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c_corpus

Id Subject Object Predicate Lexical cue
T2 0-3 CHEBI:16768 denotes Msh
T6 0-3 D009074 denotes Msh
T7 0-3 D009074 denotes Msh
T8 0-4 PR:000010666 denotes Msh2
T9 0-4 PR:P25847 denotes Msh2
T10 0-4 PR:P43246 denotes Msh2
T11 0-4 P22711 denotes Msh2
T12 0-4 PR:P22711 denotes Msh2
T13 0-4 PR:P54275 denotes Msh2
T14 0-4 PR:O74773 denotes Msh2
T15 0-4 PR:P43247 denotes Msh2
T16 0-4 PR:Q553L4 denotes Msh2
T17 0-4 PR:O24617 denotes Msh2
T18 5-15 SO:1000029 denotes deficiency
T19 60-63 CVCL_D569 denotes CAG
T20 64-70 SO:0001068 denotes repeat
T23 74-92 D006816 denotes Huntington disease
T24 74-92 D006816 denotes Huntington disease
T27 93-103 SO:0000781 denotes transgenic
T28 93-108 10090 denotes transgenic mice
T29 93-108 D008822 denotes transgenic mice
T30 104-108 PR:000005054 denotes mice
T32 104-108 O89094 denotes mice
T34 121-128 D004194 denotes disease
T35 121-128 D004194 denotes disease
T36 138-156 C566739 denotes autosomal dominant
T39 170-196 D019636 denotes neurodegenerative disorder
T40 170-196 D019636 denotes neurodegenerative disorder
T41 223-226 CVCL_D569 denotes CAG
T42 227-233 SO:0001068 denotes repeat
T43 234-242 SO:0000001 denotes sequence
T48 283-292 4885 denotes glutamine
T44 283-292 SO:0001448 denotes glutamine
T45 283-292 D005973 denotes glutamine
T46 283-292 CHEBI:28300 denotes glutamine
T47 283-292 CHEBI:18050 denotes glutamine
T49 283-292 D005973 denotes glutamine
T54 317-324 SO:0000104 denotes protein
T53 317-324 PR:000000001 denotes protein
T50 317-324 GO:0003675 denotes protein
T51 317-324 CHEBI:36080 denotes protein
T52 317-324 CHEBI:11122 denotes protein
T55 337-340 CVCL_D569 denotes CAG
T56 341-347 SO:0001068 denotes repeat
T58 439-446 D004194 denotes disease
T59 439-446 D004194 denotes disease
T60 488-491 CVCL_D569 denotes CAG
T61 572-579 D004194 denotes disease
T62 572-579 D004194 denotes disease
T63 612-618 SO:0001068 denotes repeat
T64 641-647 SO:0001068 denotes repeat
T65 684-690 SO:0001068 denotes repeat
T66 722-727 D006801 denotes human
T67 752-762 SO:0000781 denotes transgenic
T68 752-768 D008822 denotes transgenic mouse
T71 804-812 SO:0000731 denotes fragment
T72 816-821 D006801 denotes human
T73 825-829 PR:P33696 denotes exon
T74 825-829 SO:0000147 denotes exon
T75 856-862 SO:0001068 denotes repeat
T76 892-897 10090 denotes mouse
T77 892-897 D051379 denotes mouse
T78 898-902 SO:0000704 denotes gene
T79 903-906 P9WPX0 denotes Hdh
T80 903-906 Q8R882 denotes Hdh
T81 903-906 Q4UU40 denotes Hdh
T82 903-906 P56429 denotes Hdh
T83 903-906 Q8D8Q0 denotes Hdh
T84 903-906 Q5LL27 denotes Hdh
T85 903-906 Q9RSI4 denotes Hdh
T86 903-906 P59399 denotes Hdh
T87 903-906 Q8PLG9 denotes Hdh
T88 903-906 Q845V3 denotes Hdh
T89 903-906 Q313T7 denotes Hdh
T90 903-906 Q492K3 denotes Hdh
T91 903-906 Q47AL5 denotes Hdh
T92 903-906 Q8ZFX5 denotes Hdh
T93 903-906 Q3Z0G5 denotes Hdh
T94 903-906 Q97KI2 denotes Hdh
T95 903-906 Q7VQX0 denotes Hdh
T96 903-906 Q48EC9 denotes Hdh
