PubMed:10403770 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10403770","sourcedb":"PubMed","sourceid":"10403770","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10403770","text":"ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma.\nICSAT (Interferon Consensus Sequence binding protein for Activated T cells) is a lymphocyte-specific member of the interferon regulatory factor (IRF) family of transcription factors, originally identified through Southwestern screening of the ATL(Adult T-cell leukemia)-16T expression library. In this study, we created transgenic mice overexpressing ICSAT in lymphocytes. Although spontaneous tumorigenesis was not observed, IL-2 production with Concanavalin A stimulation was significantly increased in transgenic mice overexpressing ICSAT. ICSAT overexpression in lymphocytes seems insufficient for the leukemogenesis of ATL or multiple myeloma (MM), however, it may regulate T cell activation and its overexpression may lead to leukemogenesis via controlling IL-2 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