PubMed:10438731
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-9 | protein | denotes | C/EBPbeta |
| T2 | 14-20 | protein | denotes | GATA-1 |
| T3 | 62-109 | DNA | denotes | eosinophil granule major basic protein promoter |
| T4 | 127-136 | protein | denotes | C/EBPbeta |
| T5 | 177-215 | protein | denotes | Eosinophil granule major basic protein |
| T6 | 217-220 | protein | denotes | MBP |
| T7 | 250-261 | cell_type | denotes | eosinophils |
| T8 | 266-275 | cell_type | denotes | basophils |
| T9 | 279-298 | cell_type | denotes | hematopoietic cells |
| T10 | 376-382 | protein | denotes | GATA-1 |
| T11 | 418-424 | protein | denotes | GATA-2 |
| T12 | 428-431 | protein | denotes | MBP |
| T13 | 476-495 | DNA | denotes | MBP promoter region |
| T14 | 509-570 | DNA | denotes | C/EBP (CCAAT/enhancer-binding protein) consensus binding site |
| T15 | 603-620 | DNA | denotes | GATA-binding site |
| T16 | 628-636 | DNA | denotes | MBP gene |
| T17 | 645-660 | cell_line | denotes | cell line HT93A |
| T18 | 715-725 | cell_type | denotes | eosinophil |
| T19 | 785-800 | RNA | denotes | C/EBPalpha mRNA |
| T20 | 908-917 | protein | denotes | C/EBPbeta |
| T21 | 1023-1032 | protein | denotes | C/EBPbeta |
| T22 | 1069-1087 | DNA | denotes | C/EBP-binding site |
| T23 | 1089-1102 | DNA | denotes | bp -90 to -82 |
| T24 | 1111-1114 | protein | denotes | MBP |
| T25 | 1169-1178 | protein | denotes | C/EBPbeta |
| T26 | 1183-1189 | protein | denotes | GATA-1 |
| T27 | 1232-1250 | DNA | denotes | GATA-binding sites |
| T28 | 1258-1270 | DNA | denotes | MBP promoter |
| T29 | 1315-1344 | DNA | denotes | C/EBP- and GATA-binding sites |
| T30 | 1366-1375 | protein | denotes | C/EBPbeta |
| T31 | 1380-1386 | protein | denotes | GATA-1 |
| T32 | 1405-1417 | DNA | denotes | MBP promoter |
| T33 | 1425-1473 | cell_line | denotes | C/EBPbeta and GATA-1 negative Jurkat T-cell line |
| T34 | 1495-1534 | DNA | denotes | C/EBPbeta and GATA-1 expression vectors |
| T35 | 1600-1609 | protein | denotes | C/EBPbeta |
| T36 | 1613-1638 | DNA | denotes | GATA-1 expression vectors |
| T37 | 1666-1669 | protein | denotes | GST |
| T38 | 1742-1748 | protein | denotes | GATA-1 |
| T39 | 1753-1762 | protein | denotes | C/EBPbeta |
| T40 | 1778-1781 | protein | denotes | FOG |
| T41 | 1783-1792 | protein | denotes | riend ATA |
| T42 | 1810-1816 | protein | denotes | GATA-1 |
| T43 | 1844-1865 | protein | denotes | GATA-binding proteins |
| T44 | 1905-1911 | protein | denotes | GATA-1 |
| T45 | 1920-1932 | DNA | denotes | MBP promoter |
| T46 | 2010-2016 | protein | denotes | GATA-1 |
| T47 | 2021-2030 | protein | denotes | C/EBPbeta |
| T48 | 2065-2073 | DNA | denotes | promoter |
| T49 | 2080-2120 | DNA | denotes | eosinophil-specific granule protein gene |
| T50 | 2130-2133 | protein | denotes | FOG |
| T51 | 2173-2191 | cell_type | denotes | eosinophil lineage |
| T52 | 2243-2279 | cell_type | denotes | erythroid and megakaryocyte lineages |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-9 | NP | denotes | C/EBPbeta |
| C2 | 14-20 | NP | denotes | GATA-1 |
| C3 | 376-382 | NP | denotes | GATA-1 |
| C4 | 641-660 | NP | denotes | the cell line HT93A |
| C5 | 662-667 | NP | denotes | which |
| C9 | 1107-1123 | NP | denotes | the MBP promoter |
| C6 | 1169-1178 | NP | denotes | C/EBPbeta |
| C7 | 1183-1189 | NP | denotes | GATA-1 |
| C11 | 1217-1250 | NP | denotes | the C/EBP- and GATA-binding sites |
| C10 | 1254-1270 | NP | denotes | the MBP promoter |
| C12 | 1306-1344 | NP | denotes | both the C/EBP- and GATA-binding sites |
| C13 | 1366-1375 | NP | denotes | C/EBPbeta |
