PubMed:10481945 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10481945","sourcedb":"PubMed","sourceid":"10481945","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10481945","text":"Down-regulation of gelsolin expression in human breast ductal carcinoma in situ with and without invasion.\nExpression of gelsolin, an actin filament regulatory protein, in human breast ductal carcinoma in situ (DCIS) was analyzed by immunohistochemistry using a monoclonal antibody. Formalin-fixed paraffin-embedded tissues from 59 pure DCIS specimens and 33 DCIS specimens with associated invasive components were evaluated for gelsolin reactivity and compared to eight normal breast cases and 76 invasive breast cancers. The proportion of cases exhibiting negative/low expression of gelsolin in the epithelium was as follows -- normal, 0%; pure DCIS, 56%; DCIS associated with invasion, 58% in the DCIS component and 66% in the invasive component; invasive carcinoma, 70%. These data demonstrate that down-regulation of gelsolin expression in breast epithelium frequently parallels progression to malignancy. Testing gelsolin expression (normal vs. negative/low levels) in the DCIS lesions for associations with patient age or any of the following histopathologic parameters revealed no significant (95% probability level) correlations -- tumor size; pathologic (Van Nuys system) grade; nuclear grade; necrosis; presence of histologic calcifications; presence or type of adjacent benign lesions; architectural histologic pattern; and mammographic extent. Gelsolin loss was more commonly associated with mammographic soft tissue lesions as compared to calcified lesions (P = 0.009). A positive trend of borderline significance (P = 0.06) found in the DCIS with invasion group was a correlation between down-regulated gelsolin expression in the DCIS component and size (\u003c versus \u003e or = 15 mm) of the invasive tumor. In conclusion, reduced gelsolin protein is detectable in at least half of breast lesions which have progressed to DCIS. The trend between increasing gelsolin loss and malignant progression from normal epithelium to DCIS to invasive breast cancer (P \u003c 0.0001) suggests additional investigation is needed to determine the potential of altered gelsolin expression as a marker for prognosis and for therapeutic interventions in breast cancer.","tracks":[{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":5,"end":15},"obj":"GO:0065007"},{"id":"T2","span":{"begin":19,"end":27},"obj":"O93510"},{"id":"T3","span":{"begin":19,"end":27},"obj":"P14885"},{"id":"T4","span":{"begin":19,"end":27},"obj":"PR:000002202"},{"id":"T6","span":{"begin":19,"end":27},"obj":"Q28372"},{"id":"T7","span":{"begin":19,"end":27},"obj":"Q68FP1"},{"id":"T8","span":{"begin":19,"end":27},"obj":"Q3SX14"},{"id":"T9","span":{"begin":19,"end":27},"obj":"P13020"},{"id":"T10","span":{"begin":19,"end":27},"obj":"Q07171"},{"id":"T11","span":{"begin":19,"end":27},"obj":"P06396"},{"id":"T12","span":{"begin":19,"end":27},"obj":"P20305"},{"id":"T5","span":{"begin":19,"end":27},"obj":"D018260"},{"id":"T13","span":{"begin":42,"end":47},"obj":"D006801"},{"id":"T14","span":{"begin":48,"end":54},"obj":"UBERON:0000310"},{"id":"T17","span":{"begin":55,"end":79},"obj":"D002285"},{"id":"T18","span":{"begin":55,"end":79},"obj":"D002285"},{"id":"T23","span":{"begin":121,"end":129},"obj":"O93510"},{"id":"T24","span":{"begin":121,"end":129},"obj":"P14885"},{"id":"T25","span":{"begin":121,"end":129},"obj":"PR:000002202"},{"id":"T27","span":{"begin":121,"end":129},"obj":"Q28372"},{"id":"T28","span":{"begin":121,"end":129},"obj":"Q68FP1"},{"id":"T29","span":{"begin":121,"end":129},"obj":"Q3SX14"},{"id":"T30","span":{"begin":121,"end":129},"obj":"P13020"},{"id":"T31","span":{"begin":121,"end":129},"obj":"Q07171"},{"id":"T32","span":{"begin":121,"end":129},"obj":"P06396"},{"id":"T33","span":{"begin":121,"end":129},"obj":"P20305"},{"id":"T26","span":{"begin":121,"end":129},"obj":"D018260"},{"id":"T34","span":{"begin":134,"end":139},"obj":"P53491"},{"id":"T35","span":{"begin":134,"end":139},"obj":"P45520"},{"id":"T36","span":{"begin":134,"end":139},"obj":"O00937"},{"id":"T37","span":{"begin":134,"end":139},"obj":"Q05214"},{"id":"T38","span