id":"T4","span":{"begin":2182,"end":2185},"obj":"http://www.uniprot.org/uniprot/Q8C675"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-mouse"},{"subj":"T2","pred":"source","obj":"uniprot-mouse"},{"subj":"T3","pred":"source","obj":"uniprot-mouse"},{"subj":"T4","pred":"source","obj":"uniprot-mouse"}]},{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":39,"end":44},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/94193"},{"id":"T2","span":{"begin":39,"end":44},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/94464"},{"id":"T3","span":{"begin":156,"end":161},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/94193"},{"id":"T4","span":{"begin":156,"end":161},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/94464"},{"id":"T5","span":{"begin":297,"end":300},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/604139"},{"id":"T6","span":{"begin":499,"end":507},"obj":"http://purl.bioontology.org/ontology/STY/T053"},{"id":"T7","span":{"begin":600,"end":605},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/94193"},{"id":"T8","span":{"begin":600,"end":605},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/94464"},{"id":"T9","span":{"begin":975,"end":980},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/6534"},{"id":"T10","span":{"begin":987,"end":992},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/6534"},{"id":"T11","span":{"begin":1140,"end":1145},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/6534"},{"id":"T12","span":{"begin":1610,"end":1616},"obj":"http://purl.bioontology.org/ontology/STY/T096"},{"id":"T13","span":{"begin":1772,"end":1777},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/6534"},{"id":"T14","span":{"begin":1784,"end":1789},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/6534"},{"id":"T15","span":{"begin":1915,"end":1926},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/8683"},{"id":"T16","span":{"begin":1915,"end":1926},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/415099"},{"id":"T17","span":{"begin":1927,"end":1932},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/6534"},{"id":"T18","span":{"begin":2063,"end":2071},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/871272"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T2","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T3","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T4","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T5","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T6","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T7","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T8","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T9","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T10","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T11","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T12","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T13","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T14","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T15","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T16","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T17","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T18","pred":"source","obj":"GlycoBiology-NCBITAXON"}]},{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":123,"end":136},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T2","span":{"begin":301,"end":313},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T3","span":{"begin":421,"end":440},"obj":"http://purl.obolibrary.org/obo/GO_0016255"},{"id":"T4","span":{"begin":499,"end":507},"obj":"http://purl.obolibrary.org/obo/GO_0007610"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-BP"},{"subj":"T2","pred":"source","obj":"GO-BP"},{"subj":"T3","pred":"source","obj":"GO-BP"},{"subj":"T4","pred":"source","obj":"GO-BP"}]},{"project":"GO-MF","denotations":[{"id":"T1","span":{"begin":106,"end":112},"obj":"http://purl.obolibrary.org/obo/GO_0043495"},{"id":"T2","span":{"begin":425,"end":431},"obj":"http://purl.obolibrary.org/obo/GO_0043495"},{"id":"T3","span":{"begin":2133,"end":2139},"obj":"http://purl.obolibrary.org/obo/GO_0043495"},{"id":"T4","span":{"begin":2186,"end":2192},"obj":"http://purl.obolibrary.org/obo/GO_0043495"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-MF"},{"subj":"T2","pred":"source","obj":"GO-MF"},{"subj":"T3","pred":"source","obj":"GO-MF"},{"subj":"T4","pred":"source","obj":"GO-MF"}]},{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":2129,"end":2153},"obj":"http://purl.obolibrary.org/obo/GO_0046658"},{"id":"T2","span":{"begin":2133,"end":2153},"obj":"http://purl.obolibrary.org/obo/GO_0031225"},{"id":"T3","span":{"begin":2145,"end":2153},"obj":"http://purl.obolibrary.org/obo/GO_0016020"},{"id":"T4","span":{"begin":2285,"end":2293},"obj":"http://purl.obolibrary.org/obo/GO_0016020"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-CC"},{"subj":"T2","pred":"source","obj":"GO-CC"},{"subj":"T3","pred":"source","obj":"GO-CC"},{"subj":"T4","pred":"source","obj":"GO-CC"}]},{"project":"UBERON-AE","denotations":[{"id":"T1","span":{"begin":961,"end":971},"obj":"http://purl.obolibrary.org/obo/UBERON_2000106"},{"id":"T2","span":{"begin":975,"end":980},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"T3","span":{"begin":987,"end":992},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"T4","span":{"begin":1140,"end":1145},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"T5","span":{"begin":1772,"end":1777},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"T6","span":{"begin":1784,"end":1789},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