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PubMed:10395671 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-32 protein denotes Janus kinase 3
T2 32-39 protein denotes -STAT5a
T3 54-58 protein denotes CD40
T4 73-88 cell_type denotes human monocytes
T5 100-115 cell_type denotes resting B cells
T6 117-121 protein denotes CD40
T7 121-126 protein denotes /CD40
T8 190-203 cell_type denotes B lymphocytes
T9 205-214 cell_type denotes monocytes
T10 220-235 cell_type denotes dendritic cells
T11 302-315 protein denotes CD40 receptor
T12 344-356 cell_line denotes B cell lines
T13 404-408 protein denotes CD40
T14 424-433 cell_type denotes monocytes
T15 438-463 cell_line denotes resting tonsillar B cells
T16 491-495 protein denotes CD40
T17 523-538 cell_type denotes human monocytes
T18 543-558 cell_type denotes resting B cells
T19 566-570 protein denotes CD40
T20 611-620 protein denotes NF-kappaB
T21 637-641 protein denotes AP-1
T22 643-671 protein denotes transcription factor complex
T23 739-758 protein denotes NF-kappaB complexes
T24 777-786 cell_type denotes monocytes
T25 808-811 protein denotes p50
T26 827-844 protein denotes NF-kappaB complex
T27 856-860 protein denotes CD40
T28 880-889 cell_type denotes monocytes
T29 894-901 cell_type denotes B cells
T30 911-914 protein denotes p65
T31 935-942 cell_type denotes B cells
T32 970-1000 protein denotes Janus kinase 3 tyrosine kinase
T33 1021-1025 protein denotes CD40
T34 1044-1053 cell_type denotes monocytes
T35 1058-1073 cell_type denotes resting B cells
T36 1075-1089 protein denotes Janus kinase 3
T37 1137-1161 cell_line denotes CD40-activated monocytes
T38 1192-1198 protein denotes STAT5a
T39 1289-1302 cell_type denotes human B cells
T40 1307-1316 cell_type denotes monocytes
T41 1334-1338 protein denotes CD40
T42 1412-1416 protein denotes CD40
T43 1462-1466 protein denotes CD40
T44 1481-1484 protein denotes IgM
T45 1514-1518 protein denotes CD40

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 73-88 NP denotes human monocytes
C2 100-115 NP denotes resting B cells
C3 190-203 NP denotes B lymphocytes
C4 205-214 NP denotes monocytes
C6 424-433 NP denotes monocytes
C7 438-463 NP denotes resting tonsillar B cells
C5 424-463 NP denotes monocytes and resting tonsillar B cells
C8 735-758 NP denotes the NF-kappaB complexes
C10 777-786 NP denotes monocytes
C11 791-798 NP denotes B cells
C9 777-798 NP denotes monocytes and B cells
C12 823-844 NP denotes the NF-kappaB complex
C13 875-901 NP denotes both monocytes and B cells
C14 935-942 NP denotes B cells
C15 1039-1073 NP denotes both monocytes and resting B cells
C16 1289-1316 NP denotes human B cells and monocytes
C17 1448-1493 NP denotes patients with CD40 ligand+ hyper IgM syndrome
C18 1497-1501 NP denotes whom
R1 C4 C1 coref-ident monocytes,human monocytes
R2 C6 C4 coref-ident monocytes,monocytes
R3 C7 C2 coref-ident resting tonsillar B cells,resting B cells
R4 C10 C6 coref-ident monocytes,monocytes
R5 C11 C3 coref-ident B cells,B lymphocytes
R6 C12 C8 coref-ident the NF-kappaB complex,the NF-kappaB complexes
R7 C13 C9 coref-ident both monocytes and B cells,monocytes and B cells
R8 C14 C11 coref-ident B cells,B cells
R9 C15 C5 coref-ident both monocytes and resting B cells,monocytes and resting tonsillar B cells
R10 C16 C13 coref-ident human B cells and monocytes,both monocytes and B cells
R11 C18 C17 coref-relat whom,patients with CD40 ligand+ hyper IgM syndrome

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-116 Sentence denotes Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.
