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c_corpus

Id Subject Object Predicate Lexical cue
T1 5-15 GO:0065007 denotes regulation
T2 19-27 O93510 denotes gelsolin
T3 19-27 P14885 denotes gelsolin
T4 19-27 PR:000002202 denotes gelsolin
T6 19-27 Q28372 denotes gelsolin
T7 19-27 Q68FP1 denotes gelsolin
T8 19-27 Q3SX14 denotes gelsolin
T9 19-27 P13020 denotes gelsolin
T10 19-27 Q07171 denotes gelsolin
T11 19-27 P06396 denotes gelsolin
T12 19-27 P20305 denotes gelsolin
T5 19-27 D018260 denotes gelsolin
T13 42-47 D006801 denotes human
T14 48-54 UBERON:0000310 denotes breast
T17 55-79 D002285 denotes ductal carcinoma in situ
T18 55-79 D002285 denotes ductal carcinoma in situ
T23 121-129 O93510 denotes gelsolin
T24 121-129 P14885 denotes gelsolin
T25 121-129 PR:000002202 denotes gelsolin
T27 121-129 Q28372 denotes gelsolin
T28 121-129 Q68FP1 denotes gelsolin
T29 121-129 Q3SX14 denotes gelsolin
T30 121-129 P13020 denotes gelsolin
T31 121-129 Q07171 denotes gelsolin
T32 121-129 P06396 denotes gelsolin
T33 121-129 P20305 denotes gelsolin
T26 121-129 D018260 denotes gelsolin
T34 134-139 P53491 denotes actin
T35 134-139 P45520 denotes actin
T36 134-139 O00937 denotes actin
T37 134-139 Q05214 denotes actin
T38 134-139 P13363 denotes actin
T39 134-139 Q39596 denotes actin
T40 134-139 P30161 denotes actin
T41 134-139 P53476 denotes actin
T42 134-139 P51775 denotes actin
T43 134-139 P60011 denotes actin
T44 134-139 Q9P4D1 denotes actin
T45 134-139 P50138 denotes actin
T46 134-139 O65314 denotes actin
T47 134-139 P26183 denotes actin
T48 134-139 Q75D00 denotes actin
T49 134-139 P53502 denotes actin
T50 134-139 P11426 denotes actin
T51 134-139 P80709 denotes actin
T52 134-139 Q8X119 denotes actin
T53 134-139 Q6TCF2 denotes actin
T54 134-139 Q99023 denotes actin
T55 134-139 A5DQP9 denotes actin
T56 134-139 P60009 denotes actin
T57 134-139 O65315 denotes actin
T58 134-139 P26182 denotes actin
T59 134-139 Q9UVF3 denotes actin
T60 134-139 Q2U7A3 denotes actin
T61 134-139 Q92192 denotes actin
T62 134-139 Q9UVZ8 denotes actin
T63 134-139 P53689 denotes actin
T64 134-139 P68555 denotes actin
T65 134-139 P53455 denotes actin
T66 134-139 O13419 denotes actin
T67 134-139 P60010 denotes actin
T68 134-139 Q39758 denotes actin
T69 134-139 P81085 denotes actin
T70 134-139 P48465 denotes actin
T71 134-139 P78711 denotes actin
T72 134-139 P17128 denotes actin
T73 134-139 P91754 denotes actin
T74 134-139 Q24733 denotes actin
T75 134-139 P14235 denotes actin
T76 134-139 Q92193 denotes actin
T77 134-139 Q11212 denotes actin
T78 134-139 P45521 denotes actin
T79 134-139 P53477 denotes actin
T80 134-139 P53499 denotes actin
T81 134-139 P24902 denotes actin
T82 134-139 Q8SWN8 denotes actin
T83 134-139 O17320 denotes actin
T84 134-139 P10365 denotes actin
T86 134-139 O16808 denotes actin
T87 134-139 P53498 denotes actin
T88 134-139 Q9UVX4 denotes actin
T89 134-139 O81221 denotes actin
T90 134-139 P20904 denotes actin
T91 134-139 O65316 denotes actin