| C14 | 1380-1386 | NP | denotes | GATA-1 |
| C15 | 1401-1417 | NP | denotes | the MBP promoter |
| C16 | 1495-1534 | NP | denotes | C/EBPbeta and GATA-1 expression vectors |
| C17 | 1596-1638 | NP | denotes | the C/EBPbeta or GATA-1 expression vectors |
| C18 | 1736-1748 | NP | denotes | human GATA-1 |
| C19 | 1753-1762 | NP | denotes | C/EBPbeta |
| C21 | 1778-1793 | NP | denotes | FOG (riend ATA) |
| C22 | 1795-1800 | NP | denotes | which |
| C23 | 1810-1816 | NP | denotes | GATA-1 |
| C24 | 1905-1911 | NP | denotes | GATA-1 |
| C25 | 1916-1932 | NP | denotes | the MBP promoter |
| C26 | 1981-1999 | NP | denotes | the first evidence |
| C27 | 2000-2004 | NP | denotes | that |
| C28 | 2010-2016 | NP | denotes | GATA-1 |
| C29 | 2021-2030 | NP | denotes | C/EBPbeta |
| C30 | 2125-2129 | NP | denotes | that |
| C31 | 2130-2133 | NP | denotes | FOG |
| C32 | 2200-2203 | NP | denotes | its |
| R1 | C3 | C2 | coref-ident | GATA-1,GATA-1 |
| R2 | C5 | C4 | coref-relat | which,the cell line HT93A |
| R3 | C6 | C1 | coref-ident | C/EBPbeta,C/EBPbeta |
| R4 | C7 | C2 | coref-ident | GATA-1,GATA-1 |
| R5 | C10 | C9 | coref-ident | the MBP promoter,the MBP promoter |
| R6 | C12 | C11 | coref-ident | both the C/EBP- and GATA-binding sites,the C/EBP- and GATA-binding sites |
| R7 | C13 | C6 | coref-ident | C/EBPbeta,C/EBPbeta |
| R8 | C14 | C7 | coref-ident | GATA-1,GATA-1 |
| R9 | C15 | C10 | coref-ident | the MBP promoter,the MBP promoter |
| R10 | C17 | C16 | coref-ident | the C/EBPbeta or GATA-1 expression vectors,C/EBPbeta and GATA-1 expression vectors |
| R11 | C18 | C14 | coref-ident | human GATA-1,GATA-1 |
| R12 | C19 | C13 | coref-ident | C/EBPbeta,C/EBPbeta |
| R13 | C22 | C21 | coref-relat | which,FOG (riend ATA) |
| R14 | C23 | C18 | coref-ident | GATA-1,human GATA-1 |
| R15 | C24 | C23 | coref-ident | GATA-1,GATA-1 |
| R16 | C25 | C15 | coref-ident | the MBP promoter,the MBP promoter |
| R17 | C27 | C26 | coref-relat | that,the first evidence |
| R18 | C28 | C24 | coref-ident | GATA-1,GATA-1 |
| R19 | C29 | C19 | coref-ident | C/EBPbeta,C/EBPbeta |
| R20 | C30 | C26 | coref-relat | that,the first evidence |
| R21 | C31 | C21 | coref-ident | FOG,FOG (riend ATA) |
| R22 | C32 | C31 | coref-pron | its,FOG |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 0-9 | cui:C0209548 | denotes | C/EBPbeta |
| E2-ti-1 | 14-20 | cui:C1530719 | denotes | GATA-1 |
| E3-ti-1 | 46-54 | cui:C0439167 | denotes | activity |
| E4-ti-1 | 73-80 | cui:C0010837 | denotes | granule |
| E5-ti-1 | 62-100 | cui:C0059406 | denotes | eosinophil granule major basic protein |
| E6-ti-1 | 127-136 | cui:C0209548 | denotes | C/EBPbeta |
| E7-ti-1 | 137-145 | cui:C0439167 | denotes | activity |
| E8-ti-1 | 149-159 | cui:C0014467 | denotes | eosinophil |
| E9-ti-1 | 160-175 | cui:C0017262 | denotes | gene expression |
| T1 | 37-45 | INTERACTS_WITH | denotes | regulate |
| T2 | 73-100 | PART_OF | denotes | granule major basic protein |
| T3 | 146-148 | LOCATION_OF | denotes | in |
| E1-ab-1 | 188-195 | cui:C0010837 | denotes | granule |
| E2-ab-1 | 177-215 | cui:C0059406 | denotes | Eosinophil granule major basic protein |
| E3-ab-1 | 250-261 | cui:C0014467 | denotes | eosinophils |
| E4-ab-1 | 266-275 | cui:C0004827 | denotes | basophils |
| E5-ab-1 | 279-292 | cui:C0229601 | denotes | hematopoietic |
| E6-ab-1 | 293-298 | cui:C0007634 | denotes | cells |
| T4 | 188-215 | PART_OF | denotes | granule major basic protein |
| T5 | 225-234 | PART_OF | denotes | expressed |
| T6 | 225-234 | PART_OF | denotes | expressed |
| E1-ab-2 | 307-315 | cui:C0205156 | denotes | previous |
| E2-ab-2 | 316-321 | cui:C0008972 | denotes | study |
