PubMed:10455128 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10455128","sourcedb":"PubMed","sourceid":"10455128","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10455128","text":"Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.\nThe inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB. This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein. Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min. In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min. A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity. The endogenous levels of the signalsome components were unaffected by stimulation. Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells. Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated. NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta. Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it. The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C42","span":{"begin":24,"end":42},"obj":"NP"},{"id":"C43","span":{"begin":47,"end":68},"obj":"NP"},{"id":"C1","span":{"begin":144,"end":195},"obj":"NP"},{"id":"C6","span":{"begin":200,"end":227},"obj":"NP"},{"id":"C44","span":{"begin":253,"end":262},"obj":"NP"},{"id":"C18","span":{"begin":487,"end":496},"obj":"NP"},{"id":"C20","span":{"begin":498,"end":506},"obj":"NP"},{"id":"C49","span":{"begin":508,"end":518},"obj":"NP"},{"id":"C10","span":{"begin":508,"end":539},"obj":"NP"},{"id":"C41","span":{"begin":541,"end":582},"obj":"NP"},{"id":"C7","span":{"begin":646,"end":649},"obj":"NP"},{"id":"C4","span":{"begin":741,"end":750},"obj":"NP"},{"id":"C19","span":{"begin":759,"end":767},"obj":"NP"},{"id":"C2","span":{"begin":800,"end":803},"obj":"NP"},{"id":"C45","span":{"begin":829,"end":846},"obj":"NP"},{"id":"C46","span":{"begin":848,"end":853},"obj":"NP"},{"id":"C47","span":{"begin":950,"end":965},"obj":"NP"},{"id":"C48","span":{"begin":967,"end":972},"obj":"NP"},{"id":"C17","span":{"begin":991,"end":1019},"obj":"NP"},{"id":"C11","span":{"begin":1187,"end":1190},"obj":"NP"},{"id":"C22","span":{"begin":1192,"end":1205},"obj":"NP"},{"id":"C24","span":{"begin":1210,"end":1218},"obj":"NP"},{"id":"C8","span":{"begin":1254,"end":1257},"obj":"NP"},{"id":"C9","span":{"begin":1261,"end":1264},"obj":"NP"},{"id":"C23","span":{"begin":1297,"end":1310},"obj":"NP"},{"id":"C25","span":{"begin":1315,"end":1330},"obj":"NP"},{"id":"C27","span":{"begin":1394,"end":1403},"obj":"NP"},{"id":"C29","span":{"begin":1405,"end":1413},"obj":"NP"},{"id":"C15","span":{"begin":1419,"end":1422},"obj":"NP"},{"id":"C16","span":{"begin":1452,"end":1455},"obj":"NP"},{"id":"C33","span":{"begin":1477,"end":1490},"obj":"NP"},{"id":"C50","span":{"begin":1505,"end":1507},"obj":"NP"},{"id":"C39","span":{"begin":1743,"end":1774},"obj":"NP"},{"id":"C38","span":{"begin":1784,"end":1813},"obj":"NP"},{"id":"C40","span":{"begin":1823,"end":1825},"obj":"NP"},{"id":"C51","span":{"begin":1848,"end":1852},"obj":"NP"},{"id":"C52","span":{"begin":1857,"end":1861},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-xxx","subj":"C1","obj":"C42"},{"id":"R2","pred":"coref-xxx","subj":"C6","obj":"C43"},{"id":"R3","pred":"coref-ident","subj":"C10","obj":"C44"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C4","obj":"C18"},{"id":"R6","pred":"coref-ident","subj":"C19","obj":"C20"},{"id":"R7","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R8","pred":"coref-relat","subj":"C46","obj":"C45"},{"id":"R9","pred":"coref-relat","subj":"C48","obj":"C47"},{"id":"R10","pred":"coref-whole-part","subj":"C17","obj":"C45"},{"id":"R11","pred":"coref-ident","subj":"C11","obj":"C49"},{"id":"R12","pred":"coref-ident","subj":"C8","obj":"C2"},{"id":"R13","pred":"coref-ident","subj":"C9","obj":"C7"},{"id":"R14","pred":"coref-ident","subj":"C23","obj":"C22"},{"id":"R15