T97 903-906 Q9P777 denotes Hdh
T98 903-906 Q9RQ85 denotes Hdh
T99 903-906 Q5NAY4 denotes Hdh
T100 903-906 P60860 denotes Hdh
T101 903-906 Q47QS9 denotes Hdh
T102 903-906 Q6GDC6 denotes Hdh
T103 903-906 Q9CLM4 denotes Hdh
T104 903-906 Q31GY9 denotes Hdh
T105 903-906 Q8GKZ1 denotes Hdh
T106 903-906 Q318Q4 denotes Hdh
T107 903-906 Q3Z878 denotes Hdh
T108 903-906 P60859 denotes Hdh
T109 903-906 Q3J079 denotes Hdh
T110 903-906 Q9JTH9 denotes Hdh
T111 903-906 Q7VFF5 denotes Hdh
T112 903-906 Q6G5Z7 denotes Hdh
T113 903-906 P08499 denotes Hdh
T114 903-906 Q3AD53 denotes Hdh
T115 903-906 Q58851 denotes Hdh
T116 903-906 Q8G4S9 denotes Hdh
T117 903-906 Q3KHZ2 denotes Hdh
T118 903-906 Q7V5N9 denotes Hdh
T119 903-906 Q9RH05 denotes Hdh
T120 903-906 Q57MS3 denotes Hdh
T121 903-906 P19582 denotes Hdh
T122 903-906 Q3IQR5 denotes Hdh
T123 903-906 P9WPX1 denotes Hdh
T124 903-906 Q2YZB4 denotes Hdh
T125 903-906 Q9X0D1 denotes Hdh
T126 903-906 Q5H0L1 denotes Hdh
T127 903-906 P18786 denotes Hdh
T128 903-906 Q30TA4 denotes Hdh
T129 903-906 P59400 denotes Hdh
T130 903-906 Q5F7D8 denotes Hdh
T131 903-906 Q7W2Y4 denotes Hdh
T132 903-906 Q2YPB8 denotes Hdh
T133 903-906 Q5HCL9 denotes Hdh
T134 903-906 Q8NNT5 denotes Hdh
T135 903-906 Q9ZHE6 denotes Hdh
T136 903-906 Q63Q86 denotes Hdh
T137 903-906 Q81G06 denotes Hdh
T138 903-906 P60861 denotes Hdh
T139 903-906 Q8CQ95 denotes Hdh
T140 903-906 Q5P790 denotes Hdh
T141 903-906 B0S9F2 denotes Hdh
T142 903-906 Q66C49 denotes Hdh
T143 903-906 P31116 denotes Hdh
T144 903-906 Q92S26 denotes Hdh
T145 903-906 P63630 denotes Hdh
T146 903-906 Q5E638 denotes Hdh
T147 903-906 Q9K6Z2 denotes Hdh
T148 903-906 Q6FEC8 denotes Hdh
T149 903-906 Q323J2 denotes Hdh
T150 903-906 P9WNW9 denotes Hdh
T151 903-906 Q2RQM7 denotes Hdh
T152 903-906 P9WNW8 denotes Hdh
T153 903-906 Q7M8K9 denotes Hdh
T154 903-906 Q3SI67 denotes Hdh
T155 903-906 P06988 denotes Hdh
T156 903-906 Q58997 denotes Hdh
T157 903-906 Q5HKN8 denotes Hdh
T158 903-906 Q5SKC1 denotes Hdh
T159 903-906 Q63DX2 denotes Hdh
T160 903-906 Q9C5U8 denotes Hdh
T161 903-906 Q3AR25 denotes Hdh
T162 903-906 Q8Y9G1 denotes Hdh
T163 903-906 Q9HVW9 denotes Hdh
T164 903-906 P29365 denotes Hdh
T165 903-906 Q47XB8 denotes Hdh
T166 903-906 Q8DTQ7 denotes Hdh
T167 903-906 Q46J19 denotes Hdh
T168 903-906 Q8FG52 denotes Hdh
T169 903-906 Q4QN74 denotes Hdh
T170 903-906 O26327 denotes Hdh
T171 903-906 Q8ESR8 denotes Hdh
T172 903-906 Q4FNE2 denotes Hdh
T173 903-906 P59401 denotes Hdh
T174 903-906 PR:Q9C5U8 denotes Hdh
T175 903-906 Q1PW30 denotes Hdh
T176 903-906 Q3SW26 denotes Hdh
T177 903-906 P62460 denotes Hdh
T178 903-906 Q8X8T3 denotes Hdh
T179 903-906 Q7NL02 denotes Hdh
T180 903-906 P44001 denotes Hdh
T181 903-906 P63952 denotes Hdh
T182 903-906 Q5MZ26 denotes Hdh
T183 903-906 Q4JW59 denotes Hdh
T184 903-906 Q5KVC6 denotes Hdh
T185 903-906 Q7WDY4 denotes Hdh
T186 903-906 P52985 denotes Hdh
T187 903-906 Q9RQ88 denotes Hdh
T188 903-906 Q4KI73 denotes Hdh
T189 903-906 Q32EE9 denotes Hdh