| E3-ab-2 | 341-346 | cui:C0205164 | denotes | major |
| E4-ab-2 | 347-355 | cui:C1446409 | denotes | positive |
| E5-ab-2 | 356-366 | cui:C0220905 | denotes | regulatory |
| E6-ab-2 | 367-371 | cui:C0035820 | denotes | role |
| E7-ab-2 | 376-382 | cui:C1530719 | denotes | GATA-1 |
| E8-ab-2 | 389-397 | cui:C0205160 | denotes | negative |
| E9-ab-2 | 398-408 | cui:C0220905 | denotes | regulatory |
| E10-ab-2 | 409-413 | cui:C0035820 | denotes | role |
| E11-ab-2 | 418-424 | entrez:2624 | denotes | GATA-2 |
| E12-ab-2 | 428-431 | cui:C0205164 | denotes | MBP |
| E13-ab-2 | 428-431 | cui:C1527178 | denotes | MBP |
| E14-ab-2 | 428-431 | cui:C0033684 | denotes | MBP |
| E15-ab-2 | 432-450 | cui:C0040649 | denotes | gene transcription |
| E1-ab-3 | 452-459 | cui:C1517331 | denotes | Further |
| E2-ab-3 | 460-468 | cui:C0936012 | denotes | analysis |
| E3-ab-3 | 476-479 | cui:C0205164 | denotes | MBP |
| E4-ab-3 | 476-479 | cui:C0597742 | denotes | MBP |
| E5-ab-3 | 476-479 | cui:C0033684 | denotes | MBP |
| E6-ab-3 | 480-495 | cui:C0033413 | denotes | promoter region |
| E7-ab-3 | 511-514 | entrez:10682 | denotes | EBP |
| E8-ab-3 | 516-546 | cui:C0108685 | denotes | CCAAT/enhancer-binding protein |
| E9-ab-3 | 548-557 | cui:C0376298 | denotes | consensus |
| E10-ab-3 | 558-570 | cui:C0005456 | denotes | binding site |
| E11-ab-3 | 576-584 | cui:C0522505 | denotes | upstream |
| E12-ab-3 | 592-602 | cui:C0205245 | denotes | functional |
| E13-ab-3 | 608-620 | cui:C0005456 | denotes | binding site |
| E14-ab-3 | 628-631 | cui:C0205164 | denotes | MBP |
| E15-ab-3 | 628-631 | cui:C0597742 | denotes | MBP |
| E16-ab-3 | 628-631 | cui:C0033684 | denotes | MBP |
| E17-ab-3 | 632-636 | cui:C0017337 | denotes | gene |
| E1-ab-4 | 645-654 | cui:C0007600 | denotes | cell line |
| E2-ab-4 | 715-725 | cui:C0014467 | denotes | eosinophil |
| E3-ab-4 | 730-740 | cui:C0027950 | denotes | neutrophil |
| E4-ab-4 | 753-761 | cui:C0871261 | denotes | response |
| E5-ab-4 | 765-778 | cui:C0040845 | denotes | retinoic acid |
| E6-ab-4 | 785-795 | cui:C0378310 | denotes | C/EBPalpha |
| E7-ab-4 | 796-811 | cui:C1515670 | denotes | mRNA expression |
| E8-ab-4 | 836-847 | cui:C1516780 | denotes | concomitant |
| E9-ab-4 | 853-865 | cui:C0333930 | denotes | eosinophilic |
| E10-ab-4 | 870-898 | cui:C1159958 | denotes | neutrophilic differentiation |
| E11-ab-4 | 908-917 | cui:C0209548 | denotes | C/EBPbeta |
| E12-ab-4 | 918-928 | cui:C0185117 | denotes | expression |
| E13-ab-4 | 933-941 | cui:C0522501 | denotes | markedly |
| E1-ab-5 | 953-990 | cui:C0949632 | denotes | Electrophoretic mobility shift assays |
| E2-ab-5 | 1011-1040 | cui:C0034861 | denotes | recombinant C/EBPbeta protein |
| E3-ab-5 | 1059-1068 | cui:C0237399 | denotes | potential |
| E4-ab-5 | 1071-1074 | entrez:10682 | denotes | EBP |
| E5-ab-5 | 1075-1087 | cui:C0005456 | denotes | binding site |
| E6-ab-5 | 1111-1114 | cui:C0205164 | denotes | MBP |
| E7-ab-5 | 1111-1114 | cui:C0597742 | denotes | MBP |
| E8-ab-5 | 1111-1114 | cui:C0033684 | denotes | MBP |
| T7 | 1047-1051 | INTERACTS_WITH | denotes | bind |
| E1-ab-6 | 1169-1178 | cui:C0209548 | denotes | C/EBPbeta |
| E2-ab-6 | 1183-1189 | cui:C1530719 | denotes | GATA-1 |
| E3-ab-6 | 1223-1226 | entrez:10682 | denotes | EBP |
| E4-ab-6 | 1237-1250 | cui:C0005456 | denotes | binding sites |
| E5-ab-6 | 1258-1261 | cui:C0205164 | denotes | MBP |
| E6-ab-6 | 1258-1261 | cui:C1527178 | denotes | MBP |
| E7-ab-6 | 1258-1261 | cui:C0033684 | denotes | MBP |
| T8 | 1194-1198 | INTERACTS_WITH | denotes | bind |
| T9 | 1194-1198 | INTERACTS_WITH | denotes | bind |
