PubMed:10449776 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10449776","sourcedb":"PubMed","sourceid":"10449776","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10449776","text":"TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.\nAIDS-related non-Hodgkin's lymphoma (AIDS NHL) comprises a diverse and heterogeneous group of high-grade B cell tumors. Certain classes of AIDS NHL are associated with alterations in oncogenes or tumor-suppressor genes or infections by oncogenic herpesviruses. However, the clinically significant class of AIDS NHL designated immunoblastic lymphoma plasmacytoid (AIDS IBLP) lacks any consistent genetic alterations. We identified the TCL1 oncogene from a set of AIDS IBLP-associated cDNA fragments generated by subtractive hybridization with non-AIDS IBLP. Aberrant TCL1 expression has been implicated in T cell leukemia/lymphoma development, and its expression also has been seen in many established B cell tumor lines. However, TCL1 expression has not been reported in AIDS NHL. We find that TCL1 is expressed in the majority of AIDS IBLP tumors examined. TCL1 protein expression is restricted to tumor cells in AIDS IBLP tissue samples analyzed with immunohistochemical staining. Hyperplastic lymph node and tonsil also exhibit strong TCL1 protein expression in mantle zone B cells and in rare interfollicular zone cells, whereas follicle-center B cells (centroblasts and centrocytes) show weaker expression. These results establish TCL1 as the most prevalent of all of the surveyed oncogenes associated with AIDS IBLP. They also indicate that abundant TCL1 expression in quiescent mantle zone B cells is down-regulated in activated germinal center follicular B cells in parallel to the known expression pattern of BCL-2. High-level expression in nonproliferating B cells suggests that TCL1 may function in protecting naïve preactivated B cells from apoptosis.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C6","span":{"begin":0,"end":13},"obj":"NP"},{"id":"C22","span":{"begin":28,"end":33},"obj":"NP"},{"id":"C23","span":{"begin":73,"end":78},"obj":"NP"},{"id":"C1","span":{"begin":73,"end":119},"obj":"NP"},{"id":"C2","span":{"begin":212,"end":220},"obj":"NP"},{"id":"C4","span":{"begin":379,"end":446},"obj":"NP"},{"id":"C7","span":{"begin":503,"end":520},"obj":"NP"},{"id":"C5","span":{"begin":535,"end":545},"obj":"NP"},{"id":"C20","span":{"begin":630,"end":654},"obj":"NP"},{"id":"C21","span":{"begin":720,"end":723},"obj":"NP"},{"id":"C9","span":{"begin":803,"end":818},"obj":"NP"},{"id":"C10","span":{"begin":844,"end":852},"obj":"NP"},{"id":"C17","span":{"begin":867,"end":871},"obj":"NP"},{"id":"C19","span":{"begin":1309,"end":1313},"obj":"NP"},{"id":"C15","span":{"begin":1385,"end":1394},"obj":"NP"},{"id":"C18","span":{"begin":1662,"end":1666},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C23","obj":"C22"},{"id":"R2","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-ident","subj":"C5","obj":"C4"},{"id":"R5","pred":"coref-pron","subj":"C21","obj":"C20"},{"id":"R6","pred":"coref-other","subj":"C9","obj":"C20"},{"id":"R7","pred":"coref-ident","subj":"C10","obj":"C2"},{"id":"R8","pred":"coref-ident","subj":"C19","obj":"C17"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C5"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C19"}],"attributes":[{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C23","pred":"source","obj":"genia-medco-coref"},{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":86,"end":108},"obj":"HP_0012539"},{"id":"T2","span":{"begin":90,"end":108},"obj":"HP_0012189"},{"id":"T3","span":{"begin":100,"end":108},"obj":"HP_0002665"},{"id":"T4","span":{"begin":185,"end":191},"obj":"HP_0002664"},{"id":"T5","span":{"begin":269,"end":274},"obj":"HP_0002664"},{"id":"T6","span":{"begin":413,"end":421},"obj":"HP_0002665"},{"id":"T7","span":{"begin":678,"end":702},"obj":"HP_0005517"},{"id":"T8","span":{"begin":685,"end":693},"obj":"HP_0001909"},{"id":"T9","span":{"begin":694,"end":702},"obj":"HP_0002665"},{"id":"T10","span":{"begin":781,"end":786},"obj":"HP_0002664"},{"id":"T11","span":{"begin":914,"end":920},"obj":"HP_0002664"},{"id":"T12","span":{"begin":972,"end":977},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"},{"subj":"T11","pred":"source","obj":"PubmedHPO"},{"subj":"T12","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":0,"end":4},"obj":"gene:9623"},{"id":"T1","span":{"begin":28,"end":50},"obj":"disease:C0085090"},{"id":"T2","span":{"begin":0,"end":4},"obj":"gene:8115"},{"id":"T3","span":{"begin":28,"end":50},"obj":"disease:C0085090"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":13},"obj":"DNA"},{"id":"T2","span":{"begin":256,"end":265},"obj":"DNA"},{"id":"T3","span":{"begin":269,"end":291},"obj":"DNA"},{"id":"T4","span":{"begin":507,"end":520},"obj":"DNA"},{"id":"T5","span":{"begin":535,"end":570