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PubMed:10477716 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-200 Sentence denotes Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation.
T2 201-330 Sentence denotes Tumor necrosis factor alpha (TNFalpha) is a pluripotent activator of inflammation by inducing a proinflammatory cytokine cascade.
T3 331-441 Sentence denotes This phenomenon is mediated, in part, through inducible expression of the CXC chemokine, interleukin-8 (IL-8).
T4 442-603 Sentence denotes In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.
T5 604-732 Sentence denotes TNFalpha is a rapid activator of IL-8 gene expression by U937, producing a 50-fold induction of mRNA within 1 hour of treatment.
T6 733-899 Sentence denotes In gene transfection assays, the effect of TNFalpha requires the presence of an inducible nuclear factor-kappaB (NF-kappaB) (Rel A) binding site in the IL-8 promoter.
T7 900-1086 Sentence denotes TNFalpha treatment induces a rapid translocation of the 65 kD transcriptional activator NF-kappaB subunit, Rel A, whose binding in the nucleus occurs before changes in intracellular ROS.
T8 1087-1267 Sentence denotes Pretreatment (or up to 15 minutes posttreatment) relative to TNFalpha with the antioxidant dimethyl sulfoxide (DMSO) (2% [vol/vol]) blocks 80% of NF-kappaB-dependent transcription.
T9 1268-1337 Sentence denotes Surprisingly, however, DMSO has no effect on inducible Rel A binding.
T10 1338-1470 Sentence denotes Similar selective effects on NF-kappaB transcription are seen with the unrelated antioxidants, N-acetylcysteine (NAC) and vitamin C.
T11 1471-1680 Sentence denotes These data indicate that TNFalpha induces a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation.
T12 1681-1791 Sentence denotes Further definition of this pathway will yield new insights into inflammation initiated by TNFalpha signalling.
T1 0-200 Sentence denotes Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation.
T2 201-330 Sentence denotes Tumor necrosis factor alpha (TNFalpha) is a pluripotent activator of inflammation by inducing a proinflammatory cytokine cascade.
T3 331-441 Sentence denotes This phenomenon is mediated, in part, through inducible expression of the CXC chemokine, interleukin-8 (IL-8).
T4 442-603 Sentence denotes In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.
T5 604-732 Sentence denotes TNFalpha is a rapid activator of IL-8 gene expression by U937, producing a 50-fold induction of mRNA within 1 hour of treatment.
T6 733-899 Sentence denotes In gene transfection assays, the effect of TNFalpha requires the presence of an inducible nuclear factor-kappaB (NF-kappaB) (Rel A) binding site in the IL-8 promoter.
T7 900-1086 Sentence denotes TNFalpha treatment induces a rapid translocation of the 65 kD transcriptional activator NF-kappaB subunit, Rel A, whose binding in the nucleus occurs before changes in intracellular ROS.
T8 1087-1267 Sentence denotes Pretreatment (or up to 15 minutes posttreatment) relative to TNFalpha with the antioxidant dimethyl sulfoxide (DMSO) (2% [vol/vol]) blocks 80% of NF-kappaB-dependent transcription.
T9 1268-1337 Sentence denotes Surprisingly, however, DMSO has no effect on inducible Rel A binding.
T10 1338-1470 Sentence denotes Similar selective effects on NF-kappaB transcription are seen with the unrelated antioxidants, N-acetylcysteine (NAC) and vitamin C.
T11 1471-1680 Sentence denotes These data indicate that TNFalpha induces a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation.