| E1-ab-7 | 1289-1302 | cui:C0205245 | denotes | functionality |
| E2-ab-7 | 1317-1320 | entrez:10682 | denotes | EBP |
| E3-ab-7 | 1331-1344 | cui:C0005456 | denotes | binding sites |
| E4-ab-7 | 1366-1375 | cui:C0209548 | denotes | C/EBPbeta |
| E5-ab-7 | 1380-1386 | cui:C1530719 | denotes | GATA-1 |
| E6-ab-7 | 1405-1408 | cui:C0205164 | denotes | MBP |
| E7-ab-7 | 1405-1408 | cui:C1527178 | denotes | MBP |
| E8-ab-7 | 1405-1408 | cui:C0033684 | denotes | MBP |
| E9-ab-7 | 1425-1434 | cui:C0209548 | denotes | C/EBPbeta |
| E10-ab-7 | 1439-1445 | cui:C1530719 | denotes | GATA-1 |
| E11-ab-7 | 1446-1454 | cui:C0205160 | denotes | negative |
| E12-ab-7 | 1464-1473 | cui:C0007600 | denotes | cell line |
| T10 | 1418-1420 | COEXISTS_WITH | denotes | in |
| E1-ab-8 | 1495-1504 | cui:C0209548 | denotes | C/EBPbeta |
| E2-ab-8 | 1509-1515 | cui:C1530719 | denotes | GATA-1 |
| E3-ab-8 | 1516-1534 | cui:C0599566 | denotes | expression vectors |
| E4-ab-8 | 1548-1552 | cui:C0332462 | denotes | fold |
| E5-ab-8 | 1553-1561 | cui:C0442805 | denotes | increase |
| E6-ab-8 | 1600-1609 | cui:C0209548 | denotes | C/EBPbeta |
| E7-ab-8 | 1613-1619 | cui:C1530719 | denotes | GATA-1 |
| E8-ab-8 | 1620-1638 | cui:C0599566 | denotes | expression vectors |
| T11 | 1562-1570 | compared_with | denotes | compared |
| E1-ab-9 | 1656-1664 | cui:C0442796 | denotes | addition |
| E2-ab-9 | 1666-1669 | cui:C0017837 | denotes | GST |
| E3-ab-9 | 1670-1675 | cui:C0580846 | denotes | pull- |
| E4-ab-9 | 1675-1679 | cui:C0023032 | denotes | down |
| E5-ab-9 | 1680-1691 | cui:C0681814 | denotes | experiments |
| E6-ab-9 | 1707-1715 | cui:C0205485 | denotes | physical |
| E7-ab-9 | 1716-1727 | cui:C0687133 | denotes | interaction |
| E8-ab-9 | 1736-1741 | cui:C0020114 | denotes | human |
| E9-ab-9 | 1742-1748 | cui:C1530719 | denotes | GATA-1 |
| E10-ab-9 | 1753-1762 | cui:C0209548 | denotes | C/EBPbeta |
| E1-ab-10 | 1764-1774 | cui:C0185117 | denotes | Expression |
| E2-ab-10 | 1778-1781 | cui:C0450030 | denotes | FOG |
| E3-ab-10 | 1789-1792 | cui:C0919524 | denotes | ATA |
| E4-ab-10 | 1810-1816 | cui:C1530719 | denotes | GATA-1 |
| E5-ab-10 | 1831-1839 | cui:C0178555 | denotes | cofactor |
| E6-ab-10 | 1844-1865 | cui:C1333662 | denotes | GATA-binding proteins |
| E7-ab-10 | 1877-1892 | cui:C0040624 | denotes | transactivation |
| E8-ab-10 | 1867-1901 | cui:C0086439 | denotes | decreased transactivation activity |
| E9-ab-10 | 1905-1911 | cui:C1530719 | denotes | GATA-1 |
| E10-ab-10 | 1920-1923 | cui:C0205164 | denotes | MBP |
| E11-ab-10 | 1920-1923 | cui:C1527178 | denotes | MBP |
| E12-ab-10 | 1920-1923 | cui:C0033684 | denotes | MBP |
| E13-ab-10 | 1938-1952 | cui:C1512045 | denotes | dose-dependent |
| T12 | 1831-1839 | INTERACTS_WITH | denotes | cofactor |
| E1-ab-11 | 1965-1972 | cui:C1274040 | denotes | results |
| E2-ab-11 | 1985-1990 | cui:C1279901 | denotes | first |
| E3-ab-11 | 2010-2016 | cui:C1530719 | denotes | GATA-1 |
| E4-ab-11 | 2021-2030 | cui:C0209548 | denotes | C/EBPbeta |
| E5-ab-11 | 2080-2115 | cui:C0116275 | denotes | eosinophil-specific granule protein |
| E6-ab-11 | 2116-2120 | cui:C0017337 | denotes | gene |
| E7-ab-11 | 2130-2133 | cui:C0450030 | denotes | FOG |
| E8-ab-11 | 2147-2155 | cui:C0205160 | denotes | negative |
| E9-ab-11 | 2156-2164 | cui:C0178555 | denotes | cofactor |
| E10-ab-11 | 2173-2183 | cui:C0014467 | denotes | eosinophil |
| E11-ab-11 | 2215-2225 | cui:C0220905 | denotes | regulatory |
| E12-ab-11 | 2226-2234 | cui:C0542341 | denotes | function |
| E13-ab-11 | 2243-2252 | cui:C1516960 | denotes | erythroid |