":{"begin":134,"end":139},"obj":"P13363"},{"id":"T39","span":{"begin":134,"end":139},"obj":"Q39596"},{"id":"T40","span":{"begin":134,"end":139},"obj":"P30161"},{"id":"T41","span":{"begin":134,"end":139},"obj":"P53476"},{"id":"T42","span":{"begin":134,"end":139},"obj":"P51775"},{"id":"T43","span":{"begin":134,"end":139},"obj":"P60011"},{"id":"T44","span":{"begin":134,"end":139},"obj":"Q9P4D1"},{"id":"T45","span":{"begin":134,"end":139},"obj":"P50138"},{"id":"T46","span":{"begin":134,"end":139},"obj":"O65314"},{"id":"T47","span":{"begin":134,"end":139},"obj":"P26183"},{"id":"T48","span":{"begin":134,"end":139},"obj":"Q75D00"},{"id":"T49","span":{"begin":134,"end":139},"obj":"P53502"},{"id":"T50","span":{"begin":134,"end":139},"obj":"P11426"},{"id":"T51","span":{"begin":134,"end":139},"obj":"P80709"},{"id":"T52","span":{"begin":134,"end":139},"obj":"Q8X119"},{"id":"T53","span":{"begin":134,"end":139},"obj":"Q6TCF2"},{"id":"T54","span":{"begin":134,"end":139},"obj":"Q99023"},{"id":"T55","span":{"begin":134,"end":139},"obj":"A5DQP9"},{"id":"T56","span":{"begin":134,"end":139},"obj":"P60009"},{"id":"T57","span":{"begin":134,"end":139},"obj":"O65315"},{"id":"T58","span":{"begin":134,"end":139},"obj":"P26182"},{"id":"T59","span":{"begin":134,"end":139},"obj":"Q9UVF3"},{"id":"T60","span":{"begin":134,"end":139},"obj":"Q2U7A3"},{"id":"T61","span":{"begin":134,"end":139},"obj":"Q92192"},{"id":"T62","span":{"begin":134,"end":139},"obj":"Q9UVZ8"},{"id":"T63","span":{"begin":134,"end":139},"obj":"P53689"},{"id":"T64","span":{"begin":134,"end":139},"obj":"P68555"},{"id":"T65","span":{"begin":134,"end":139},"obj":"P53455"},{"id":"T66","span":{"begin":134,"end":139},"obj":"O13419"},{"id":"T67","span":{"begin":134,"end":139},"obj":"P60010"},{"id":"T68","span":{"begin":134,"end":139},"obj":"Q39758"},{"id":"T69","span":{"begin":134,"end":139},"obj":"P81085"},{"id":"T70","span":{"begin":134,"end":139},"obj":"P48465"},{"id":"T71","span":{"begin":134,"end":139},"obj":"P78711"},{"id":"T72","span":{"begin":134,"end":139},"obj":"P17128"},{"id":"T73","span":{"begin":134,"end":139},"obj":"P91754"},{"id":"T74","span":{"begin":134,"end":139},"obj":"Q24733"},{"id":"T75","span":{"begin":134,"end":139},"obj":"P14235"},{"id":"T76","span":{"begin":134,"end":139},"obj":"Q92193"},{"id":"T77","span":{"begin":134,"end":139},"obj":"Q11212"},{"id":"T78","span":{"begin":134,"end":139},"obj":"P45521"},{"id":"T79","span":{"begin":134,"end":139},"obj":"P53477"},{"id":"T80","span":{"begin":134,"end":139},"obj":"P53499"},{"id":"T81","span":{"begin":134,"end":139},"obj":"P24902"},{"id":"T82","span":{"begin":134,"end":139},"obj":"Q8SWN8"},{"id":"T83","span":{"begin":134,"end":139},"obj":"O17320"},{"id":"T84","span":{"begin":134,"end":139},"obj":"P10365"},{"id":"T86","span":{"begin":134,"end":139},"obj":"O16808"},{"id":"T87","span":{"begin":134,"end":139},"obj":"P53498"},{"id":"T88","span":{"begin":134,"end":139},"obj":"Q9UVX4"},{"id":"T89","span":{"begin":134,"end":139},"obj":"O81221"},{"id":"T90","span":{"begin":134,"end":139},"obj":"P20904"},{"id":"T91","span":{"begin":134,"end":139},"obj":"O65316"},{"id":"T92","span":{"begin":134,"end":139},"obj":"O74258"},{"id":"T93","span":{"begin":134,"end":139},"obj":"P53500"},{"id":"T94","span":{"begin":134,"end":139},"obj":"P10989"},{"id":"T95","span":{"begin":134,"end":139},"obj":"P90689"},{"id":"T85","span":{"begin":134,"end":139},"obj":"D000199"},{"id":"T97","span":{"begin":134,"end":148},"obj":"GO:0005884"},{"id":"T96","span":{"begin":134,"end":148},"obj":"UBERON:0003003"},{"id":"T98","span":{"begin":160,"end":167},"obj":"GO:0003675"},{"id":"T102","span":{"begin":160,"end":167},"obj":"SO:0000104"},{"id":"T101","span":{"begin":160,"end":167},"obj":"PR:000000001"},{"id":"T99","span":{"begin":160,"end":167},"obj":"CHEBI:36080"},{"id":"T100","span":{"begin":160,"end":167},"obj":"CHEBI:11122"},{"id":"T103","span":{"begin":172,"end":177},"obj":"D006801"},{"id":"T104","span":{"begin":178,"end":184},"obj":"UBERON:0000310"},{"id":"T107","span":{"begin":185,"end":209},"obj":"D002285"},{"id":"T108","span":{"begin":185,"end":209},"obj":"D002285"},{"id":"T114","span":{"begin":211,"end":215},"obj":"CVCL_5552"},{"id":"T113","span":{"begin":211,"end":215},"obj":"D002285"},{"id