"T7","span":{"begin":1927,"end":1932},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"}],"attributes":[{"subj":"T1","pred":"source","obj":"UBERON-AE"},{"subj":"T2","pred":"source","obj":"UBERON-AE"},{"subj":"T3","pred":"source","obj":"UBERON-AE"},{"subj":"T4","pred":"source","obj":"UBERON-AE"},{"subj":"T5","pred":"source","obj":"UBERON-AE"},{"subj":"T6","pred":"source","obj":"UBERON-AE"},{"subj":"T7","pred":"source","obj":"UBERON-AE"}]},{"project":"EDAM-topics","denotations":[{"id":"T1","span":{"begin":0,"end":18},"obj":"http://edamontology.org/topic_0176"},{"id":"T2","span":{"begin":33,"end":38},"obj":"http://edamontology.org/topic_2815"},{"id":"T3","span":{"begin":45,"end":52},"obj":"http://edamontology.org/topic_0078"},{"id":"T4","span":{"begin":162,"end":169},"obj":"http://edamontology.org/topic_0078"},{"id":"T5","span":{"begin":221,"end":228},"obj":"http://edamontology.org/topic_0634"},{"id":"T6","span":{"begin":274,"end":277},"obj":"http://edamontology.org/topic_0593"},{"id":"T7","span":{"begin":535,"end":553},"obj":"http://edamontology.org/topic_0176"},{"id":"T8","span":{"begin":575,"end":583},"obj":"http://edamontology.org/topic_0749"},{"id":"T9","span":{"begin":594,"end":599},"obj":"http://edamontology.org/topic_2815"},{"id":"T10","span":{"begin":606,"end":613},"obj":"http://edamontology.org/topic_0078"},{"id":"T11","span":{"begin":755,"end":764},"obj":"http://edamontology.org/topic_2839"},{"id":"T12","span":{"begin":807,"end":819},"obj":"http://edamontology.org/topic_0602"},{"id":"T13","span":{"begin":868,"end":875},"obj":"http://edamontology.org/topic_0078"},{"id":"T14","span":{"begin":1262,"end":1271},"obj":"http://edamontology.org/topic_2839"},{"id":"T15","span":{"begin":1295,"end":1307},"obj":"http://edamontology.org/topic_0602"},{"id":"T16","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/topic_0694"},{"id":"T17","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/topic_3542"},{"id":"T18","span":{"begin":1732,"end":1740},"obj":"http://edamontology.org/topic_0749"},{"id":"T19","span":{"begin":1824,"end":1832},"obj":"http://edamontology.org/topic_0749"},{"id":"T20","span":{"begin":2235,"end":2242},"obj":"http://edamontology.org/topic_0078"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-topics"},{"subj":"T2","pred":"source","obj":"EDAM-topics"},{"subj":"T3","pred":"source","obj":"EDAM-topics"},{"subj":"T4","pred":"source","obj":"EDAM-topics"},{"subj":"T5","pred":"source","obj":"EDAM-topics"},{"subj":"T6","pred":"source","obj":"EDAM-topics"},{"subj":"T7","pred":"source","obj":"EDAM-topics"},{"subj":"T8","pred":"source","obj":"EDAM-topics"},{"subj":"T9","pred":"source","obj":"EDAM-topics"},{"subj":"T10","pred":"source","obj":"EDAM-topics"},{"subj":"T11","pred":"source","obj":"EDAM-topics"},{"subj":"T12","pred":"source","obj":"EDAM-topics"},{"subj":"T13","pred":"source","obj":"EDAM-topics"},{"subj":"T14","pred":"source","obj":"EDAM-topics"},{"subj":"T15","pred":"source","obj":"EDAM-topics"},{"subj":"T16","pred":"source","obj":"EDAM-topics"},{"subj":"T17","pred":"source","obj":"EDAM-topics"},{"subj":"T18","pred":"source","obj":"EDAM-topics"},{"subj":"T19","pred":"source","obj":"EDAM-topics"},{"subj":"T20","pred":"source","obj":"EDAM-topics"}]},{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":0,"end":29},"obj":"http://edamontology.org/operation_2476"},{"id":"T2","span":{"begin":45,"end":52},"obj":"http://edamontology.org/data_1467"},{"id":"T3","span":{"begin":45,"end":52},"obj":"http://edamontology.org/format_1208"},{"id":"T4","span":{"begin":162,"end":169},"obj":"http://edamontology.org/data_1467"},{"id":"T5","span":{"begin":162,"end":169},"obj":"http://edamontology.org/format_1208"},{"id":"T6","span":{"begin":278,"end":288},"obj":"http://edamontology.org/data_0883"},{"id":"T7","span":{"begin":459,"end":469},"obj":"http://edamontology.org/data_0883"},{"id":"T8","span":{"begin":535,"end":565},"obj":"http://edamontology.org/operation_2476"},{"id":"T9","span":{"begin":606,"end":613},"obj":"http://edamontology.org/format_1208"},{"id":"T10","span":{"begin":606,"end":613},"obj":"http://edamontology.org/data_1467"},{"id":"T11","span":{"begin":845,"end":855},"obj":"http://edamontology.org/data_0883"},{"id":"T12","span":{"begin":868,"end":875},"obj":"http://edamontology.org/format_1208"},{"id":"T13","span":{"begin":868,"end":875},"obj":"http://edamontology.org/data_1467"},{"id":"T14","span":{"begin":1088,"end":1096},"obj":"http://edamontology.org/data_1756"},{"id":"T15","span":{"begin":1127,"end":1133},"obj":"http://edamontology.org/data_0853"},{"id":"T16","span":{"begin":1331,"end":1336},"obj":"http://edamontology.org/format_1996"},{"id":"T17","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/data_2366"},{"id":"T18","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/data_2081"},{"id":"T19","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/data_0880"},{"id":"T20","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/operation_2488"},{"id":"T21","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/operation_0500"},{"id":"T22","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/data_2973"},{"id":"T23","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/data_2880"},{"id":"T24","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/operation_2482"},{"id":"T25","span":{"begin":1475,"end":1494},"obj":"http://edamontology.org/data_2881"},{"id":"T26","span":{"begin":1485,"end":1494},"obj":"http://edamontology.org/data_0883"},{"id":"T27","span":{"begin":1863,"end":1872},"obj":"http://edamontology.org/data_0883"},{"id":"T28","span":{"begin":2235,"end":2242},"obj":"