PubMed:10938272 / 813-1110 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T4","span":{"begin":96,"end":110},"obj":"HP_0009919"}],"text":"Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin"}

{"project":"bionlp-st-epi-2011-training","denotations":[{"id":"T5","span":{"begin":46,"end":49},"obj":"Protein"},{"id":"T6","span":{"begin":50,"end":54},"obj":"Protein"},{"id":"T7","span":{"begin":96,"end":110},"obj":"Protein"},{"id":"T8","span":{"begin":143,"end":152},"obj":"Protein"},{"id":"T9","span":{"begin":237,"end":244},"obj":"Protein"}],"text":"Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin"}

{"project":"2015-BEL-Sample-2","denotations":[{"id":"BEL:20024938","span":{"begin":0,"end":297},"obj":"a(CHEBI:quinidine) decreases p(HGNC:CCND1)"},{"id":"BEL:20024940","span":{"begin":0,"end":297},"obj":"a(CHEBI:quinidine) increases p(HGNC:CDKN1A)"},{"id":"BEL:20024942","span":{"begin":0,"end":297},"obj":"a(CHEBI:quinidine) decreases p(HGNC:RB1)"},{"id":"BEL:20024944","span":{"begin":0,"end":297},"obj":"a(CHEBI:quinidine) decreases p(HGNC:RB1,pmod(P))"}],"text":"Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin"}

{"project":"HP-phenotype","denotations":[{"id":"T3","span":{"begin":96,"end":110},"obj":"Phenotype"}],"attributes":[{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0009919"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin"}

{"project":"mondo_disease","denotations":[{"id":"T5","span":{"begin":96,"end":110},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0008380"}],"text":"Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin"}

{"project":"Anatomy-UBERON","denotations":[{"id":"T6","span":{"begin":169,"end":179},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_2000098"}],"text":"Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin"}