T190 903-906 Q8Z5K0 denotes Hdh
T191 903-906 P28736 denotes Hdh
T192 903-906 Q5B998 denotes Hdh
T193 903-906 Q64RE7 denotes Hdh
T194 903-906 Q9HPW5 denotes Hdh
T195 903-906 Q5JFR5 denotes Hdh
T196 903-906 Q9RQ82 denotes Hdh
T197 903-906 Q989E7 denotes Hdh
T198 903-906 Q46WL2 denotes Hdh
T199 903-906 Q5ZW87 denotes Hdh
T200 903-906 Q5PDP3 denotes Hdh
T201 903-906 Q67KH6 denotes Hdh
T202 903-906 PR:000008840 denotes Hdh
T203 903-906 Q6D411 denotes Hdh
T204 903-906 Q9CC57 denotes Hdh
T205 903-906 Q39YP7 denotes Hdh
T206 903-906 Q9L6I1 denotes Hdh
T207 903-906 P62457 denotes Hdh
T208 903-906 PR:P51111 denotes Hdh
T209 903-906 Q4FQF8 denotes Hdh
T210 903-906 O94671 denotes Hdh
T211 903-906 Q4ZNV9 denotes Hdh
T212 903-906 P16245 denotes Hdh
T213 903-906 Q5WX91 denotes Hdh
T214 903-906 O34651 denotes Hdh
T215 903-906 Q6KZD1 denotes Hdh
T216 903-906 Q87WV5 denotes Hdh
T217 903-906 Q65RB1 denotes Hdh
T218 903-906 Q5WDH8 denotes Hdh
T219 903-906 Q6AE76 denotes Hdh
T220 903-906 Q8TXG3 denotes Hdh
T221 903-906 Q7VSZ1 denotes Hdh
T222 903-906 P57201 denotes Hdh
T223 903-906 Q8FNZ0 denotes Hdh
T224 903-906 Q2YAU5 denotes Hdh
T225 903-906 P62456 denotes Hdh
T226 903-906 Q9PM77 denotes Hdh
T227 903-906 Q82W26 denotes Hdh
T228 903-906 Q9F854 denotes Hdh
T229 903-906 Q8EFB1 denotes Hdh
T230 903-906 O30027 denotes Hdh
T231 903-906 B0SS41 denotes Hdh
T232 903-906 Q7V004 denotes Hdh
T233 903-906 O66976 denotes Hdh
T234 903-906 Q9ZL20 denotes Hdh
T235 903-906 Q970Y9 denotes Hdh
T236 903-906 PR:000022894 denotes Hdh
T237 903-906 PR:000044407 denotes Hdh
T238 903-906 Q465R4 denotes Hdh
T239 903-906 P63951 denotes Hdh
T240 903-906 Q8ZY17 denotes Hdh
T241 903-906 Q3ZXL7 denotes Hdh
T242 903-906 Q8XV79 denotes Hdh
T243 903-906 Q9CGD8 denotes Hdh
T244 903-906 Q8KEY6 denotes Hdh
T245 903-906 Q9A5V1 denotes Hdh
T246 903-906 Q7UX39 denotes Hdh
T247 903-906 Q7VA26 denotes Hdh
T248 903-906 Q81T62 denotes Hdh
T249 903-906 Q722Y3 denotes Hdh
T250 903-906 P37143 denotes Hdh
T251 903-906 Q8PZR8 denotes Hdh
T252 903-906 Q7P0F6 denotes Hdh
T253 903-906 P59397 denotes Hdh
T254 903-906 P60858 denotes Hdh
T255 903-906 Q7U8K7 denotes Hdh
T256 903-906 Q2RGV8 denotes Hdh
T257 903-906 Q606Q2 denotes Hdh
T258 903-906 P73058 denotes Hdh
T259 903-906 Q8UHX1 denotes Hdh
T260 903-906 Q6A8L5 denotes Hdh
T261 903-906 Q8YF59 denotes Hdh
T262 903-906 Q8TL41 denotes Hdh
T263 903-906 O33775 denotes Hdh
T264 903-906 Q8ABA9 denotes Hdh
T265 903-906 P59398 denotes Hdh
T266 903-906 Q6ANR3 denotes Hdh
T267 903-906 Q5QWP8 denotes Hdh
T268 903-906 Q2P3K3 denotes Hdh
T269 903-906 Q5FS83 denotes Hdh
T270 903-906 Q8F393 denotes Hdh
T271 903-906 Q9PBC5 denotes Hdh
T272 903-906 Q8DGR2 denotes Hdh
T273 903-906 Q6HLE7 denotes Hdh
T274 903-906 P63954 denotes Hdh
T275 903-906 P10370 denotes Hdh
T276 903-906 Q57F99 denotes Hdh
T277 903-906 Q3A133 denotes Hdh
T278 903-906 PR:P42859 denotes Hdh
T279 903-906 O59626 denotes Hdh
T280 903-906 Q7MLS6 denotes Hdh
T281 903-906 Q8G2R2 denotes Hdh
T282 903-906 Q92E84 denotes Hdh