":"T115","span":{"begin":211,"end":215},"obj":"D002285"},{"id":"T116","span":{"begin":273,"end":281},"obj":"GO:0019815"},{"id":"T117","span":{"begin":273,"end":281},"obj":"GO:0042571"},{"id":"T118","span":{"begin":273,"end":281},"obj":"GO:0019814"},{"id":"T119","span":{"begin":273,"end":281},"obj":"GO:0003823"},{"id":"T120","span":{"begin":283,"end":291},"obj":"D005557"},{"id":"T121","span":{"begin":283,"end":291},"obj":"CHEBI:16842"},{"id":"T122","span":{"begin":283,"end":291},"obj":"D005557"},{"id":"T125","span":{"begin":298,"end":306},"obj":"7906"},{"id":"T123","span":{"begin":298,"end":306},"obj":"D010232"},{"id":"T124","span":{"begin":298,"end":306},"obj":"D010232"},{"id":"T126","span":{"begin":332,"end":336},"obj":"PR:Q8FYW3"},{"id":"T127","span":{"begin":332,"end":336},"obj":"PR:Q54QE4"},{"id":"T128","span":{"begin":332,"end":336},"obj":"PR:P52558"},{"id":"T129","span":{"begin":332,"end":336},"obj":"PR:P0AG18"},{"id":"T131","span":{"begin":332,"end":336},"obj":"PR:000023640"},{"id":"T130","span":{"begin":332,"end":336},"obj":"GO:0034023"},{"id":"T133","span":{"begin":337,"end":341},"obj":"CVCL_5552"},{"id":"T132","span":{"begin":337,"end":341},"obj":"D002285"},{"id":"T134","span":{"begin":337,"end":341},"obj":"D002285"},{"id":"T136","span":{"begin":359,"end":363},"obj":"CVCL_5552"},{"id":"T135","span":{"begin":359,"end":363},"obj":"D002285"},{"id":"T137","span":{"begin":359,"end":363},"obj":"D002285"},{"id":"T138","span":{"begin":429,"end":437},"obj":"O93510"},{"id":"T139","span":{"begin":429,"end":437},"obj":"P14885"},{"id":"T140","span":{"begin":429,"end":437},"obj":"PR:000002202"},{"id":"T142","span":{"begin":429,"end":437},"obj":"Q28372"},{"id":"T143","span":{"begin":429,"end":437},"obj":"Q68FP1"},{"id":"T144","span":{"begin":429,"end":437},"obj":"Q3SX14"},{"id":"T145","span":{"begin":429,"end":437},"obj":"P13020"},{"id":"T146","span":{"begin":429,"end":437},"obj":"Q07171"},{"id":"T147","span":{"begin":429,"end":437},"obj":"P06396"},{"id":"T148","span":{"begin":429,"end":437},"obj":"P20305"},{"id":"T141","span":{"begin":429,"end":437},"obj":"D018260"},{"id":"T149","span":{"begin":478,"end":484},"obj":"UBERON:0000310"},{"id":"T150","span":{"begin":507,"end":513},"obj":"UBERON:0000310"},{"id":"T151","span":{"begin":514,"end":521},"obj":"D009369"},{"id":"T152","span":{"begin":514,"end":521},"obj":"D009369"},{"id":"T153","span":{"begin":585,"end":593},"obj":"O93510"},{"id":"T154","span":{"begin":585,"end":593},"obj":"P14885"},{"id":"T155","span":{"begin":585,"end":593},"obj":"PR:000002202"},{"id":"T157","span":{"begin":585,"end":593},"obj":"Q28372"},{"id":"T158","span":{"begin":585,"end":593},"obj":"Q68FP1"},{"id":"T159","span":{"begin":585,"end":593},"obj":"Q3SX14"},{"id":"T160","span":{"begin":585,"end":593},"obj":"P13020"},{"id":"T161","span":{"begin":585,"end":593},"obj":"Q07171"},{"id":"T162","span":{"begin":585,"end":593},"obj":"P06396"},{"id":"T163","span":{"begin":585,"end":593},"obj":"P20305"},{"id":"T156","span":{"begin":585,"end":593},"obj":"D018260"},{"id":"T164","span":{"begin":601,"end":611},"obj":"UBERON:0000483"},{"id":"T165","span":{"begin":642,"end":646},"obj":"PR:Q8FYW3"},{"id":"T166","span":{"begin":642,"end":646},"obj":"PR:Q54QE4"},{"id":"T167","span":{"begin":642,"end":646},"obj":"PR:P52558"},{"id":"T168","span":{"begin":642,"end":646},"obj":"PR:P0AG18"},{"id":"T170","span":{"begin":642,"end":646},"obj":"PR:000023640"},{"id":"T169","span":{"begin":642,"end":646},"obj":"GO:0034023"},{"id":"T172","span":{"begin":647,"end":651},"obj":"CVCL_5552"},{"id":"T171","span":{"begin":647,"end":651},"obj":"D002285"},{"id":"T173","span":{"begin":647,"end":651},"obj":"D002285"},{"id":"T175","span":{"begin":658,"end":662},"obj":"CVCL_5552"},{"id":"T174","span":{"begin":658,"end":662},"obj":"D002285"},{"id":"T176","span":{"begin":658,"end":662},"obj":"D002285"},{"id":"T178","span":{"begin":700,"end":704},"obj":"CVCL_5552"},{"id":"T177","span":{"begin":700,"end":704},"obj":"D002285"},{"id":"T179","span":{"begin":700,"end":704},"obj":"D002285"},{"id":"T180","span":{"begin":759,"end":768},"obj":"D002277"},{"id":"T181","span":{"begin":759,"end":768},"obj":"D002277"},{"id":"T182","span":{"begin":808,"end":818},"obj":"GO:0065007"},{"id":"T183","span":{