T12 1681-1791 Sentence denotes Further definition of this pathway will yield new insights into inflammation initiated by TNFalpha signalling.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 201-206 HP_0002664 denotes Tumor
T2 588-596 HP_0002665 denotes lymphoma

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-21 protein denotes Nuclear factor-kappaB
T2 45-58 protein denotes interleukin-8
T3 78-105 protein denotes tumor necrosis factor alpha
T4 201-228 protein denotes Tumor necrosis factor alpha
T5 230-238 protein denotes TNFalpha
T6 297-321 protein denotes proinflammatory cytokine
T7 405-418 protein denotes CXC chemokine
T8 420-433 protein denotes interleukin-8
T9 484-492 protein denotes TNFalpha
T10 536-540 protein denotes IL-8
T11 571-602 cell_line denotes U937 histiocytic lymphoma cells
T12 604-612 protein denotes TNFalpha
T13 637-646 DNA denotes IL-8 gene
T14 661-665 cell_line denotes U937
T15 700-704 RNA denotes mRNA
T16 776-784 protein denotes TNFalpha
T17 813-877 DNA denotes inducible nuclear factor-kappaB (NF-kappaB) (Rel A) binding site
T18 885-898 DNA denotes IL-8 promoter
T19 900-908 protein denotes TNFalpha
T20 956-987 protein denotes 65 kD transcriptional activator
T21 988-1005 protein denotes NF-kappaB subunit
T22 1007-1012 protein denotes Rel A
T23 1148-1156 protein denotes TNFalpha
T24 1233-1242 protein denotes NF-kappaB
T25 1323-1328 protein denotes Rel A
T26 1367-1376 protein denotes NF-kappaB
T27 1496-1504 protein denotes TNFalpha
T28 1577-1586 protein denotes NF-kappaB
T29 1771-1779 protein denotes TNFalpha

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-200 Sentence denotes Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation.
S2 201-330 Sentence denotes Tumor necrosis factor alpha (TNFalpha) is a pluripotent activator of inflammation by inducing a proinflammatory cytokine cascade.
S3 331-441 Sentence denotes This phenomenon is mediated, in part, through inducible expression of the CXC chemokine, interleukin-8 (IL-8).
S4 442-603 Sentence denotes In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.
S5 604-732 Sentence denotes TNFalpha is a rapid activator of IL-8 gene expression by U937, producing a 50-fold induction of mRNA within 1 hour of treatment.
S6 733-899 Sentence denotes In gene transfection assays, the effect of TNFalpha requires the presence of an inducible nuclear factor-kappaB (NF-kappaB) (Rel A) binding site in the IL-8 promoter.
S7 900-1086 Sentence denotes TNFalpha treatment induces a rapid translocation of the 65 kD transcriptional activator NF-kappaB subunit, Rel A, whose binding in the nucleus occurs before changes in intracellular ROS.
S8 1087-1267 Sentence denotes Pretreatment (or up to 15 minutes posttreatment) relative to TNFalpha with the antioxidant dimethyl sulfoxide (DMSO) (2% [vol/vol]) blocks 80% of NF-kappaB-dependent transcription.
S9 1268-1337 Sentence denotes Surprisingly, however, DMSO has no effect on inducible Rel A binding.
S10 1338-1470 Sentence denotes Similar selective effects on NF-kappaB transcription are seen with the unrelated antioxidants, N-acetylcysteine (NAC) and vitamin C.
S11 1471-1680 Sentence denotes These data indicate that TNFalpha induces a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation.
S12 1681-1791 Sentence denotes Further definition of this pathway will yield new insights into inflammation initiated by TNFalpha signalling.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 45-74 NP denotes interleukin-8 gene expression
C2 78-105 NP denotes tumor necrosis factor alpha
C3 201-239 NP denotes Tumor necrosis factor alpha (TNFalpha)
C4 401-418 NP denotes the CXC chemokine
C5 420-440 NP denotes interleukin-8 (IL-8)
C6 536-551 NP denotes IL-8 expression
C7 555-602 NP denotes "monocyte-like" U937 histiocytic lymphoma cells
C8 604-612 NP denotes TNFalpha
C9 637-657 NP denotes IL-8 gene expression
C10 661-665 NP denotes U937
C11 776-784 NP denotes TNFalpha
C12 952-1005 NP denotes the 65 kD transcriptional activator NF-kappaB subunit
