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PubMed:10704523 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-198 Sentence denotes Protein structure controls the processing of the N-linked oligosaccharides and glycosylphosphatidylinositol glycans of variant surface glycoproteins expressed in bloodstream form Trypanosoma brucei.
TextSentencer_T2 199-330 Sentence denotes The variant surface glycoproteins (VSGs) of Trypanosoma brucei are a family of homodimeric glycoproteins that adopt similar shapes.
TextSentencer_T3 331-453 Sentence denotes An individual trypanosome expresses one VSG at a time in the form of a dense protective mono-layer on the plasma membrane.
TextSentencer_T4 454-605 Sentence denotes VSG genes are expressed from one of several polycistronic transcription units (expression sites) that contain several expression site associated genes.
TextSentencer_T5 606-901 Sentence denotes We used a transformed trypanosome clone expressing two different VSGs (VSG121 and VSG221) from the same expression site (that of VSG221) to establish whether the genotype of the trypanosome clone or the VSG structure itself controls VSG N-linked oligosaccharide and GPI anchor glycan processing.
TextSentencer_T6 902-1237 Sentence denotes In-gel release and fluorescent labeling of N-linked oligosaccharides and on-blot fluorescent labeling and release of GPI anchor glycans were employed to compare the carbohydrate structures of VSG121 and VSG221 when expressed individually in wild-type trypanosome clones and when expressed together in the transformed trypanosome clone.
TextSentencer_T7 1238-1437 Sentence denotes The data indicate that the genotype of the trypanosome clone has no effect on the N-linked oligosaccharide structures present on a given VSG variant and only a minor effect on the GPI anchor glycans.
TextSentencer_T8 1438-1549 Sentence denotes The latter is most likely an effect of changes in inter-VSG packing when two VGSs are expressed simultaneously.
TextSentencer_T9 1550-1851 Sentence denotes Thus, N-linked oligosaccharide and GPI anchor processing enzymes appear to be constitutively expressed in bloodstream form African trypanosomes and the tertiary and quaternary structures of the VSG homodimers appear to dictate the processing and glycoform microheterogeneity of surface-expressed VSGs.
T1 0-198 Sentence denotes Protein structure controls the processing of the N-linked oligosaccharides and glycosylphosphatidylinositol glycans of variant surface glycoproteins expressed in bloodstream form Trypanosoma brucei.
T2 199-330 Sentence denotes The variant surface glycoproteins (VSGs) of Trypanosoma brucei are a family of homodimeric glycoproteins that adopt similar shapes.
T3 331-453 Sentence denotes An individual trypanosome expresses one VSG at a time in the form of a dense protective mono-layer on the plasma membrane.
T4 454-605 Sentence denotes VSG genes are expressed from one of several polycistronic transcription units (expression sites) that contain several expression site associated genes.
T5 606-901 Sentence denotes We used a transformed trypanosome clone expressing two different VSGs (VSG121 and VSG221) from the same expression site (that of VSG221) to establish whether the genotype of the trypanosome clone or the VSG structure itself controls VSG N-linked oligosaccharide and GPI anchor glycan processing.
T6 902-1237 Sentence denotes In-gel release and fluorescent labeling of N-linked oligosaccharides and on-blot fluorescent labeling and release of GPI anchor glycans were employed to compare the carbohydrate structures of VSG121 and VSG221 when expressed individually in wild-type trypanosome clones and when expressed together in the transformed trypanosome clone.
T7 1238-1437 Sentence denotes The data indicate that the genotype of the trypanosome clone has no effect on the N-linked oligosaccharide structures present on a given VSG variant and only a minor effect on the GPI anchor glycans.
T8 1438-1549 Sentence denotes The latter is most likely an effect of changes in inter-VSG packing when two VGSs are expressed simultaneously.
T9 1550-1851 Sentence denotes Thus, N-linked oligosaccharide and GPI anchor processing enzymes appear to be constitutively expressed in bloodstream form African trypanosomes and the tertiary and quaternary structures of the VSG homodimers appear to dictate the processing and glycoform microheterogeneity of surface-expressed VSGs.
T1 0-198 Sentence denotes Protein structure controls the processing of the N-linked oligosaccharides and glycosylphosphatidylinositol glycans of variant surface glycoproteins expressed in bloodstream form Trypanosoma brucei.
T2 199-330 Sentence denotes The variant surface glycoproteins (VSGs) of Trypanosoma brucei are a family of homodimeric glycoproteins that adopt similar shapes.
T3 331-453 Sentence denotes An individual trypanosome expresses one VSG at a time in the form of a dense protective mono-layer on the plasma membrane.
T4 454-605 Sentence denotes VSG genes are expressed from one of several polycistronic transcription units (expression sites) that contain several expression site associated genes.
T5 606-901 Sentence denotes We used a transformed trypanosome clone expressing two different VSGs (VSG121 and VSG221) from the same expression site (that of VSG221) to establish whether the genotype of the trypanosome clone or the VSG structure itself controls VSG N-linked oligosaccharide and GPI anchor glycan processing.
T6 902-1237 Sentence denotes In-gel release and fluorescent labeling of N-linked oligosaccharides and on-blot fluorescent labeling and release of GPI anchor glycans were employed to compare the carbohydrate structures of VSG121 and VSG221 when expressed individually in wild-type trypanosome clones and when expressed together in the transformed trypanosome clone.
T7 1238-1437 Sentence denotes The data indicate that the genotype of the trypanosome clone has no effect on the N-linked oligosaccharide structures present on a given VSG variant and only a minor effect on the GPI anchor glycans.
T8 1438-1549 Sentence denotes The latter is most likely an effect of changes in inter-VSG packing when two VGSs are expressed simultaneously.
T9 1550-1851 Sentence denotes Thus, N-linked oligosaccharide and GPI anchor processing enzymes appear to be constitutively expressed in bloodstream form African trypanosomes and the tertiary and quaternary structures of the VSG homodimers appear to dictate the processing and glycoform microheterogeneity of surface-expressed VSGs.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 402-407 HP_0011088 denotes dense