T283 903-906 P60862 denotes Hdh
T284 903-906 P46806 denotes Hdh
T285 903-906 Q3B5E3 denotes Hdh
T286 903-906 Q5HSJ3 denotes Hdh
T287 903-906 P24226 denotes Hdh
T288 903-906 Q02136 denotes Hdh
T289 903-906 Q9JYH8 denotes Hdh
T290 903-906 Q3BUF7 denotes Hdh
T291 903-906 Q5YYQ0 denotes Hdh
T292 903-906 Q65EF9 denotes Hdh
T293 903-906 Q8GDP4 denotes Hdh
T294 903-906 Q39K91 denotes Hdh
T295 903-906 Q62GD9 denotes Hdh
T296 903-906 P62458 denotes Hdh
T297 903-906 P37144 denotes Hdh
T298 903-906 Q5LAZ8 denotes Hdh
T299 903-906 Q3ICF0 denotes Hdh
T300 903-906 Q87C29 denotes Hdh
T301 903-906 Q5V574 denotes Hdh
T302 903-906 Q8P9P2 denotes Hdh
T303 903-906 Q3JMZ6 denotes Hdh
T304 903-906 Q87QL1 denotes Hdh
T305 903-906 P62459 denotes Hdh
T306 903-906 Q3J7H1 denotes Hdh
T307 903-906 P52986 denotes Hdh
T308 903-906 Q82AA6 denotes Hdh
T309 903-906 Q4J8I8 denotes Hdh
T310 903-906 Q4A044 denotes Hdh
T311 903-906 Q5X5W9 denotes Hdh
T312 903-906 P63953 denotes Hdh
T313 934-940 SO:0001068 denotes repeat
T317 953-960 PR:000000001 denotes protein
T314 953-960 GO:0003675 denotes protein
T318 953-960 SO:0000104 denotes protein
T315 953-960 CHEBI:36080 denotes protein
T316 953-960 CHEBI:11122 denotes protein
T319 1082-1088 SO:0001068 denotes repeat
T320 1119-1131 CHEBI:47885 denotes dinucleotide
T321 1132-1138 SO:0001068 denotes repeat
T322 1181-1196 GO:0006298 denotes mismatch repair
T324 1204-1207 CHEBI:16768 denotes MSH
T328 1204-1207 D009074 denotes MSH
T329 1204-1207 D009074 denotes MSH
T330 1204-1208 PR:000010666 denotes MSH2
T331 1204-1208 PR:P25847 denotes MSH2
T332 1204-1208 PR:P43246 denotes MSH2
T333 1204-1208 P22711 denotes MSH2
T334 1204-1208 PR:P22711 denotes MSH2
T335 1204-1208 PR:P54275 denotes MSH2
T336 1204-1208 PR:O74773 denotes MSH2
T337 1204-1208 PR:P43247 denotes MSH2
T338 1204-1208 PR:Q553L4 denotes MSH2
T339 1204-1208 PR:O24617 denotes MSH2
T340 1255-1258 CVCL_D569 denotes CAG
T341 1259-1265 SO:0001068 denotes repeat
T342 1278-1288 SO:0000781 denotes transgenic
T343 1278-1293 10090 denotes transgenic mice
T344 1278-1293 D008822 denotes transgenic mice
T345 1289-1293 PR:000005054 denotes mice
T347 1289-1293 O89094 denotes mice
T350 1303-1307 SO:0000147 denotes exon
T349 1303-1307 PR:P33696 denotes exon
T351 1313-1318 D006801 denotes human
T353 1337-1340 CHEBI:16768 denotes Msh
T357 1337-1340 D009074 denotes Msh
T358 1337-1340 D009074 denotes Msh
T359 1337-1341 PR:000010666 denotes Msh2
T360 1337-1341 PR:P25847 denotes Msh2
T361 1337-1341 PR:P43246 denotes Msh2
T362 1337-1341 P22711 denotes Msh2
T363 1337-1341 PR:P22711 denotes Msh2
T364 1337-1341 PR:P54275 denotes Msh2
T365 1337-1341 PR:O74773 denotes Msh2
T366 1337-1341 PR:P43247 denotes Msh2
T367 1337-1341 PR:Q553L4 denotes Msh2
T368 1337-1341 PR:O24617 denotes Msh2
T369 1345-1349 PR:000005054 denotes mice
T371 1345-1349 O89094 denotes mice
T370 1345-1349 D051379 denotes mice
T372 1345-1349 10095 denotes mice
T374 1373-1376 CHEBI:16768 denotes Msh
T378 1373-1376 D009074 denotes Msh