http://edamontology.org/data_1467"},{"id":"T29","span":{"begin":2235,"end":2242},"obj":"http://edamontology.org/format_1208"},{"id":"T30","span":{"begin":2235,"end":2245},"obj":"http://edamontology.org/data_1755"},{"id":"T31","span":{"begin":2332,"end":2341},"obj":"http://edamontology.org/data_0883"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-DFO"},{"subj":"T2","pred":"source","obj":"EDAM-DFO"},{"subj":"T3","pred":"source","obj":"EDAM-DFO"},{"subj":"T4","pred":"source","obj":"EDAM-DFO"},{"subj":"T5","pred":"source","obj":"EDAM-DFO"},{"subj":"T6","pred":"source","obj":"EDAM-DFO"},{"subj":"T7","pred":"source","obj":"EDAM-DFO"},{"subj":"T8","pred":"source","obj":"EDAM-DFO"},{"subj":"T9","pred":"source","obj":"EDAM-DFO"},{"subj":"T10","pred":"source","obj":"EDAM-DFO"},{"subj":"T11","pred":"source","obj":"EDAM-DFO"},{"subj":"T12","pred":"source","obj":"EDAM-DFO"},{"subj":"T13","pred":"source","obj":"EDAM-DFO"},{"subj":"T14","pred":"source","obj":"EDAM-DFO"},{"subj":"T15","pred":"source","obj":"EDAM-DFO"},{"subj":"T16","pred":"source","obj":"EDAM-DFO"},{"subj":"T17","pred":"source","obj":"EDAM-DFO"},{"subj":"T18","pred":"source","obj":"EDAM-DFO"},{"subj":"T19","pred":"source","obj":"EDAM-DFO"},{"subj":"T20","pred":"source","obj":"EDAM-DFO"},{"subj":"T21","pred":"source","obj":"EDAM-DFO"},{"subj":"T22","pred":"source","obj":"EDAM-DFO"},{"subj":"T23","pred":"source","obj":"EDAM-DFO"},{"subj":"T24","pred":"source","obj":"EDAM-DFO"},{"subj":"T25","pred":"source","obj":"EDAM-DFO"},{"subj":"T26","pred":"source","obj":"EDAM-DFO"},{"subj":"T27","pred":"source","obj":"EDAM-DFO"},{"subj":"T28","pred":"source","obj":"EDAM-DFO"},{"subj":"T29","pred":"source","obj":"EDAM-DFO"},{"subj":"T30","pred":"source","obj":"EDAM-DFO"},{"subj":"T31","pred":"source","obj":"EDAM-DFO"}]},{"project":"GlycoBiology-Motifs","denotations":[{"id":"T1","span":{"begin":102,"end":112},"obj":"http://rdf.glycoinfo.org/glycan/G00045MO"},{"id":"T2","span":{"begin":421,"end":431},"obj":"http://rdf.glycoinfo.org/glycan/G00045MO"},{"id":"T3","span":{"begin":2129,"end":2139},"obj":"http://rdf.glycoinfo.org/glycan/G00045MO"},{"id":"T4","span":{"begin":2182,"end":2192},"obj":"http://rdf.glycoinfo.org/glycan/G00045MO"},{"id":"T5","span":{"begin":1621,"end":1629},"obj":"http://rdf.glycoinfo.org/glycan/G00027MO"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-Motifs"},{"subj":"T2","pred":"source","obj":"GlycoBiology-Motifs"},{"subj":"T3","pred":"source","obj":"GlycoBiology-Motifs"},{"subj":"T4","pred":"source","obj":"GlycoBiology-Motifs"},{"subj":"T5","pred":"source","obj":"GlycoBiology-Motifs"}]},{"project":"GlycoBiology-Epitope","denotations":[{"id":"PD-GlycoEpitope-B_T1","span":{"begin":1845,"end":1848},"obj":"http://www.glycoepitope.jp/epitopes/AN0580"}],"attributes":[{"subj":"PD-GlycoEpitope-B_T1","pred":"source","obj":"GlycoBiology-Epitope"}]},{"project":"GlyTouCan-IUPAC","denotations":[{"id":"GlycanIUPAC_T1","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G02780QX\""},{"id":"GlycanIUPAC_T2","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G18425DX\""},{"id":"GlycanIUPAC_T3","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G18630JE\""},{"id":"GlycanIUPAC_T4","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G01004IT\""},{"id":"GlycanIUPAC_T5","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G87301QZ\""},{"id":"GlycanIUPAC_T6","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G39790GW\""},{"id":"GlycanIUPAC_T7","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G42928BB\""},{"id":"GlycanIUPAC_T8","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G51134HC\""},{"id":"GlycanIUPAC_T9","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G68183GR\""},{"id":"GlycanIUPAC_T10","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G46883FA\""},{"id":"GlycanIUPAC_T11","span":{"begin":297,"end":300},"obj":"\"http://rdf.glycoinfo.org/glycan/G54702VY\""},{"id":"GlycanIUPAC_T12","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G41652MJ\""},{"id":"GlycanIUPAC_T13","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G20761YC\""},{"id":"GlycanIUPAC_T14","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G19807HM\""},{"id":"GlycanIUPAC_T15","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G20351TE\""},{"id":"GlycanIUPAC_T16","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G71957MR\""},{"id":"GlycanIUPAC_T17","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G59040AE\""},{"id":"GlycanIUPAC_T18","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G14987PW\""},{"id":"GlycanIUPAC_T19","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G95064PC\""},{"id":"GlycanIUPAC_T20","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G39143AQ\""},{"id":"GlycanIUPAC_T21","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G65149OO\""},{"id":"GlycanIUPAC_T22","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G02766SY\""},{"id":"GlycanIUPAC_T23","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G26019KJ\""},{"id":"GlycanIUPAC_T24","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G36429CZ\""},{"id":"GlycanIUPAC_T25","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G89633TP\""},{"id":"GlycanIUPAC_T26","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G28494FO\""},{"id":"GlycanIUPAC_T27","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G06219CP\""},{"id":"GlycanIUPAC_T28","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G44237SM\""},{"id":"GlycanIUPAC_T29","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G57948RL\""},{"id":"GlycanIUPAC_T30","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