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 0-7 FMAID:165447 denotes Protein
_T2 0-7 FMAID:67257 denotes Protein
_T3 58-74 FMAID:82742 denotes oligosaccharides
_T4 58-74 FMAID:196731 denotes oligosaccharides
_T5 79-107 FMAID:82806 denotes glycosylphosphatidylinositol
_T6 79-107 FMAID:196801 denotes glycosylphosphatidylinositol
_T7 79-107 FMAID:85436 denotes glycosylphosphatidylinositol
_T8 79-107 FMAID:199790 denotes glycosylphosphatidylinositol
_T9 127-134 FMAID:146300 denotes surface
_T10 127-134 FMAID:50594 denotes surface
_T11 135-148 FMAID:167256 denotes glycoproteins
_T12 135-148 FMAID:62925 denotes glycoproteins
_T13 211-218 FMAID:146300 denotes surface
_T14 211-218 FMAID:50594 denotes surface
_T15 219-232 FMAID:167256 denotes glycoproteins
_T16 219-232 FMAID:62925 denotes glycoproteins
_T17 290-303 FMAID:167256 denotes glycoproteins
_T18 290-303 FMAID:62925 denotes glycoproteins
_T19 424-452 FMAID:165262 denotes layer on the plasma membrane
_T20 424-452 FMAID:67269 denotes layer on the plasma membrane
_T21 437-443 FMAID:162307 denotes plasma
_T22 437-452 FMAID:63841 denotes plasma membrane
_T23 437-452 FMAID:164993 denotes plasma membrane
_T24 437-452 FMAID:162306 denotes plasma membrane
_T25 437-452 FMAID:166047 denotes plasma membrane
_T26 437-452 FMAID:210691 denotes plasma membrane
_T27 437-452 FMAID:66843 denotes plasma membrane
_T28 458-463 FMAID:198663 denotes genes
_T29 599-604 FMAID:198663 denotes genes
_T30 852-867 FMAID:196731 denotes oligosaccharide
_T31 852-867 FMAID:82742 denotes oligosaccharide
_T32 954-970 FMAID:82742 denotes oligosaccharides
_T33 954-970 FMAID:196731 denotes oligosaccharides
_T34 1067-1079 FMAID:82737 denotes carbohydrate
_T35 1067-1079 FMAID:197276 denotes carbohydrate
_T36 1329-1344 FMAID:82742 denotes oligosaccharide
_T37 1329-1344 FMAID:196731 denotes oligosaccharide
_T38 1442-1448 FMAID:30332 denotes latter
_T39 1442-1448 FMAID:171168 denotes latter
_T40 1565-1580 FMAID:196731 denotes oligosaccharide
_T41 1565-1580 FMAID:82742 denotes oligosaccharide
_T42 1828-1835 FMAID:146300 denotes surface
_T43 1828-1835 FMAID:50594 denotes surface