","pred":"coref-ident","subj":"C25","obj":"C24"},{"id":"R16","pred":"coref-ident","subj":"C27","obj":"C18"},{"id":"R17","pred":"coref-ident","subj":"C29","obj":"C20"},{"id":"R18","pred":"coref-ident","subj":"C15","obj":"C11"},{"id":"R19","pred":"coref-ident","subj":"C16","obj":"C15"},{"id":"R20","pred":"coref-ident","subj":"C33","obj":"C23"},{"id":"R21","pred":"coref-pron","subj":"C50","obj":"C16"},{"id":"R22","pred":"coref-ident","subj":"C38","obj":"C41"},{"id":"R23","pred":"coref-pron","subj":"C40","obj":"C39"},{"id":"R24","pred":"coref-ident","subj":"C51","obj":"C8"},{"id":"R25","pred":"coref-ident","subj":"C52","obj":"C9"}],"attributes":[{"subj":"C42","pred":"source","obj":"genia-medco-coref"},{"subj":"C43","pred":"source","obj":"genia-medco-coref"},{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C44","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C49","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C41","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C45","pred":"source","obj":"genia-medco-coref"},{"subj":"C46","pred":"source","obj":"genia-medco-coref"},{"subj":"C47","pred":"source","obj":"genia-medco-coref"},{"subj":"C48","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C24","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C23","pred":"source","obj":"genia-medco-coref"},{"subj":"C25","pred":"source","obj":"genia-medco-coref"},{"subj":"C27","pred":"source","obj":"genia-medco-coref"},{"subj":"C29","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C33","pred":"source","obj":"genia-medco-coref"},{"subj":"C50","pred":"source","obj":"genia-medco-coref"},{"subj":"C39","pred":"source","obj":"genia-medco-coref"},{"subj":"C38","pred":"source","obj":"genia-medco-coref"},{"subj":"C40","pred":"source","obj":"genia-medco-coref"},{"subj":"C51","pred":"source","obj":"genia-medco-coref"},{"subj":"C52","pred":"source","obj":"genia-medco-coref"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":200,"end":205},"obj":"HP_0002664"},{"id":"T2","span":{"begin":1937,"end":1943},"obj":"HP_0100806"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"protein"},{"id":"T2","span":{"begin":72,"end":96},"obj":"protein"},{"id":"T3","span":{"begin":123,"end":130},"obj":"protein"},{"id":"T4","span":{"begin":200,"end":221},"obj":"protein"},{"id":"T5","span":{"begin":223,"end":226},"obj":"protein"},{"id":"T6","span":{"begin":253,"end":262},"obj":"protein"},{"id":"T7","span":{"begin":326,"end":340},"obj":"protein"},{"id":"T8","span":{"begin":342,"end":345},"obj":"protein"},{"id":"T9","span":{"begin":373,"end":380},"obj":"protein"},{"id":"T10","span":{"begin":412,"end":433},"obj":"cell_type"},{"id":"T11","span":{"begin":467,"end":486},"obj":"protein"},{"id":"T12","span":{"begin":487,"end":496},"obj":"protein"},{"id":"T13","span":{"begin":498,"end":506},"obj":"protein"},{"id":"T14","span":{"begin":508,"end":533},"obj":"protein"},{"id":"T15","span":{"begin":535,"end":538},"obj":"protein"},{"id":"T16","span":{"begin":541,"end":550},"obj":"protein"},{"id":"T17","span":{"begin":552,"end":561},"obj":"protein"},{"id":"T18","span":{"begin":588,"end":618},"obj":"protein"},{"id":"T19","span":{"begin":646,"end":649},"obj":"protein"},{"id":"T20","span":{"begin":696,"end":699},"obj":"protein"},{"id":"T21","span":{"begin":741,"end":750},"obj":"protein"},{"id":"T22","span":{"begin":759,"end":767},"obj":"protein"},{"id":"T23","span":{"begin":829,"end":837},"obj":"protein"},{"id":"T24","span":{"begin":1155,"end":1181},"obj":"protein"},{"id":"T25","span":{"begin":1187,"end":1190},"obj":"protein"},{"id":"T26","span":{"begin":1192,"end":1205},"obj":"protein"},{"id":"T27","span":{"begin":1210,"end":1218},"obj":"protein"},{"id":"T28","span":{"begin":1222,"end":1240},"obj":"cell_type"},{"id":"T29","span":