},"obj":"DNA"},{"id":"T6","span":{"begin":639,"end":643},"obj":"protein"},{"id":"T7","span":{"begin":774,"end":792},"obj":"cell_line"},{"id":"T8","span":{"begin":803,"end":807},"obj":"protein"},{"id":"T9","span":{"begin":867,"end":871},"obj":"protein"},{"id":"T10","span":{"begin":931,"end":935},"obj":"protein"},{"id":"T11","span":{"begin":1111,"end":1115},"obj":"protein"},{"id":"T12","span":{"begin":1138,"end":1157},"obj":"cell_type"},{"id":"T13","span":{"begin":1170,"end":1196},"obj":"cell_type"},{"id":"T14","span":{"begin":1206,"end":1229},"obj":"cell_type"},{"id":"T15","span":{"begin":1231,"end":1243},"obj":"cell_type"},{"id":"T16","span":{"begin":1248,"end":1259},"obj":"cell_type"},{"id":"T17","span":{"begin":1309,"end":1313},"obj":"protein"},{"id":"T18","span":{"begin":1359,"end":1368},"obj":"DNA"},{"id":"T19","span":{"begin":1429,"end":1433},"obj":"protein"},{"id":"T20","span":{"begin":1448,"end":1477},"obj":"cell_type"},{"id":"T21","span":{"begin":1509,"end":1543},"obj":"cell_type"},{"id":"T22","span":{"begin":1591,"end":1596},"obj":"protein"},{"id":"T23","span":{"begin":1623,"end":1647},"obj":"cell_type"},{"id":"T24","span":{"begin":1662,"end":1666},"obj":"protein"},{"id":"T25","span":{"begin":1694,"end":1720},"obj":"cell_type"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":72},"obj":"Sentence"},{"id":"S2","span":{"begin":73,"end":192},"obj":"Sentence"},{"id":"S3","span":{"begin":193,"end":333},"obj":"Sentence"},{"id":"S4","span":{"begin":334,"end":488},"obj":"Sentence"},{"id":"S5","span":{"begin":489,"end":629},"obj":"Sentence"},{"id":"S6","span":{"begin":630,"end":793},"obj":"Sentence"},{"id":"S7","span":{"begin":794,"end":853},"obj":"Sentence"},{"id":"S8","span":{"begin":854,"end":930},"obj":"Sentence"},{"id":"S9","span":{"begin":931,"end":1055},"obj":"Sentence"},{"id":"S10","span":{"begin":1056,"end":1284},"obj":"Sentence"},{"id":"S11","span":{"begin":1285,"end":1395},"obj":"Sentence"},{"id":"S12","span":{"begin":1396,"end":1597},"obj":"Sentence"},{"id":"S13","span":{"begin":1598,"end":1736},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S10","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S11","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S12","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S13","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":13},"obj":"DNA_domain_or_region"},{"id":"T2","span":{"begin":28,"end":50},"obj":"tissue"},{"id":"T3","span":{"begin":55,"end":71},"obj":"tissue"},{"id":"T4","span":{"begin":73,"end":108},"obj":"other_name"},{"id":"T5","span":{"begin":110,"end":118},"obj":"other_name"},{"id":"T6","span":{"begin":167,"end":191},"obj":"tissue"},{"id":"T7","span":{"begin":212,"end":220},"obj":"other_name"},{"id":"T8","span":{"begin":256,"end":265},"obj":"DNA_family_or_group"},{"id":"T9","span":{"begin":269,"end":291},"obj":"DNA_family_or_group"},{"id":"T10","span":{"begin":309,"end":332},"obj":"virus"},{"id":"T11","span":{"begin":379,"end":387},"obj":"other_name"},{"id":"T12","span":{"begin":399,"end":434},"obj":"other_name"},{"id":"T13","span":{"begin":436,"end":445},"obj":"other_name"},{"id":"T14","span":{"begin":507,"end":520},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":535,"end":544},"obj":"other_name"},{"id":"T16","span":{"begin":584,"end":609},"obj":"other_name"},{"id":"T17","span":{"begin":615,"end":619},"obj":"other_name"},{"id":"T18","span":{"begin":619,"end":628},"obj":"other_name"},{"id":"T19","span":{"begin":639,"end":643},"obj":"protein_molecule"},{"id":"T20","span":{"begin":678,"end":714},"obj":"other_name"},{"id":"T21","span":{"begin":774,"end":792},"obj":"cell_line"},{"id":"T22","span":{"begin":803,"end":807},"obj":"protein_molecule"},{"id":"T23","span":{"begin":844,"end":852},"obj":"other_name"},{"id":"T24","span":{"begin":867,"end":871},"obj":"protein_molecule"},{"id":"T25","span":{"begin":904,"end":913},"obj":"other_name"},{"id":"T26","span":{"begin":931,"end":935},"obj":"protein_molecule"},{"id":"T27","span":{"begin":987,"end":996},"obj":"other_name"},{"id":"T28","span":{"begin":1026,"end":1054},"obj":"other_name"},{"id":"T29","span":{"begin":1056,"end":1079},"obj":"body_part"},{"id":"T30","span":{"begin":1084,"end":1090},"obj":"body_part"},{"id":"T31","span":{"begin":1111,"end":1115},"obj":"protein_molecule"},{"id":"T32","span":{"begin":1138,"end":1157},"obj":"cell_type"},{"id":"T33","span":{"begin":1170,"end":1196},"obj":"cell_type"},{"id":"T34","span":{"begin":1206,"end":1229},"obj":"cell_type"},{"id":"T35","span":{"begin":1231,"end":1243},"obj":"cell_type"},{"id":"T36","span":{"begin":1248,"end":1259},"obj":"cell_type"},{"id":"T37","span":{"begin":1309,"end":1313},"obj":"protein_molecule"},{"id":"T38","span":{"begin":1359,"end":1368},"obj":"DNA_family_or_group"},{"id":"T39","span":{"begin":1385,"end":1394},"obj":"other_name"},{"id":"T40","span":{"begin":1429,"end":1433},