PubMed:10942810 JSONTXT

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":508,"end":511},"obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":549,"end":552},"obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":647,"end":651},"obj":"http://purl.obolibrary.org/obo/UBERON_0001460"}],"text":"Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.\nWe report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":222,"end":253},"obj":"HP_0012325"},{"id":"T2","span":{"begin":245,"end":253},"obj":"HP_0001909"},{"id":"T3","span":{"begin":280,"end":304},"obj":"HP_0004845"},{"id":"T4","span":{"begin":296,"end":304},"obj":"HP_0001909"},{"id":"T5","span":{"begin":543,"end":552},"obj":"HP_0009824"}],"text":"Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.\nWe report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8."}

{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":222,"end":253},"obj":"HP:0012325"},{"id":"TI1","span":{"begin":125,"end":133},"obj":"HP:0001909"},{"id":"AB2","span":{"begin":280,"end":304},"obj":"HP:0004845"}],"text":"Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.\nWe report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8."}

{"project":"PubCasesORDO","denotations":[{"id":"AB1","span":{"begin":222,"end":253},"obj":"ORDO:98823"},{"id":"AB2","span":{"begin":280,"end":304},"obj":"ORDO:514"},{"id":"AB3","span":{"begin":306,"end":312},"obj":"ORDO:514"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"text":"Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.\nWe report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":508,"end":511},"obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":549,"end":552},"obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":647,"end":651},"obj":"http://purl.obolibrary.org/obo/UBERON_0001460"}],"text":"Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.\nWe report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":134},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":135,"end":204},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":205,"end":318},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":319,"end":391},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":392,"end":564},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":565,"end":668},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":134},"obj":"Sentence"},{"id":"T2","span":{"begin":135,"end":204},"obj":"Sentence"},{"id":"T3","span":{"begin":205,"end":318},"obj":"Sentence"},{"id":"T4","span":{"begin":319,"end":391},"obj":"Sentence"},{"id":"T5","span":{"begin":392,"end":564},"obj":"Sentence"},{"id":"T6","span":{"begin":565,"end":668},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.\nWe report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":313,"end":316},"obj":"gene:2187"},{"id":"T1","span":{"begin":222,"end":253},"obj":"disease:C0023480"},{"id":"T2","span":{"begin":313,"end":316},"obj":"gene:2187"},{"id":"T3","span":{"begin":255,"end":260},"obj":"disease:C0023480"},{"id":"T4","span":{"begin":313,"end":316},"obj":"gene:2187"},{"id":"T5","span":{"begin":280,"end":304},"obj":"disease:C0023465"},{"id":"T6","span":{"begin":313,"end":316},"obj":"gene:2187"},{"id":"T7","span":{"begin":280,"end":304},"obj":"disease:C1318544"},{"id":"T8","span":{"begin":313,"end":316},"obj":"gene:2187"},{"id":"T9","span":{"begin":306,"end":309},"obj":"disease:C0023467"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.\nWe report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8."}