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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 117-237 DRI_Challenge denotes Fibroblast growth factors (FGFs) are known to play an important role in the growth of normal prostatic epithelial cells.
T2 238-426 DRI_Background denotes In addition to their effects on proliferation, FGFs can promote cell motility, increase tumor angiogenesis, and inhibit apoptosis, all of which play an important role in tumor progression.
T3 427-672 DRI_Challenge denotes To determine whether FGFs are overexpressed in human prostate cancers, we analyzed 26 prostate cancer RNAs by reverse transcription-PCR for expression of FGF3, FGF4, and FGF6, which cannot be detected in normal prostate tissue by this technique.
T4 673-725 DRI_Background denotes Fourteen of 26 prostate cancers expressed FGF6 mRNA.
T5 726-769 DRI_Background denotes No expression of FGF3 or FGF4 was detected.
T6 770-1058 DRI_Background denotes An ELISA of tissue extracts of normal prostate, high-grade prostatic intraepithelial neoplasia (PIN), and prostate cancer for FGF6 showed that this growth factor was undetectable in normal prostate but was present at elevated levels in 4 of 9 PIN lesions and in 15 of 24 prostate cancers.
T7 1059-1213 DRI_Background denotes Immunohistochemical analysis with anti-FGF6 antibody revealed weak staining of prostatic basal cells in normal prostate that was markedly elevated in PIN.
T8 1214-1329 DRI_Background denotes In the prostate cancers, the majority of cases revealed expression of FGF6 by the prostate cancer cells themselves.
T9 1330-1394 DRI_Background denotes In two cases, expression was present in prostatic stromal cells.
T10 1395-1587 DRI_Background denotes Exogenous FGF6 was able to stimulate proliferation of primary prostatic epithelial and stromal cells, immortalized prostatic epithelial cells, and prostate cancer cell lines in tissue culture.
T11 1588-1733 DRI_Outcome denotes FGF receptor 4, which is the most potent FGF receptor for FGF6, is expressed in the human prostate in vivo and in all of the cultured cell lines.
T12 1734-1904 DRI_Background denotes Thus, FGF6 is increased in PIN and prostate cancer and can promote the proliferation of the transformed prostatic epithelial cells via paracrine and autocrine mechanisms.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 326-331 HP_0002664 denotes tumor
T2 408-413 HP_0002664 denotes tumor
T3 480-496 HP_0012125 denotes prostate cancers
T4 489-496 HP_0002664 denotes cancers
T5 513-528 HP_0012125 denotes prostate cancer
T6 522-528 HP_0002664 denotes cancer
T7 688-704 HP_0012125 denotes prostate cancers
T8 697-704 HP_0002664 denotes cancers
T9 855-864 HP_0002664 denotes neoplasia
T10 876-891 HP_0012125 denotes prostate cancer
T11 885-891 HP_0002664 denotes cancer
T12 1041-1057 HP_0012125 denotes prostate cancers
T13 1050-1057 HP_0002664 denotes cancers
T14 1221-1237 HP_0012125 denotes prostate cancers
T15 1230-1237 HP_0002664 denotes cancers
T16 1296-1311 HP_0012125 denotes prostate cancer
T17 1305-1311 HP_0002664 denotes cancer
T18 1542-1557 HP_0012125 denotes prostate cancer
T19 1551-1557 HP_0002664 denotes cancer
T20 1769-1784 HP_0012125 denotes prostate cancer
T21 1778-1784 HP_0002664 denotes cancer

CoMAGC

Id Subject Object Predicate Lexical cue
T1 1740-1744 Gene denotes FGF6
E2 1748-1757 Positive_regulation denotes increased
T2 1769-1784 prostate cancer denotes prostate cancer
R1 T1 E2 themeOf FGF6,increased
R3 T1 T2 CGE-increased FGF6,prostate cancer
R4 T1 T2 CCS-normalTOcancer FGF6,prostate cancer
R5 T1 T2 PT-causality FGF6,prostate cancer
R3 T1 T2 IGE-unchanged FGF6,prostate cancer