G64016DN\""},{"id":"GlycanIUPAC_T31","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G14536PC\""},{"id":"GlycanIUPAC_T32","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G14356FW\""},{"id":"GlycanIUPAC_T33","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G34565UO\""},{"id":"GlycanIUPAC_T34","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G67124MW\""},{"id":"GlycanIUPAC_T35","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G71457ZU\""},{"id":"GlycanIUPAC_T36","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G55228VZ\""},{"id":"GlycanIUPAC_T37","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G31034MJ\""},{"id":"GlycanIUPAC_T38","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G25776IP\""},{"id":"GlycanIUPAC_T39","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G64442BV\""},{"id":"GlycanIUPAC_T40","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G57018LE\""},{"id":"GlycanIUPAC_T41","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G61761GX\""},{"id":"GlycanIUPAC_T42","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G76318UX\""},{"id":"GlycanIUPAC_T43","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G61906ER\""},{"id":"GlycanIUPAC_T44","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G68723GR\""},{"id":"GlycanIUPAC_T45","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G19540LE\""},{"id":"GlycanIUPAC_T46","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G74944PO\""},{"id":"GlycanIUPAC_T47","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G89489ZJ\""},{"id":"GlycanIUPAC_T48","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G04434YU\""},{"id":"GlycanIUPAC_T49","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G21450PB\""},{"id":"GlycanIUPAC_T50","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G93629QY\""},{"id":"GlycanIUPAC_T51","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G02603TR\""},{"id":"GlycanIUPAC_T52","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G40280JP\""},{"id":"GlycanIUPAC_T53","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G95259IC\""},{"id":"GlycanIUPAC_T54","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G26900FE\""},{"id":"GlycanIUPAC_T55","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G21346KK\""},{"id":"GlycanIUPAC_T56","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G62509FF\""},{"id":"GlycanIUPAC_T57","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G83932AK\""},{"id":"GlycanIUPAC_T58","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G96978IB\""},{"id":"GlycanIUPAC_T59","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G34275DN\""},{"id":"GlycanIUPAC_T60","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G07071JF\""},{"id":"GlycanIUPAC_T61","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G80639QD\""},{"id":"GlycanIUPAC_T62","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G99460PJ\""},{"id":"GlycanIUPAC_T63","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G22024BZ\""},{"id":"GlycanIUPAC_T64","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G74097ZY\""},{"id":"GlycanIUPAC_T65","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G84439YP\""},{"id":"GlycanIUPAC_T66","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G52207WQ\""},{"id":"GlycanIUPAC_T67","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G90695MS\""},{"id":"GlycanIUPAC_T68","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G50398QX\""},{"id":"GlycanIUPAC_T69","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G12166ZT\""},{"id":"GlycanIUPAC_T70","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G48368BR\""},{"id":"GlycanIUPAC_T71","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G57407RW\""},{"id":"GlycanIUPAC_T72","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G00386TY\""},{"id":"GlycanIUPAC_T73","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G18723JK\""},{"id":"GlycanIUPAC_T74","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G93757OR\""},{"id":"GlycanIUPAC_T75","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G29006SI\""},{"id":"GlycanIUPAC_T76","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G03099OQ\""},{"id":"GlycanIUPAC_T77","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G53739OW\""},{"id":"GlycanIUPAC_T78","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G70440ZO\""},{"id":"GlycanIUPAC_T79","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G29951RR\""},{"id":"GlycanIUPAC_T80","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G58402TI\""},{"id":"GlycanIUPAC_T81","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G39875TP\""},{"id":"GlycanIUPAC_T82","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G83439QV\""},{"id":"GlycanIUPAC_T83","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G41762RC\""},{"id":"GlycanIUPAC_T84","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G91604UI\""},{"id":"GlycanIUPAC_T85","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G88447WE\""},{"id":"GlycanIUPAC_T86","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G93634BS\""},{"id":"GlycanIUPAC_T87","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G02587BH\""},{"id":"GlycanIUPAC_T88","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G43511MX\""},{"id":"GlycanIUPAC_T89","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G64958DH\""},{"id":"GlycanIUPAC_T90","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G30384TR\""},{"id":"GlycanIUPAC_T91","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G15624EX\""},{"id":"GlycanIUPAC_T92","