| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-158 |
DRI_Background |
denotes |
Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices. |
| T2 |
159-438 |
DRI_Challenge |
denotes |
This study compared the ability of memantine and (+)MK-801 to counteract deficits in the induction of long term potentiation (LTP) following reduction of Mg2+ in hippocampal slices--a model of increased synaptic noise due to tonic N-methyl-D-aspartate (NMDA) receptor activation. |
| T3 |
439-658 |
DRI_Outcome |
denotes |
Decreasing Mg2+ from 1 mM to 10 microM for 60 min enhanced baseline field excitatory post-synaptic potential (fEPSP) slopes (87.2 +/- 10.6% above control) and impaired LTP (-4.1 +/- 9.8% compared to pre-tetanic levels). |
| T4 |
659-902 |
DRI_Outcome |
denotes |
Long pre-incubations with memantine (1 microM), a concentration achieved in the CSF of dementia patients, almost fully restored the induction of LTP (to 43.4 +/- 8.4%) without changing the enhancement of baseline fEPSP slopes (84.1 +/- 11.6%). |
| T5 |
903-1053 |
DRI_Outcome |
denotes |
Memantine (10 microM) fully restored the induction of LTP (61.5 +/- 5.3%) and also decreased the enhancement of baseline fEPSP slopes (30.1 +/- 4.9%). |
| T6 |
1054-1164 |
DRI_Outcome |
denotes |
In contrast, although (+)MK-801 (0.01, 0.1 and 1 microM) caused a concentration-dependent reduction in the low |
| T7 |
1165-1178 |
Token_Label.OUTSIDE |
denotes |
Mg2+ -induced |
| T8 |
1179-1325 |
DRI_Outcome |
denotes |
enhancement of baseline fEPSP slopes, it was not able to restore the induction of LTP (3.0 +/- 9.8%, 16.3 +/- 5.7% and 4.8 +/- 6.7% respectively). |
| T9 |
1326-1588 |
DRI_Challenge |
denotes |
These data indicate that memantine could produce symptomatological improvement in learning under conditions of tonic NMDA receptor activation such as those occurring in chronic neurodegenerative diseases whereas (+)MK-801 is likely to have only negative effects. |