"obj":"protein_molecule"},{"id":"T41","span":{"begin":1448,"end":1457},"obj":"cell_type"},{"id":"T42","span":{"begin":1458,"end":1477},"obj":"cell_type"},{"id":"T43","span":{"begin":1509,"end":1543},"obj":"cell_type"},{"id":"T44","span":{"begin":1591,"end":1596},"obj":"protein_molecule"},{"id":"T45","span":{"begin":1623,"end":1647},"obj":"cell_type"},{"id":"T46","span":{"begin":1662,"end":1666},"obj":"protein_molecule"},{"id":"T47","span":{"begin":1694,"end":1720},"obj":"cell_type"},{"id":"T48","span":{"begin":1726,"end":1735},"obj":"other_name"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"},{"subj":"T40","pred":"source","obj":"GENIAcorpus"},{"subj":"T41","pred":"source","obj":"GENIAcorpus"},{"subj":"T42","pred":"source","obj":"GENIAcorpus"},{"subj":"T43","pred":"source","obj":"GENIAcorpus"},{"subj":"T44","pred":"source","obj":"GENIAcorpus"},{"subj":"T45","pred":"source","obj":"GENIAcorpus"},{"subj":"T46","pred":"source","obj":"GENIAcorpus"},{"subj":"T47","pred":"source","obj":"GENIAcorpus"},{"subj":"T48","pred":"source","obj":"GENIAcorpus"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"10449776-0#0#4#gene8115","span":{"begin":0,"end":4},"obj":"gene8115"},{"id":"10449776-0#0#4#gene9623","span":{"begin":0,"end":4},"obj":"gene9623"},{"id":"10449776-0#28#50#diseaseC0085090","span":{"begin":28,"end":50},"obj":"diseaseC0085090"},{"id":"10449776-5#9#13#gene8115","span":{"begin":639,"end":643},"obj":"gene8115"},{"id":"10449776-5#9#13#gene9623","span":{"begin":639,"end":643},"obj":"gene9623"},{"id":"10449776-5#9#13#gene8115","span":{"begin":639,"end":643},"obj":"gene8115"},{"id":"10449776-5#9#13#gene9623","span":{"begin":639,"end":643},"obj":"gene9623"},{"id":"10449776-5#48#63#diseaseC0023492","span":{"begin":678,"end":693},"obj":"diseaseC0023492"},{"id":"10449776-5#64#72#diseaseC0024299","span":{"begin":694,"end":702},"obj":"diseaseC0024299"},{"id":"10449776-9#55#59#gene8115","span":{"begin":1111,"end":1115},"obj":"gene8115"},{"id":"10449776-9#55#59#gene9623","span":{"begin":1111,"end":1115},"obj":"gene9623"},{"id":"10449776-9#0#23#diseaseC0340782","span":{"begin":1056,"end":1079},"obj":"diseaseC0340782"}],"relations":[{"id":"0#4#gene811528#50#diseaseC0085090","pred":"associated_with","subj":"10449776-0#0#4#gene8115","obj":"10449776-0#28#50#diseaseC0085090"},{"id":"0#4#gene962328#50#diseaseC0085090","pred":"associated_with","subj":"10449776-0#0#4#gene9623","obj":"10449776-0#28#50#diseaseC0085090"},{"id":"9#13#gene811548#63#diseaseC0023492","pred":"associated_with","subj":"10449776-5#9#13#gene8115","obj":"10449776-5#48#63#diseaseC0023492"},{"id":"9#13#gene811564#72#diseaseC0024299","pred":"associated_with","subj":"10449776-5#9#13#gene8115","obj":"10449776-5#64#72#diseaseC0024299"},{"id":"9#13#gene962348#63#diseaseC0023492","pred":"associated_with","subj":"10449776-5#9#13#gene9623","obj":"10449776-5#48#63#diseaseC0023492"},{"id":"9#13#gene962364#72#diseaseC0024299","pred":"associated_with","subj":"10449776-5#9#13#gene9623","obj":"10449776-5#64#72#diseaseC0024299"},{"id":"9#13#gene811548#63#diseaseC0023492","pred":"associated_with","subj":"10449776-5#9#13#gene8115","obj":"10449776-5#48#63#diseaseC0023492"},{"id":"9#13#gene811564#72#diseaseC0024299","pred":"associated_with","subj":"10449776-5#9#13#gene8115","obj":"10449776-5#64#72#diseaseC0024299"},{"id":"9#13#gene962348#63#diseaseC0023492","pred":"associated_with","subj":"10449776-5#9#13#gene9623","obj":"10449776-5#48#63#diseaseC0023492"},{"id":"9#13#gene962364#72#diseaseC0024299","pred":"associated_with","subj":"10449776-5#9#13#gene9623","obj":"10449776-5#64#72#diseaseC0024299"},{"id":"55#59#gene81150#23#diseaseC0340782","pred":"associated_with","subj":"10449776-9#55#59#gene8115","obj":"10449776-9#0#23#diseaseC0340782"},{"id":"55#59#gene96230#23#diseaseC0340782","pred":"associated_with","subj":"10449776-9#55#59#gene9623","obj":"10449776-9#0#23#diseaseC0340782"}],"attributes":[{"subj":"10449776-0#0#4#gene8115","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-0#0#4#gene9623","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-0#28#50#diseaseC0085090","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-5#9#13#gene8115","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-5#9#13#gene9623","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-5#9#13#gene8115","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-5#9#13#gene9623","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-5#48#63#diseaseC0023492","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-5#64#72#diseaseC0024299","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-9#55#59#gene8115","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-9#55#59#gene9623","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10449776-9#0#23#diseaseC0340782","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":28,"end":50},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