T92 134-139 O74258 denotes actin
T93 134-139 P53500 denotes actin
T94 134-139 P10989 denotes actin
T95 134-139 P90689 denotes actin
T85 134-139 D000199 denotes actin
T97 134-148 GO:0005884 denotes actin filament
T96 134-148 UBERON:0003003 denotes actin filament
T98 160-167 GO:0003675 denotes protein
T102 160-167 SO:0000104 denotes protein
T101 160-167 PR:000000001 denotes protein
T99 160-167 CHEBI:36080 denotes protein
T100 160-167 CHEBI:11122 denotes protein
T103 172-177 D006801 denotes human
T104 178-184 UBERON:0000310 denotes breast
T107 185-209 D002285 denotes ductal carcinoma in situ
T108 185-209 D002285 denotes ductal carcinoma in situ
T114 211-215 CVCL_5552 denotes DCIS
T113 211-215 D002285 denotes DCIS
T115 211-215 D002285 denotes DCIS
T116 273-281 GO:0019815 denotes antibody
T117 273-281 GO:0042571 denotes antibody
T118 273-281 GO:0019814 denotes antibody
T119 273-281 GO:0003823 denotes antibody
T120 283-291 D005557 denotes Formalin
T121 283-291 CHEBI:16842 denotes Formalin
T122 283-291 D005557 denotes Formalin
T125 298-306 7906 denotes paraffin
T123 298-306 D010232 denotes paraffin
T124 298-306 D010232 denotes paraffin
T126 332-336 PR:Q8FYW3 denotes pure
T127 332-336 PR:Q54QE4 denotes pure
T128 332-336 PR:P52558 denotes pure
T129 332-336 PR:P0AG18 denotes pure
T131 332-336 PR:000023640 denotes pure
T130 332-336 GO:0034023 denotes pure
T133 337-341 CVCL_5552 denotes DCIS
T132 337-341 D002285 denotes DCIS
T134 337-341 D002285 denotes DCIS
T136 359-363 CVCL_5552 denotes DCIS
T135 359-363 D002285 denotes DCIS
T137 359-363 D002285 denotes DCIS
T138 429-437 O93510 denotes gelsolin
T139 429-437 P14885 denotes gelsolin
T140 429-437 PR:000002202 denotes gelsolin
T142 429-437 Q28372 denotes gelsolin
T143 429-437 Q68FP1 denotes gelsolin
T144 429-437 Q3SX14 denotes gelsolin
T145 429-437 P13020 denotes gelsolin
T146 429-437 Q07171 denotes gelsolin
T147 429-437 P06396 denotes gelsolin
T148 429-437 P20305 denotes gelsolin
T141 429-437 D018260 denotes gelsolin
T149 478-484 UBERON:0000310 denotes breast
T150 507-513 UBERON:0000310 denotes breast
T151 514-521 D009369 denotes cancers
T152 514-521 D009369 denotes cancers
T153 585-593 O93510 denotes gelsolin
T154 585-593 P14885 denotes gelsolin
T155 585-593 PR:000002202 denotes gelsolin
T157 585-593 Q28372 denotes gelsolin
T158 585-593 Q68FP1 denotes gelsolin
T159 585-593 Q3SX14 denotes gelsolin
T160 585-593 P13020 denotes gelsolin
T161 585-593 Q07171 denotes gelsolin
T162 585-593 P06396 denotes gelsolin
T163 585-593 P20305 denotes gelsolin
T156 585-593 D018260 denotes gelsolin
T164 601-611 UBERON:0000483 denotes epithelium
T165 642-646 PR:Q8FYW3 denotes pure
T166 642-646 PR:Q54QE4 denotes pure
T167 642-646 PR:P52558 denotes pure
T168 642-646 PR:P0AG18 denotes pure
T170 642-646 PR:000023640 denotes pure
T169 642-646 GO:0034023 denotes pure
T172 647-651 CVCL_5552 denotes DCIS
T171 647-651 D002285 denotes DCIS
T173 647-651 D002285 denotes DCIS
T175 658-662 CVCL_5552 denotes DCIS