{"begin":1261,"end":1264},"obj":"protein"},{"id":"T30","span":{"begin":1297,"end":1310},"obj":"protein"},{"id":"T31","span":{"begin":1315,"end":1330},"obj":"protein"},{"id":"T32","span":{"begin":1394,"end":1403},"obj":"protein"},{"id":"T33","span":{"begin":1405,"end":1413},"obj":"protein"},{"id":"T34","span":{"begin":1419,"end":1422},"obj":"protein"},{"id":"T35","span":{"begin":1452,"end":1455},"obj":"protein"},{"id":"T36","span":{"begin":1477,"end":1490},"obj":"protein"},{"id":"T37","span":{"begin":1572,"end":1575},"obj":"protein"},{"id":"T38","span":{"begin":1603,"end":1609},"obj":"protein"},{"id":"T39","span":{"begin":1664,"end":1673},"obj":"protein"},{"id":"T40","span":{"begin":1677,"end":1682},"obj":"protein"},{"id":"T41","span":{"begin":1702,"end":1732},"obj":"protein"},{"id":"T42","span":{"begin":1784,"end":1793},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"},{"subj":"T27","pred":"source","obj":"jnlpba-st-training"},{"subj":"T28","pred":"source","obj":"jnlpba-st-training"},{"subj":"T29","pred":"source","obj":"jnlpba-st-training"},{"subj":"T30","pred":"source","obj":"jnlpba-st-training"},{"subj":"T31","pred":"source","obj":"jnlpba-st-training"},{"subj":"T32","pred":"source","obj":"jnlpba-st-training"},{"subj":"T33","pred":"source","obj":"jnlpba-st-training"},{"subj":"T34","pred":"source","obj":"jnlpba-st-training"},{"subj":"T35","pred":"source","obj":"jnlpba-st-training"},{"subj":"T36","pred":"source","obj":"jnlpba-st-training"},{"subj":"T37","pred":"source","obj":"jnlpba-st-training"},{"subj":"T38","pred":"source","obj":"jnlpba-st-training"},{"subj":"T39","pred":"source","obj":"jnlpba-st-training"},{"subj":"T40","pred":"source","obj":"jnlpba-st-training"},{"subj":"T41","pred":"source","obj":"jnlpba-st-training"},{"subj":"T42","pred":"source","obj":"jnlpba-st-training"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"T2","span":{"begin":144,"end":263},"obj":"Sentence"},{"id":"T3","span":{"begin":264,"end":619},"obj":"Sentence"},{"id":"T4","span":{"begin":620,"end":786},"obj":"Sentence"},{"id":"T5","span":{"begin":787,"end":890},"obj":"Sentence"},{"id":"T6","span":{"begin":891,"end":1020},"obj":"Sentence"},{"id":"T7","span":{"begin":1021,"end":1103},"obj":"Sentence"},{"id":"T8","span":{"begin":1104,"end":1241},"obj":"Sentence"},{"id":"T9","span":{"begin":1242,"end":1451},"obj":"Sentence"},{"id":"T10","span":{"begin":1452,"end":1683},"obj":"Sentence"},{"id":"T11","span":{"begin":1684,"end":1826},"obj":"Sentence"},{"id":"T12","span":{"begin":1827,"end":1963},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":412,"end":417},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":1937,"end":1943},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"137507"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"S2","span":{"begin":144,"end":263},"obj":"Sentence"},{"id":"S3","span":{"begin":264,"end":619},"obj":"Sentence"},{"id":"S4","span":{"begin":620,"end":786},"obj":"Sentence"},{"id":"S5","span":{"begin":787,"end":890},"obj":"Sentence"},{"id":"S6","span":{"begin":891,"end":1020},"obj":"Sentence"},{"id":"S7","span":{"begin":1021,"end":1103},"obj":"Sentence"},{"id":"S8","span":{"begin":1104,"end":1241},"obj":"Sentence"},{"id":"S9","span":{"begin":1242,"end":1451},"obj":"Sentence"},{"id":"S10","span":{"begin":1452,"end":1683},"obj":"Sentence"},{"id":"S11","span":{"begin":1684,"end":1826},"obj":"Sentence"},{"id":"S12","span":{"begin":1827,"end":1963},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S10","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S11","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S12","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":24,"end":42},"obj":"lipid"},{"id":"T2","span":{"begin":47,"end":68},"obj":"protein_family_or_group"},{"