PubMed:10395671 JSONTXT

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    jnlpba-st-training

    {"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":18,"end":32},"obj":"protein"},{"id":"T2","span":{"begin":32,"end":39},"obj":"protein"},{"id":"T3","span":{"begin":54,"end":58},"obj":"protein"},{"id":"T4","span":{"begin":73,"end":88},"obj":"cell_type"},{"id":"T5","span":{"begin":100,"end":115},"obj":"cell_type"},{"id":"T6","span":{"begin":117,"end":121},"obj":"protein"},{"id":"T7","span":{"begin":121,"end":126},"obj":"protein"},{"id":"T8","span":{"begin":190,"end":203},"obj":"cell_type"},{"id":"T9","span":{"begin":205,"end":214},"obj":"cell_type"},{"id":"T10","span":{"begin":220,"end":235},"obj":"cell_type"},{"id":"T11","span":{"begin":302,"end":315},"obj":"protein"},{"id":"T12","span":{"begin":344,"end":356},"obj":"cell_line"},{"id":"T13","span":{"begin":404,"end":408},"obj":"protein"},{"id":"T14","span":{"begin":424,"end":433},"obj":"cell_type"},{"id":"T15","span":{"begin":438,"end":463},"obj":"cell_line"},{"id":"T16","span":{"begin":491,"end":495},"obj":"protein"},{"id":"T17","span":{"begin":523,"end":538},"obj":"cell_type"},{"id":"T18","span":{"begin":543,"end":558},"obj":"cell_type"},{"id":"T19","span":{"begin":566,"end":570},"obj":"protein"},{"id":"T20","span":{"begin":611,"end":620},"obj":"protein"},{"id":"T21","span":{"begin":637,"end":641},"obj":"protein"},{"id":"T22","span":{"begin":643,"end":671},"obj":"protein"},{"id":"T23","span":{"begin":739,"end":758},"obj":"protein"},{"id":"T24","span":{"begin":777,"end":786},"obj":"cell_type"},{"id":"T25","span":{"begin":808,"end":811},"obj":"protein"},{"id":"T26","span":{"begin":827,"end":844},"obj":"protein"},{"id":"T27","span":{"begin":856,"end":860},"obj":"protein"},{"id":"T28","span":{"begin":880,"end":889},"obj":"cell_type"},{"id":"T29","span":{"begin":894,"end":901},"obj":"cell_type"},{"id":"T30","span":{"begin":911,"end":914},"obj":"protein"},{"id":"T31","span":{"begin":935,"end":942},"obj":"cell_type"},{"id":"T32","span":{"begin":970,"end":1000},"obj":"protein"},{"id":"T33","span":{"begin":1021,"end":1025},"obj":"protein"},{"id":"T34","span":{"begin":1044,"end":1053},"obj":"cell_type"},{"id":"T35","span":{"begin":1058,"end":1073},"obj":"cell_type"},{"id":"T36","span":{"begin":1075,"end":1089},"obj":"protein"},{"id":"T37","span":{"begin":1137,"end":1161},"obj":"cell_line"},{"id":"T38","span":{"begin":1192,"end":1198},"obj":"protein"},{"id":"T39","span":{"begin":1289,"end":1302},"obj":"cell_type"},{"id":"T40","span":{"begin":1307,"end":1316},"obj":"cell_type"},{"id":"T41","span":{"begin":1334,"end":1338},"obj":"protein"},{"id":"T42","span":{"begin":1412,"end":1416},"obj":"protein"},{"id":"T43","span":{"begin":1462,"end":1466},"obj":"protein"},{"id":"T44","span":{"begin":1481,"end":1484},"obj":"protein"},{"id":"T45","span":{"begin":1514,"end":1518},"obj":"protein"}],"text":"Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.\nCD40/CD40 ligand interactions play a key role in the immune responses of B lymphocytes, monocytes, and dendritic cells. The signal transduction events triggered by cross-linking of the CD40 receptor have been widely studied in B cell lines, but little is known about signaling following CD40 stimulation of monocytes and resting tonsillar B cells. Therefore, we studied the CD40 pathway in highly purified human monocytes and resting B cells. After CD40 triggering, a similar activation of the NF-kappaB (but not of the AP-1) transcription factor complex occurred in both cell preparations. However, the components of the NF-kappaB complexes were different in monocytes and B cells, because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells, whereas p65 was only induced in B cells. In contrast, although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells, Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes, with subsequent induction of STAT5a DNA binding activity in the nucleus. These results suggest that the activation signals in human B cells and monocytes differ following CD40 stimulation. This observation is consistent with the detection of normal CD40-induced monocyte activation in patients with CD40 ligand+ hyper IgM syndrome in whom a defect in CD40-induced B cell activation has been reported."}

