PubMed:10480426 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10480426","sourcedb":"PubMed","sourceid":"10480426","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10480426","text":"Neutrophil maturation and the role of retinoic acid.\nNeutrophil maturation occurs in well defined morphological stages that correlate with the acquisition of molecular markers associated with neutrophil function. A variety of factors are known to play a role in terminal neutrophil maturation, including the vitamin A derivative, retinoic acid. Retinoic acid can directly modulate gene expression via binding to its nuclear receptors, which can, in turn, activate transcription of target genes. A role for retinoic acid during neutrophil maturation has been suggested from a variety of sources. Here we present a review of the mechanism of retinoic acid receptor action and the major evidence showing that normal retinoid signaling is required for neutrophil 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