id":"T3","span":{"begin":72,"end":81},"obj":"protein_molecule"},{"id":"T4","span":{"begin":82,"end":89},"obj":"protein_molecule"},{"id":"T5","span":{"begin":123,"end":130},"obj":"protein_molecule"},{"id":"T6","span":{"begin":148,"end":170},"obj":"other_organic_compound"},{"id":"T7","span":{"begin":171,"end":189},"obj":"lipid"},{"id":"T8","span":{"begin":191,"end":194},"obj":"lipid"},{"id":"T9","span":{"begin":200,"end":221},"obj":"protein_family_or_group"},{"id":"T10","span":{"begin":223,"end":226},"obj":"protein_family_or_group"},{"id":"T11","span":{"begin":253,"end":262},"obj":"protein_complex"},{"id":"T12","span":{"begin":326,"end":333},"obj":"protein_molecule"},{"id":"T13","span":{"begin":342,"end":345},"obj":"protein_molecule"},{"id":"T14","span":{"begin":373,"end":380},"obj":"protein_molecule"},{"id":"T15","span":{"begin":412,"end":433},"obj":"cell_type"},{"id":"T16","span":{"begin":467,"end":486},"obj":"protein_family_or_group"},{"id":"T17","span":{"begin":487,"end":496},"obj":"protein_molecule"},{"id":"T18","span":{"begin":498,"end":506},"obj":"protein_molecule"},{"id":"T19","span":{"begin":508,"end":517},"obj":"protein_complex"},{"id":"T20","span":{"begin":535,"end":538},"obj":"protein_molecule"},{"id":"T21","span":{"begin":541,"end":550},"obj":"protein_molecule"},{"id":"T22","span":{"begin":552,"end":561},"obj":"protein_molecule"},{"id":"T23","span":{"begin":588,"end":599},"obj":"protein_complex"},{"id":"T24","span":{"begin":646,"end":649},"obj":"protein_family_or_group"},{"id":"T25","span":{"begin":696,"end":699},"obj":"protein_family_or_group"},{"id":"T26","span":{"begin":741,"end":744},"obj":"protein_family_or_group"},{"id":"T27","span":{"begin":759,"end":767},"obj":"protein_molecule"},{"id":"T28","span":{"begin":800,"end":803},"obj":"lipid"},{"id":"T29","span":{"begin":829,"end":837},"obj":"protein_molecule"},{"id":"T30","span":{"begin":950,"end":953},"obj":"lipid"},{"id":"T31","span":{"begin":1155,"end":1164},"obj":"protein_molecule"},{"id":"T32","span":{"begin":1187,"end":1190},"obj":"protein_molecule"},{"id":"T33","span":{"begin":1192,"end":1199},"obj":"protein_molecule"},{"id":"T34","span":{"begin":1210,"end":1218},"obj":"protein_molecule"},{"id":"T35","span":{"begin":1222,"end":1240},"obj":"cell_type"},{"id":"T36","span":{"begin":1254,"end":1257},"obj":"lipid"},{"id":"T37","span":{"begin":1261,"end":1264},"obj":"protein_family_or_group"},{"id":"T38","span":{"begin":1297,"end":1304},"obj":"protein_molecule"},{"id":"T39","span":{"begin":1315,"end":1322},"obj":"protein_molecule"},{"id":"T40","span":{"begin":1394,"end":1403},"obj":"protein_molecule"},{"id":"T41","span":{"begin":1405,"end":1413},"obj":"protein_molecule"},{"id":"T42","span":{"begin":1419,"end":1422},"obj":"protein_molecule"},{"id":"T43","span":{"begin":1452,"end":1455},"obj":"protein_molecule"},{"id":"T44","span":{"begin":1477,"end":1484},"obj":"protein_molecule"},{"id":"T45","span":{"begin":1572,"end":1575},"obj":"protein_molecule"},{"id":"T46","span":{"begin":1603,"end":1609},"obj":"protein_molecule"},{"id":"T47","span":{"begin":1664,"end":1673},"obj":"protein_molecule"},{"id":"T48","span":{"begin":1677,"end":1682},"obj":"protein_molecule"},{"id":"T49","span":{"begin":1702,"end":1713},"obj":"protein_complex"},{"id":"T50","span":{"begin":1784,"end":1793},"obj":"protein_complex"},{"id":"T51","span":{"begin":1937,"end":1962},"obj":"other_name"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"},{"subj":"T40","pred":"source","obj":"GENIAcorpus"},{"subj":"T41","pred":"source","obj":"GENIAcorpus"},{"subj":"T42","pred":"source","obj":"GENIAcorpus"},{"subj":"T43","pred":"source","obj":"GENIAcorpus"},{"subj":"T44","pred":"source","obj":"GENIAcorpus"},{"subj":"T45","pred":"source","obj":"GENIAcorpus"},{"subj":"T46","pred