":73,"end":77},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":86,"end":108},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":110,"end":114},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":115,"end":118},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":212,"end":216},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":217,"end":220},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":269,"end":274},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":379,"end":383},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":384,"end":387},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":399,"end":421},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":436,"end":440},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":535,"end":539},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":619,"end":623},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":678,"end":693},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":694,"end":702},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T19","span":{"begin":781,"end":786},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T20","span":{"begin":844,"end":848},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T21","span":{"begin":849,"end":852},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T22","span":{"begin":904,"end":908},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T23","span":{"begin":972,"end":977},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T24","span":{"begin":987,"end":991},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T25","span":{"begin":1056,"end":1068},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T26","span":{"begin":1385,"end":1389},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0018842"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0012268"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0018908"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0012268"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0018908"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0012268"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0018908"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0005070"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0012268"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0018908"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"0022037"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"0012268"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"0012268"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"0012268"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"0005525"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"0003659"},{"id":"A17","pred":"mondo_id","subj":"T16","obj":"0003660"},{"id":"A18","pred":"mondo_id","subj":"T16","obj":"0005062"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"0005070"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"0012268"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"0018908"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"0012268"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"0005070"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"0012268"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"0005043"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"0012268"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T6","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T7","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T8","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T9","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T10","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T11","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T12","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T13","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T14","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T15","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T16","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T19","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T20","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T21","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T22","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T23","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T24","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T25","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T26","pred":"source","obj":"PMID_GLOBAL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#deec93","default":true},{"id":"PubmedHPO","color":"#df93ec"},{"id":"DisGeNET","color":"#93ecc5"},{"id":"jnlpba-st-training","color":"#ecab93"},{"id":"pubmed-sentences-benchmark","color":"#9394ec"},{"id":"GENIAcorpus","color":"#aeec93"},{"id":"DisGeNET5_gene_disease","color":"#ec93c8"},{"id":"PMID_GLOBAL","color":"#93e2ec"}]}]}}