| E14-ab-11 | 2257-2270 | cui:C0025166 | denotes | megakaryocyte |
| R1 | E2-ti-1 | T1 | subjectOf | GATA-1,regulate |
| R2 | E5-ti-1 | T1 | objectOf | eosinophil granule major basic protein,regulate |
| R3 | E5-ti-1 | T2 | subjectOf | eosinophil granule major basic protein,granule major basic protein |
| R4 | E4-ti-1 | T2 | objectOf | granule,granule major basic protein |
| R5 | E8-ti-1 | T3 | subjectOf | eosinophil,in |
| R6 | E6-ti-1 | T3 | objectOf | C/EBPbeta,in |
| R7 | E2-ab-1 | T4 | subjectOf | Eosinophil granule major basic protein,granule major basic protein |
| R8 | E1-ab-1 | T4 | objectOf | granule,granule major basic protein |
| R9 | E2-ab-1 | T5 | subjectOf | Eosinophil granule major basic protein,expressed |
| R10 | E3-ab-1 | T5 | objectOf | eosinophils,expressed |
| R11 | E2-ab-1 | T6 | subjectOf | Eosinophil granule major basic protein,expressed |
| R12 | E4-ab-1 | T6 | objectOf | basophils,expressed |
| R13 | E2-ab-5 | T7 | subjectOf | recombinant C/EBPbeta protein,bind |
| R14 | E5-ab-5 | T7 | objectOf | binding site,bind |
| R15 | E2-ab-6 | T8 | subjectOf | GATA-1,bind |
| R16 | E3-ab-6 | T8 | objectOf | EBP,bind |
| R17 | E2-ab-6 | T9 | subjectOf | GATA-1,bind |
| R18 | E4-ab-6 | T9 | objectOf | binding sites,bind |
| R19 | E5-ab-7 | T10 | subjectOf | GATA-1,in |
| R20 | E9-ab-7 | T10 | objectOf | C/EBPbeta,in |
| R21 | E3-ab-8 | T11 | subjectOf | expression vectors,compared |
| R22 | E6-ab-8 | T11 | objectOf | C/EBPbeta,compared |
| R23 | E4-ab-10 | T12 | subjectOf | GATA-1,cofactor |
| R24 | E6-ab-10 | T12 | objectOf | GATA-binding proteins,cofactor |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-176 | Sentence | denotes | C/EBPbeta and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: implication for C/EBPbeta activity in eosinophil gene expression. |
| S2 | 177-299 | Sentence | denotes | Eosinophil granule major basic protein (MBP) is expressed exclusively in eosinophils and basophils in hematopoietic cells. |
| S3 | 300-451 | Sentence | denotes | In our previous study, we demonstrated a major positive regulatory role for GATA-1 and a negative regulatory role for GATA-2 in MBP gene transcription. |
| S4 | 452-637 | Sentence | denotes | Further analysis of the MBP promoter region identified a C/EBP (CCAAT/enhancer-binding protein) consensus binding site 6 bp upstream of the functional GATA-binding site in the MBP gene. |
| S5 | 638-952 | Sentence | denotes | In the cell line HT93A, which is capable of differentiating towards both the eosinophil and neutrophil lineages in response to retinoic acid (RA), C/EBPalpha mRNA expression decreased significantly concomitant with eosinophilic and neutrophilic differentiation, whereas C/EBPbeta expression was markedly increased. |
| S6 | 953-1124 | Sentence | denotes | Electrophoretic mobility shift assays (EMSAs) showed that recombinant C/EBPbeta protein could bind to the potential C/EBP-binding site (bp -90 to -82) in the MBP promoter. |
| S7 | 1125-1271 | Sentence | denotes | Furthermore, we have demonstrated that both C/EBPbeta and GATA-1 can bind simultaneously to the C/EBP- and GATA-binding sites in the MBP promoter. |
| S8 | 1272-1474 | Sentence | denotes | To determine the functionality of both the C/EBP- and GATA-binding sites, we analyzed whether C/EBPbeta and GATA-1 can stimulate the MBP promoter in the C/EBPbeta and GATA-1 negative Jurkat T-cell line. |
| S9 | 1475-1652 | Sentence | denotes | Cotransfection with C/EBPbeta and GATA-1 expression vectors produced a 5-fold increase compared with cotransfection with the C/EBPbeta or GATA-1 expression vectors individually. |