"begin":822,"end":830},"obj":"O93510"},{"id":"T184","span":{"begin":822,"end":830},"obj":"P14885"},{"id":"T185","span":{"begin":822,"end":830},"obj":"PR:000002202"},{"id":"T187","span":{"begin":822,"end":830},"obj":"Q28372"},{"id":"T188","span":{"begin":822,"end":830},"obj":"Q68FP1"},{"id":"T189","span":{"begin":822,"end":830},"obj":"Q3SX14"},{"id":"T190","span":{"begin":822,"end":830},"obj":"P13020"},{"id":"T191","span":{"begin":822,"end":830},"obj":"Q07171"},{"id":"T192","span":{"begin":822,"end":830},"obj":"P06396"},{"id":"T193","span":{"begin":822,"end":830},"obj":"P20305"},{"id":"T186","span":{"begin":822,"end":830},"obj":"D018260"},{"id":"T195","span":{"begin":845,"end":862},"obj":"UBERON:0008367"},{"id":"T197","span":{"begin":899,"end":909},"obj":"D009369"},{"id":"T198","span":{"begin":899,"end":909},"obj":"D009369"},{"id":"T199","span":{"begin":919,"end":927},"obj":"O93510"},{"id":"T200","span":{"begin":919,"end":927},"obj":"P14885"},{"id":"T201","span":{"begin":919,"end":927},"obj":"PR:000002202"},{"id":"T203","span":{"begin":919,"end":927},"obj":"Q28372"},{"id":"T204","span":{"begin":919,"end":927},"obj":"Q68FP1"},{"id":"T205","span":{"begin":919,"end":927},"obj":"Q3SX14"},{"id":"T206","span":{"begin":919,"end":927},"obj":"P13020"},{"id":"T207","span":{"begin":919,"end":927},"obj":"Q07171"},{"id":"T208","span":{"begin":919,"end":927},"obj":"P06396"},{"id":"T209","span":{"begin":919,"end":927},"obj":"P20305"},{"id":"T202","span":{"begin":919,"end":927},"obj":"D018260"},{"id":"T211","span":{"begin":979,"end":983},"obj":"CVCL_5552"},{"id":"T210","span":{"begin":979,"end":983},"obj":"D002285"},{"id":"T212","span":{"begin":979,"end":983},"obj":"D002285"},{"id":"T213","span":{"begin":1141,"end":1146},"obj":"D009369"},{"id":"T214","span":{"begin":1141,"end":1146},"obj":"D009369"},{"id":"T215","span":{"begin":1204,"end":1212},"obj":"GO:0019835"},{"id":"T216","span":{"begin":1204,"end":1212},"obj":"GO:0008219"},{"id":"T219","span":{"begin":1204,"end":1212},"obj":"GO:0008220"},{"id":"T220","span":{"begin":1204,"end":1212},"obj":"GO:0001906"},{"id":"T221","span":{"begin":1204,"end":1212},"obj":"GO:0070265"},{"id":"T217","span":{"begin":1204,"end":1212},"obj":"D009336"},{"id":"T218","span":{"begin":1204,"end":1212},"obj":"D009336"},{"id":"T222","span":{"begin":1357,"end":1365},"obj":"O93510"},{"id":"T223","span":{"begin":1357,"end":1365},"obj":"P14885"},{"id":"T224","span":{"begin":1357,"end":1365},"obj":"PR:000002202"},{"id":"T226","span":{"begin":1357,"end":1365},"obj":"Q28372"},{"id":"T227","span":{"begin":1357,"end":1365},"obj":"Q68FP1"},{"id":"T228","span":{"begin":1357,"end":1365},"obj":"Q3SX14"},{"id":"T229","span":{"begin":1357,"end":1365},"obj":"P13020"},{"id":"T230","span":{"begin":1357,"end":1365},"obj":"Q07171"},{"id":"T231","span":{"begin":1357,"end":1365},"obj":"P06396"},{"id":"T232","span":{"begin":1357,"end":1365},"obj":"P20305"},{"id":"T225","span":{"begin":1357,"end":1365},"obj":"D018260"},{"id":"T233","span":{"begin":1423,"end":1429},"obj":"UBERON:0000479"},{"id":"T235","span":{"begin":1552,"end":1556},"obj":"CVCL_5552"},{"id":"T234","span":{"begin":1552,"end":1556},"obj":"D002285"},{"id":"T236","span":{"begin":1552,"end":1556},"obj":"D002285"},{"id":"T237","span":{"begin":1608,"end":1617},"obj":"SO:0000119"},{"id":"T238","span":{"begin":1618,"end":1626},"obj":"O93510"},{"id":"T239","span":{"begin":1618,"end":1626},"obj":"P14885"},{"id":"T240","span":{"begin":1618,"end":1626},"obj":"PR:000002202"},{"id":"T242","span":{"begin":1618,"end":1626},"obj":"Q28372"},{"id":"T243","span":{"begin":1618,"end":1626},"obj":"Q68FP1"},{"id":"T244","span":{"begin":1618,"end":1626},"obj":"Q3SX14"},{"id":"T245","span":{"begin":1618,"end":1626},"obj":"P13020"},{"id":"T246","span":{"begin":1618,"end":1626},"obj":"Q07171"},{"id":"T247","span":{"begin":1618,"end":1626},"obj":"P06396"},{"id":"T248","span":{"begin":1618,"end":1626},"obj":"P20305"},{"id":"T241","span":{"begin":1618,"end":1626},"obj":"D018260"},{"id":"T250","span":{"begin":1645,"end":1649},"obj":"CVCL_5552"},{"id":"T249","span":{"begin":1645,"end":1649},"obj":"D002285"},{"id":"T251","span":{"begin":1645,"end":1649},"obj":"D002285"},{"id":"T253","span":{"begin":1709,"end":1714},"obj":"D009369"},{"id":"T