PubMed:10480426 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"cell_type"},{"id":"T2","span":{"begin":53,"end":63},"obj":"cell_type"},{"id":"T3","span":{"begin":158,"end":175},"obj":"protein"},{"id":"T4","span":{"begin":271,"end":281},"obj":"cell_type"},{"id":"T5","span":{"begin":416,"end":433},"obj":"protein"},{"id":"T6","span":{"begin":481,"end":493},"obj":"DNA"},{"id":"T7","span":{"begin":527,"end":537},"obj":"cell_type"},{"id":"T8","span":{"begin":640,"end":662},"obj":"protein"},{"id":"T9","span":{"begin":748,"end":758},"obj":"cell_type"}],"text":"Neutrophil maturation and the role of retinoic acid.\nNeutrophil maturation occurs in well defined morphological stages that correlate with the acquisition of molecular markers associated with neutrophil function. A variety of factors are known to play a role in terminal neutrophil maturation, including the vitamin A derivative, retinoic acid. Retinoic acid can directly modulate gene expression via binding to its nuclear receptors, which can, in turn, activate transcription of target genes. A role for retinoic acid during neutrophil maturation has been suggested from a variety of sources. Here we present a review of the mechanism of retinoic acid receptor action and the major evidence showing that normal retinoid signaling is required for neutrophil maturation."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":52},"obj":"Sentence"},{"id":"S2","span":{"begin":53,"end":212},"obj":"Sentence"},{"id":"S3","span":{"begin":213,"end":344},"obj":"Sentence"},{"id":"S4","span":{"begin":345,"end":494},"obj":"Sentence"},{"id":"S5","span":{"begin":495,"end":594},"obj":"Sentence"},{"id":"S6","span":{"begin":595,"end":770},"obj":"Sentence"}],"text":"Neutrophil maturation and the role of retinoic acid.\nNeutrophil maturation occurs in well defined morphological stages that correlate with the acquisition of molecular markers associated with neutrophil function. A variety of factors are known to play a role in terminal neutrophil maturation, including the vitamin A derivative, retinoic acid. Retinoic acid can directly modulate gene expression via binding to its nuclear receptors, which can, in turn, activate transcription of target genes. A role for retinoic acid during neutrophil maturation has been suggested from a variety of sources. Here we present a review of the mechanism of retinoic acid receptor action and the major evidence showing that normal retinoid signaling is required for neutrophil maturation."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":21},"obj":"NP"},{"id":"C6","span":{"begin":38,"end":51},"obj":"NP"},{"id":"C15","span":{"begin":26,"end":51},"obj":"NP"},{"id":"C2","span":{"begin":53,"end":74},"obj":"NP"},{"id":"C3","span":{"begin":271,"end":292},"obj":"NP"},{"id":"C7","span":{"begin":330,"end":343},"obj":"NP"},{"id":"C8","span":{"begin":345,"end":358},"obj":"NP"},{"id":"C11","span":{"begin":412,"end":415},"obj":"NP"},{"id":"C12","span":{"begin":412,"end":433},"obj":"NP"},{"id":"C13","span":{"begin":435,"end":440},"obj":"NP"},{"id":"C9","span":{"begin":506,"end":519},"obj":"NP"},{"id":"C4","span":{"begin":527,"end":548},"obj":"NP"},{"id":"C14","span":{"begin":495,"end":548},"obj":"NP"},{"id":"C10","span":{"begin":640,"end":653},"obj":"NP"},{"id":"C5","span":{"begin":748,"end":769},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C15","obj":"C14"},{"id":"R2","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R3","pred":"coref-ident","subj":"C3","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C7"},{"id":"R6","pred":"coref-pron","subj":"C11","obj":"C8"},{"id":"R7","pred":"coref-relat","subj":"C13","obj":"C12"},{"id":"R8","pred":"coref-ident","subj":"C9","obj":"C8"},{"id":"R9","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R10","pred":"coref-ident","subj":"C10","obj":"C9"},{"id":"R11","pred":"coref-ident","subj":"C5","obj":"C4"}],"text":"Neutrophil maturation and the role of retinoic acid.\nNeutrophil maturation occurs in well defined morphological stages that correlate with the acquisition of molecular markers associated with neutrophil function. A variety of factors are known to play a role in terminal neutrophil maturation, including the vitamin A derivative, retinoic acid. Retinoic acid can directly modulate gene expression via binding to its nuclear receptors, which can, in turn, activate transcription of target genes. A role for retinoic acid during neutrophil maturation has been suggested from a variety of sources. Here we present a review of the mechanism of retinoic acid receptor action and the major evidence showing that normal retinoid signaling is required for neutrophil maturation."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"cell_type"},{"id":"T2","span":{"begin":53,"end":63},"obj":"cell_type"},{"id":"T3","span":{"begin":158,"end":175},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":192,"end":211},"obj":"other_name"},{"id":"T5","span":{"begin":271,"end":281},"obj":"cell_type"},{"id":"T6","span":{"begin":308,"end":317},"obj":"lipid"},{"id":"T7","span":{"begin":330,"end":343},"obj":"other_organic_compound"},{"id":"T8","span":{"begin":381,"end":396},"obj":"other_name"},{"id":"T9","span":{"begin":416,"end":433},"obj":"protein_family_or_group"},{"id":"T10","span":{"begin":481,"end":493},"obj":"DNA_family_or_group"},{"id":"T11","span":{"begin":506,"end":519},"obj":"other_organic_compound"},{"id":"T12","span":{"begin":527,"end":537},"obj":"cell_type"},{"id":"T13","span":{"begin":640,"end":653},"obj":"other_organic_compound"},{"id":"T14","span":{"begin":713,"end":731},"obj":"other_name"},{"id":"T15","span":{"begin":748,"end":758},"obj":"cell_type"}],"text":"Neutrophil maturation and the role of retinoic acid.\nNeutrophil maturation occurs in well defined morphological stages that correlate with the acquisition of molecular markers associated with neutrophil function. A variety of factors are known to play a role in terminal neutrophil maturation, including the vitamin A derivative, retinoic acid. Retinoic acid can directly modulate gene expression via binding to its nuclear receptors, which can, in turn, activate transcription of target genes. A role for retinoic acid during neutrophil maturation has been suggested from a variety of sources. Here we present a review of the mechanism of retinoic acid receptor action and the major evidence showing that normal retinoid signaling is required for neutrophil maturation."}