PubMed:10945643 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10945643","sourcedb":"PubMed","sourceid":"10945643","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10945643","text":"Effects of a pure antiestrogen on apoptosis and proliferation within human breast ductal carcinoma in situ.\nAdjuvant antiestrogen (AE) therapy has been proposed for all women with ductal carcinoma in situ (DCIS). However, many cases of DCIS are of the high-grade, estrogen receptor (ER)-negative subtype that are unlikely to respond to AE treatment. Hormonal agents work by increasing apoptosis and/or decreasing cell proliferation; therefore, we studied the effect of a pure AE on levels of apoptosis and proliferation in human DCIS xenografts using an in vivo model. Women (n = 23) with mammographic microcalcification suggestive of DCIS were identified at the time of surgery (day 0), a sample of representative tissue was obtained, divided into multiple 2x2x1-mm xenografts, and implanted s.c. into female BALB/c nu/nu mice (eight xenografts/mouse). Day 0 grafts underwent immunohistochemical assessment of ER status. Fourteen days after implantation, four xenografts were retrieved and mice were randomly divided into one of three treatment groups: (a) insertion of a slow release 2-mg 17beta-estradiol pellet; (b) weekly 5-mg injections of the pure AE Faslodex (Zeneca Pharmaceuticals); and (c) injections of a control vehicle oil alone. After 2 weeks of treatment, the remaining four xenografts were retrieved from each mouse. Retrieved xenografts containing DCIS were assessed for morphological evidence of apoptotic cell death [apoptotic index (AI)] and cell proliferation (by immunohistochemical detection of the Ki67 proliferation antigen LI). Both AI and LI were higher in the day 0 specimens of 16 ER- DCIS lesions compared with 7 ER+ DCIS lesions (mean values, 1.47% versus 0.32% and 20.6% versus 3.1%; both P\u003c0.0001). AI and LI values within ER- DCIS did not differ between xenografts exposed to 17beta-estradiol or AE treatment compared with the controls or pretreatment values (mean AI and LI in estradiol-treated, antiestrogen-treated, and control groups 1.04% versus 0.98% versus 1.29% and 17.2% versus 20.5% versus 17.7% respectively). In contrast, treatment of mice bearing ER+ DCIS xenografts with 17beta-estradiol raised both the AI (1.03% versus 0.40%, P = 0.03) and LI (11.0% versus 5.1%, P = 0.007) compared with controls. AE therapy of ER+ DCIS xenografts did not affect proliferation but resulted in higher apoptosis than in controls (0.9% versus 0.4% respectively, P = 0.04). AE therapy should be reserved for patients with estrogen receptor positive DCIS.","tracks":[{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":13,"end":17},"obj":"PR:Q8FYW3"},{"id":"T2","span":{"begin":13,"end":17},"obj":"PR:Q54QE4"},{"id":"T3","span":{"begin":13,"end":17},"obj":"PR:P52558"},{"id":"T4","span":{"begin":13,"end":17},"obj":"PR:P0AG18"},{"id":"T6","span":{"begin":13,"end":17},"obj":"PR:000023640"},{"id":"T5","span":{"begin":13,"end":17},"obj":"GO:0034023"},{"id":"T7","span":{"begin":18,"end":30},"obj":"D020847"},{"id":"T8","span":{"begin":18,"end":30},"obj":"D020847"},{"id":"T9","span":{"begin":18,"end":30},"obj":"CHEBI:50751"},{"id":"T10","span":{"begin":34,"end":43},"obj":"GO:0097194"},{"id":"