> top > docs > PubMed:10430908 > annotations

PubMed:10430908 JSONTXT

Annnotations TAB JSON ListView MergeView

PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.
T2 113-227 Sentence denotes Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis.
T3 228-316 Sentence denotes Many of the effects of CD40 are believed to be achieved through altered gene expression.
T4 317-469 Sentence denotes In addition to Bcl-x, a known CD40-regulated antiapoptotic molecule, we identified a related antiapoptotic molecule, A1/Bfl-1, as a CD40-inducible gene.
T5 470-712 Sentence denotes Inhibition of the NF-kappaB pathway by overexpression of a dominant-active inhibitor of NF-kappaB abolished CD40-induced up-regulation of both the Bfl-1 and Bcl-x genes and also eliminated the ability of CD40 to rescue Fas-induced cell death.
T6 713-866 Sentence denotes Within the upstream promoter region of Bcl-x, a potential NF-kappaB-binding sequence was found to support NF-kappaB-dependent transcriptional activation.
T7 867-1008 Sentence denotes Furthermore, expression of physiological levels of Bcl-x protected B cells from Fas-mediated apoptosis in the absence of NF-kappaB signaling.
T8 1009-1143 Sentence denotes Thus, our results suggest that CD40-mediated cell survival proceeds through NF-kappaB-dependent up-regulation of Bcl-2 family members.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-32 cell_type denotes NF-kappaB-mediated up-regulation
T2 36-41 protein denotes Bcl-x
T3 46-54 protein denotes Bfl-1/A1
T4 71-75 protein denotes CD40
T5 98-111 cell_type denotes B lymphocytes
T6 127-131 protein denotes CD40
T7 204-211 cell_type denotes B cells
T8 251-255 protein denotes CD40
T9 332-337 protein denotes Bcl-x
T10 347-384 protein denotes CD40-regulated antiapoptotic molecule
T11 410-432 protein denotes antiapoptotic molecule
T12 434-442 protein denotes A1/Bfl-1
T13 449-468 DNA denotes CD40-inducible gene
T14 488-497 protein denotes NF-kappaB
T15 558-567 protein denotes NF-kappaB
T16 578-582 protein denotes CD40
T17 617-622 protein denotes Bfl-1
T18 627-632 protein denotes Bcl-x
T19 674-678 protein denotes CD40
T20 689-692 protein denotes Fas
T21 724-748 DNA denotes upstream promoter region
T22 752-757 protein denotes Bcl-x
T23 771-797 DNA denotes NF-kappaB-binding sequence
T24 819-828 protein denotes NF-kappaB
T25 918-941 cell_type denotes Bcl-x protected B cells
T26 988-997 protein denotes NF-kappaB
T27 1040-1044 protein denotes CD40
T28 1085-1094 protein denotes NF-kappaB
T29 1122-1142 protein denotes Bcl-2 family members

genia-medco-coref

Id Subject Object Predicate Lexical cue
C20 918-923 NP denotes Bcl-x
C21 934-941 NP denotes B cells
C23 947-951 NP denotes Fas-
C13 0-10 NP denotes NF-kappaB-
C9 36-41 NP denotes Bcl-x
C11 46-54 NP denotes Bfl-1/A1
C1 98-111 NP denotes B lymphocytes
C3 127-131 NP denotes CD40
C2 204-211 NP denotes B cells
C4 251-255 NP denotes CD40
C10 332-337 NP denotes Bcl-x
C5 347-352 NP denotes CD40-
C7 400-432 NP denotes a related antiapoptotic molecule
C8 434-442 NP denotes A1/Bfl-1
C6 449-454 NP denotes CD40-
C12 558-567 NP denotes NF-kappaB
C14 578-583 NP denotes CD40-
C16 674-678 NP denotes CD40
C22 689-693 NP denotes Fas-
C17 752-757 NP denotes Bcl-x
C18 771-781 NP denotes NF-kappaB-
C19 819-829 NP denotes NF-kappaB-
C24 1040-1045 NP denotes CD40-
C25 1085-1095 NP denotes NF-kappaB-
R1 C2 C1 coref-ident B cells,B lymphocytes
R2 C4 C3 coref-ident CD40,CD40
R3 C10 C9 coref-ident Bcl-x,Bcl-x
R4 C5 C4 coref-ident CD40-,CD40
R5 C7 C11 coref-ident a related antiapoptotic molecule,Bfl-1/A1
R6 C8 C7 coref-appos A1/Bfl-1,a related antiapoptotic molecule
R7 C6 C5 coref-ident CD40-,CD40-
R8 C12 C13 coref-ident NF-kappaB,NF-kappaB-
R9 C14 C6 coref-ident CD40-,CD40-
R10 C16 C14 coref-ident CD40,CD40-
R11 C17 C10 coref-ident Bcl-x,Bcl-x
R12 C18 C12 coref-ident NF-kappaB-,NF-kappaB
R13 C19 C18 coref-ident NF-kappaB-,NF-kappaB-
R14 C20 C17 coref-ident Bcl-x,Bcl-x
R15 C21 C2 coref-ident B cells,B cells
R16 C23 C22 coref-ident Fas-,Fas-
R17 C24 C16 coref-ident CD40-,CD40
R18 C25 C19 coref-ident NF-kappaB-,NF-kappaB-