uniprot-human

Id Subject Object Predicate Lexical cue
T1 872-875 http://www.uniprot.org/uniprot/P06744 denotes GPI
T2 1019-1022 http://www.uniprot.org/uniprot/P06744 denotes GPI
T3 1418-1421 http://www.uniprot.org/uniprot/P06744 denotes GPI
T4 1585-1588 http://www.uniprot.org/uniprot/P06744 denotes GPI

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 872-875 http://www.uniprot.org/uniprot/Q8C675 denotes GPI
T2 1019-1022 http://www.uniprot.org/uniprot/Q8C675 denotes GPI
T3 1418-1421 http://www.uniprot.org/uniprot/Q8C675 denotes GPI
T4 1585-1588 http://www.uniprot.org/uniprot/Q8C675 denotes GPI

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 179-190 http://purl.bioontology.org/ontology/NCBITAXON/5690 denotes Trypanosoma
T2 179-190 http://purl.bioontology.org/ontology/NCBITAXON/71805 denotes Trypanosoma
T3 179-190 http://purl.bioontology.org/ontology/NCBITAXON/5654 denotes Trypanosoma
T4 179-190 http://purl.bioontology.org/ontology/NCBITAXON/56869 denotes Trypanosoma
T5 179-197 http://purl.bioontology.org/ontology/NCBITAXON/5691 denotes Trypanosoma brucei
T6 243-254 http://purl.bioontology.org/ontology/NCBITAXON/5690 denotes Trypanosoma
T7 243-254 http://purl.bioontology.org/ontology/NCBITAXON/71805 denotes Trypanosoma
T8 243-254 http://purl.bioontology.org/ontology/NCBITAXON/56869 denotes Trypanosoma
T9 243-254 http://purl.bioontology.org/ontology/NCBITAXON/5654 denotes Trypanosoma
T10 243-261 http://purl.bioontology.org/ontology/NCBITAXON/5691 denotes Trypanosoma brucei
T11 345-356 http://purl.bioontology.org/ontology/NCBITAXON/5690 denotes trypanosome
T12 628-639 http://purl.bioontology.org/ontology/NCBITAXON/5690 denotes trypanosome
T13 784-795 http://purl.bioontology.org/ontology/NCBITAXON/5690 denotes trypanosome
T14 1153-1164 http://purl.bioontology.org/ontology/NCBITAXON/5690 denotes trypanosome
T15 1219-1230 http://purl.bioontology.org/ontology/NCBITAXON/5690 denotes trypanosome
T16 1281-1292 http://purl.bioontology.org/ontology/NCBITAXON/5690 denotes trypanosome
T17 1681-1693 http://purl.bioontology.org/ontology/NCBITAXON/5690 denotes trypanosomes

GO-BP

Id Subject Object Predicate Lexical cue
T1 458-477 http://purl.obolibrary.org/obo/GO_0010467 denotes genes are expressed
T2 512-525 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3 1008-1029 http://purl.obolibrary.org/obo/GO_0006507 denotes release of GPI anchor
T4 1585-1606 http://purl.obolibrary.org/obo/GO_0006506 denotes GPI anchor processing

GO-MF

Id Subject Object Predicate Lexical cue
T1 876-882 http://purl.obolibrary.org/obo/GO_0043495 denotes anchor
T2 1023-1029 http://purl.obolibrary.org/obo/GO_0043495 denotes anchor
T3 1422-1428 http://purl.obolibrary.org/obo/GO_0043495 denotes anchor
T4 1589-1595 http://purl.obolibrary.org/obo/GO_0043495 denotes anchor