| S10 | 1653-1763 | Sentence | denotes | In addition, GST pull-down experiments demonstrated a physical interaction between human GATA-1 and C/EBPbeta. |
| S11 | 1764-1960 | Sentence | denotes | Expression of FOG (riend ATA), which binds to GATA-1 and acts as a cofactor for GATA-binding proteins, decreased transactivation activity of GATA-1 for the MBP promoter in a dose-dependent manner. |
| S12 | 1961-2280 | Sentence | denotes | Our results provide the first evidence that both GATA-1 and C/EBPbeta synergistically transactivate the promoter of an eosinophil-specific granule protein gene and that FOG may act as a negative cofactor for the eosinophil lineage, unlike its positively regulatory function for the erythroid and megakaryocyte lineages. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-9 | protein_molecule | denotes | C/EBPbeta |
| T2 | 14-20 | protein_molecule | denotes | GATA-1 |
| T3 | 62-109 | DNA_domain_or_region | denotes | eosinophil granule major basic protein promoter |
| T4 | 127-136 | protein_molecule | denotes | C/EBPbeta |
| T5 | 149-175 | other_name | denotes | eosinophil gene expression |
| T6 | 177-215 | protein_molecule | denotes | Eosinophil granule major basic protein |
| T7 | 217-220 | protein_molecule | denotes | MBP |
| T8 | 250-261 | cell_type | denotes | eosinophils |
| T9 | 266-275 | cell_type | denotes | basophils |
| T10 | 279-298 | cell_type | denotes | hematopoietic cells |
| T11 | 347-371 | other_name | denotes | positive regulatory role |
| T12 | 376-382 | protein_molecule | denotes | GATA-1 |
| T13 | 389-413 | other_name | denotes | negative regulatory role |
| T14 | 418-424 | protein_molecule | denotes | GATA-2 |
| T15 | 428-431 | protein_molecule | denotes | MBP |
| T16 | 476-479 | protein_molecule | denotes | MBP |
| T17 | 509-514 | protein_family_or_group | denotes | C/EBP |
| T18 | 516-546 | protein_family_or_group | denotes | CCAAT/enhancer-binding protein |
| T19 | 603-620 | DNA_domain_or_region | denotes | GATA-binding site |
| T20 | 628-631 | protein_molecule | denotes | MBP |
| T21 | 645-660 | cell_line | denotes | cell line HT93A |
| T22 | 715-725 | cell_type | denotes | eosinophil |
| T23 | 765-778 | other_organic_compound | denotes | retinoic acid |
| T24 | 780-782 | other_organic_compound | denotes | RA |
| T25 | 785-795 | protein_molecule | denotes | C/EBPalpha |
| T26 | 908-917 | protein_molecule | denotes | C/EBPbeta |
| T27 | 953-990 | other_name | denotes | Electrophoretic mobility shift assays |
| T28 | 992-997 | other_name | denotes | EMSAs |
| T29 | 1023-1032 | protein_molecule | denotes | C/EBPbeta |
| T30 | 1069-1087 | DNA_domain_or_region | denotes | C/EBP-binding site |
| T31 | 1089-1102 | DNA_domain_or_region | denotes | bp -90 to -82 |
| T32 | 1111-1114 | protein_molecule | denotes | MBP |
| T33 | 1169-1178 | protein_molecule | denotes | C/EBPbeta |
| T34 | 1183-1189 | protein_molecule | denotes | GATA-1 |
| T35 | 1232-1250 | DNA_domain_or_region | denotes | GATA-binding sites |
| T36 | 1258-1261 | protein_molecule | denotes | MBP |
| T37 | 1366-1375 | protein_molecule | denotes | C/EBPbeta |
| T38 | 1380-1386 | protein_molecule | denotes | GATA-1 |
| T39 | 1405-1408 | protein_molecule | denotes | MBP |
| T40 | 1425-1434 | protein_molecule | denotes | C/EBPbeta |
| T41 | 1439-1445 | protein_molecule | denotes | GATA-1 |
| T42 | 1455-1473 | cell_line | denotes | Jurkat T-cell line |
| T43 | 1600-1609 | protein_molecule | denotes | C/EBPbeta |
| T44 | 1613-1619 | protein_molecule | denotes | GATA-1 |
| T45 | 1666-1669 | protein_molecule | denotes | GST |
| T46 | 1742-1748 | protein_molecule | denotes | GATA-1 |
