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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
T2 144-263 Sentence denotes The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.
T3 264-619 Sentence denotes This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.
T4 620-786 Sentence denotes Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.
T5 787-890 Sentence denotes In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.
T6 891-1020 Sentence denotes A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.
T7 1021-1103 Sentence denotes The endogenous levels of the signalsome components were unaffected by stimulation.
T8 1104-1241 Sentence denotes Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.
T9 1242-1451 Sentence denotes Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.
T10 1452-1683 Sentence denotes NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.
T11 1684-1826 Sentence denotes Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.
T12 1827-1963 Sentence denotes The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.
T1 0-143 Sentence denotes Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
T2 144-263 Sentence denotes The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.
T3 264-619 Sentence denotes This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.
T4 620-786 Sentence denotes Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.
T5 787-890 Sentence denotes In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.
T6 891-1020 Sentence denotes A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.
T7 1021-1103 Sentence denotes The endogenous levels of the signalsome components were unaffected by stimulation.
T8 1104-1241 Sentence denotes Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.
T9 1242-1451 Sentence denotes Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.
T10 1452-1683 Sentence denotes NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.
T11 1684-1826 Sentence denotes Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.
T12 1827-1963 Sentence denotes The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.

sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
T2 144-263 Sentence denotes The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.
T3 264-619 Sentence denotes This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.
T4 620-786 Sentence denotes Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.
T5 787-890 Sentence denotes In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.
T6 891-1020 Sentence denotes A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.
T7 1021-1103 Sentence denotes The endogenous levels of the signalsome components were unaffected by stimulation.
T8 1104-1241 Sentence denotes Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.
T9 1242-1451 Sentence denotes Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.
T10 1452-1683 Sentence denotes NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.
T11 1684-1826 Sentence denotes Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.
T12 1827-1963 Sentence denotes The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 923-928 http://purl.obolibrary.org/obo/MAT_0000488 denotes later

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 200-205 HP_0002664 denotes tumor
T2 1937-1943 HP_0100806 denotes sepsis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 47-68 protein denotes tumor necrosis factor
T2 72-96 protein denotes monocytic IkappaB kinase
T3 123-130 protein denotes IkappaB
T4 200-221 protein denotes tumor necrosis factor
T5 223-226 protein denotes TNF
T6 253-262 protein denotes NF-kappaB
T7 326-340 protein denotes IkappaB kinase
T8 342-345 protein denotes IKK
T9 373-380 protein denotes IkappaB
T10 412-433 cell_type denotes human monocytic cells
T11 467-486 protein denotes signalsome proteins
T12 487-496 protein denotes IKK-alpha
T13 498-506 protein denotes IKK-beta
T14 508-533 protein denotes NF-kappaB-inducing kinase
T15 535-538 protein denotes NIK
T16 541-550 protein denotes IKK-gamma
T17 552-561 protein denotes NF-kappaB
T18 588-618 protein denotes IKK complex-associated protein
T19 646-649 protein denotes TNF
T20 696-699 protein denotes IKK
T21 741-750 protein denotes IKK-alpha
T22 759-767 protein denotes IKK-beta
T23 829-837 protein denotes IKK-beta
T24 1155-1181 protein denotes IKK-alpha/beta heterodimer
T25 1187-1190 protein denotes NIK
T26 1192-1205 protein denotes IkappaB-alpha
T27 1210-1218 protein denotes -epsilon
T28 1222-1240 cell_type denotes unstimulated cells
T29 1261-1264 protein denotes TNF
T30 1297-1310 protein denotes IkappaB-alpha
T31 1315-1330 protein denotes IkappaB-epsilon
T32 1394-1403 protein denotes IKK-alpha
T33 1405-1413 protein denotes IKK-beta
T34 1419-1422 protein denotes NIK
T35 1452-1455 protein denotes NIK
T36 1477-1490 protein denotes IkappaB-alpha
T37 1572-1575 protein denotes NIK
T38 1603-1609 protein denotes kappaB
T39 1664-1673 protein denotes IKK-alpha
T40 1677-1682 protein denotes -beta
T41 1702-1732 protein denotes IKK complex-associated protein
T42 1784-1793 protein denotes NF-kappaB

