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PubMed:10446065 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 376-386 HP_0003651 denotes foam cells
T2 407-422 HP_0002621 denotes atherosclerosis
T3 1753-1762 HP_0003651 denotes foam cell

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 30-43 protein denotes interleukin-6
T2 51-88 protein denotes class A macrophage scavenger receptor
T3 92-103 cell_type denotes macrophages
T4 117-143 cell_type denotes human peripheral monocytes
T5 152-177 cell_line denotes THP-1 monocytic cell line
T6 197-240 protein denotes class A macrophage scavenger receptor (MSR)
T7 270-309 protein denotes modified low density lipoproteins (LDL)
T8 313-324 cell_type denotes macrophages
T9 364-386 cell_type denotes lipid-laden foam cells
T10 467-492 protein denotes proinflammatory cytokines
T11 497-511 protein denotes growth factors
T12 545-548 protein denotes MSR
T13 637-640 protein denotes MSR
T14 763-783 protein denotes interleukin-6 (IL-6)
T15 788-804 protein denotes immunoregulatory
T16 806-829 protein denotes multipotential cytokine
T17 878-881 protein denotes MSR
T18 885-896 cell_type denotes macrophages
T19 916-920 protein denotes IL-6
T20 922-933 cell_type denotes macrophages
T21 947-967 cell_type denotes peripheral monocytes
T22 972-1046 cell_line denotes phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells
T23 1105-1108 protein denotes MSR
T24 1117-1131 protein denotes acetylated LDL
T25 1196-1199 protein denotes MSR
T26 1212-1216 RNA denotes mRNA
T27 1230-1242 DNA denotes MSR promoter
T28 1255-1266 cell_line denotes THP-1 cells
T29 1287-1323 DNA denotes MSR promoter-reporter gene construct
T30 1363-1375 DNA denotes MSR promoter
T31 1379-1383 protein denotes IL-6
T32 1392-1397 cell_line denotes THP-1
T33 1398-1409 cell_type denotes macrophages
T34 1496-1516 protein denotes transcription factor
T35 1524-1554 DNA denotes MSR promoter AP-1/ets elements
T36 1558-1562 protein denotes IL-6
T37 1596-1600 protein denotes IL-6
T38 1631-1642 protein denotes class A MSR
T39 1661-1672 cell_type denotes macrophages
T40 1731-1739 protein denotes cytokine

genia-medco-coref

Id Subject Object Predicate Lexical cue
C21 30-43 NP denotes interleukin-6
C2 47-88 NP denotes the class A macrophage scavenger receptor
C3 92-177 NP denotes macrophages derived from human peripheral monocytes and the THP-1 monocytic cell line
C1 193-240 NP denotes the class A macrophage scavenger receptor (MSR)
C23 270-309 NP denotes modified low density lipoproteins (LDL)
C4 313-324 NP denotes macrophages
C24 347-358 NP denotes these cells
C25 364-386 NP denotes lipid-laden foam cells
C26 388-393 NP denotes which
C27 424-450 NP denotes Many environmental factors
C28 467-511 NP denotes proinflammatory cytokines and growth factors
C30 569-610 NP denotes intracellular accumulation of cholesterol
C29 611-617 NP denotes itself
C31 763-783 NP denotes interleukin-6 (IL-6)
C32 785-829 NP denotes an immunoregulatory, multipotential cytokine
C7 874-881 NP denotes the MSR
C8 885-896 NP denotes macrophages
C22 916-920 NP denotes IL-6
C9 922-1046 NP denotes macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells
C33 1101-1115 NP denotes the MSR ligand
C34 1117-1131 NP denotes acetylated LDL
C16 1287-1300 NP denotes MSR promoter-
C17 1359-1375 NP denotes the MSR promoter
C35 1379-1384 NP denotes IL-6-
C36 1558-1563 NP denotes IL-6-
C37 1596-1600 NP denotes IL-6
C20 1627-1642 NP denotes the class A MSR
C38 1726-1739 NP denotes this cytokine
R1 C1 C2 coref-ident the class A macrophage scavenger receptor (MSR),the class A macrophage scavenger receptor
R2 C24 C23 coref-ident these cells,modified low density lipoproteins (LDL)
R3 C26 C25 coref-relat which,lipid-laden foam cells
R4 C28 C27 coref-part-whole proinflammatory cytokines and growth factors,Many environmental factors
R5 C29 C30 coref-pron itself,intracellular accumulation of cholesterol
R6 C31 C21 coref-ident interleukin-6 (IL-6),interleukin-6
R7 C32 C31 coref-appos "an immunoregulatory, multipotential cytokine",interleukin-6 (IL-6)
R8 C7 C1 coref-ident the MSR,the class A macrophage scavenger receptor (MSR)
R9 C8 C4 coref-ident macrophages,macrophages
R10 C22 C31 coref-ident IL-6,interleukin-6 (IL-6)
R11 C9 C3 coref-ident macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells,macrophages derived from human peripheral monocytes and the THP-1 monocytic cell line
R12 C34 C33 coref-appos acetylated LDL,the MSR ligand
R13 C17 C16 coref-ident the MSR promoter,MSR promoter-
R14 C35 C22 coref-ident IL-6-,IL-6
R15 C36 C35 coref-ident IL-6-,IL-6-
R16 C37 C36 coref-ident IL-6,IL-6-
R17 C20 C1 coref-ident the class A MSR,the class A macrophage scavenger receptor (MSR)
R18 C38 C37 coref-ident this cytokine,IL-6

