PubMed:10942810 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10942810","sourcedb":"PubMed","sourceid":"10942810","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10942810","text":"Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.\nWe report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 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