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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 102-389 BACKGROUND denotes Patients with stage II colorectal cancer and no histologic evidence of lymph node invasion develop recurrent disease, presumably because of undetected micrometastases. Guanylyl cyclase C is expressed by intestinal and colorectal cancer cells but not by extraintestinal tissues or tumors.
T2 401-577 OBJECTIVE denotes To examine the expression of guanylyl cyclase C messenger RNA (mRNA) in lymph nodes of patients with node-negative colorectal cancer who did and did not have recurrent disease.
T3 586-605 METHODS denotes Case-control study.
T4 615-653 METHODS denotes Tertiary care academic medical center.
T5 664-998 METHODS denotes Paraffin-embedded lymph nodes were obtained from 21 patients with histologically confirmed node-negative colorectal cancer who had undergone resection. Controls included 11 patients without disease recurrence 6 or more years after resection, and case-patients included 10 patients whose disease recurred up to 3 years after resection.
T6 1013-1191 METHODS denotes Sections of paraffin-embedded lymph nodes were obtained from each patient and were pooled, and their RNA was analyzed by reverse transcriptase polymerase chain reaction (RT-PCR).
T7 1201-1759 RESULTS denotes Guanylyl cyclase C mRNA was expressed in lymph nodes from all patients with recurrent disease but not in those from patients without recurrent disease (P = 0.004). Nested RT-PCR that used primers for carcinoembryonic antigen, a marker for colorectal cancer, identified carcinoembryonic antigen mRNA in lymph nodes from only 1 of 10 patients with recurrent disease and those from 0 of 11 patients without recurrent disease. The odds ratio for death associated with expression of guanylyl cyclase C mRNA in regional lymph nodes was 15.0 (95% CI, 1.1 to 756.7).
T8 1773-2011 CONCLUSIONS denotes Expression of guanylyl cyclase C mRNA in lymph nodes is associated with recurrence of colorectal cancer in patients with stage II disease. Analysis of guanylyl cyclase mRNA expression by RT-PCR may be useful for colorectal cancer staging.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 136-142 HP_0002664 denotes cancer
T2 331-337 HP_0002664 denotes cancer
T3 382-388 HP_0002664 denotes tumors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10610624-0#0#18#gene2984 270-288 gene2984 denotes Guanylyl cyclase C
10610624-0#62#88#diseaseC0677948 1559-1876 diseaseC0677948 denotes sease and those from 0 of 11 patients without recurrent disease. The odds ratio for death associated with expression of guanylyl cyclase C mRNA in regional lymph nodes was 15.0 (95% CI, 1.1 to 756.7). CONCLUSIONS: Expression of guanylyl cyclase C mRNA in lymph nodes is associated with recurrence of colorectal cancer
10610624-0#62#88#diseaseC3146252 1559-1876 diseaseC3146252 denotes sease and those from 0 of 11 patients without recurrent disease. The odds ratio for death associated with expression of guanylyl cyclase C mRNA in regional lymph nodes was 15.0 (95% CI, 1.1 to 756.7). CONCLUSIONS: Expression of guanylyl cyclase C mRNA in lymph nodes is associated with recurrence of colorectal cancer
10610624-10#36#60#gene1048 1401-1425 gene1048 denotes carcinoembryonic antigen
10610624-10#75#92#diseaseC0009402 1440-1457 diseaseC0009402 denotes colorectal cancer
10610624-10#75#92#diseaseC1527249 1440-1457 diseaseC1527249 denotes colorectal cancer
10610624-12#14#32#gene2984 1787-1805 gene2984 denotes guanylyl cyclase C
10610624-12#86#103#diseaseC0009402 1859-1876 diseaseC0009402 denotes colorectal cancer
10610624-12#86#103#diseaseC1527249 1859-1876 diseaseC1527249 denotes colorectal cancer
0#18#gene298462#88#diseaseC0677948 10610624-0#0#18#gene2984 10610624-0#62#88#diseaseC0677948 associated_with Guanylyl cyclase C,"sease and those from 0 of 11 patients without recurrent disease. The odds ratio for death associated with expression of guanylyl cyclase C mRNA in regional lymph nodes was 15.0 (95% CI, 1.1 to 756.7). CONCLUSIONS: Expression of guanylyl cyclase C mRNA in lymph nodes is associated with recurrence of colorectal cancer"
0#18#gene298462#88#diseaseC3146252 10610624-0#0#18#gene2984 10610624-0#62#88#diseaseC3146252 associated_with Guanylyl cyclase C,"sease and those from 0 of 11 patients without recurrent disease. The odds ratio for death associated with expression of guanylyl cyclase C mRNA in regional lymph nodes was 15.0 (95% CI, 1.1 to 756.7). CONCLUSIONS: Expression of guanylyl cyclase C mRNA in lymph nodes is associated with recurrence of colorectal cancer"
36#60#gene104875#92#diseaseC0009402 10610624-10#36#60#gene1048 10610624-10#75#92#diseaseC0009402 associated_with carcinoembryonic antigen,colorectal cancer
36#60#gene104875#92#diseaseC1527249 10610624-10#36#60#gene1048 10610624-10#75#92#diseaseC1527249 associated_with carcinoembryonic antigen,colorectal cancer
14#32#gene298486#103#diseaseC0009402 10610624-12#14#32#gene2984 10610624-12#86#103#diseaseC0009402 associated_with guanylyl cyclase C,colorectal cancer
14#32#gene298486#103#diseaseC1527249 10610624-12#14#32#gene2984 10610624-12#86#103#diseaseC1527249 associated_with guanylyl cyclase C,colorectal cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 270-288 gene:2984 denotes Guanylyl cyclase C
T1 320-337 disease:C0009402 denotes colorectal cancer
T2 270-288 gene:2984 denotes Guanylyl cyclase C
T3 320-337 disease:C1527249 denotes colorectal cancer
R1 T0 T1 associated_with Guanylyl cyclase C,colorectal cancer
R2 T2 T3 associated_with Guanylyl cyclase C,colorectal cancer