T11","span":{"begin":34,"end":43},"obj":"GO:0006915"},{"id":"T12","span":{"begin":48,"end":61},"obj":"UBERON:2000098"},{"id":"T13","span":{"begin":69,"end":74},"obj":"D006801"},{"id":"T14","span":{"begin":75,"end":81},"obj":"UBERON:0000310"},{"id":"T17","span":{"begin":82,"end":106},"obj":"D002285"},{"id":"T18","span":{"begin":82,"end":106},"obj":"D002285"},{"id":"T23","span":{"begin":117,"end":129},"obj":"D020847"},{"id":"T24","span":{"begin":117,"end":129},"obj":"D020847"},{"id":"T25","span":{"begin":117,"end":129},"obj":"CHEBI:50751"},{"id":"T28","span":{"begin":180,"end":204},"obj":"D002285"},{"id":"T29","span":{"begin":180,"end":204},"obj":"D002285"},{"id":"T35","span":{"begin":206,"end":210},"obj":"CVCL_5552"},{"id":"T34","span":{"begin":206,"end":210},"obj":"D002285"},{"id":"T36","span":{"begin":206,"end":210},"obj":"D002285"},{"id":"T38","span":{"begin":236,"end":240},"obj":"CVCL_5552"},{"id":"T37","span":{"begin":236,"end":240},"obj":"D002285"},{"id":"T39","span":{"begin":236,"end":240},"obj":"D002285"},{"id":"T40","span":{"begin":264,"end":272},"obj":"D004967"},{"id":"T41","span":{"begin":264,"end":272},"obj":"D004967"},{"id":"T42","span":{"begin":264,"end":272},"obj":"CHEBI:50114"},{"id":"T43","span":{"begin":264,"end":281},"obj":"Q9PVZ9"},{"id":"T44","span":{"begin":264,"end":281},"obj":"Q9YHT3"},{"id":"T45","span":{"begin":264,"end":281},"obj":"P57717"},{"id":"T46","span":{"begin":264,"end":281},"obj":"Q9QZJ5"},{"id":"T47","span":{"begin":264,"end":281},"obj":"Q29040"},{"id":"T48","span":{"begin":264,"end":281},"obj":"P49886"},{"id":"T49","span":{"begin":264,"end":281},"obj":"P50240"},{"id":"T50","span":{"begin":264,"end":281},"obj":"Q91424"},{"id":"T51","span":{"begin":264,"end":281},"obj":"Q9YHZ7"},{"id":"T52","span":{"begin":264,"end":281},"obj":"P06211"},{"id":"T53","span":{"begin":264,"end":281},"obj":"P16058"},{"id":"T54","span":{"begin":264,"end":281},"obj":"P50242"},{"id":"T55","span":{"begin":264,"end":281},"obj":"Q53AD2"},{"id":"T56","span":{"begin":264,"end":281},"obj":"P49885"},{"id":"T57","span":{"begin":264,"end":281},"obj":"P49884"},{"id":"T58","span":{"begin":264,"end":281},"obj":"P19785"},{"id":"T59","span":{"begin":264,"end":281},"obj":"Q91250"},{"id":"T60","span":{"begin":264,"end":281},"obj":"P81559"},{"id":"T61","span":{"begin":264,"end":281},"obj":"Q9TV98"},{"id":"T62","span":{"begin":264,"end":281},"obj":"PR:000007204"},{"id":"T63","span":{"begin":264,"end":281},"obj":"Q9YH33"},{"id":"T64","span":{"begin":264,"end":281},"obj":"P50241"},{"id":"T65","span":{"begin":264,"end":281},"obj":"P06212"},{"id":"T66","span":{"begin":264,"end":281},"obj":"P03372"},{"id":"T67","span":{"begin":264,"end":281},"obj":"O42132"},{"id":"T68","span":{"begin":264,"end":281},"obj":"P57753"},{"id":"T69","span":{"begin":385,"end":394},"obj":"GO:0097194"},{"id":"T70","span":{"begin":385,"end":394},"obj":"GO:0006915"},{"id":"T71","span":{"begin":413,"end":431},"obj":"GO:0008283"},{"id":"T72","span":{"begin":418,"end":431},"obj":"UBERON:2000098"},{"id":"T73","span":{"begin":471,"end":475},"obj":"PR:Q8FYW3"},{"id":"T74","span":{"begin":471,"end":475},"obj":"PR:Q54QE4"},{"id":"T75","span":{"begin":471,"end":475},"obj":"PR:P52558"},{"id":"T76","span":{"begin":471,"end":475},"obj":"PR:P0AG18"},{"id":"T78","span":{"begin":471,"end":475},"obj":"PR:000023640"},{"id