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-112 Sentence denotes NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.
S2 113-227 Sentence denotes Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis.
S3 228-316 Sentence denotes Many of the effects of CD40 are believed to be achieved through altered gene expression.
S4 317-469 Sentence denotes In addition to Bcl-x, a known CD40-regulated antiapoptotic molecule, we identified a related antiapoptotic molecule, A1/Bfl-1, as a CD40-inducible gene.
S5 470-712 Sentence denotes Inhibition of the NF-kappaB pathway by overexpression of a dominant-active inhibitor of NF-kappaB abolished CD40-induced up-regulation of both the Bfl-1 and Bcl-x genes and also eliminated the ability of CD40 to rescue Fas-induced cell death.
S6 713-866 Sentence denotes Within the upstream promoter region of Bcl-x, a potential NF-kappaB-binding sequence was found to support NF-kappaB-dependent transcriptional activation.
S7 867-1008 Sentence denotes Furthermore, expression of physiological levels of Bcl-x protected B cells from Fas-mediated apoptosis in the absence of NF-kappaB signaling.
S8 1009-1143 Sentence denotes Thus, our results suggest that CD40-mediated cell survival proceeds through NF-kappaB-dependent up-regulation of Bcl-2 family members.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-9 protein_complex denotes NF-kappaB
T2 36-41 protein_molecule denotes Bcl-x
T3 46-54 protein_molecule denotes Bfl-1/A1
T4 71-75 protein_molecule denotes CD40
T5 98-111 cell_type denotes B lymphocytes
T6 127-131 protein_molecule denotes CD40
T7 149-190 other_name denotes thymus-dependent humoral immune responses
T8 204-211 cell_type denotes B cells
T9 217-226 other_name denotes apoptosis
T10 251-255 protein_molecule denotes CD40
T11 300-315 other_name denotes gene expression
T12 332-337 protein_molecule denotes Bcl-x
T13 347-351 protein_molecule denotes CD40
T14 410-432 protein_family_or_group denotes antiapoptotic molecule
T15 434-442 protein_molecule denotes A1/Bfl-1
T16 449-453 protein_molecule denotes CD40
T17 488-497 protein_complex denotes NF-kappaB
T18 558-567 protein_complex denotes NF-kappaB
T19 578-582 protein_molecule denotes CD40
T20 617-622 protein_molecule denotes Bfl-1
T21 627-632 protein_molecule denotes Bcl-x
T22 674-678 protein_molecule denotes CD40
T23 689-692 protein_molecule denotes Fas
T24 724-748 DNA_domain_or_region denotes upstream promoter region
T25 752-757 protein_molecule denotes Bcl-x
T26 771-780 protein_complex denotes NF-kappaB
T27 819-828 protein_complex denotes NF-kappaB
T28 918-923 protein_molecule denotes Bcl-x
T29 934-941 cell_type denotes B cells
T30 960-969 other_name denotes apoptosis
T31 988-997 protein_complex denotes NF-kappaB
T32 1040-1044 protein_molecule denotes CD40
T33 1085-1094 protein_complex denotes NF-kappaB
T34 1122-1142 protein_family_or_group denotes Bcl-2 family members