genia-medco-coref

Id Subject Object Predicate Lexical cue
C42 24-42 NP denotes lipopolysaccharide
C43 47-68 NP denotes tumor necrosis factor
C1 144-195 NP denotes The inflammatory mediators lipopolysaccharide (LPS)
C6 200-227 NP denotes tumor necrosis factor (TNF)
C44 253-262 NP denotes NF-kappaB
C18 487-496 NP denotes IKK-alpha
C20 498-506 NP denotes IKK-beta
C49 508-518 NP denotes NF-kappaB-
C10 508-539 NP denotes NF-kappaB-inducing kinase (NIK)
C41 541-582 NP denotes IKK-gamma (NF-kappaB essential modulator)
C7 646-649 NP denotes TNF
C4 741-750 NP denotes IKK-alpha
C19 759-767 NP denotes IKK-beta
C2 800-803 NP denotes LPS
C45 829-846 NP denotes IKK-beta activity
C46 848-853 NP denotes which
C47 950-965 NP denotes LPS stimulation
C48 967-972 NP denotes which
C17 991-1019 NP denotes IKK-alpha and -beta activity
C11 1187-1190 NP denotes NIK
C22 1192-1205 NP denotes IkappaB-alpha
C24 1210-1218 NP denotes -epsilon
C8 1254-1257 NP denotes LPS
C9 1261-1264 NP denotes TNF
C23 1297-1310 NP denotes IkappaB-alpha
C25 1315-1330 NP denotes IkappaB-epsilon
C27 1394-1403 NP denotes IKK-alpha
C29 1405-1413 NP denotes IKK-beta
C15 1419-1422 NP denotes NIK
C16 1452-1455 NP denotes NIK
C33 1477-1490 NP denotes IkappaB-alpha
C50 1505-1507 NP denotes it
C39 1743-1774 NP denotes stimulus-mediated transcription
C38 1784-1813 NP denotes NF-kappaB essential modulator
C40 1823-1825 NP denotes it
C51 1848-1852 NP denotes LPS-
C52 1857-1861 NP denotes TNF-
R1 C1 C42 coref-xxx The inflammatory mediators lipopolysaccharide (LPS),lipopolysaccharide
R2 C6 C43 coref-xxx tumor necrosis factor (TNF),tumor necrosis factor
R3 C10 C44 coref-ident NF-kappaB-inducing kinase (NIK),NF-kappaB
R4 C7 C6 coref-ident TNF,tumor necrosis factor (TNF)
R5 C4 C18 coref-ident IKK-alpha,IKK-alpha
R6 C19 C20 coref-ident IKK-beta,IKK-beta
R7 C2 C1 coref-ident LPS,The inflammatory mediators lipopolysaccharide (LPS)
R8 C46 C45 coref-relat which,IKK-beta activity
R9 C48 C47 coref-relat which,LPS stimulation
R10 C17 C45 coref-whole-part IKK-alpha and -beta activity,IKK-beta activity
R11 C11 C49 coref-ident NIK,NF-kappaB-
R12 C8 C2 coref-ident LPS,LPS
R13 C9 C7 coref-ident TNF,TNF
R14 C23 C22 coref-ident IkappaB-alpha,IkappaB-alpha
R15 C25 C24 coref-ident IkappaB-epsilon,-epsilon
R16 C27 C18 coref-ident IKK-alpha,IKK-alpha
R17 C29 C20 coref-ident IKK-beta,IKK-beta
R18 C15 C11 coref-ident NIK,NIK
R19 C16 C15 coref-ident NIK,NIK
R20 C33 C23 coref-ident IkappaB-alpha,IkappaB-alpha
R21 C50 C16 coref-pron it,NIK
R22 C38 C41 coref-ident NF-kappaB essential modulator,IKK-gamma (NF-kappaB essential modulator)
R23 C40 C39 coref-pron it,stimulus-mediated transcription
R24 C51 C8 coref-ident LPS-,LPS
R25 C52 C9 coref-ident TNF-,TNF