":"T77","span":{"begin":471,"end":475},"obj":"GO:0034023"},{"id":"T79","span":{"begin":492,"end":501},"obj":"GO:0097194"},{"id":"T80","span":{"begin":492,"end":501},"obj":"GO:0006915"},{"id":"T81","span":{"begin":506,"end":519},"obj":"UBERON:2000098"},{"id":"T82","span":{"begin":523,"end":528},"obj":"D006801"},{"id":"T84","span":{"begin":529,"end":533},"obj":"CVCL_5552"},{"id":"T83","span":{"begin":529,"end":533},"obj":"D002285"},{"id":"T85","span":{"begin":529,"end":533},"obj":"D002285"},{"id":"T87","span":{"begin":602,"end":620},"obj":"D002114"},{"id":"T88","span":{"begin":602,"end":620},"obj":"D002114"},{"id":"T90","span":{"begin":635,"end":639},"obj":"CVCL_5552"},{"id":"T89","span":{"begin":635,"end":639},"obj":"D002285"},{"id":"T91","span":{"begin":635,"end":639},"obj":"D002285"},{"id":"T92","span":{"begin":715,"end":721},"obj":"UBERON:0000479"},{"id":"T93","span":{"begin":803,"end":809},"obj":"UBERON:0003100"},{"id":"T94","span":{"begin":823,"end":827},"obj":"PR:000005054"},{"id":"T96","span":{"begin":823,"end":827},"obj":"O89094"},{"id":"T95","span":{"begin":823,"end":827},"obj":"D051379"},{"id":"T97","span":{"begin":823,"end":827},"obj":"10095"},{"id":"T98","span":{"begin":846,"end":851},"obj":"10090"},{"id":"T99","span":{"begin":846,"end":851},"obj":"D051379"},{"id":"T100","span":{"begin":991,"end":995},"obj":"PR:000005054"},{"id":"T102","span":{"begin":991,"end":995},"obj":"O89094"},{"id":"T101","span":{"begin":991,"end":995},"obj":"D051379"},{"id":"T103","span":{"begin":991,"end":995},"obj":"10095"},{"id":"T104","span":{"begin":1058,"end":1067},"obj":"SO:0000667"},{"id":"T105","span":{"begin":1088,"end":1093},"obj":"B3TPQ7"},{"id":"T106","span":{"begin":1091,"end":1107},"obj":"D004958"},{"id":"T107","span":{"begin":1091,"end":1107},"obj":"CHEBI:16469"},{"id":"T108","span":{"begin":1091,"end":1107},"obj":"D004958"},{"id":"T115","span":{"begin":1098,"end":1107},"obj":"4083"},{"id":"T117","span":{"begin":1108,"end":1114},"obj":"UBERON:0036018"},{"id":"T118","span":{"begin":1150,"end":1154},"obj":"PR:Q8FYW3"},{"id":"T119","span":{"begin":1150,"end":1154},"obj":"PR:Q54QE4"},{"id":"T120","span":{"begin":1150,"end":1154},"obj":"PR:P52558"},{"id":"T121","span":{"begin":1150,"end":1154},"obj":"PR:P0AG18"},{"id":"T123","span":{"begin":1150,"end":1154},"obj":"PR:000023640"},{"id":"T122","span":{"begin":1150,"end":1154},"obj":"GO:0034023"},{"id":"T126","span":{"begin":1158,"end":1166},"obj":"203870"},{"id":"T124","span":{"begin":1158,"end":1166},"obj":"CHEBI:31638"},{"id":"T125","span":{"begin":1158,"end":1166},"obj":"D000077267"},{"id":"T127","span":{"begin":1158,"end":1166},"obj":"D000077267"},{"id":"T128","span":{"begin":1175,"end":1190},"obj":"D004364"},{"id":"T129","span":{"begin":1175,"end":1190},"obj":"CHEBI:52217"},{"id":"T130","span":{"begin":1327,"end":1332},"obj":"10090"},{"id":"T131","span":{"begin":1327,"end":1332},"obj":"D051379"},{"id":"T133","span":{"begin":1366,"end":1370},"obj":"CVCL_5552"},{"id":"T132","span":{"begin":1366,"end":1370},"obj":"D002285"},{"id":"T134","span":{"begin":1366,"end":1370},"obj":"D002285"},{"id":"T135","span":{"begin":1415,"end":1435},"obj":"GO:0006915"},{"id":"T137","span":{"begin":1463,"end":1481},"obj":"GO:0008283"},{"id":"T138","span":{"begin":1468,"end":1481},"obj":"UBERON:2000098"},{"id":"T139","span":{"begin":1528,"end