254","span":{"begin":1709,"end":1714},"obj":"D009369"},{"id":"T255","span":{"begin":1739,"end":1747},"obj":"O93510"},{"id":"T256","span":{"begin":1739,"end":1747},"obj":"P14885"},{"id":"T257","span":{"begin":1739,"end":1747},"obj":"PR:000002202"},{"id":"T259","span":{"begin":1739,"end":1747},"obj":"Q28372"},{"id":"T260","span":{"begin":1739,"end":1747},"obj":"Q68FP1"},{"id":"T261","span":{"begin":1739,"end":1747},"obj":"Q3SX14"},{"id":"T262","span":{"begin":1739,"end":1747},"obj":"P13020"},{"id":"T263","span":{"begin":1739,"end":1747},"obj":"Q07171"},{"id":"T264","span":{"begin":1739,"end":1747},"obj":"P06396"},{"id":"T265","span":{"begin":1739,"end":1747},"obj":"P20305"},{"id":"T266","span":{"begin":1739,"end":1755},"obj":"D018260"},{"id":"T271","span":{"begin":1748,"end":1755},"obj":"SO:0000104"},{"id":"T270","span":{"begin":1748,"end":1755},"obj":"PR:000000001"},{"id":"T267","span":{"begin":1748,"end":1755},"obj":"GO:0003675"},{"id":"T272","span":{"begin":1790,"end":1796},"obj":"UBERON:0000310"},{"id":"T274","span":{"begin":1830,"end":1834},"obj":"CVCL_5552"},{"id":"T273","span":{"begin":1830,"end":1834},"obj":"D002285"},{"id":"T275","span":{"begin":1830,"end":1834},"obj":"D002285"},{"id":"T276","span":{"begin":1865,"end":1873},"obj":"O93510"},{"id":"T277","span":{"begin":1865,"end":1873},"obj":"P14885"},{"id":"T278","span":{"begin":1865,"end":1873},"obj":"PR:000002202"},{"id":"T280","span":{"begin":1865,"end":1873},"obj":"Q28372"},{"id":"T281","span":{"begin":1865,"end":1873},"obj":"Q68FP1"},{"id":"T282","span":{"begin":1865,"end":1873},"obj":"Q3SX14"},{"id":"T283","span":{"begin":1865,"end":1873},"obj":"P13020"},{"id":"T284","span":{"begin":1865,"end":1873},"obj":"Q07171"},{"id":"T285","span":{"begin":1865,"end":1873},"obj":"P06396"},{"id":"T286","span":{"begin":1865,"end":1873},"obj":"P20305"},{"id":"T279","span":{"begin":1865,"end":1873},"obj":"D018260"},{"id":"T287","span":{"begin":1917,"end":1927},"obj":"UBERON:0000483"},{"id":"T289","span":{"begin":1931,"end":1935},"obj":"CVCL_5552"},{"id":"T288","span":{"begin":1931,"end":1935},"obj":"D002285"},{"id":"T290","span":{"begin":1931,"end":1935},"obj":"D002285"},{"id":"T291","span":{"begin":1948,"end":1954},"obj":"UBERON:0000310"},{"id":"T292","span":{"begin":1948,"end":1961},"obj":"D001943"},{"id":"T293","span":{"begin":1948,"end":1961},"obj":"D001943"},{"id":"T294","span":{"begin":2057,"end":2065},"obj":"O93510"},{"id":"T295","span":{"begin":2057,"end":2065},"obj":"P14885"},{"id":"T296","span":{"begin":2057,"end":2065},"obj":"PR:000002202"},{"id":"T298","span":{"begin":2057,"end":2065},"obj":"Q28372"},{"id":"T299","span":{"begin":2057,"end":2065},"obj":"Q68FP1"},{"id":"T300","span":{"begin":2057,"end":2065},"obj":"Q3SX14"},{"id":"T301","span":{"begin":2057,"end":2065},"obj":"P13020"},{"id":"T302","span":{"begin":2057,"end":2065},"obj":"Q07171"},{"id":"T303","span":{"begin":2057,"end":2065},"obj":"P06396"},{"id":"T304","span":{"begin":2057,"end":2065},"obj":"P20305"},{"id":"T297","span":{"begin":2057,"end":2065},"obj":"D018260"},{"id":"T305","span":{"begin":2140,"end":2146},"obj":"UBERON:0000310"},{"id":"T306","span":{"begin":2140,"end":2153},"obj":"D001943"},{"id":"T307","span":{"begin":2140,"end":2153},"obj":"D001943"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T149","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T151","pred":"source","obj":"c_corpus"},{"subj":"T152","pred":"source","obj":"c_corpus"},{"subj":"T153","pred":"source","obj":"c_corpus"},{"subj":"T154","pred":"source","obj":"c_corpus"},{"subj":"T155","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T159","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T156","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T168","pred":"source","obj":"c_corpus"},{"subj":"T170","pred":"source","obj":"c_corpus"},{"subj":"T169","pred":"source","obj":"c_corpus"},{"subj":"T172","pred":"source","obj":"c_corpus"},{"subj":"T171","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T179","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T182","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T184","pred":"source","obj":"c_corpus"},{"subj":"T185","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T190","pred":"source","obj":"