PubMed:10425206 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10425206","sourcedb":"PubMed","sourceid":"10425206","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10425206","text":"PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes.\nThe peroxisome-proliferator activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily of ligand activated transcription factors, plays a key role in the anti-diabetic actions of the thiazolidinediones (TZDs). PPARgamma induces the expression of many genes involved in lipid anabolism, including the adipocyte fatty acid binding protein (aP2), and is a key regulator of adipocyte differentiation. PPARgamma is also expressed in hematopoietic cells and is up-regulated in activated monocytes/macrophages. Activation of PPARgamma may play a role in the induction of differentiation of macrophages to foam cells that are associated with atherosclerotic lesions. We report that both natural and synthetic PPARgamma agonists induce time- and dose-dependent increases in aP2 mRNA in both primary human monocytes and the monocytic cell line, THP-1. These data suggest that PPARgamma activation may play a role in monocyte differentiation and function analogous to its well-characterized role in 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