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PubMed:10998426 JSONTXT

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Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 159-171 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 280-291 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T3 1441-1453 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064

sentences

Id Subject Object Predicate Lexical cue
T1 0-172 Sentence denotes Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells.
T2 173-377 Sentence denotes We report that transfection of insulin-like growth factor-binding protein-3 (IGFBP-3) cDNA in human breast cancer cell lines expressing either mutant p53 (T47D) or wild-type p53 (MCF-7) induces apoptosis.
T3 378-474 Sentence denotes IGFBP-3 also increases the ratio of pro-apoptotic to anti-apoptotic members of the Bcl-2 family.
T4 475-607 Sentence denotes In MCF-7, an increase in Bad and Bax protein expression and a decrease in Bcl-x(L) protein and Bcl-2 protein and mRNA were observed.
T5 608-702 Sentence denotes In T47D, Bax and Bad proteins were up-regulated; Bcl-2 protein is undetectable in these cells.
T6 703-835 Sentence denotes As T47D expresses mutant p53 protein, these modulations of pro-apoptotic proteins and induction of apoptosis are independent of p53.
T7 836-922 Sentence denotes The effect of IGFBP-3 on the response of T47D to ionizing radiation (IR) was examined.
T8 923-1006 Sentence denotes These cells do not G(1) arrest in response to IR and are relatively radioresistant.
T9 1007-1144 Sentence denotes Transfection of IGFBP-3 increased the radiosensitivity of T47D and increased IR-induced apoptosis but did not effect a rapid G(1) arrest.
T10 1145-1254 Sentence denotes IR also caused a much greater increase in Bax protein in IGFBP-3 transfectants compared with vector controls.
T11 1255-1504 Sentence denotes Thus, IGFBP-3 increases the expression of pro-apoptotic proteins and apoptosis both basally and in response to IR, suggesting it may be a p53-independent effector of apoptosis in breast cancer cells via its modulation of the Bax:Bcl-2 protein ratio.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 273-286 HP_0003002 denotes breast cancer
T2 273-286 HP_0100013 denotes breast cancer
T3 280-286 HP_0002664 denotes cancer
T4 1434-1447 HP_0003002 denotes breast cancer
T5 1434-1447 HP_0100013 denotes breast cancer
T6 1441-1447 HP_0002664 denotes cancer

CoMAGC

Id Subject Object Predicate Lexical cue
T1 1023-1030 Gene denotes IGFBP-3
E1 1007-1019 Gene_expression denotes Transfection
E2 1007-1019 Positive_regulation denotes Transfection
T2 1065-1069 breast cancer denotes T47D
R1 T1 E1 themeOf IGFBP-3,Transfection
R2 E1 E2 themeOf Transfection,Transfection
R3 T1 T2 CGE-increased IGFBP-3,T47D
R4 T1 T2 CCS-cancerTOnormal IGFBP-3,T47D
R5 T1 T2 PT-causality IGFBP-3,T47D
R3 T1 T2 IGE-unidentifiable IGFBP-3,T47D

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 152-165 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 273-286 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 1434-1447 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 152-165 Phenotype denotes breast cancer HP:0003002
T2 273-286 Phenotype denotes breast cancer HP:0003002
T3 1434-1447 Phenotype denotes breast cancer HP:0003002

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 146-151 OrganismTaxon denotes human 9606
T2 267-272 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 152-158 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 273-279 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 1434-1440 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310