    genia-medco-coref

    {"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":73,"end":88},"obj":"NP"},{"id":"C2","span":{"begin":100,"end":115},"obj":"NP"},{"id":"C3","span":{"begin":190,"end":203},"obj":"NP"},{"id":"C4","span":{"begin":205,"end":214},"obj":"NP"},{"id":"C6","span":{"begin":424,"end":433},"obj":"NP"},{"id":"C7","span":{"begin":438,"end":463},"obj":"NP"},{"id":"C5","span":{"begin":424,"end":463},"obj":"NP"},{"id":"C8","span":{"begin":735,"end":758},"obj":"NP"},{"id":"C10","span":{"begin":777,"end":786},"obj":"NP"},{"id":"C11","span":{"begin":791,"end":798},"obj":"NP"},{"id":"C9","span":{"begin":777,"end":798},"obj":"NP"},{"id":"C12","span":{"begin":823,"end":844},"obj":"NP"},{"id":"C13","span":{"begin":875,"end":901},"obj":"NP"},{"id":"C14","span":{"begin":935,"end":942},"obj":"NP"},{"id":"C15","span":{"begin":1039,"end":1073},"obj":"NP"},{"id":"C16","span":{"begin":1289,"end":1316},"obj":"NP"},{"id":"C17","span":{"begin":1448,"end":1493},"obj":"NP"},{"id":"C18","span":{"begin":1497,"end":1501},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C6","obj":"C4"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C10","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C11","obj":"C3"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C8"},{"id":"R7","pred":"coref-ident","subj":"C13","obj":"C9"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C11"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C5"},{"id":"R10","pred":"coref-ident","subj":"C16","obj":"C13"},{"id":"R11","pred":"coref-relat","subj":"C18","obj":"C17"}],"text":"Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.\nCD40/CD40 ligand interactions play a key role in the immune responses of B lymphocytes, monocytes, and dendritic cells. The signal transduction events triggered by cross-linking of the CD40 receptor have been widely studied in B cell lines, but little is known about signaling following CD40 stimulation of monocytes and resting tonsillar B cells. Therefore, we studied the CD40 pathway in highly purified human monocytes and resting B cells. After CD40 triggering, a similar activation of the NF-kappaB (but not of the AP-1) transcription factor complex occurred in both cell preparations. However, the components of the NF-kappaB complexes were different in monocytes and B cells, because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells, whereas p65 was only induced in B cells. In contrast, although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells, Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes, with subsequent induction of STAT5a DNA binding activity in the nucleus. These results suggest that the activation signals in human B cells and monocytes differ following CD40 stimulation. This observation is consistent with the detection of normal CD40-induced monocyte activation in patients with CD40 ligand+ hyper IgM syndrome in whom a defect in CD40-induced B cell activation has been reported."}

    pubmed-sentences-benchmark

    {"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"S2","span":{"begin":117,"end":236},"obj":"Sentence"},{"id":"S3","span":{"begin":237,"end":464},"obj":"Sentence"},{"id":"S4","span":{"begin":465,"end":559},"obj":"Sentence"},{"id":"S5","span":{"begin":560,"end":707},"obj":"Sentence"},{"id":"S6","span":{"begin":708,"end":943},"obj":"Sentence"},{"id":"S7","span":{"begin":944,"end":1235},"obj":"Sentence"},{"id":"S8","span":{"begin":1236,"end":1351},"obj":"Sentence"},{"id":"S9","span":{"begin":1352,"end":1563},"obj":"Sentence"}],"text":"Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.\nCD40/CD40 ligand interactions play a key role in the immune responses of B lymphocytes, monocytes, and dendritic cells. The signal transduction events triggered by cross-linking of the CD40 receptor have been widely studied in B cell lines, but little is known about signaling following CD40 stimulation of monocytes and resting tonsillar B cells. Therefore, we studied the CD40 pathway in highly purified human monocytes and resting B cells. After CD40 triggering, a similar activation of the NF-kappaB (but not of the AP-1) transcription factor complex occurred in both cell preparations. However, the components of the NF-kappaB complexes were different in monocytes and B cells, because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells, whereas p65 was only induced in B cells. In contrast, although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells, Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes, with subsequent induction of STAT5a DNA binding activity in the nucleus. These results suggest that the activation signals in human B cells and monocytes differ following CD40 stimulation. This observation is consistent with the detection of normal CD40-induced monocyte activation in patients with CD40 ligand+ hyper IgM syndrome in whom a defect in CD40-induced B cell activation has been reported."}

