PubMed:10426278 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue
T1	188-191	protein	denotes	TCR
T2	227-240	protein	denotes	MHC molecules
T3	389-402	protein	denotes	MHC molecules
T4	429-502	cell_line	denotes	CD4+, DQA10501/DQB10201 (DQ2.1)-restricted, HSV-2-specific T cell clone
T5	810-816	cell_type	denotes	T cell
T6	886-892	cell_type	denotes	T cell
T7	903-915	protein	denotes	MHC class II
T8	931-934	cell_type	denotes	APC
T9	954-987	cell_line	denotes	DQ2 homo- and heterozygous B-LCLs
T10	991-995	cell_type	denotes	APCs
T11	1058-1064	cell_type	denotes	T cell
T12	1155-1167	cell_line	denotes	T cell clone
T13	1186-1189	protein	denotes	MHC

Id	Subject	Object	Predicate	Lexical cue
T1	0-11	peptide	denotes	MHC-peptide
T2	69-104	other_name	denotes	antigen-specific T cell recognition
T3	106-141	other_name	denotes	Antigen-specific T cell recognition
T4	188-191	protein_family_or_group	denotes	TCR
T5	227-240	protein_family_or_group	denotes	MHC molecules
T6	247-273	peptide	denotes	specifically bound peptide
T7	343-360	peptide	denotes	exogenous peptide
T8	389-402	protein_family_or_group	denotes	MHC molecules
T9	429-474	cell_line	denotes	CD4+, DQA10501/DQB10201 (DQ2.1)-restricted,
T10	475-480	virus	denotes	HSV-2
T11	510-533	peptide	denotes	antigen peptide analogs
T12	568-587	amino_acid_monomer	denotes	DQ2-anchor residues
T13	589-604	other_name	denotes	T cell response
T14	623-675	other_name	denotes	peptide-affinity and - concentration specific manner
T15	696-719	peptide	denotes	weaker binding peptides
T16	754-761	peptide	denotes	peptide
T17	810-816	cell_type	denotes	T cell
T18	839-862	peptide	denotes	poorest binding peptide
T19	886-892	cell_type	denotes	T cell
T20	903-915	protein_family_or_group	denotes	MHC class II
T21	931-934	cell_type	denotes	APC
T22	991-995	cell_type	denotes	APCs
T23	1058-1064	cell_type	denotes	T cell
T24	1155-1161	cell_type	denotes	T cell
T25	1178-1186	other_name	denotes	peptide-
T26	1186-1189	protein_complex	denotes	MHC
T27	1248-1261	other_name	denotes	ligand signal

Id	Subject	Object	Predicate	Lexical cue
C1	69-104	NP	denotes	antigen-specific T cell recognition
C2	106-141	NP	denotes	Antigen-specific T cell recognition
C3	184-198	NP	denotes	the TCR-ligand
C4	200-205	NP	denotes	which
C5	1151-1167	NP	denotes	the T cell clone
C6	1172-1177	NP	denotes	which
R1	C2	C1	coref-ident	Antigen-specific T cell recognition,antigen-specific T cell recognition
R2	C4	C3	coref-relat	which,the TCR-ligand
R3	C6	C5	coref-relat	which,the T cell clone

Id	Subject	Object	Predicate	Lexical cue
S1	0-105	Sentence	denotes	MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition.
S2	106-274	Sentence	denotes	Antigen-specific T cell recognition is dependent on the functional density of the TCR-ligand, which consists of specific MHC molecules and a specifically bound peptide.
S3	275-503	Sentence	denotes	We have examined the influence of the affinity and concentration of exogenous peptide and the density of specific MHC molecules on the proliferation of a CD4+, DQA10501/DQB10201 (DQ2.1)-restricted, HSV-2-specific T cell clone.
S4	504-676	Sentence	denotes	Using antigen peptide analogs with different mutations of known DQ2-anchor residues, T cell response was reduced in an peptide-affinity and - concentration specific manner.
S5	677-902	Sentence	denotes	The decrease using weaker binding peptides was gradual as stimulation with a peptide with intermediate affinity yielded intermediate T cell proliferation and the poorest binding peptide induced an even weaker T cell response.
S6	903-1079	Sentence	denotes	MHC class II density on the APC was modified using DQ2 homo- and heterozygous B-LCLs as APCs, however this variation of MHC concentration had no effect on T cell proliferation.
S7	1080-1262	Sentence	denotes	We interpret this as a reflection of a low threshold for activation of the T cell clone, in which peptide-MHC avidity is the over-riding determinant of the strength of ligand signal.