S2 117-236 Sentence denotes CD40/CD40 ligand interactions play a key role in the immune responses of B lymphocytes, monocytes, and dendritic cells.
S3 237-464 Sentence denotes The signal transduction events triggered by cross-linking of the CD40 receptor have been widely studied in B cell lines, but little is known about signaling following CD40 stimulation of monocytes and resting tonsillar B cells.
S4 465-559 Sentence denotes Therefore, we studied the CD40 pathway in highly purified human monocytes and resting B cells.
S5 560-707 Sentence denotes After CD40 triggering, a similar activation of the NF-kappaB (but not of the AP-1) transcription factor complex occurred in both cell preparations.
S6 708-943 Sentence denotes However, the components of the NF-kappaB complexes were different in monocytes and B cells, because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells, whereas p65 was only induced in B cells.
S7 944-1235 Sentence denotes In contrast, although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells, Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes, with subsequent induction of STAT5a DNA binding activity in the nucleus.
S8 1236-1351 Sentence denotes These results suggest that the activation signals in human B cells and monocytes differ following CD40 stimulation.
S9 1352-1563 Sentence denotes This observation is consistent with the detection of normal CD40-induced monocyte activation in patients with CD40 ligand+ hyper IgM syndrome in whom a defect in CD40-induced B cell activation has been reported.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-32 protein_molecule denotes Janus kinase 3
T2 32-39 protein_molecule denotes -STAT5a
T3 54-58 protein_molecule denotes CD40
T4 73-88 cell_type denotes human monocytes
T5 100-115 cell_type denotes resting B cells
T6 117-121 protein_molecule denotes CD40
T7 121-126 protein_molecule denotes /CD40
T8 170-186 other_name denotes immune responses
T9 190-203 cell_type denotes B lymphocytes
T10 205-214 cell_type denotes monocytes
T11 220-235 cell_type denotes dendritic cells
T12 241-267 other_name denotes signal transduction events
T13 302-306 protein_molecule denotes CD40
T14 344-356 cell_line denotes B cell lines
T15 404-408 protein_molecule denotes CD40
T16 424-433 cell_type denotes monocytes
T17 438-463 cell_line denotes resting tonsillar B cells
T18 491-495 protein_molecule denotes CD40
T19 523-538 cell_type denotes human monocytes
T20 543-558 cell_type denotes resting B cells
T21 566-570 protein_molecule denotes CD40
T22 611-620 protein_complex denotes NF-kappaB
T23 637-641 protein_complex denotes AP-1
T24 643-671 protein_complex denotes transcription factor complex
T25 739-748 protein_complex denotes NF-kappaB
T26 777-786 cell_type denotes monocytes
T27 808-811 protein_subunit denotes p50
T28 827-836 protein_complex denotes NF-kappaB
T29 856-860 protein_molecule denotes CD40
T30 880-889 cell_type denotes monocytes
T31 894-901 cell_type denotes B cells
T32 911-914 protein_subunit denotes p65
T33 935-942 cell_type denotes B cells
T34 970-984 protein_molecule denotes Janus kinase 3
T35 985-993 amino_acid_monomer denotes tyrosine
T36 1021-1025 protein_molecule denotes CD40
T37 1044-1053 cell_type denotes monocytes
T38 1058-1073 cell_type denotes resting B cells
T39 1075-1089 protein_molecule denotes Janus kinase 3
T40 1137-1141 protein_molecule denotes CD40
T41 1192-1198 protein_molecule denotes STAT5a
T42 1227-1234 cell_component denotes nucleus
T43 1289-1302 cell_type denotes human B cells
T44 1307-1316 cell_type denotes monocytes
T45 1334-1338 protein_molecule denotes CD40
T46 1405-1411 other_name denotes normal
T47 1412-1416 protein_molecule denotes CD40
T48 1448-1456 multi_cell denotes patients
T49 1462-1466 protein_molecule denotes CD40
T50 1481-1484 protein_family_or_group denotes IgM
T51 1514-1518 protein_molecule denotes CD40