":1541},"obj":"UBERON:2000098"},{"id":"T140","span":{"begin":1542,"end":1549},"obj":"D000941"},{"id":"T141","span":{"begin":1542,"end":1549},"obj":"CHEBI:59132"},{"id":"T142","span":{"begin":1542,"end":1549},"obj":"D000941"},{"id":"T144","span":{"begin":1615,"end":1619},"obj":"CVCL_5552"},{"id":"T143","span":{"begin":1615,"end":1619},"obj":"D002285"},{"id":"T145","span":{"begin":1615,"end":1619},"obj":"D002285"},{"id":"T147","span":{"begin":1648,"end":1652},"obj":"CVCL_5552"},{"id":"T146","span":{"begin":1648,"end":1652},"obj":"D002285"},{"id":"T148","span":{"begin":1648,"end":1652},"obj":"D002285"},{"id":"T150","span":{"begin":1761,"end":1765},"obj":"CVCL_5552"},{"id":"T149","span":{"begin":1761,"end":1765},"obj":"D002285"},{"id":"T151","span":{"begin":1761,"end":1765},"obj":"D002285"},{"id":"T152","span":{"begin":1811,"end":1827},"obj":"D004958"},{"id":"T153","span":{"begin":1811,"end":1827},"obj":"CHEBI:16469"},{"id":"T154","span":{"begin":1811,"end":1827},"obj":"D004958"},{"id":"T161","span":{"begin":1818,"end":1827},"obj":"4083"},{"id":"T166","span":{"begin":1913,"end":1922},"obj":"4083"},{"id":"T163","span":{"begin":1913,"end":1922},"obj":"CHEBI:16469"},{"id":"T164","span":{"begin":1913,"end":1922},"obj":"CHEBI:23965"},{"id":"T165","span":{"begin":1913,"end":1922},"obj":"D004958"},{"id":"T167","span":{"begin":1913,"end":1922},"obj":"D004958"},{"id":"T168","span":{"begin":1932,"end":1944},"obj":"D020847"},{"id":"T169","span":{"begin":1932,"end":1944},"obj":"D020847"},{"id":"T170","span":{"begin":1932,"end":1944},"obj":"CHEBI:50751"},{"id":"T171","span":{"begin":2082,"end":2086},"obj":"PR:000005054"},{"id":"T173","span":{"begin":2082,"end":2086},"obj":"O89094"},{"id":"T172","span":{"begin":2082,"end":2086},"obj":"D051379"},{"id":"T174","span":{"begin":2082,"end":2086},"obj":"10095"},{"id":"T176","span":{"begin":2099,"end":2103},"obj":"CVCL_5552"},{"id":"T175","span":{"begin":2099,"end":2103},"obj":"D002285"},{"id":"T177","span":{"begin":2099,"end":2103},"obj":"D002285"},{"id":"T178","span":{"begin":2120,"end":2136},"obj":"D004958"},{"id":"T179","span":{"begin":2120,"end":2136},"obj":"CHEBI:16469"},{"id":"T180","span":{"begin":2120,"end":2136},"obj":"D004958"},{"id":"T187","span":{"begin":2127,"end":2136},"obj":"4083"},{"id":"T189","span":{"begin":2153,"end":2158},"obj":"PR:P03875"},{"id":"T191","span":{"begin":2267,"end":2271},"obj":"CVCL_5552"},{"id":"T190","span":{"begin":2267,"end":2271},"obj":"D002285"},{"id":"T192","span":{"begin":2267,"end":2271},"obj":"D002285"},{"id":"T193","span":{"begin":2298,"end":2311},"obj":"UBERON:2000098"},{"id":"T194","span":{"begin":2335,"end":2344},"obj":"GO:0097194"},{"id":"T195","span":{"begin":2335,"end":2344},"obj":"GO:0006915"},{"id":"T196","span":{"begin":2453,"end":2461},"obj":"D004967"},{"id":"T197","span":{"begin":2453,"end":2461},"obj":"D004967"},{"id":"T198","span":{"begin":2453,"end":2461},"obj":"CHEBI:50114"},{"id":"T199","span":{"begin":2453,"end":2470},"obj":"Q9PVZ9"},{"id":"T200","span":{"begin":2453,"end":2470},"obj":"Q9YHT3"},{"id":"T201","span":{"begin":2453,"end":2470},"obj":"P57717"},{"id":"T202","span":{"begin":2453,"end":2470},"obj":"Q9QZJ5"},{"id":"T203","span":{"begin":2453,"end":2470},"obj":"Q29040"},{"id":"T204","span":{"begin":2453,"end":2470},"obj":"P49886"},{"id":"T205","span":{"begin":2453,"end":