GO-CC

Id Subject Object Predicate Lexical cue
T1 437-452 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membrane
T2 444-452 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 0-7 http://edamontology.org/topic_0078 denotes Protein
T2 0-17 http://edamontology.org/topic_2814 denotes Protein structure
T3 0-17 http://edamontology.org/topic_0166 denotes Protein structure
T4 0-17 http://edamontology.org/topic_0698 denotes Protein structure
T5 0-17 http://edamontology.org/topic_3538 denotes Protein structure
T6 0-17 http://edamontology.org/topic_2826 denotes Protein structure
T7 0-17 http://edamontology.org/topic_0694 denotes Protein structure
T8 0-17 http://edamontology.org/topic_3542 denotes Protein structure
T9 135-158 http://edamontology.org/topic_0121 denotes glycoproteins expressed
T10 135-158 http://edamontology.org/topic_0108 denotes glycoproteins expressed
T11 458-477 http://edamontology.org/topic_0203 denotes genes are expressed
T12 512-525 http://edamontology.org/topic_0110 denotes transcription
T13 512-525 http://edamontology.org/topic_3308 denotes transcription
T14 512-525 http://edamontology.org/topic_0203 denotes transcription
T15 512-525 http://edamontology.org/topic_3512 denotes transcription
T16 768-776 http://edamontology.org/topic_0625 denotes genotype
T17 1067-1079 http://edamontology.org/topic_0152 denotes carbohydrate
T18 1265-1273 http://edamontology.org/topic_0625 denotes genotype

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 0-7 http://edamontology.org/data_1467 denotes Protein
T2 0-7 http://edamontology.org/format_1208 denotes Protein
T3 0-17 http://edamontology.org/operation_0321 denotes Protein structure
T4 0-17 http://edamontology.org/data_1460 denotes Protein structure
T5 0-17 http://edamontology.org/operation_2488 denotes Protein structure
T6 0-17 http://edamontology.org/data_1481 denotes Protein structure
T7 0-17 http://edamontology.org/data_2992 denotes Protein structure
T8 0-17 http://edamontology.org/data_2878 denotes Protein structure
T9 8-17 http://edamontology.org/data_0883 denotes structure
T10 31-41 http://edamontology.org/operation_2409 denotes processing
T11 31-41 http://edamontology.org/operation_0004 denotes processing
T12 768-776 http://edamontology.org/operation_3196 denotes genotype
T13 813-822 http://edamontology.org/data_0883 denotes structure
T14 890-900 http://edamontology.org/operation_0004 denotes processing
T15 890-900 http://edamontology.org/operation_2409 denotes processing
T16 1067-1090 http://edamontology.org/data_1462 denotes carbohydrate structures
T17 1080-1090 http://edamontology.org/data_0883 denotes structures
T18 1242-1246 http://edamontology.org/data_0006 denotes data
T19 1265-1273 http://edamontology.org/operation_3196 denotes genotype
T20 1345-1355 http://edamontology.org/data_0883 denotes structures
T21 1596-1606 http://edamontology.org/operation_0004 denotes processing
T22 1596-1606 http://edamontology.org/operation_2409 denotes processing
T23 1726-1736 http://edamontology.org/data_0883 denotes structures
T24 1781-1791 http://edamontology.org/operation_2409 denotes processing
T25 1781-1791 http://edamontology.org/operation_0004 denotes processing

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1442-1448 http://purl.obolibrary.org/obo/MAT_0000488 denotes latter

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 872-882 http://rdf.glycoinfo.org/glycan/G00045MO denotes GPI anchor
T2 1019-1029 http://rdf.glycoinfo.org/glycan/G00045MO denotes GPI anchor
T3 1418-1428 http://rdf.glycoinfo.org/glycan/G00045MO denotes GPI anchor
T4 1585-1595 http://rdf.glycoinfo.org/glycan/G00045MO denotes GPI anchor

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 933-941 id denotes labeling
PD-GlycoEpitope-B_T2 995-1003 id denotes labeling

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 179-197 OrganismTaxon denotes Trypanosoma brucei 5691
T2 243-261 OrganismTaxon denotes Trypanosoma brucei 5691

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 424-429 Body_part denotes layer http://purl.obolibrary.org/obo/UBERON_0000119|http://purl.obolibrary.org/obo/UBERON_0022303
T3 437-452 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886