c_corpus"},{"subj":"T191","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"},{"subj":"T193","pred":"source","obj":"c_corpus"},{"subj":"T186","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T197","pred":"source","obj":"c_corpus"},{"subj":"T198","pred":"source","obj":"c_corpus"},{"subj":"T199","pred":"source","obj":"c_corpus"},{"subj":"T200","pred":"source","obj":"c_corpus"},{"subj":"T201","pred":"source","obj":"c_corpus"},{"subj":"T203","pred":"source","obj":"c_corpus"},{"subj":"T204","pred":"source","obj":"c_corpus"},{"subj":"T205","pred":"source","obj":"c_corpus"},{"subj":"T206","pred":"source","obj":"c_corpus"},{"subj":"T207","pred":"source","obj":"c_corpus"},{"subj":"T208","pred":"source","obj":"c_corpus"},{"subj":"T209","pred":"source","obj":"c_corpus"},{"subj":"T202","pred":"source","obj":"c_corpus"},{"subj":"T211","pred":"source","obj":"c_corpus"},{"subj":"T210","pred":"source","obj":"c_corpus"},{"subj":"T212","pred":"source","obj":"c_corpus"},{"subj":"T213","pred":"source","obj":"c_corpus"},{"subj":"T214","pred":"source","obj":"c_corpus"},{"subj":"T215","pred":"source","obj":"c_corpus"},{"subj":"T216","pred":"source","obj":"c_corpus"},{"subj":"T219","pred":"source","obj":"c_corpus"},{"subj":"T220","pred":"source","obj":"c_corpus"},{"subj":"T221","pred":"source","obj":"c_corpus"},{"subj":"T217","pred":"source","obj":"c_corpus"},{"subj":"T218","pred":"source","obj":"c_corpus"},{"subj":"T222","pred":"source","obj":"c_corpus"},{"subj":"T223","pred":"source","obj":"c_corpus"},{"subj":"T224","pred":"source","obj":"c_corpus"},{"subj":"T226","pred":"source","obj":"c_corpus"},{"subj":"T227","pred":"source","obj":"c_corpus"},{"subj":"T228","pred":"source","obj":"c_corpus"},{"subj":"T229","pred":"source","obj":"c_corpus"},{"subj":"T230","pred":"source","obj":"c_corpus"},{"subj":"T231","pred":"source","obj":"c_corpus"},{"subj":"T232","pred":"source","obj":"c_corpus"},{"subj":"T225","pred":"source","obj":"c_corpus"},{"subj":"T233","pred":"source","obj":"c_corpus"},{"subj":"T235","pred":"source","obj":"c_corpus"},{"subj":"T234","pred":"source","obj":"c_corpus"},{"subj":"T236","pred":"source","obj":"c_corpus"},{"subj":"T237","pred":"source","obj":"c_corpus"},{"subj":"T238","pred":"source","obj":"c_corpus"},{"subj":"T239","pred":"source","obj":"c_corpus"},{"subj":"T240","pred":"source","obj":"c_corpus"},{"subj":"T242","pred":"source","obj":"c_corpus"},{"subj":"T243","pred":"source","obj":"c_corpus"},{"subj":"T244","pred":"source","obj":"c_corpus"},{"subj":"T245","pred":"source","obj":"c_corpus"},{"subj":"T246","pred":"source","obj":"c_corpus"},{"subj":"T247","pred":"source","obj":"c_corpus"},{"subj":"T248","pred":"source","obj":"c_corpus"},{"subj":"T241","pred":"source","obj":"c_corpus"},{"subj":"T250","pred":"source","obj":"c_corpus"},{"subj":"T249","pred":"source","obj":"c_corpus"},{"subj":"T251","pred":"source","obj":"c_corpus"},{"subj":"T253","pred":"source","obj":"c_corpus"},{"subj":"T254","pred":"source","obj":"c_corpus"},{"subj":"T255","pred":"source","obj":"c_corpus"},{"subj":"T256","pred":"source","obj":"c_corpus"},{"subj":"T257","pred":"source","obj":"c_corpus"},{"subj":"T259","pred":"source","obj":"c_corpus"},{"subj":"T260","pred":"source","obj":"c_corpus"},{"subj":"T261","pred":"source","obj":"c_corpus"},{"subj":"T262","pred":"source","obj":"c_corpus"},{"subj":"T263","pred":"source","obj":"c_corpus"},{"subj":"T264","pred":"source","obj":"c_corpus"},{"subj":"T265","pred":"source","obj":"c_corpus"},{"subj":"T266","pred":"source","obj":"c_corpus"},{"subj":"T271","pred":"source","obj":"c_corpus"},{"subj":"T270","pred":"source","obj":"c_corpus"},{"subj":"T267","pred":"source","obj":"c_corpus"},{"subj":"T272","pred":"source","obj":"c_corpus"},{"subj":"T274","pred":"source","obj":"c_corpus"},{"subj":"T273","pred":"source","obj":"c_corpus"},{"subj":"T275","pred":"source","obj":"c_corpus"},{"subj":"T276","pred":"source","obj":"c_corpus"},{"subj":"T277","pred":"source","obj":"c_corpus"},{"subj":"T278","pred":"source","obj":"c_corpus"},{"subj":"T280","pred":"source","obj":"c_corpus"},{"subj":"T281","pred":"source","obj":"c_corpus"},{"subj":"T282","pred":"source","obj":"c_corpus"},{"subj":"T283","pred":"source","obj":"c_corpus"},{"subj":"T284","pred":"source