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G22706ST\""},{"id":"GlycanIUPAC_T93","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G57408PI\""},{"id":"GlycanIUPAC_T94","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G86403XX\""},{"id":"GlycanIUPAC_T95","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G78043YB\""},{"id":"GlycanIUPAC_T96","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G18952JK\""},{"id":"GlycanIUPAC_T97","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G49020ND\""},{"id":"GlycanIUPAC_T98","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G63590YW\""},{"id":"GlycanIUPAC_T99","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G22793KS\""},{"id":"GlycanIUPAC_T100","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G64134SS\""},{"id":"GlycanIUPAC_T101","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G17338HY\""},{"id":"GlycanIUPAC_T102","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G99745XF\""},{"id":"GlycanIUPAC_T103","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G27782HN\""},{"id":"GlycanIUPAC_T104","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G57496DC\""},{"id":"GlycanIUPAC_T105","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G93169WB\""},{"id":"GlycanIUPAC_T106","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G05518TD\""},{"id":"GlycanIUPAC_T107","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G62603DN\""},{"id":"GlycanIUPAC_T108","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G59574FS\""},{"id":"GlycanIUPAC_T109","span":{"begin":778,"end":781},"obj":"\"http://rdf.glycoinfo.org/glycan/G47567WC\""}],"attributes":[{"subj":"GlycanIUPAC_T1","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T2","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T3","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T4","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T5","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T6","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T7","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T8","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T9","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T10","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T11","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T12","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T13","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T14","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T15","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T16","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T17","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T18","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T19","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T20","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T21","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T22","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T23","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T24","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T25","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T26","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T27","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T28","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T29","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T30","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T31","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T32","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T33","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T34","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T35","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T36","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T37","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T38","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T39","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T40","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T41","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T42","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T43","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T44","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T45","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T46","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T47","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T48","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T49","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T50","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T51","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T52","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T53","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T54","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T55","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T56","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T57","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T58","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T59","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T60","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T61","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T62","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T63","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T64","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T65","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T66","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T67","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T68","