T174 658-662 D002285 denotes DCIS
T176 658-662 D002285 denotes DCIS
T178 700-704 CVCL_5552 denotes DCIS
T177 700-704 D002285 denotes DCIS
T179 700-704 D002285 denotes DCIS
T180 759-768 D002277 denotes carcinoma
T181 759-768 D002277 denotes carcinoma
T182 808-818 GO:0065007 denotes regulation
T183 822-830 O93510 denotes gelsolin
T184 822-830 P14885 denotes gelsolin
T185 822-830 PR:000002202 denotes gelsolin
T187 822-830 Q28372 denotes gelsolin
T188 822-830 Q68FP1 denotes gelsolin
T189 822-830 Q3SX14 denotes gelsolin
T190 822-830 P13020 denotes gelsolin
T191 822-830 Q07171 denotes gelsolin
T192 822-830 P06396 denotes gelsolin
T193 822-830 P20305 denotes gelsolin
T186 822-830 D018260 denotes gelsolin
T195 845-862 UBERON:0008367 denotes breast epithelium
T197 899-909 D009369 denotes malignancy
T198 899-909 D009369 denotes malignancy
T199 919-927 O93510 denotes gelsolin
T200 919-927 P14885 denotes gelsolin
T201 919-927 PR:000002202 denotes gelsolin
T203 919-927 Q28372 denotes gelsolin
T204 919-927 Q68FP1 denotes gelsolin
T205 919-927 Q3SX14 denotes gelsolin
T206 919-927 P13020 denotes gelsolin
T207 919-927 Q07171 denotes gelsolin
T208 919-927 P06396 denotes gelsolin
T209 919-927 P20305 denotes gelsolin
T202 919-927 D018260 denotes gelsolin
T211 979-983 CVCL_5552 denotes DCIS
T210 979-983 D002285 denotes DCIS
T212 979-983 D002285 denotes DCIS
T213 1141-1146 D009369 denotes tumor
T214 1141-1146 D009369 denotes tumor
T215 1204-1212 GO:0019835 denotes necrosis
T216 1204-1212 GO:0008219 denotes necrosis
T219 1204-1212 GO:0008220 denotes necrosis
T220 1204-1212 GO:0001906 denotes necrosis
T221 1204-1212 GO:0070265 denotes necrosis
T217 1204-1212 D009336 denotes necrosis
T218 1204-1212 D009336 denotes necrosis
T222 1357-1365 O93510 denotes Gelsolin
T223 1357-1365 P14885 denotes Gelsolin
T224 1357-1365 PR:000002202 denotes Gelsolin
T226 1357-1365 Q28372 denotes Gelsolin
T227 1357-1365 Q68FP1 denotes Gelsolin
T228 1357-1365 Q3SX14 denotes Gelsolin
T229 1357-1365 P13020 denotes Gelsolin
T230 1357-1365 Q07171 denotes Gelsolin
T231 1357-1365 P06396 denotes Gelsolin
T232 1357-1365 P20305 denotes Gelsolin
T225 1357-1365 D018260 denotes Gelsolin
T233 1423-1429 UBERON:0000479 denotes tissue
T235 1552-1556 CVCL_5552 denotes DCIS
T234 1552-1556 D002285 denotes DCIS
T236 1552-1556 D002285 denotes DCIS
T237 1608-1617 SO:0000119 denotes regulated
T238 1618-1626 O93510 denotes gelsolin
T239 1618-1626 P14885 denotes gelsolin
T240 1618-1626 PR:000002202 denotes gelsolin
T242 1618-1626 Q28372 denotes gelsolin
T243 1618-1626 Q68FP1 denotes gelsolin
T244 1618-1626 Q3SX14 denotes gelsolin
T245 1618-1626 P13020 denotes gelsolin
T246 1618-1626 Q07171 denotes gelsolin
T247 1618-1626 P06396 denotes gelsolin
T248 1618-1626 P20305 denotes gelsolin
T241 1618-1626 D018260 denotes gelsolin
T250 1645-1649 CVCL_5552 denotes DCIS
T249 1645-1649 D002285 denotes DCIS
T251 1645-1649 D002285 denotes DCIS
T253 1709-1714 D009369 denotes tumor
T254 1709-1714 D009369 denotes tumor