    GENIAcorpus

    {"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":18,"end":32},"obj":"protein_molecule"},{"id":"T2","span":{"begin":32,"end":39},"obj":"protein_molecule"},{"id":"T3","span":{"begin":54,"end":58},"obj":"protein_molecule"},{"id":"T4","span":{"begin":73,"end":88},"obj":"cell_type"},{"id":"T5","span":{"begin":100,"end":115},"obj":"cell_type"},{"id":"T6","span":{"begin":117,"end":121},"obj":"protein_molecule"},{"id":"T7","span":{"begin":121,"end":126},"obj":"protein_molecule"},{"id":"T8","span":{"begin":170,"end":186},"obj":"other_name"},{"id":"T9","span":{"begin":190,"end":203},"obj":"cell_type"},{"id":"T10","span":{"begin":205,"end":214},"obj":"cell_type"},{"id":"T11","span":{"begin":220,"end":235},"obj":"cell_type"},{"id":"T12","span":{"begin":241,"end":267},"obj":"other_name"},{"id":"T13","span":{"begin":302,"end":306},"obj":"protein_molecule"},{"id":"T14","span":{"begin":344,"end":356},"obj":"cell_line"},{"id":"T15","span":{"begin":404,"end":408},"obj":"protein_molecule"},{"id":"T16","span":{"begin":424,"end":433},"obj":"cell_type"},{"id":"T17","span":{"begin":438,"end":463},"obj":"cell_line"},{"id":"T18","span":{"begin":491,"end":495},"obj":"protein_molecule"},{"id":"T19","span":{"begin":523,"end":538},"obj":"cell_type"},{"id":"T20","span":{"begin":543,"end":558},"obj":"cell_type"},{"id":"T21","span":{"begin":566,"end":570},"obj":"protein_molecule"},{"id":"T22","span":{"begin":611,"end":620},"obj":"protein_complex"},{"id":"T23","span":{"begin":637,"end":641},"obj":"protein_complex"},{"id":"T24","span":{"begin":643,"end":671},"obj":"protein_complex"},{"id":"T25","span":{"begin":739,"end":748},"obj":"protein_complex"},{"id":"T26","span":{"begin":777,"end":786},"obj":"cell_type"},{"id":"T27","span":{"begin":808,"end":811},"obj":"protein_subunit"},{"id":"T28","span":{"begin":827,"end":836},"obj":"protein_complex"},{"id":"T29","span":{"begin":856,"end":860},"obj":"protein_molecule"},{"id":"T30","span":{"begin":880,"end":889},"obj":"cell_type"},{"id":"T31","span":{"begin":894,"end":901},"obj":"cell_type"},{"id":"T32","span":{"begin":911,"end":914},"obj":"protein_subunit"},{"id":"T33","span":{"begin":935,"end":942},"obj":"cell_type"},{"id":"T34","span":{"begin":970,"end":984},"obj":"protein_molecule"},{"id":"T35","span":{"begin":985,"end":993},"obj":"amino_acid_monomer"},{"id":"T36","span":{"begin":1021,"end":1025},"obj":"protein_molecule"},{"id":"T37","span":{"begin":1044,"end":1053},"obj":"cell_type"},{"id":"T38","span":{"begin":1058,"end":1073},"obj":"cell_type"},{"id":"T39","span":{"begin":1075,"end":1089},"obj":"protein_molecule"},{"id":"T40","span":{"begin":1137,"end":1141},"obj":"protein_molecule"},{"id":"T41","span":{"begin":1192,"end":1198},"obj":"protein_molecule"},{"id":"T42","span":{"begin":1227,"end":1234},"obj":"cell_component"},{"id":"T43","span":{"begin":1289,"end":1302},"obj":"cell_type"},{"id":"T44","span":{"begin":1307,"end":1316},"obj":"cell_type"},{"id":"T45","span":{"begin":1334,"end":1338},"obj":"protein_molecule"},{"id":"T46","span":{"begin":1405,"end":1411},"obj":"other_name"},{"id":"T47","span":{"begin":1412,"end":1416},"obj":"protein_molecule"},{"id":"T48","span":{"begin":1448,"end":1456},"obj":"multi_cell"},{"id":"T49","span":{"begin":1462,"end":1466},"obj":"protein_molecule"},{"id":"T50","span":{"begin":1481,"end":1484},"obj":"protein_family_or_group"},{"id":"T51","span":{"begin":1514,"end":1518},"obj":"protein_molecule"}],"text":"Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.\nCD40/CD40 ligand interactions play a key role in the immune responses of B lymphocytes, monocytes, and dendritic cells. The signal transduction events triggered by cross-linking of the CD40 receptor have been widely studied in B cell lines, but little is known about signaling following CD40 stimulation of monocytes and resting tonsillar B cells. Therefore, we studied the CD40 pathway in highly purified human monocytes and resting B cells. After CD40 triggering, a similar activation of the NF-kappaB (but not of the AP-1) transcription factor complex occurred in both cell preparations. However, the components of the NF-kappaB complexes were different in monocytes and B cells, because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells, whereas p65 was only induced in B cells. In contrast, although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells, Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes, with subsequent induction of STAT5a DNA binding activity in the nucleus. These results suggest that the activation signals in human B cells and monocytes differ following CD40 stimulation. This observation is consistent with the detection of normal CD40-induced monocyte activation in patients with CD40 ligand+ hyper IgM syndrome in whom a defect in CD40-induced B cell activation has been reported."}