2470},"obj":"P50240"},{"id":"T206","span":{"begin":2453,"end":2470},"obj":"Q91424"},{"id":"T207","span":{"begin":2453,"end":2470},"obj":"Q9YHZ7"},{"id":"T208","span":{"begin":2453,"end":2470},"obj":"P06211"},{"id":"T209","span":{"begin":2453,"end":2470},"obj":"P16058"},{"id":"T210","span":{"begin":2453,"end":2470},"obj":"P50242"},{"id":"T211","span":{"begin":2453,"end":2470},"obj":"Q53AD2"},{"id":"T212","span":{"begin":2453,"end":2470},"obj":"P49885"},{"id":"T213","span":{"begin":2453,"end":2470},"obj":"P49884"},{"id":"T214","span":{"begin":2453,"end":2470},"obj":"P19785"},{"id":"T215","span":{"begin":2453,"end":2470},"obj":"Q91250"},{"id":"T216","span":{"begin":2453,"end":2470},"obj":"P81559"},{"id":"T217","span":{"begin":2453,"end":2470},"obj":"Q9TV98"},{"id":"T218","span":{"begin":2453,"end":2470},"obj":"PR:000007204"},{"id":"T219","span":{"begin":2453,"end":2470},"obj":"Q9YH33"},{"id":"T220","span":{"begin":2453,"end":2470},"obj":"P50241"},{"id":"T221","span":{"begin":2453,"end":2470},"obj":"P06212"},{"id":"T222","span":{"begin":2453,"end":2470},"obj":"P03372"},{"id":"T223","span":{"begin":2453,"end":2470},"obj":"O42132"},{"id":"T224","span":{"begin":2453,"end":2470},"obj":"P57753"},{"id":"T226","span":{"begin":2480,"end":2484},"obj":"CVCL_5552"},{"id":"T225","span":{"begin":2480,"end":2484},"obj":"D002285"},{"id":"T227","span":{"begin":2480,"end":2484},"obj":"D002285"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T149","pred":"source","obj":"c_corpus"},{"subj":"T151","pred":"source","obj":"c_corpus"},{"subj":"T152","pred":"source","obj":"c_corpus"},{"subj":"T153","pred":"source","obj":"c_corpus"},{"subj":"T154","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T168","pred":"source","obj":"c_corpus"},{"subj":"T169","pred":"source","obj":"c_corpus"},{"subj":"T170","pred":"source","obj":"c_corpus"},{"subj":"T171","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T172","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T179","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T191","pred":"source","obj":"c_corpus"},{"subj":"T190","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"},{"subj":"T193","pred":"source","obj":"c_corpus"},{"subj":"T194","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T196","pred":"source","obj":"c_corpus"},{"subj":"T197","pred":"source","obj":"c_corpus"},{"subj":"T198","pred":"source","obj":"c_corpus"},{"subj":"T199","pred":"source","obj":"c_corpus"},{"subj":"T200","pred":"source","obj":"c_corpus"},{"subj":"T201","pred":"source","obj":"c_corpus"},{"subj":"T202","pred":"source","obj":"c_corpus"},{"subj":"T203","pred":"source","obj":"c_corpus"},{"subj":"T204","pred":"source","obj":"c_corpus"},{"subj":"T205","pred":"source","obj":"c_corpus"},{"subj":"T206","pred":"source","obj":"c_corpus"},{"subj":"T207","pred":"source","obj":"c_corpus"},{"subj":"T208","pred":"source","obj":"c_corpus"},{"subj":"T209","pred":"source","obj":"c_corpus"},{"subj":"T210","pred":"source","obj":"c_corpus"},{"subj":"T211","pred":"source","obj":"c_corpus"},{"subj":"T212","pred":"source","obj":"c_corpus"},{"subj":"T213","pred":"source","obj":"c_corpus"},{"subj":"T214","pred":"source","obj":"c_corpus"},{"subj":"T215","pred":"source","obj":"c_corpus"},{"subj":"T216","pred":"source","obj":"c_corpus"},{"subj":"T217","pred":"source","obj":"c_corpus"},{"subj":"T218","pred":"source","obj":"c_corpus"},{"subj":"T219","pred":"source","obj":"c_corpus"},{"subj":"T220","pred":"source","obj":"c_corpus"},{"subj":"T221","pred":"source","obj":"c_corpus"},{"subj":"T222","pred":"source","obj":"c_corpus"},{"subj":"T223","pred":"source","obj":"c_corpus"},{"subj":"T224","pred":"source","obj":"c_corpus"},{"subj":"T226","pred":"source","obj":"c_corpus"},{"subj":"T225","pred":"source","obj":"c_corpus"},{"subj":"T227","pred":"source","obj":"c_corpus"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":107},"obj":"DRI_Background"},{"id":"T2","span":{"begin":108,"end":212},"obj":"DRI_Background"},{"id":"T3","span":{"begin":213,"end":349},"obj":"DRI_Background"},{"id":"T4","span":{"begin":350,"end":568},"obj":"DRI_Background"},{"id":"T5","span":{"begin":569,"end":809},"obj":"DRI_Approach"},{"id":"T6","span":{"begin":810,"end":822},"obj":"Token_Label.OUTSIDE"},{"id":"T7","span":{"begin":823,"end":853},"obj":"DRI_Approach"},{"id":"T8","span":{"begin":854,"end":921},"obj":"DRI_Background"},{"id":"T9","span":{"begin":922,"end":1085},"obj":"DRI_Unspecified"},{"id":"T10","span":{"begin":1086,"end":1107},"obj":"Token_Label.OUTSIDE"},{"id":"T11","span":{"begin":1108,"end":1243},"obj":"DRI_Unspecified"},{"id":"T12","span":{"begin":1244,"end":1333},"obj":"DRI_Background"},{"id":"T13","span":{"begin":1334,"end":1554},"obj":"DRI_Background"},{"id":"T14","span":{"begin":1555,"end":1732},"obj":"DRI_Outcome"},{"id":"T15","span":{"begin":1733,"end":2055},"obj":"DRI_Unspecified"},{"id":"T16","span":{"begin":2056,"end":2248},"obj":"DRI_Background"},{"id":"T17","span":{"begin":2249,"end":2404},"obj":"DRI_Background"},{"id":"T18","span":{"begin":2405,"end":2485},"obj":"DRI_Outcome"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T13","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T14","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T15","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T16","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T17","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T18","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":108,"end":212},"obj":"DRI_Background"},{"id":"T2","span":{"begin":213,"end":349},"obj":"DRI_Background"},{"id":"T3","span":{"begin":350,"end":568},"obj":"DRI_Background"},{"id":"T4","span":{"begin":569,"end":809},"obj":"DRI_Approach"},{"id":"T5","span":{"begin":823,"end":853},"obj":"DRI_Approach"},{"id":"T6","span":{"begin":854,"end":921},"obj":"DRI_Background"},{"id":"T7","span":{"begin":1244,"end":1333},"obj":"DRI_Background"},{"id":"T8","span":{"begin":1334,"end":1554},"obj":"DRI_Background"},{"id":"T9","span":{"begin":1555,"end":1732},"obj":"DRI_Outcome"},{"id":"T10","span":{"begin":2056,"end":2248},"obj":"DRI_Background"},{"id":"T11","span":{"begin":2249,"end":2404},"obj":"DRI_Background"},{"id":"T12","span":{"begin":2405,"end":2485},"obj":"DRI_Outcome"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T10","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T11","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T12","pred":"source","obj":"PubMed_ArguminSci"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"c_corpus","color":"#9dec93","default":true},{"id":"UseCases_ArguminSci_Discourse","color":"#ec93b7"},{"id":"PubMed_ArguminSci","color":"#93d1ec"}]}]}}