C13 1007-1012 NP denotes Rel A
C14 1014-1019 NP denotes whose
C15 1148-1156 NP denotes TNFalpha
C16 1162-1203 NP denotes the antioxidant dimethyl sulfoxide (DMSO)
C17 1291-1295 NP denotes DMSO
C18 1405-1431 NP denotes the unrelated antioxidants
C19 1433-1469 NP denotes N-acetylcysteine (NAC) and vitamin C
C20 1496-1504 NP denotes TNFalpha
C22 1513-1555 NP denotes a delayed ROS-dependent signalling pathway
C23 1556-1560 NP denotes that
C24 1636-1640 NP denotes that
C21 1513-1679 NP denotes a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation
C25 1703-1715 NP denotes this pathway
R1 C3 C2 coref-ident Tumor necrosis factor alpha (TNFalpha),tumor necrosis factor alpha
R2 C5 C4 coref-appos interleukin-8 (IL-8),the CXC chemokine
R3 C6 C1 coref-ident IL-8 expression,interleukin-8 gene expression
R4 C8 C3 coref-ident TNFalpha,Tumor necrosis factor alpha (TNFalpha)
R5 C9 C6 coref-ident IL-8 gene expression,IL-8 expression
R6 C10 C7 coref-ident U937,"""monocyte-like"" U937 histiocytic lymphoma cells"
R7 C11 C8 coref-ident TNFalpha,TNFalpha
R8 C13 C12 coref-appos Rel A,the 65 kD transcriptional activator NF-kappaB subunit
R9 C14 C12 coref-relat whose,the 65 kD transcriptional activator NF-kappaB subunit
R10 C15 C11 coref-ident TNFalpha,TNFalpha
R11 C17 C16 coref-ident DMSO,the antioxidant dimethyl sulfoxide (DMSO)
R12 C19 C18 coref-appos N-acetylcysteine (NAC) and vitamin C,the unrelated antioxidants
R13 C20 C15 coref-ident TNFalpha,TNFalpha
R14 C23 C22 coref-relat that,a delayed ROS-dependent signalling pathway
R15 C24 C22 coref-pron that,a delayed ROS-dependent signalling pathway
R16 C25 C21 coref-ident this pathway,a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-21 protein_complex denotes Nuclear factor-kappaB
T2 45-58 protein_molecule denotes interleukin-8
T3 78-105 protein_molecule denotes tumor necrosis factor alpha
T4 178-199 other_name denotes nuclear translocation
T5 201-228 protein_molecule denotes Tumor necrosis factor alpha
T6 230-238 protein_molecule denotes TNFalpha
T7 245-282 other_name denotes pluripotent activator of inflammation
T8 297-321 protein_family_or_group denotes proinflammatory cytokine
T9 405-418 protein_family_or_group denotes CXC chemokine
T10 420-433 protein_molecule denotes interleukin-8
T11 484-492 protein_molecule denotes TNFalpha
T12 536-540 protein_molecule denotes IL-8
T13 571-602 cell_line denotes U937 histiocytic lymphoma cells
T14 604-612 protein_molecule denotes TNFalpha
T15 637-641 protein_molecule denotes IL-8
T16 661-665 cell_line denotes U937
T17 700-704 RNA_family_or_group denotes mRNA
T18 776-784 protein_molecule denotes TNFalpha
T19 813-846 DNA_domain_or_region denotes inducible nuclear factor-kappaB (
T20 846-855 protein_complex denotes NF-kappaB
T21 858-863 protein_subunit denotes Rel A
T22 885-889 protein_molecule denotes IL-8
T23 900-908 protein_molecule denotes TNFalpha
T24 956-987 protein_molecule denotes 65 kD transcriptional activator
T25 988-997 protein_complex denotes NF-kappaB
T26 1007-1012 protein_subunit denotes Rel A
T27 1035-1042 cell_component denotes nucleus
T28 1068-1085 other_name denotes intracellular ROS
T29 1148-1156 protein_molecule denotes TNFalpha
T30 1166-1177 other_organic_compound denotes antioxidant
T31 1178-1196 other_organic_compound denotes dimethyl sulfoxide
T32 1198-1202 other_organic_compound denotes DMSO
T33 1233-1242 protein_complex denotes NF-kappaB
T34 1291-1295 other_organic_compound denotes DMSO
T35 1323-1328 protein_subunit denotes Rel A
T36 1367-1376 protein_complex denotes NF-kappaB
T37 1433-1449 amino_acid_monomer denotes N-acetylcysteine
T38 1451-1454 amino_acid_monomer denotes NAC
T39 1460-1469 other_organic_compound denotes vitamin C
T40 1496-1504 protein_molecule denotes TNFalpha
T41 1523-1555 other_name denotes ROS-dependent signalling pathway
T42 1577-1586 protein_complex denotes NF-kappaB
T43 1658-1679 other_name denotes nuclear translocation
T44 1745-1757 other_name denotes inflammation
T45 1771-1779 protein_molecule denotes TNFalpha