":"source","obj":"GENIAcorpus"},{"subj":"T47","pred":"source","obj":"GENIAcorpus"},{"subj":"T48","pred":"source","obj":"GENIAcorpus"},{"subj":"T49","pred":"source","obj":"GENIAcorpus"},{"subj":"T50","pred":"source","obj":"GENIAcorpus"},{"subj":"T51","pred":"source","obj":"GENIAcorpus"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":47,"end":52},"obj":"Disease"},{"id":"T2","span":{"begin":200,"end":205},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":923,"end":928},"obj":"http://purl.obolibrary.org/obo/MAT_0000488"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"T2","span":{"begin":144,"end":263},"obj":"Sentence"},{"id":"T3","span":{"begin":264,"end":619},"obj":"Sentence"},{"id":"T4","span":{"begin":620,"end":786},"obj":"Sentence"},{"id":"T5","span":{"begin":787,"end":890},"obj":"Sentence"},{"id":"T6","span":{"begin":891,"end":1020},"obj":"Sentence"},{"id":"T7","span":{"begin":1021,"end":1103},"obj":"Sentence"},{"id":"T8","span":{"begin":1104,"end":1241},"obj":"Sentence"},{"id":"T9","span":{"begin":1242,"end":1451},"obj":"Sentence"},{"id":"T10","span":{"begin":1452,"end":1683},"obj":"Sentence"},{"id":"T11","span":{"begin":1684,"end":1826},"obj":"Sentence"},{"id":"T12","span":{"begin":1827,"end":1963},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"T2","span":{"begin":144,"end":263},"obj":"Sentence"},{"id":"T3","span":{"begin":264,"end":619},"obj":"Sentence"},{"id":"T4","span":{"begin":620,"end":786},"obj":"Sentence"},{"id":"T5","span":{"begin":787,"end":890},"obj":"Sentence"},{"id":"T6","span":{"begin":891,"end":1020},"obj":"Sentence"},{"id":"T7","span":{"begin":1021,"end":1103},"obj":"Sentence"},{"id":"T8","span":{"begin":1104,"end":1241},"obj":"Sentence"},{"id":"T9","span":{"begin":1242,"end":1451},"obj":"Sentence"},{"id":"T10","span":{"begin":1452,"end":1683},"obj":"Sentence"},{"id":"T11","span":{"begin":1684,"end":1826},"obj":"Sentence"},{"id":"T12","span":{"begin":1827,"end":1963},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":923,"end":928},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000488"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":47,"end":52},"obj":"Phenotype"},{"id":"T2","span":{"begin":200,"end":205},"obj":"Phenotype"},{"id":"T3","span":{"begin":1937,"end":1943},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002664"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002664"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0100806"},{"subj":"T1","pred":"source","obj":"HP-phenotype"},{"subj":"T2","pred":"source","obj":"HP-phenotype"},{"subj":"T3","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":72,"end":81},"obj":"Cell"},{"id":"T3","span":{"begin":418,"end":427},"obj":"Cell"},{"id":"T5","span":{"begin":1211,"end":1218},"obj":"Cell"},{"id":"T6","span":{"begin":1323,"end":1330},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A2","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A4","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0003025"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0003025"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T3","pred":"source","obj":"CL-cell"},{"subj":"T5","pred":"source","obj":"CL-cell"},{"subj":"T6","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#a0ec93","default":true},{"id":"PubmedHPO","color":"#ec93ba"},{"id":"jnlpba-st-training","color":"#93d4ec"},{"id":"sentences","color":"#ecea93"},{"id":"NCBITAXON","color":"#d093ec"},{"id":"pubmed-sentences-benchmark","color":"#93ecb6"},{"id":"GENIAcorpus","color":"#ec9c93"},{"id":"mondo_disease","color":"#93a4ec"},{"id":"Glycosmos6-MAT","color":"#beec93"},{"id":"Inflammaging","color":"#ec93d8"},{"id":"Anatomy-MAT","color":"#93ece6"},{"id":"HP-phenotype","color":"#eccc93"},{"id":"CL-cell","color":"#b293ec"}]}]}}