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-178 Sentence denotes Transcriptional inhibition by interleukin-6 of the class A macrophage scavenger receptor in macrophages derived from human peripheral monocytes and the THP-1 monocytic cell line.
S2 179-423 Sentence denotes Expression of the class A macrophage scavenger receptor (MSR) contributes to the uptake of modified low density lipoproteins (LDL) by macrophages and transformation of these cells into lipid-laden foam cells, which characterize atherosclerosis.
S3 424-675 Sentence denotes Many environmental factors, in particular, proinflammatory cytokines and growth factors, can exert regulatory effects on MSR expression, whereas intracellular accumulation of cholesterol itself does not influence MSR levels to any considerable extent.
S4 676-897 Sentence denotes In the present study, by using an in vitro model, we examined whether stimulation with interleukin-6 (IL-6), an immunoregulatory, multipotential cytokine, modulates the expression and activities of the MSR in macrophages.
S5 898-1132 Sentence denotes When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL.
S6 1133-1217 Sentence denotes This effect was paralleled by a reduction in the expression of MSR protein and mRNA.
S7 1218-1410 Sentence denotes Analysis of MSR promoter activity in THP-1 cells transfected with an MSR promoter-reporter gene construct demonstrated decreased activity of the MSR promoter in IL-6-treated THP-1 macrophages.
S8 1411-1577 Sentence denotes Electrophoretic mobility gel shift assay also showed a reduction in the binding of a transcription factor to the MSR promoter AP-1/ets elements in IL-6-treated cells.
S9 1578-1699 Sentence denotes Thus, exposure to IL-6 may inhibit expression of the class A MSR in differentiated macrophages at transcriptional levels.
S10 1700-1794 Sentence denotes This result suggests that this cytokine may modulate foam cell formation during atherogenesis.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-26 other_name denotes Transcriptional inhibition
T2 30-43 protein_molecule denotes interleukin-6
T3 92-103 cell_type denotes macrophages
T4 117-143 cell_type denotes human peripheral monocytes
T5 152-157 cell_line denotes THP-1
T6 197-236 protein_complex denotes class A macrophage scavenger receptor (
T7 236-239 protein_complex denotes MSR
T8 270-305 protein_family_or_group denotes modified low density lipoproteins (
T9 305-308 protein_family_or_group denotes LDL
T10 313-324 cell_type denotes macrophages
T11 364-386 cell_type denotes lipid-laden foam cells
T12 407-422 other_name denotes atherosclerosis
T13 467-492 protein_family_or_group denotes proinflammatory cytokines
T14 497-511 protein_family_or_group denotes growth factors
T15 545-548 protein_complex denotes MSR
T16 637-640 protein_complex denotes MSR
T17 763-783 protein_molecule denotes interleukin-6 (IL-6)
T18 788-804 protein_family_or_group denotes immunoregulatory
T19 806-829 protein_family_or_group denotes multipotential cytokine
T20 878-881 protein_complex denotes MSR
T21 885-896 cell_type denotes macrophages
T22 916-920 protein_molecule denotes IL-6
T23 922-933 cell_type denotes macrophages
T24 947-967 cell_type denotes peripheral monocytes
T25 972-1046 cell_line denotes phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells
T26 1105-1108 protein_complex denotes MSR
T27 1117-1127 protein_family_or_group denotes acetylated
T28 1128-1131 protein_family_or_group denotes LDL
T29 1196-1199 protein_complex denotes MSR
T30 1212-1216 RNA_family_or_group denotes mRNA
T31 1230-1233 protein_complex denotes MSR
T32 1255-1260 cell_line denotes THP-1
T33 1287-1290 protein_complex denotes MSR
T34 1363-1366 protein_complex denotes MSR
T35 1379-1383 protein_molecule denotes IL-6
T36 1392-1397 cell_line denotes THP-1
T37 1398-1409 cell_type denotes macrophages
T38 1411-1451 other_name denotes Electrophoretic mobility gel shift assay
T39 1496-1516 protein_family_or_group denotes transcription factor
T40 1524-1527 protein_complex denotes MSR
T41 1558-1562 protein_molecule denotes IL-6
T42 1596-1600 protein_molecule denotes IL-6
T43 1631-1638 protein_family_or_group denotes class A
T44 1639-1642 protein_complex denotes MSR
T45 1661-1672 cell_type denotes macrophages
T46 1731-1739 protein_family_or_group denotes cytokine
T47 1780-1793 other_name denotes atherogenesis