","obj":"c_corpus"},{"subj":"T285","pred":"source","obj":"c_corpus"},{"subj":"T286","pred":"source","obj":"c_corpus"},{"subj":"T279","pred":"source","obj":"c_corpus"},{"subj":"T287","pred":"source","obj":"c_corpus"},{"subj":"T289","pred":"source","obj":"c_corpus"},{"subj":"T288","pred":"source","obj":"c_corpus"},{"subj":"T290","pred":"source","obj":"c_corpus"},{"subj":"T291","pred":"source","obj":"c_corpus"},{"subj":"T292","pred":"source","obj":"c_corpus"},{"subj":"T293","pred":"source","obj":"c_corpus"},{"subj":"T294","pred":"source","obj":"c_corpus"},{"subj":"T295","pred":"source","obj":"c_corpus"},{"subj":"T296","pred":"source","obj":"c_corpus"},{"subj":"T298","pred":"source","obj":"c_corpus"},{"subj":"T299","pred":"source","obj":"c_corpus"},{"subj":"T300","pred":"source","obj":"c_corpus"},{"subj":"T301","pred":"source","obj":"c_corpus"},{"subj":"T302","pred":"source","obj":"c_corpus"},{"subj":"T303","pred":"source","obj":"c_corpus"},{"subj":"T304","pred":"source","obj":"c_corpus"},{"subj":"T297","pred":"source","obj":"c_corpus"},{"subj":"T305","pred":"source","obj":"c_corpus"},{"subj":"T306","pred":"source","obj":"c_corpus"},{"subj":"T307","pred":"source","obj":"c_corpus"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":507,"end":521},"obj":"HP_0003002"},{"id":"T2","span":{"begin":507,"end":521},"obj":"HP_0100013"},{"id":"T3","span":{"begin":514,"end":521},"obj":"HP_0002664"},{"id":"T4","span":{"begin":1141,"end":1146},"obj":"HP_0002664"},{"id":"T5","span":{"begin":1709,"end":1714},"obj":"HP_0002664"},{"id":"T6","span":{"begin":1948,"end":1961},"obj":"HP_0003002"},{"id":"T7","span":{"begin":1948,"end":1961},"obj":"HP_0100013"},{"id":"T8","span":{"begin":1955,"end":1961},"obj":"HP_0002664"},{"id":"T9","span":{"begin":2140,"end":2153},"obj":"HP_0003002"},{"id":"T10","span":{"begin":2140,"end":2153},"obj":"HP_0100013"},{"id":"T11","span":{"begin":2147,"end":2153},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"},{"subj":"T11","pred":"source","obj":"PubmedHPO"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T3","span":{"begin":283,"end":297},"obj":"REPLACED"},{"id":"T1","span":{"begin":0,"end":106},"obj":"DRI_Background"},{"id":"T2","span":{"begin":107,"end":282},"obj":"DRI_Background"},{"id":"T4","span":{"begin":298,"end":315},"obj":"Token_Label.OUTSIDE"},{"id":"T5","span":{"begin":316,"end":522},"obj":"DRI_Background"},{"id":"T6","span":{"begin":523,"end":774},"obj":"DRI_Background"},{"id":"T7","span":{"begin":775,"end":910},"obj":"DRI_Outcome"},{"id":"T8","span":{"begin":911,"end":1356},"obj":"DRI_Unspecified"},{"id":"T9","span":{"begin":1357,"end":1483},"obj":"DRI_Background"},{"id":"T10","span":{"begin":1484,"end":1715},"obj":"DRI_Approach"},{"id":"T11","span":{"begin":1716,"end":1835},"obj":"DRI_Outcome"},{"id":"T12","span":{"begin":1836,"end":2154},"obj":"DRI_Approach"}],"attributes":[{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"10481945-0#19#27#gene2934","span":{"begin":822,"end":830},"obj":"gene2934"},{"id":"10481945-0#48#79#diseaseC0007124","span":{"begin":1109,"end":1542},"obj":"diseaseC0007124"},{"id":"10481945-3#62#70#gene2934","span":{"begin":585,"end":593},"obj":"gene2934"},{"id":"10481945-3#227#245#diseaseC1334274","span":{"begin":750,"end":768},"obj":"diseaseC1334274"},{"id":"10481945-9#29#37#gene2934","span":{"begin":1865,"end":1873},"obj":"gene2934"},{"id":"10481945-9#221#229#gene2934","span":{"begin":2057,"end":2065},"obj":"gene2934"},{"id":"10481945-9#29#37#gene2934","span":{"begin":1865,"end":1873},"obj":"gene2934"},{"id":"10481945-9#221#229#gene2934","span":{"begin":2057,"end":2065},"obj":"gene2934"},{"id":"10481945-9#304#317#diseaseC0006142","span":{"begin":2140,"end":2153},"obj":"diseaseC0006142"},{"id":"10481945-9#304#317#diseaseC0678222","span":{"begin":2140,"end":2153},"obj":"diseaseC0678222"},{"id":"10481945-9#304#317#diseaseC0006142","span":{"begin":2140,"end":2153},"obj":"diseaseC0006142"},{"id":"10481945-9#304#317#diseaseC0678222","span":{"begin":2140,"end":2153},"obj":"diseaseC0678222"},{"id":"10481945-9#103#125#diseaseC0853879","span":{"begin":1939,"end":1961},"obj":"diseaseC0853879"}],"relations":[{"id":"19#27#gene293448#79#diseaseC0007124","pred":"associated_with","subj":"10481945-0#19#27#gene2934