| T47 | 1753-1762 | protein_molecule | denotes | C/EBPbeta |
| T48 | 1778-1781 | protein_molecule | denotes | FOG |
| T49 | 1783-1792 | protein_molecule | denotes | riend ATA |
| T50 | 1810-1816 | protein_molecule | denotes | GATA-1 |
| T51 | 1844-1865 | protein_family_or_group | denotes | GATA-binding proteins |
| T52 | 1905-1911 | protein_molecule | denotes | GATA-1 |
| T53 | 1920-1923 | protein_molecule | denotes | MBP |
| T54 | 2010-2016 | protein_molecule | denotes | GATA-1 |
| T55 | 2021-2030 | protein_molecule | denotes | C/EBPbeta |
| T56 | 2065-2073 | DNA_domain_or_region | denotes | promoter |
| T57 | 2080-2120 | DNA_family_or_group | denotes | eosinophil-specific granule protein gene |
| T58 | 2130-2133 | protein_molecule | denotes | FOG |
| T59 | 2173-2191 | cell_type | denotes | eosinophil lineage |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 2022-2031 | C0209548 | denotes | /EBPbeta |
| T2 | 1754-1763 | C0209548 | denotes | /EBPbeta. |
| T3 | 1601-1610 | C0209548 | denotes | /EBPbeta |
| T4 | 1367-1376 | C0209548 | denotes | /EBPbeta |
| T5 | 1170-1179 | C0209548 | denotes | /EBPbeta |
| T6 | 909-918 | C0209548 | denotes | /EBPbeta |
| T7 | 1-10 | C0209548 | denotes | /EBPbeta |
| T8 | 716-726 | C0014467 | denotes | osinophil |
| T9 | 150-159 | C0014467 | denotes | osinophil |
| T10 | 161-176 | C0017262 | denotes | ene expression. |
| T11 | 178-216 | C1418889 | denotes | osinophil granule major basic protein |
| T12 | 2011-2017 | C1333663 | denotes | ATA-1 |
| T13 | 1743-1749 | C1333663 | denotes | ATA-1 |
| T14 | 1184-1190 | C1333663 | denotes | ATA-1 |
| T15 | 377-383 | C1333663 | denotes | ATA-1 |
| T16 | 15-21 | C1333663 | denotes | ATA-1 |
| T17 | 2066-2074 | C0086860 | denotes | romoter |
| T18 | 1925-1933 | C0086860 | denotes | romoter |
| T19 | 1410-1418 | C0086860 | denotes | romoter |
| T20 | 1263-1271 | C0086860 | denotes | romoter. |
| T21 | 1116-1124 | C0086860 | denotes | romoter. |
| T22 | 102-110 | C0086860 | denotes | romoter: |
| T23 | 2139-2142 | C0079613 | denotes | ct |
| T24 | 1822-1826 | C0079613 | denotes | cts |
| T25 | 1316-1321 | C0108685 | denotes | /EBP- |
| T26 | 517-547 | C0108685 | denotes | CAAT/enhancer-binding protein) |
| T27 | 2131-2134 | C0450030 | denotes | OG |
| T28 | 1779-1782 | C0450030 | denotes | OG |
| T29 | 1921-1924 | C0205164 | denotes | BP |
| T30 | 1406-1409 | C0205164 | denotes | BP |
| T31 | 1259-1261 | C0205164 | denotes | BP |
| T32 | 1112-1115 | C0205164 | denotes | BP |
| T33 | 429-432 | C0205164 | denotes | BP |
| T34 | 342-347 | C0205164 | denotes | ajor |
| T35 | 766-779 | C0040845 | denotes | etinoic acid |
| T36 | 1737-1742 | C0086418 | denotes | uman |
| T37 | 2109-2116 | C0033684 | denotes | rotein |
| T38 | 1921-1924 | C0033684 | denotes | BP |
| T39 | 1112-1115 | C0033684 | denotes | BP |
| T40 | 429-432 | C0033684 | denotes | BP |
| T41 | 1921-1924 | C1527178 | denotes | BP |
| T42 | 1406-1409 | C1527178 | denotes | BP |
| T43 | 1259-1261 | C1527178 | denotes | BP |
| T44 | 1112-1115 | C1527178 | denotes | BP |
| T45 | 429-432 | C1527178 | denotes | BP |
| T46 | 1076-1088 | C0005456 | denotes | inding site |
| T47 | 433-451 | C0040649 | denotes | ene transcription. |
| T48 | 438-451 | C0040649 | denotes | ranscription. |
| T49 | 481-496 | C0033413 | denotes | romoter region |
| T50 | 2109-2121 | C0751455 | denotes | rotein gene |
| T51 | 629-637 | C0751455 | denotes | BP gene. |
| T52 | 429-437 | C0751455 | denotes | BP gene |
| T53 | 1465-1474 | C0007600 | denotes | ell line. |
| T54 | 646-655 | C0007600 | denotes | ell line |
| T55 | 267-276 | C0004827 | denotes | asophils |