T255 1739-1747 O93510 denotes gelsolin
T256 1739-1747 P14885 denotes gelsolin
T257 1739-1747 PR:000002202 denotes gelsolin
T259 1739-1747 Q28372 denotes gelsolin
T260 1739-1747 Q68FP1 denotes gelsolin
T261 1739-1747 Q3SX14 denotes gelsolin
T262 1739-1747 P13020 denotes gelsolin
T263 1739-1747 Q07171 denotes gelsolin
T264 1739-1747 P06396 denotes gelsolin
T265 1739-1747 P20305 denotes gelsolin
T266 1739-1755 D018260 denotes gelsolin protein
T271 1748-1755 SO:0000104 denotes protein
T270 1748-1755 PR:000000001 denotes protein
T267 1748-1755 GO:0003675 denotes protein
T272 1790-1796 UBERON:0000310 denotes breast
T274 1830-1834 CVCL_5552 denotes DCIS
T273 1830-1834 D002285 denotes DCIS
T275 1830-1834 D002285 denotes DCIS
T276 1865-1873 O93510 denotes gelsolin
T277 1865-1873 P14885 denotes gelsolin
T278 1865-1873 PR:000002202 denotes gelsolin
T280 1865-1873 Q28372 denotes gelsolin
T281 1865-1873 Q68FP1 denotes gelsolin
T282 1865-1873 Q3SX14 denotes gelsolin
T283 1865-1873 P13020 denotes gelsolin
T284 1865-1873 Q07171 denotes gelsolin
T285 1865-1873 P06396 denotes gelsolin
T286 1865-1873 P20305 denotes gelsolin
T279 1865-1873 D018260 denotes gelsolin
T287 1917-1927 UBERON:0000483 denotes epithelium
T289 1931-1935 CVCL_5552 denotes DCIS
T288 1931-1935 D002285 denotes DCIS
T290 1931-1935 D002285 denotes DCIS
T291 1948-1954 UBERON:0000310 denotes breast
T292 1948-1961 D001943 denotes breast cancer
T293 1948-1961 D001943 denotes breast cancer
T294 2057-2065 O93510 denotes gelsolin
T295 2057-2065 P14885 denotes gelsolin
T296 2057-2065 PR:000002202 denotes gelsolin
T298 2057-2065 Q28372 denotes gelsolin
T299 2057-2065 Q68FP1 denotes gelsolin
T300 2057-2065 Q3SX14 denotes gelsolin
T301 2057-2065 P13020 denotes gelsolin
T302 2057-2065 Q07171 denotes gelsolin
T303 2057-2065 P06396 denotes gelsolin
T304 2057-2065 P20305 denotes gelsolin
T297 2057-2065 D018260 denotes gelsolin
T305 2140-2146 UBERON:0000310 denotes breast
T306 2140-2153 D001943 denotes breast cancer
T307 2140-2153 D001943 denotes breast cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 507-521 HP_0003002 denotes breast cancers
T2 507-521 HP_0100013 denotes breast cancers
T3 514-521 HP_0002664 denotes cancers
T4 1141-1146 HP_0002664 denotes tumor
T5 1709-1714 HP_0002664 denotes tumor
T6 1948-1961 HP_0003002 denotes breast cancer
T7 1948-1961 HP_0100013 denotes breast cancer
T8 1955-1961 HP_0002664 denotes cancer
T9 2140-2153 HP_0003002 denotes breast cancer
T10 2140-2153 HP_0100013 denotes breast cancer
T11 2147-2153 HP_0002664 denotes cancer

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T3 283-297 REPLACED denotes Formalin-fixed
T1 0-106 DRI_Background denotes Down-regulation of gelsolin expression in human breast ductal carcinoma in situ with and without invasion.
T2 107-282 DRI_Background denotes Expression of gelsolin, an actin filament regulatory protein, in human breast ductal carcinoma in situ (DCIS) was analyzed by immunohistochemistry using a monoclonal antibody.