","obj":"10481945-0#48#79#diseaseC0007124"},{"id":"62#70#gene2934227#245#diseaseC1334274","pred":"associated_with","subj":"10481945-3#62#70#gene2934","obj":"10481945-3#227#245#diseaseC1334274"},{"id":"29#37#gene2934304#317#diseaseC0006142","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#304#317#diseaseC0006142"},{"id":"29#37#gene2934304#317#diseaseC0678222","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#304#317#diseaseC0678222"},{"id":"29#37#gene2934304#317#diseaseC0006142","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#304#317#diseaseC0006142"},{"id":"29#37#gene2934304#317#diseaseC0678222","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#304#317#diseaseC0678222"},{"id":"29#37#gene2934103#125#diseaseC0853879","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#103#125#diseaseC0853879"},{"id":"221#229#gene2934304#317#diseaseC0006142","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#304#317#diseaseC0006142"},{"id":"221#229#gene2934304#317#diseaseC0678222","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#304#317#diseaseC0678222"},{"id":"221#229#gene2934304#317#diseaseC0006142","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#304#317#diseaseC0006142"},{"id":"221#229#gene2934304#317#diseaseC0678222","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#304#317#diseaseC0678222"},{"id":"221#229#gene2934103#125#diseaseC0853879","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#103#125#diseaseC0853879"},{"id":"29#37#gene2934304#317#diseaseC0006142","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#304#317#diseaseC0006142"},{"id":"29#37#gene2934304#317#diseaseC0678222","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#304#317#diseaseC0678222"},{"id":"29#37#gene2934304#317#diseaseC0006142","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#304#317#diseaseC0006142"},{"id":"29#37#gene2934304#317#diseaseC0678222","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#304#317#diseaseC0678222"},{"id":"29#37#gene2934103#125#diseaseC0853879","pred":"associated_with","subj":"10481945-9#29#37#gene2934","obj":"10481945-9#103#125#diseaseC0853879"},{"id":"221#229#gene2934304#317#diseaseC0006142","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#304#317#diseaseC0006142"},{"id":"221#229#gene2934304#317#diseaseC0678222","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#304#317#diseaseC0678222"},{"id":"221#229#gene2934304#317#diseaseC0006142","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#304#317#diseaseC0006142"},{"id":"221#229#gene2934304#317#diseaseC0678222","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#304#317#diseaseC0678222"},{"id":"221#229#gene2934103#125#diseaseC0853879","pred":"associated_with","subj":"10481945-9#221#229#gene2934","obj":"10481945-9#103#125#diseaseC0853879"}],"attributes":[{"subj":"10481945-0#19#27#gene2934","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-0#48#79#diseaseC0007124","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-3#62#70#gene2934","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-3#227#245#diseaseC1334274","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-9#29#37#gene2934","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-9#221#229#gene2934","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-9#29#37#gene2934","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-9#221#229#gene2934","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-9#304#317#diseaseC0006142","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-9#304#317#diseaseC0678222","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-9#304#317#diseaseC0006142","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-9#304#317#diseaseC0678222","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10481945-9#103#125#diseaseC0853879","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":19,"end":27},"obj":"gene:2934"},{"id":"T1","span":{"begin":48,"end":79},"obj":"disease:C0007124"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"c_corpus","color":"#b093ec","default":true},{"id":"PubmedHPO","color":"#93ec96"},{"id":"UseCases_ArguminSci_Discourse","color":"#ec93aa"},{"id":"DisGeNET5_gene_disease","color":"#93c4ec"},{"id":"DisGeNET","color":"#deec93"}]}]}}