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-143 Sentence denotes Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
S2 144-263 Sentence denotes The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.
S3 264-619 Sentence denotes This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.
S4 620-786 Sentence denotes Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.
S5 787-890 Sentence denotes In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.
S6 891-1020 Sentence denotes A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.
S7 1021-1103 Sentence denotes The endogenous levels of the signalsome components were unaffected by stimulation.
S8 1104-1241 Sentence denotes Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.
S9 1242-1451 Sentence denotes Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.
S10 1452-1683 Sentence denotes NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.
S11 1684-1826 Sentence denotes Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.
S12 1827-1963 Sentence denotes The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 24-42 lipid denotes lipopolysaccharide
T2 47-68 protein_family_or_group denotes tumor necrosis factor
T3 72-81 protein_molecule denotes monocytic
T4 82-89 protein_molecule denotes IkappaB
T5 123-130 protein_molecule denotes IkappaB
T6 148-170 other_organic_compound denotes inflammatory mediators
T7 171-189 lipid denotes lipopolysaccharide
T8 191-194 lipid denotes LPS
T9 200-221 protein_family_or_group denotes tumor necrosis factor
T10 223-226 protein_family_or_group denotes TNF
T11 253-262 protein_complex denotes NF-kappaB
T12 326-333 protein_molecule denotes IkappaB
T13 342-345 protein_molecule denotes IKK
T14 373-380 protein_molecule denotes IkappaB
T15 412-433 cell_type denotes human monocytic cells
T16 467-486 protein_family_or_group denotes signalsome proteins
T17 487-496 protein_molecule denotes IKK-alpha
T18 498-506 protein_molecule denotes IKK-beta
T19 508-517 protein_complex denotes NF-kappaB
T20 535-538 protein_molecule denotes NIK
T21 541-550 protein_molecule denotes IKK-gamma
T22 552-561 protein_molecule denotes NF-kappaB
T23 588-599 protein_complex denotes IKK complex
T24 646-649 protein_family_or_group denotes TNF
T25 696-699 protein_family_or_group denotes IKK
T26 741-744 protein_family_or_group denotes IKK
T27 759-767 protein_molecule denotes IKK-beta
T28 800-803 lipid denotes LPS
T29 829-837 protein_molecule denotes IKK-beta
T30 950-953 lipid denotes LPS
T31 1155-1164 protein_molecule denotes IKK-alpha
T32 1187-1190 protein_molecule denotes NIK
T33 1192-1199 protein_molecule denotes IkappaB
T34 1210-1218 protein_molecule denotes -epsilon
T35 1222-1240 cell_type denotes unstimulated cells
T36 1254-1257 lipid denotes LPS
T37 1261-1264 protein_family_or_group denotes TNF
T38 1297-1304 protein_molecule denotes IkappaB
T39 1315-1322 protein_molecule denotes IkappaB
T40 1394-1403 protein_molecule denotes IKK-alpha
T41 1405-1413 protein_molecule denotes IKK-beta
T42 1419-1422 protein_molecule denotes NIK
T43 1452-1455 protein_molecule denotes NIK
T44 1477-1484 protein_molecule denotes IkappaB
T45 1572-1575 protein_molecule denotes NIK
T46 1603-1609 protein_molecule denotes kappaB
T47 1664-1673 protein_molecule denotes IKK-alpha
T48 1677-1682 protein_molecule denotes -beta
T49 1702-1713 protein_complex denotes IKK complex
T50 1784-1793 protein_complex denotes NF-kappaB
T51 1937-1962 other_name denotes sepsis-associated disease

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 47-52 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 200-205 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 412-417 OrganismTaxon denotes human 9606
T2 1937-1943 OrganismTaxon denotes sepsis 137507

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 923-928 Body_part denotes later http://purl.obolibrary.org/obo/MAT_0000488

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 47-52 Phenotype denotes tumor HP:0002664
T2 200-205 Phenotype denotes tumor HP:0002664
T3 1937-1943 Phenotype denotes sepsis HP:0100806

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 72-81 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 418-427 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 1211-1218 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025
T6 1323-1330 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025