T4 298-315 Token_Label.OUTSIDE denotes paraffin-embedded
T5 316-522 DRI_Background denotes tissues from 59 pure DCIS specimens and 33 DCIS specimens with associated invasive components were evaluated for gelsolin reactivity and compared to eight normal breast cases and 76 invasive breast cancers.
T6 523-774 DRI_Background denotes The proportion of cases exhibiting negative/low expression of gelsolin in the epithelium was as follows -- normal, 0%; pure DCIS, 56%; DCIS associated with invasion, 58% in the DCIS component and 66% in the invasive component; invasive carcinoma, 70%.
T7 775-910 DRI_Outcome denotes These data demonstrate that down-regulation of gelsolin expression in breast epithelium frequently parallels progression to malignancy.
T8 911-1356 DRI_Unspecified denotes Testing gelsolin expression (normal vs. negative/low levels) in the DCIS lesions for associations with patient age or any of the following histopathologic parameters revealed no significant (95% probability level) correlations -- tumor size; pathologic (Van Nuys system) grade; nuclear grade; necrosis; presence of histologic calcifications; presence or type of adjacent benign lesions; architectural histologic pattern; and mammographic extent.
T9 1357-1483 DRI_Background denotes Gelsolin loss was more commonly associated with mammographic soft tissue lesions as compared to calcified lesions (P = 0.009).
T10 1484-1715 DRI_Approach denotes A positive trend of borderline significance (P = 0.06) found in the DCIS with invasion group was a correlation between down-regulated gelsolin expression in the DCIS component and size (< versus > or = 15 mm) of the invasive tumor.
T11 1716-1835 DRI_Outcome denotes In conclusion, reduced gelsolin protein is detectable in at least half of breast lesions which have progressed to DCIS.
T12 1836-2154 DRI_Approach denotes The trend between increasing gelsolin loss and malignant progression from normal epithelium to DCIS to invasive breast cancer (P < 0.0001) suggests additional investigation is needed to determine the potential of altered gelsolin expression as a marker for prognosis and for therapeutic interventions in breast cancer.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10481945-0#19#27#gene2934 822-830 gene2934 denotes gelsolin
10481945-0#48#79#diseaseC0007124 1109-1542 diseaseC0007124 denotes bability level) correlations -- tumor size; pathologic (Van Nuys system) grade; nuclear grade; necrosis; presence of histologic calcifications; presence or type of adjacent benign lesions; architectural histologic pattern; and mammographic extent. Gelsolin loss was more commonly associated with mammographic soft tissue lesions as compared to calcified lesions (P = 0.009). A positive trend of borderline significance (P = 0.06) fou
10481945-3#62#70#gene2934 585-593 gene2934 denotes gelsolin
10481945-3#227#245#diseaseC1334274 750-768 diseaseC1334274 denotes invasive carcinoma
10481945-9#29#37#gene2934 1865-1873 gene2934 denotes gelsolin
10481945-9#221#229#gene2934 2057-2065 gene2934 denotes gelsolin
10481945-9#29#37#gene2934 1865-1873 gene2934 denotes gelsolin
10481945-9#221#229#gene2934 2057-2065 gene2934 denotes gelsolin
10481945-9#304#317#diseaseC0006142 2140-2153 diseaseC0006142 denotes breast cancer
10481945-9#304#317#diseaseC0678222 2140-2153 diseaseC0678222 denotes breast cancer
10481945-9#304#317#diseaseC0006142 2140-2153 diseaseC0006142 denotes breast cancer
10481945-9#304#317#diseaseC0678222 2140-2153 diseaseC0678222 denotes breast cancer
10481945-9#103#125#diseaseC0853879 1939-1961 diseaseC0853879 denotes invasive breast cancer