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T69","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T70","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T71","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T72","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T73","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T74","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T75","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T76","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T77","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T78","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T79","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T80","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T81","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T82","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T83","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T84","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T85","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T86","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T87","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T88","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T89","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T90","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T91","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T92","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T93","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T94","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T95","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T96","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T97","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T98","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T99","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T100","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T101","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T102","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T103","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T104","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T105","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T106","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T107","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T108","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T109","pred":"source","obj":"GlyTouCan-IUPAC"}]},{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":961,"end":971},"obj":"http://purl.obolibrary.org/obo/UBERON_2000106"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":975,"end":980},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":987,"end":992},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":1140,"end":1145},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":1772,"end":1777},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":1784,"end":1789},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":1927,"end":1932},"obj":"http://purl.obolibrary.org/obo/UBERON_0002488"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T6","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T7","pred":"source","obj":"performance-test"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":240,"end":247},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0006961"},{"subj":"T1","pred":"source","obj":"mondo_disease"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":33,"end":38},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":594,"end":599},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":961,"end":971},"obj":"Body_part"},{"id":"T2","span":{"begin":975,"end":980},"obj":"Body_part"},{"id":"T3","span":{"begin":987,"end":992},"obj":"Body_part"},{"id":"T4","span":{"begin":1140,"end":1145},"obj":"Body_part"},{"id":"T5","span":{"begin":1772,"end":1777},"obj":"Body_part"},{"id":"T6","span":{"begin":1784,"end":1789},"obj":"Body_part"},{"id":"T7","span":{"begin":1927,"end":1932},"obj":"Body_part"},{"id":"T8","span":{"begin":2145,"end":2153},"obj":"Body_part"},{"id":"T11","span":{"begin":2285,"end":2293},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_2000106"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0002488"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/GO_0016020"},{"id":"A9","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000094"},{"id":"A10","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/GO_0016020"},{"id":"A12","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0000094"},{"id":"A13","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T6","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T7","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T8","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T11","pred":"source","obj":"Anatomy-UBERON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#93ecde","default":true},{"id":"ICD10","color":"#ecc493"},{"id":"GlycoBiology-FMA","color":"#aa93ec"},{"id":"uniprot-human","color":"#96ec93"},{"id":"uniprot-mouse","color":"#ec93b0"},{"id":"GlycoBiology-NCBITAXON","color":"#93caec"},{"id":"GO-BP","color":"#e4ec93"},{"id":"GO-MF","color":"#da93ec"},{"id":"GO-CC","color":"#93ecc0"},{"id":"UBERON-AE","color":"#eca693"},{"id":"EDAM-topics","color":"#9399ec"},{"id":"EDAM-DFO","color":"#b3ec93"},{"id":"GlycoBiology-Motifs","color":"#ec93ce"},{"id":"GlycoBiology-Epitope","color":"#93e8ec"},{"id":"GlyTouCan-IUPAC","color":"#ecd693"},{"id":"performance-test","color":"#bc93ec"},{"id":"mondo_disease","color":"#93eca2"},{"id":"NCBITAXON","color":"#ec939d"},{"id":"Anatomy-UBERON","color":"#93b7ec"}]}]}}