PubMed:10783264
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10783264","sourcedb":"PubMed","sourceid":"10783264","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10783264","text":"Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope.\nThe HNK-1 carbohydrate is expressed on various cell adhesion molecules in the nervous system and is suggested to play a role in cell-cell and cell-substrate interactions. Here we describe the isolation of a cDNA encoding human glucuronyltransferase (GlcAT-P), which is a key enzyme in the biosynthesis of the HNK-1 carbohydrate. The primary structure deduced from the cDNA sequence predicted a type II transmembrane protein of 334 amino acids. Human GlcAT-P was 98.2% identical with rat GlcAT-P in amino acid sequence, the exception being the length of the cytoplasmic tail. Northern blot analysis indicated that human GlcAT-P is expressed mainly in the brain. There is a single copy of the human GlcAT-P gene (HGMW-approved symbol B3GAT1), and it was mapped to chromosome 11q25.","tracks":[{"project":"ggdb-test","denotations":[{"id":"T1","span":{"begin":855,"end":861},"obj":"https://acgg.asia/db/ggdb/info/gg157"}],"attributes":[{"subj":"T1","pred":"source","obj":"ggdb-test"}]},{"project":"glycogenes","denotations":[{"id":"PD-GlycoGenes20190927-B_T1","span":{"begin":373,"end":380},"obj":"https://acgg.asia/db/ggdb/info/gg157"},{"id":"PD-GlycoGenes20190927-B_T2","span":{"begin":522,"end":524},"obj":"https://acgg.asia/db/ggdb/info/gg111"},{"id":"PD-GlycoGenes20190927-B_T3","span":{"begin":573,"end":580},"obj":"https://acgg.asia/db/ggdb/info/gg157"},{"id":"PD-GlycoGenes20190927-B_T4","span":{"begin":610,"end":617},"obj":"https://acgg.asia/db/ggdb/info/gg157"},{"id":"PD-GlycoGenes20190927-B_T5","span":{"begin":742,"end":749},"obj":"https://acgg.asia/db/ggdb/info/gg157"},{"id":"PD-GlycoGenes20190927-B_T6","span":{"begin":820,"end":827},"obj":"https://acgg.asia/db/ggdb/info/gg157"},{"id":"PD-GlycoGenes20190927-B_T7","span":{"begin":848,"end":854},"obj":"url"},{"id":"PD-GlycoGenes20190927-B_T8","span":{"begin":855,"end":861},"obj":"https://acgg.asia/db/ggdb/info/gg157"}],"attributes":[{"subj":"PD-GlycoGenes20190927-B_T1","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T2","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T3","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T4","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T5","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T6","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T7","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T8","pred":"source","obj":"glycogenes"}]},{"project":"GGDB-2020","denotations":[{"id":"T1","span":{"begin":855,"end":861},"obj":"https://acgg.asia/db/ggdb/info/gg157"}],"attributes":[{"subj":"T1","pred":"source","obj":"GGDB-2020"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"ggdb-test","color":"#cc93ec","default":true},{"id":"glycogenes","color":"#93ecb2"},{"id":"GGDB-2020","color":"#ec9893"}]}]}}