19#27#gene293448#79#diseaseC0007124 10481945-0#19#27#gene2934 10481945-0#48#79#diseaseC0007124 associated_with gelsolin,bability level) correlations -- tumor size; pathologic (Van Nuys system) grade; nuclear grade; necrosis; presence of histologic calcifications; presence or type of adjacent benign lesions; architectural histologic pattern; and mammographic extent. Gelsolin loss was more commonly associated with mammographic soft tissue lesions as compared to calcified lesions (P = 0.009). A positive trend of borderline significance (P = 0.06) fou
62#70#gene2934227#245#diseaseC1334274 10481945-3#62#70#gene2934 10481945-3#227#245#diseaseC1334274 associated_with gelsolin,invasive carcinoma
29#37#gene2934304#317#diseaseC0006142 10481945-9#29#37#gene2934 10481945-9#304#317#diseaseC0006142 associated_with gelsolin,breast cancer
29#37#gene2934304#317#diseaseC0678222 10481945-9#29#37#gene2934 10481945-9#304#317#diseaseC0678222 associated_with gelsolin,breast cancer
29#37#gene2934304#317#diseaseC0006142 10481945-9#29#37#gene2934 10481945-9#304#317#diseaseC0006142 associated_with gelsolin,breast cancer
29#37#gene2934304#317#diseaseC0678222 10481945-9#29#37#gene2934 10481945-9#304#317#diseaseC0678222 associated_with gelsolin,breast cancer
29#37#gene2934103#125#diseaseC0853879 10481945-9#29#37#gene2934 10481945-9#103#125#diseaseC0853879 associated_with gelsolin,invasive breast cancer
221#229#gene2934304#317#diseaseC0006142 10481945-9#221#229#gene2934 10481945-9#304#317#diseaseC0006142 associated_with gelsolin,breast cancer
221#229#gene2934304#317#diseaseC0678222 10481945-9#221#229#gene2934 10481945-9#304#317#diseaseC0678222 associated_with gelsolin,breast cancer
221#229#gene2934304#317#diseaseC0006142 10481945-9#221#229#gene2934 10481945-9#304#317#diseaseC0006142 associated_with gelsolin,breast cancer
221#229#gene2934304#317#diseaseC0678222 10481945-9#221#229#gene2934 10481945-9#304#317#diseaseC0678222 associated_with gelsolin,breast cancer
221#229#gene2934103#125#diseaseC0853879 10481945-9#221#229#gene2934 10481945-9#103#125#diseaseC0853879 associated_with gelsolin,invasive breast cancer
29#37#gene2934304#317#diseaseC0006142 10481945-9#29#37#gene2934 10481945-9#304#317#diseaseC0006142 associated_with gelsolin,breast cancer
29#37#gene2934304#317#diseaseC0678222 10481945-9#29#37#gene2934 10481945-9#304#317#diseaseC0678222 associated_with gelsolin,breast cancer
29#37#gene2934304#317#diseaseC0006142 10481945-9#29#37#gene2934 10481945-9#304#317#diseaseC0006142 associated_with gelsolin,breast cancer
29#37#gene2934304#317#diseaseC0678222 10481945-9#29#37#gene2934 10481945-9#304#317#diseaseC0678222 associated_with gelsolin,breast cancer
29#37#gene2934103#125#diseaseC0853879 10481945-9#29#37#gene2934 10481945-9#103#125#diseaseC0853879 associated_with gelsolin,invasive breast cancer
221#229#gene2934304#317#diseaseC0006142 10481945-9#221#229#gene2934 10481945-9#304#317#diseaseC0006142 associated_with gelsolin,breast cancer
221#229#gene2934304#317#diseaseC0678222 10481945-9#221#229#gene2934 10481945-9#304#317#diseaseC0678222 associated_with gelsolin,breast cancer
221#229#gene2934304#317#diseaseC0006142 10481945-9#221#229#gene2934 10481945-9#304#317#diseaseC0006142 associated_with gelsolin,breast cancer
221#229#gene2934304#317#diseaseC0678222 10481945-9#221#229#gene2934 10481945-9#304#317#diseaseC0678222 associated_with gelsolin,breast cancer
221#229#gene2934103#125#diseaseC0853879 10481945-9#221#229#gene2934 10481945-9#103#125#diseaseC0853879 associated_with gelsolin,invasive breast cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 19-27 gene:2934 denotes gelsolin
T1 48-79 disease:C0007124 denotes breast ductal carcinoma in situ
R1 T0 T1 associated_with gelsolin,breast ductal carcinoma in situ