> top > docs > PubMed:10449169 > annotations

PubMed:10449169 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-61 Sentence denotes Dendritic cells and the pathogenesis of rheumatoid arthritis.
T2 62-203 Sentence denotes Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease in which unknown arthrogenic autoantigen is presented to CD4+ T cells.
T3 204-382 Sentence denotes The strong association of the disease with an epitope within the HLA-DR chain shared between various alleles of HLA-DR4 and DR1 emphasizes the importance of antigen presentation.
T4 383-565 Sentence denotes This immune response predominantly occurs in the synovial tissue and fluid of the joints and autoreactive T cells are readily demonstrable in both the synovial compartment and blood.
T5 566-682 Sentence denotes Circulating dendritic cells (DC) are phenotypically and functionally identical with normal peripheral blood (PB) DC.
T6 683-850 Sentence denotes In the synovial tissue, fully differentiated perivascular DC are found in close association with T cells and with B cell follicles, sometimes containing follicular DC.
T7 851-1035 Sentence denotes These perivascular DC migrate across the activated endothelium from blood and receive differentiative signals within the joint from monocyte-derived cytokines and CD40-ligand+ T cells.
T8 1036-1134 Sentence denotes In the SF, DC manifest an intermediate phenotype, similar to that of monocyte-derived DC in vitro.
T9 1135-1234 Sentence denotes Like a delayed-type hypersensitivity response, the rheumatoid synovium represents an effector site.
T10 1235-1327 Sentence denotes DC at many effector sites have a characteristic pattern of infiltration and differentiation.
T11 1328-1430 Sentence denotes It is important to note that the effector response is not self-limiting in RA autoimmune inflammation.
T12 1431-1599 Sentence denotes In this article, we argue that the presentation of self-antigen by DC and by autoantibody-producing B cells is critical for the perpetuation of the autoimmune response.
T13 1600-1738 Sentence denotes Permanently arresting this ongoing immune response with either pharmaceutical agents or immunotherapy is a major challenge for immunology.
T1 0-61 Sentence denotes Dendritic cells and the pathogenesis of rheumatoid arthritis.
T2 62-203 Sentence denotes Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease in which unknown arthrogenic autoantigen is presented to CD4+ T cells.
T3 204-382 Sentence denotes The strong association of the disease with an epitope within the HLA-DR chain shared between various alleles of HLA-DR4 and DR1 emphasizes the importance of antigen presentation.
T4 383-565 Sentence denotes This immune response predominantly occurs in the synovial tissue and fluid of the joints and autoreactive T cells are readily demonstrable in both the synovial compartment and blood.
T5 566-682 Sentence denotes Circulating dendritic cells (DC) are phenotypically and functionally identical with normal peripheral blood (PB) DC.
T6 683-850 Sentence denotes In the synovial tissue, fully differentiated perivascular DC are found in close association with T cells and with B cell follicles, sometimes containing follicular DC.
T7 851-1035 Sentence denotes These perivascular DC migrate across the activated endothelium from blood and receive differentiative signals within the joint from monocyte-derived cytokines and CD40-ligand+ T cells.
T8 1036-1134 Sentence denotes In the SF, DC manifest an intermediate phenotype, similar to that of monocyte-derived DC in vitro.
T9 1135-1234 Sentence denotes Like a delayed-type hypersensitivity response, the rheumatoid synovium represents an effector site.
T10 1235-1327 Sentence denotes DC at many effector sites have a characteristic pattern of infiltration and differentiation.
T11 1328-1430 Sentence denotes It is important to note that the effector response is not self-limiting in RA autoimmune inflammation.
T12 1431-1599 Sentence denotes In this article, we argue that the presentation of self-antigen by DC and by autoantibody-producing B cells is critical for the perpetuation of the autoimmune response.
T13 1600-1738 Sentence denotes Permanently arresting this ongoing immune response with either pharmaceutical agents or immunotherapy is a major challenge for immunology.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 62-82 HP_0001370 denotes Rheumatoid arthritis
T2 73-82 HP_0001369 denotes arthritis
T3 101-111 HP_0002960 denotes autoimmune
T4 1406-1416 HP_0002960 denotes autoimmune
T5 1579-1589 HP_0002960 denotes autoimmune

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-15 cell_type denotes Dendritic cells
T2 150-173 protein denotes arthrogenic autoantigen
T3 190-202 cell_type denotes CD4+ T cells
T4 250-257 protein denotes epitope
T5 269-281 protein denotes HLA-DR chain
T6 316-323 protein denotes HLA-DR4
T7 328-331 protein denotes DR1
T8 476-496 cell_type denotes autoreactive T cells
T9 566-593 cell_type denotes Circulating dendritic cells
T10 595-597 cell_type denotes DC
T11 650-681 cell_type denotes normal peripheral blood (PB) DC
T12 728-743 cell_type denotes perivascular DC
T13 780-787 cell_type denotes T cells
T14 797-813 cell_type denotes B cell follicles
T15 836-849 cell_type denotes follicular DC
T16 857-872 cell_type denotes perivascular DC
T17 983-1009 protein denotes monocyte-derived cytokines
T18 1014-1034 cell_type denotes CD40-ligand+ T cells
T19 1047-1049 cell_type denotes DC
T20 1105-1124 cell_type denotes monocyte-derived DC
T21 1482-1494 protein denotes self-antigen
T22 1498-1500 cell_type denotes DC
T23 1508-1538 cell_type denotes autoantibody-producing B cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C20 0-15 NP denotes Dendritic cells
C24 62-87 NP denotes Rheumatoid arthritis (RA)
C21 91-132 NP denotes a chronic autoimmune inflammatory disease
C22 136-141 NP denotes which
C23 230-241 NP denotes the disease
C26 428-447 NP denotes the synovial tissue
C5 566-598 NP denotes Circulating dendritic cells (DC)
C30 650-681 NP denotes normal peripheral blood (PB) DC
C27 686-705 NP denotes the synovial tissue
C11 707-743 NP denotes fully differentiated perivascular DC
C10 851-872 NP denotes These perivascular DC
C13 1047-1049 NP denotes DC
C28 1059-1084 NP denotes an intermediate phenotype
C29 1097-1101 NP denotes that
C18 1235-1237 NP denotes DC
C19 1498-1500 NP denotes DC
R1 C22 C21 coref-relat which,a chronic autoimmune inflammatory disease
R2 C23 C24 coref-ident the disease,Rheumatoid arthritis (RA)
R3 C5 C20 coref-other Circulating dendritic cells (DC),Dendritic cells
R4 C30 C5 coref-ident normal peripheral blood (PB) DC,Circulating dendritic cells (DC)
R5 C27 C26 coref-ident the synovial tissue,the synovial tissue
R6 C10 C11 coref-ident These perivascular DC,fully differentiated perivascular DC
R7 C13 C20 coref-ident DC,Dendritic cells
R8 C29 C28 coref-pron that,an intermediate phenotype
R9 C18 C13 coref-ident DC,DC
R10 C19 C18 coref-ident DC,DC

