PubMed:10403770 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	351-359	HP_0001909	denotes	leukemia
T2	722-738	HP_0006775	denotes	multiple myeloma

Id	Subject	Object	Predicate	Lexical cue
T1	0-5	protein	denotes	ICSAT
T2	91-96	protein	denotes	ICSAT
T3	98-165	protein	denotes	Interferon Consensus Sequence binding protein for Activated T cells
T4	206-247	protein	denotes	interferon regulatory factor (IRF) family
T5	334-383	DNA	denotes	ATL(Adult T-cell leukemia)-16T expression library
T6	442-447	protein	denotes	ICSAT
T7	451-462	cell_type	denotes	lymphocytes
T8	517-521	protein	denotes	IL-2
T9	627-632	protein	denotes	ICSAT
T10	634-639	protein	denotes	ICSAT
T11	658-669	cell_type	denotes	lymphocytes
T12	854-858	protein	denotes	IL-2

Id	Subject	Object	Predicate	Lexical cue
C1	0-20	NP	denotes	ICSAT overexpression
C2	48-89	NP	denotes	adult T-cell leukemia or multiple myeloma
C3	91-166	NP	denotes	ICSAT (Interferon Consensus Sequence binding protein for Activated T cells)
C4	411-447	NP	denotes	transgenic mice overexpressing ICSAT
C5	451-462	NP	denotes	lymphocytes
C6	596-632	NP	denotes	transgenic mice overexpressing ICSAT
C7	658-669	NP	denotes	lymphocytes
C8	715-743	NP	denotes	ATL or multiple myeloma (MM)
C9	754-756	NP	denotes	it
C11	792-795	NP	denotes	its
C10	792-810	NP	denotes	its overexpression
R1	C6	C4	coref-ident	transgenic mice overexpressing ICSAT,transgenic mice overexpressing ICSAT
R2	C7	C5	coref-ident	lymphocytes,lymphocytes
R3	C8	C2	coref-ident	ATL or multiple myeloma (MM),adult T-cell leukemia or multiple myeloma
R4	C9	C3	coref-pron	it,ICSAT (Interferon Consensus Sequence binding protein for Activated T cells)
R5	C11	C3	coref-pron	its,ICSAT (Interferon Consensus Sequence binding protein for Activated T cells)
R6	C10	C1	coref-ident	its overexpression,ICSAT overexpression

Id	Subject	Object	Predicate	Lexical cue
S1	0-90	Sentence	denotes	ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma.
S2	91-384	Sentence	denotes	ICSAT (Interferon Consensus Sequence binding protein for Activated T cells) is a lymphocyte-specific member of the interferon regulatory factor (IRF) family of transcription factors, originally identified through Southwestern screening of the ATL(Adult T-cell leukemia)-16T expression library.
S3	385-463	Sentence	denotes	In this study, we created transgenic mice overexpressing ICSAT in lymphocytes.
S4	464-633	Sentence	denotes	Although spontaneous tumorigenesis was not observed, IL-2 production with Concanavalin A stimulation was significantly increased in transgenic mice overexpressing ICSAT.
S5	634-870	Sentence	denotes	ICSAT overexpression in lymphocytes seems insufficient for the leukemogenesis of ATL or multiple myeloma (MM), however, it may regulate T cell activation and its overexpression may lead to leukemogenesis via controlling IL-2 production.

Id	Subject	Object	Predicate	Lexical cue
T1	0-5	protein_molecule	denotes	ICSAT
T2	48-69	other_name	denotes	adult T-cell leukemia
T3	73-89	other_name	denotes	multiple myeloma
T4	91-96	protein_molecule	denotes	ICSAT
T5	98-165	protein_molecule	denotes	Interferon Consensus Sequence binding protein for Activated T cells
T6	172-198	other_name	denotes	lymphocyte-specific member
T7	206-247	protein_family_or_group	denotes	interferon regulatory factor (IRF) family
T8	304-326	other_name	denotes	Southwestern screening
T9	334-337	other_name	denotes	ATL
T10	338-359	other_name	denotes	Adult T-cell leukemia
T11	411-426	other_artificial_source	denotes	transgenic mice
T12	442-447	protein_molecule	denotes	ICSAT
T13	451-462	cell_type	denotes	lymphocytes
T14	473-498	other_name	denotes	spontaneous tumorigenesis
T15	517-521	protein_molecule	denotes	IL-2
T16	538-552	other_organic_compound	denotes	Concanavalin A
T17	627-632	protein_molecule	denotes	ICSAT
T18	634-639	protein_molecule	denotes	ICSAT
T19	658-669	cell_type	denotes	lymphocytes
T20	697-711	other_name	denotes	leukemogenesis
T21	715-718	other_name	denotes	ATL
T22	722-738	other_name	denotes	multiple myeloma
T23	740-742	other_name	denotes	MM
T24	796-810	other_name	denotes	overexpression
T25	823-837	other_name	denotes	leukemogenesis
T26	854-858	protein_molecule	denotes	IL-2

Id	Subject	Object	Predicate	Lexical cue
T0	854-858	gene:3558	denotes	IL-2
T1	697-711	disease:C0598766	denotes	leukemogenesis
T2	854-858	gene:3558	denotes	IL-2
T3	722-742	disease:C0026764	denotes	multiple myeloma (MM
T4	854-858	gene:3558	denotes	IL-2
T5	823-837	disease:C0598766	denotes	leukemogenesis
R1	T0	T1	associated_with	IL-2,leukemogenesis
R2	T2	T3	associated_with	IL-2,multiple myeloma (MM
R3	T4	T5	associated_with	IL-2,leukemogenesis