| T56 | 786-796 | C0378310 | denotes | /EBPalpha |
| T57 | 731-741 | C0027950 | denotes | eutrophil |
| T58 | 1802-1807 | C1167622 | denotes | inds |
| T59 | 1708-1728 | C1167622 | denotes | hysical interaction |
| T60 | 1195-1199 | C1167622 | denotes | ind |
| T61 | 1048-1052 | C1167622 | denotes | ind |
| T62 | 559-566 | C1167622 | denotes | inding |
| T63 | 549-557 | C0376298 | denotes | onsensus |
| T64 | 954-991 | C0949632 | denotes | lectrophoretic mobility shift assays |
| T65 | 2258-2271 | C0025166 | denotes | egakaryocyte |
| T66 | 1878-1892 | C0040624 | denotes | ransactivation |
| T67 | 2185-2192 | C1881379 | denotes | ineage, |
| T68 | 2272-2280 | C1881379 | denotes | ineages. |
| T69 | 742-750 | C1881379 | denotes | ineages |
| T70 | 2148-2156 | C0205160 | denotes | egative |
| T71 | 1447-1455 | C0205160 | denotes | egative |
| T72 | 390-397 | C0205160 | denotes | egative |
| T73 | 2216-2226 | C1704735 | denotes | egulatory |
| T74 | 1327-1331 | C1427248 | denotes | ATA- |
| T75 | 604-608 | C1427248 | denotes | ATA- |
| T76 | 419-423 | C1427248 | denotes | ATA- |
| T77 | 1845-1866 | C1333662 | denotes | ATA-binding proteins, |
| T78 | 1765-1775 | C0185117 | denotes | xpression |
| T79 | 919-929 | C0185117 | denotes | xpression |
| T80 | 1200-1214 | C0521115 | denotes | imultaneously |
| T81 | 837-848 | C0521115 | denotes | oncomitant |
| T82 | 2157-2165 | C0178555 | denotes | ofactor |
| T83 | 1832-1840 | C0178555 | denotes | ofactor |
| T84 | 1246-1251 | C0205145 | denotes | ites |
| T85 | 1084-1088 | C0205145 | denotes | ite |
| T86 | 1290-1303 | C2700217 | denotes | unctionality |
| T87 | 593-603 | C2700217 | denotes | unctional |
| T88 | 1657-1665 | C1883712 | denotes | ddition, |
| T89 | 1350-1358 | C0936012 | denotes | nalyzed |
| T90 | 813-822 | C0205216 | denotes | ecreased |
| T91 | 2244-2253 | C1516960 | denotes | rythroid |
| T92 | 497-507 | C0205396 | denotes | dentified |
| T93 | 943-952 | C0205217 | denotes | ncreased. |
| T94 | 934-941 | C0522501 | denotes | arkedly |
| T95 | 1974-1981 | C1999230 | denotes | rovide |
| T96 | 1273-1275 | C1883351 | denotes | o |
| T97 | 1966-1972 | C1274040 | denotes | esults |
| T98 | 1000-1006 | C1547282 | denotes | howed |
| T99 | 871-899 | C1159958 | denotes | eutrophilic differentiation, |
| T100 | 1992-2000 | C0332120 | denotes | vidence |
| T101 | 317-322 | C2603343 | denotes | tudy, |
| T102 | 797-812 | C1515670 | denotes | RNA expression |
| T103 | 2227-2235 | C0542341 | denotes | unction |
| T104 | 1554-1562 | C0442805 | denotes | ncrease |
| T105 | 1094-1096 | C0439087 | denotes | 0 |
| T106 | 1681-1692 | C0681814 | denotes | xperiments |
| T107 | 1563-1571 | C1707455 | denotes | ompared |
| T108 | 251-262 | C0200638 | denotes | osinophils |
| T109 | 683-698 | C0205615 | denotes | ifferentiating |
| T110 | 672-679 | C2698977 | denotes | apable |
| T111 | 1060-1069 | C3245505 | denotes | otential |
| T112 | 1939-1953 | C1512045 | denotes | ose-dependent |
| T113 | 308-316 | C1552607 | denotes | revious |
| T114 | 1986-1991 | C0205435 | denotes | irst |
| T115 | 1547-1548 | C0728893 | denotes | - |
| T116 | 1549-1553 | C0332462 | denotes | old |
| T117 | 280-299 | C2323499 | denotes | ematopoietic cells. |
| T118 | 1671-1675 | C0580846 | denotes | ull- |
| T119 | 854-866 | C0333930 | denotes | osinophilic |
| T120 | 754-762 | C2911692 | denotes | esponse |
| T121 | 2092-2108 | C1325605 | denotes | pecific granule |
| T122 | 1676-1680 | C0423866 | denotes | own |
| T123 | 348-356 | C0439178 | denotes | ositive |
| T124 | 453-460 | C1517331 | denotes | urther |
| T125 | 577-585 | C0522505 | denotes | pstream |