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-61 Sentence denotes Dendritic cells and the pathogenesis of rheumatoid arthritis.
S2 62-203 Sentence denotes Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease in which unknown arthrogenic autoantigen is presented to CD4+ T cells.
S3 204-382 Sentence denotes The strong association of the disease with an epitope within the HLA-DR chain shared between various alleles of HLA-DR4 and DR1 emphasizes the importance of antigen presentation.
S4 383-565 Sentence denotes This immune response predominantly occurs in the synovial tissue and fluid of the joints and autoreactive T cells are readily demonstrable in both the synovial compartment and blood.
S5 566-682 Sentence denotes Circulating dendritic cells (DC) are phenotypically and functionally identical with normal peripheral blood (PB) DC.
S6 683-850 Sentence denotes In the synovial tissue, fully differentiated perivascular DC are found in close association with T cells and with B cell follicles, sometimes containing follicular DC.
S7 851-1035 Sentence denotes These perivascular DC migrate across the activated endothelium from blood and receive differentiative signals within the joint from monocyte-derived cytokines and CD40-ligand+ T cells.
S8 1036-1134 Sentence denotes In the SF, DC manifest an intermediate phenotype, similar to that of monocyte-derived DC in vitro.
S9 1135-1234 Sentence denotes Like a delayed-type hypersensitivity response, the rheumatoid synovium represents an effector site.
S10 1235-1327 Sentence denotes DC at many effector sites have a characteristic pattern of infiltration and differentiation.
S11 1328-1430 Sentence denotes It is important to note that the effector response is not self-limiting in RA autoimmune inflammation.
S12 1431-1599 Sentence denotes In this article, we argue that the presentation of self-antigen by DC and by autoantibody-producing B cells is critical for the perpetuation of the autoimmune response.
S13 1600-1738 Sentence denotes Permanently arresting this ongoing immune response with either pharmaceutical agents or immunotherapy is a major challenge for immunology.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-15 cell_type denotes Dendritic cells
T2 62-82 other_name denotes Rheumatoid arthritis
T3 84-86 other_name denotes RA
T4 93-132 other_name denotes chronic autoimmune inflammatory disease
T5 150-173 protein_molecule denotes arthrogenic autoantigen
T6 190-193 protein_molecule denotes CD4
T7 250-257 protein_domain_or_region denotes epitope
T8 269-281 protein_subunit denotes HLA-DR chain
T9 316-323 protein_molecule denotes HLA-DR4
T10 328-331 protein_molecule denotes DR1
T11 361-381 other_name denotes antigen presentation
T12 432-447 tissue denotes synovial tissue
T13 476-488 cell_type denotes autoreactive
T14 489-496 cell_type denotes T cells
T15 534-554 tissue denotes synovial compartment
T16 559-564 tissue denotes blood
T17 566-593 cell_type denotes Circulating dendritic cells
T18 595-597 cell_type denotes DC
T19 650-673 tissue denotes normal peripheral blood
T20 675-677 tissue denotes PB
T21 679-681 cell_type denotes DC
T22 690-705 tissue denotes synovial tissue
T23 728-743 cell_type denotes perivascular DC
T24 780-787 cell_type denotes T cells
T25 797-813 cell_type denotes B cell follicles
T26 836-849 cell_type denotes follicular DC
T27 857-872 cell_type denotes perivascular DC
T28 892-913 tissue denotes activated endothelium
T29 919-924 tissue denotes blood
T30 983-1009 protein_family_or_group denotes monocyte-derived cytokines
T31 1014-1018 protein_molecule denotes CD40
T32 1027-1034 cell_type denotes T cells
T33 1047-1049 cell_type denotes DC
T34 1105-1124 cell_type denotes monocyte-derived DC
T35 1142-1180 other_name denotes delayed-type hypersensitivity response
T36 1186-1205 tissue denotes rheumatoid synovium
T37 1294-1306 other_name denotes infiltration
T38 1311-1326 other_name denotes differentiation
T39 1403-1405 other_name denotes RA
T40 1482-1494 protein_molecule denotes self-antigen
T41 1498-1500 cell_type denotes DC
T42 1508-1530 cell_type denotes autoantibody-producing
T43 1531-1538 cell_type denotes B cells
T44 1579-1598 other_name denotes autoimmune response
T45 1663-1684 other_organic_compound denotes pharmaceutical agents
T46 1688-1701 other_name denotes immunotherapy
T47 1727-1737 other_name denotes immunology