T379 1373-1376 D009074 denotes Msh
T380 1373-1377 PR:000010666 denotes Msh2
T381 1373-1377 PR:P25847 denotes Msh2
T382 1373-1377 PR:P43246 denotes Msh2
T383 1373-1377 P22711 denotes Msh2
T384 1373-1377 PR:P22711 denotes Msh2
T385 1373-1377 PR:P54275 denotes Msh2
T386 1373-1377 PR:O74773 denotes Msh2
T387 1373-1377 PR:P43247 denotes Msh2
T388 1373-1377 PR:Q553L4 denotes Msh2
T389 1373-1377 PR:O24617 denotes Msh2
T390 1421-1424 CVCL_D569 denotes CAG
T391 1425-1431 SO:0001068 denotes repeat

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 138-156 HP_0000006 denotes autosomal dominant

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-109 DRI_Outcome denotes Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice.
T2 110-325 DRI_Background denotes Huntington disease (HD), an autosomal dominant, progressive neurodegenerative disorder, is caused by an expanded CAG repeat sequence leading to an increase in the number of glutamine residues in the encoded protein.
T3 326-500 DRI_Outcome denotes The normal CAG repeat range is 5-36, whereas 38 or more repeats are found in the diseased state; the severity of disease is roughly proportional to the number of CAG repeats.
T4 501-629 DRI_Outcome denotes HD shows anticipation, in which subsequent generations display earlier disease onsets due to intergenerational repeat expansion.
T5 630-837 DRI_Outcome denotes For longer repeat lengths, somatic instability of the repeat size has been observed both in human cases at autopsy and in transgenic mouse models containing either a genomic fragment of human HD exon 1 (ref.
T6 838-912 DRI_Approach denotes 9) or an expanded repeat inserted into the endogenous mouse gene Hdh (ref.
T7 913-917 DRI_Unspecified denotes 10).
T8 918-1110 DRI_Outcome denotes With increasing repeat number, the protein changes conformation and becomes increasingly prone to aggregation, suggesting important functional correlations between repeat length and pathology.
T9 1111-1327 DRI_Challenge denotes Because dinucleotide repeat instability is known to increase when the mismatch repair enzyme MSH2 is missing, we examined instability of the HD CAG repeat by crossing transgenic mice carrying exon 1 of human HD (ref.
T10 1328-1350 DRI_Unspecified denotes 16) with Msh2-/- mice.
T11 1351-1432 DRI_Outcome denotes Our results show that Msh2 is required for somatic instability of the CAG repeat.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10581038-0#0#4#gene4436 0-4 gene4436 denotes Msh2
10581038-0#74#92#diseaseC0020179 74-92 diseaseC0020179 denotes Huntington disease
0#4#gene443674#92#diseaseC0020179 10581038-0#0#4#gene4436 10581038-0#74#92#diseaseC0020179 associated_with Msh2,Huntington disease

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1204-1208 gene:4436 denotes MSH2
T1 1252-1254 disease:C0020179 denotes HD
T2 1204-1208 gene:4436 denotes MSH2
T3 1319-1321 disease:C0020179 denotes HD
R1 T0 T1 associated_with MSH2,HD
R2 T2 T3 associated_with MSH2,HD