PubMed:10400605 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10400605","sourcedb":"PubMed","sourceid":"10400605","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10400605","text":"Biochemical and genetic evidence for participation of DevR in a phosphorelay signal transduction pathway essential for heterocyst maturation in Nostoc punctiforme ATCC 29133.\nIn a test of the hypothesis that DevR is a response regulator protein that functions in a phosphorelay signal transduction system involved in heterocyst development in Nostoc punctiforme ATCC 29133, purified affinity-tagged DevR was shown to be phosphorylated in vitro by the noncognate sensor kinase EnvZ. Site-directed mutagenesis was used to generate N. punctiforme mutants with single amino acid substitutions at the putative phosphorylation site of DevR. These mutants exhibited a Fox- phenotype like the original devR insertion mutant UCD 311, consistent with a phosphotransferase role for DevR.","tracks":[{"project":"CyanoBase","denotations":[{"id":"T1","span":{"begin":54,"end":58},"obj":"protein"},{"id":"T2","span":{"begin":208,"end":212},"obj":"protein"},{"id":"T3","span":{"begin":399,"end":403},"obj":"protein"},{"id":"T4","span":{"begin":629,"end":633},"obj":"protein"},{"id":"T5","span":{"begin":694,"end":698},"obj":"protein"},{"id":"T6","span":{"begin":771,"end":775},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"CyanoBase"},{"subj":"T2","pred":"source","obj":"CyanoBase"},{"subj":"T3","pred":"source","obj":"CyanoBase"},{"subj":"T4","pred":"source","obj":"CyanoBase"},{"subj":"T5","pred":"source","obj":"CyanoBase"},{"subj":"T6","pred":"source","obj":"CyanoBase"}]},{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":716,"end":719},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0004739"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"CyanoBase","color":"#ecd193","default":true},{"id":"PMID_GLOBAL","color":"#b793ec"}]}]}}